| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lina Y Dimberg, Anna Dimberg, Karolina Ivarsson, Mårten Fryknäs, Linda Rickardson, Gerard Tobin, Simon Ekman, Rolf Larsson, Urban Gullberg, Kenneth Nilsson, Fredrik Öberg, Helena Jernberg Wiklun. Stat1 activation attenuates IL-6 induced Stat3 activity but does not alter apoptosis sensitivity in multiple myeloma. BMC cancer. vol 12. 2013-06-17. PMID:22838736. |
conversely, il-6 induction of stat3 is known to confer resistance to apoptosis in mm. |
2013-06-17 |
2023-08-12 |
Not clear |
| Sebastian Michels, Marcel Trautmann, Elisabeth Sievers, Dagmar Kindler, Sebastian Huss, Marcus Renner, Nicolaus Friedrichs, Jutta Kirfel, Susanne Steiner, Elmar Endl, Peter Wurst, Lukas Heukamp, Roland Penzel, Olle Larsson, Akira Kawai, Shinya Tanaka, Hiroshi Sonobe, Peter Schirmacher, Gunhild Mechtersheimer, Eva Wardelmann, Reinhard Büttner, Wolfgang Hartman. SRC signaling is crucial in the growth of synovial sarcoma cells. Cancer research. vol 73. issue 8. 2013-06-12. PMID:23580575. |
treatment of synovial sarcoma cells with dasatinib led to apoptosis and inhibition of cellular proliferation, associated with reduced phosphorylation of fak (ptk2), stat3, igf-ir, and akt. |
2013-06-12 |
2023-08-12 |
mouse |
| L Liu, W Li, X Wei, Q Cui, W Lou, G Wang, X Hu, C Qia. Potent antitumor activity of oncolytic adenovirus-mediated SOCS1 for hepatocellular carcinoma. Gene therapy. vol 20. issue 1. 2013-06-11. PMID:22318090. |
signal transducer and activator of transcription 3 (stat3) is constitutively activated in diverse cancers, which contributes to the proliferation and survival of cancer cells by upregulating apoptosis inhibitors and cell cycle regulators. |
2013-06-11 |
2023-08-12 |
Not clear |
| Q Li, X H Yang, F Xu, C Sharma, H-X Wang, K Knoblich, I Rabinovitz, S R Granter, M E Hemle. Tetraspanin CD151 plays a key role in skin squamous cell carcinoma. Oncogene. vol 32. issue 14. 2013-05-23. PMID:22824799. |
cd151 support of keratinocyte survival and proliferation may depend on activation of transcription factor stat3 (signal transducers and activators of transcription), a regulator of cell proliferation and apoptosis. |
2013-05-23 |
2023-08-12 |
mouse |
| Jin Fu, Dan Chen, Bo Zhao, Zhihui Zhao, Jiahong Zhou, Yimiao Xu, Yinqiang Xin, Chang Liu, Lan Luo, Zhimin Yi. Luteolin induces carcinoma cell apoptosis through binding Hsp90 to suppress constitutive activation of STAT3. PloS one. vol 7. issue 11. 2013-05-23. PMID:23145121. |
luteolin induces carcinoma cell apoptosis through binding hsp90 to suppress constitutive activation of stat3. |
2013-05-23 |
2023-08-12 |
human |
| Juncheng Wei, Yanzhi Yuan, Chaozhi Jin, Hui Chen, Ling Leng, Fuchu He, Jian Wan. The ubiquitin ligase TRAF6 negatively regulates the JAK-STAT signaling pathway by binding to STAT3 and mediating its ubiquitination. PloS one. vol 7. issue 11. 2013-05-22. PMID:23185365. |
stat3 is a key transcription factor that mediates various cellular and organismal processes, such as cell growth, apoptosis, immune response and cancer. |
2013-05-22 |
2023-08-12 |
Not clear |
| Chi-Keung Wan, Jangsuk Oh, Peng Li, Erin E West, Elizabeth A Wong, Allison B Andraski, Rosanne Spolski, Zu-Xi Yu, Jianping He, Brian L Kelsall, Warren J Leonar. The cytokines IL-21 and GM-CSF have opposing regulatory roles in the apoptosis of conventional dendritic cells. Immunity. vol 38. issue 3. 2013-05-17. PMID:23453633. |
here we show that il-21 induced apoptosis of conventional dendritic cells (cdcs) via stat3 and bim, and this was inhibited by granulocyte-macrophage colony-stimulating factor (gm-csf). |
2013-05-17 |
2023-08-12 |
mouse |
| Shreeram C Nallar, Sudhakar Kalakonda, Daniel J Lindner, Robert R Lorenz, Eric Lamarre, Xiao Weihua, Dhananjaya V Kalvakolan. Tumor-derived mutations in the gene associated with retinoid interferon-induced mortality (GRIM-19) disrupt its anti-signal transducer and activator of transcription 3 (STAT3) activity and promote oncogenesis. The Journal of biological chemistry. vol 288. issue 11. 2013-05-14. PMID:23386605. |
constitutive activation of stat3 imparts resistance to apoptosis, promotes cell proliferation, and induces de novo micro-angiogenesis, three of the six cardinal hallmarks of a typical cancer cell. |
2013-05-14 |
2023-08-12 |
human |
| Bora Oh, Tae Y Kim, Hyun J Min, Miyoung Kim, Myung S Kang, Ji Y Huh, Youngsoo Kim, Dong S Le. Synergistic killing effect of imatinib and simvastatin on imatinib-resistant chronic myelogenous leukemia cells. Anti-cancer drugs. vol 24. issue 1. 2013-05-09. PMID:23075630. |
mechanisms of killing were an induction of apoptosis and cell cycle arrest, through inhibition of tyrosine phosphorylation, and activated stat5 and stat3. |
2013-05-09 |
2023-08-12 |
mouse |
| Joana P Couto, Ana Almeida, Laura Daly, Manuel Sobrinho-Simões, Jacqueline F Bromberg, Paula Soare. AZD1480 blocks growth and tumorigenesis of RET- activated thyroid cancer cell lines. PloS one. vol 7. issue 10. 2013-05-07. PMID:23056499. |
this inhibitor led to growth inhibition and/or apoptosis of the thyroid cancer cell lines in vitro, as well as to tumor regression of tpc-1 xenografts, where it efficiently blocked stat3 activation in tumor and stromal cells. |
2013-05-07 |
2023-08-12 |
Not clear |
| Aiguo Liu, Yan Liu, Zhigang Jin, Qun Hu, Li Lin, David Jou, Jing Yang, Zhenghu Xu, Hong Wang, Chenglong Li, Jiayuh Li. XZH-5 inhibits STAT3 phosphorylation and enhances the cytotoxicity of chemotherapeutic drugs in human breast and pancreatic cancer cells. PloS one. vol 7. issue 10. 2013-05-03. PMID:23056374. |
xzh-5 was found to inhibit stat3 phosphorylation (tyr705) and induce apoptosis in human breast and pancreatic cancer cell lines expressing elevated levels of phosphorylated stat3. |
2013-05-03 |
2023-08-12 |
human |
| Maximilian J Waldner, Sebastian Foersch, Markus F Neurat. Interleukin-6--a key regulator of colorectal cancer development. International journal of biological sciences. vol 8. issue 9. 2013-04-29. PMID:23136553. |
according to experimental studies, these effects are mediated through il-6 trans-signaling promoting tumor cell proliferation and inhibiting apoptosis through gp130 activation on tumor cells with subsequent signaling through janus kinases (jaks) and signal transducer and activator of transcription 3 (stat3). |
2013-04-29 |
2023-08-12 |
Not clear |
| Chulwon Kim, Moo-Chang Kim, Sung-Moo Kim, Dongwoo Nam, Seung-Hoon Choi, Sung-Hoon Kim, Kyoo Seok Ahn, Eun Ha Lee, Sang Hoon Jung, Kwang Seok Ah. Chrysanthemum indicum L. extract induces apoptosis through suppression of constitutive STAT3 activation in human prostate cancer DU145 cells. Phytotherapy research : PTR. vol 27. issue 1. 2013-04-26. PMID:22438130. |
chrysanthemum indicum l. extract induces apoptosis through suppression of constitutive stat3 activation in human prostate cancer du145 cells. |
2013-04-26 |
2023-08-12 |
human |
| Chulwon Kim, Moo-Chang Kim, Sung-Moo Kim, Dongwoo Nam, Seung-Hoon Choi, Sung-Hoon Kim, Kyoo Seok Ahn, Eun Ha Lee, Sang Hoon Jung, Kwang Seok Ah. Chrysanthemum indicum L. extract induces apoptosis through suppression of constitutive STAT3 activation in human prostate cancer DU145 cells. Phytotherapy research : PTR. vol 27. issue 1. 2013-04-26. PMID:22438130. |
sudachitin, chrysoeriol, and acacetin also exerted significantly cytotoxicity, clearly suppressed constitutive stat3 activation, and induced apoptosis, although hesperetin did not show any significant effect in du145 cells. |
2013-04-26 |
2023-08-12 |
human |
| Chulwon Kim, Moo-Chang Kim, Sung-Moo Kim, Dongwoo Nam, Seung-Hoon Choi, Sung-Hoon Kim, Kyoo Seok Ahn, Eun Ha Lee, Sang Hoon Jung, Kwang Seok Ah. Chrysanthemum indicum L. extract induces apoptosis through suppression of constitutive STAT3 activation in human prostate cancer DU145 cells. Phytotherapy research : PTR. vol 27. issue 1. 2013-04-26. PMID:22438130. |
overall, our results demonstrate that mci could induce apoptosis through inhibition of the jak1/2 and stat3 signaling pathways. |
2013-04-26 |
2023-08-12 |
human |
| Zhipeng Wang, Shaojun Zhu, Min Shen, Juanjuan Liu, Meng Wang, Chen Li, Yukun Wang, Anmei Deng, Qibing Me. STAT3 is involved in esophageal carcinogenesis through regulation of Oct-1. Carcinogenesis. vol 34. issue 3. 2013-04-19. PMID:23172665. |
the transcription factor signal transducer and activator of transcription 3 (stat3) contributes to cell proliferation, apoptosis and motility in human cancer cells. |
2013-04-19 |
2023-08-12 |
human |
| Zhipeng Wang, Shaojun Zhu, Min Shen, Juanjuan Liu, Meng Wang, Chen Li, Yukun Wang, Anmei Deng, Qibing Me. STAT3 is involved in esophageal carcinogenesis through regulation of Oct-1. Carcinogenesis. vol 34. issue 3. 2013-04-19. PMID:23172665. |
in conjunction with oct-1, stat3 inhibited apoptosis in esophageal squamous cell carcinoma cells. |
2013-04-19 |
2023-08-12 |
human |
| Zhipeng Wang, Shaojun Zhu, Min Shen, Juanjuan Liu, Meng Wang, Chen Li, Yukun Wang, Anmei Deng, Qibing Me. STAT3 is involved in esophageal carcinogenesis through regulation of Oct-1. Carcinogenesis. vol 34. issue 3. 2013-04-19. PMID:23172665. |
constitutively activated stat3 in normal human esophageal epithelium cells (het-1a) elevated oct-1 expression,and promoted proliferation and decreased apoptosis. |
2013-04-19 |
2023-08-12 |
human |
| Zhipeng Wang, Shaojun Zhu, Min Shen, Juanjuan Liu, Meng Wang, Chen Li, Yukun Wang, Anmei Deng, Qibing Me. STAT3 is involved in esophageal carcinogenesis through regulation of Oct-1. Carcinogenesis. vol 34. issue 3. 2013-04-19. PMID:23172665. |
together, our results indicate that stat3 plays a crucial role in esophageal carcinogenesis by regulating the cell proliferation and apoptosis in conjunction with oct-1. |
2013-04-19 |
2023-08-12 |
human |
| Craig M Nelson, Ryne A Gorsuch, Travis J Bailey, Kristin M Ackerman, Sean C Kassen, David R Hyd. Stat3 defines three populations of Müller glia and is required for initiating maximal müller glia proliferation in the regenerating zebrafish retina. The Journal of comparative neurology. vol 520. issue 18. 2013-04-18. PMID:22886421. |
immunohistochemical analysis was employed to determine the temporal and spatial expression of stat3 and ascl1a proteins following rod and cone photoreceptor cell apoptosis. |
2013-04-18 |
2023-08-12 |
zebrafish |