| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chao-Yuan Huang, Chen-Si Lin, Wei-Tien Tai, Chi-Ying Hsieh, Chung-Wai Shiau, Ann-Lii Cheng, Kuen-Feng Che. Sorafenib enhances radiation-induced apoptosis in hepatocellular carcinoma by inhibiting STAT3. International journal of radiation oncology, biology, physics. vol 86. issue 3. 2013-07-25. PMID:23474115. |
sorafenib enhances radiation-induced apoptosis in hepatocellular carcinoma by inhibiting stat3. |
2013-07-25 |
2023-08-12 |
human |
| Hidetoshi Nara, Mizanur Rahman, Akemi Araki, Lianjin Jin, Yuji Takeda, Hironobu Asa. IL-21 isoform is a membrane-bound ligand and activates directly interacted cells. Cytokine. vol 61. issue 2. 2013-07-23. PMID:23312859. |
il-21-sensitive reporter cells co-cultured with cells producing il-21iso showed stat3 activation, apoptosis, and proliferation. |
2013-07-23 |
2023-08-12 |
mouse |
| P Ozenne, D Dayde, E Brambilla, B Eymin, S Gazzer. p14(ARF) inhibits the growth of lung adenocarcinoma cells harbouring an EGFR L858R mutation by activating a STAT3-dependent pro-apoptotic signalling pathway. Oncogene. vol 32. issue 8. 2013-07-12. PMID:22450744. |
in this study, we demonstrate that p14(arf) promotes apoptosis in lung tumour cells harbouring the egfr l858r mutation through the accumulation of phosphorylated signal transducer and activator of transcription 3 (stat3) on tyr 705 residue, which leads to bcl-2 downregulation. |
2013-07-12 |
2023-08-12 |
Not clear |
| Lucy Liu, Marina Kritsanida, Prokopios Magiatis, Nicolas Gaboriaud, Yan Wang, Jun Wu, Ralf Buettner, Fan Yang, Sangkil Nam, Leandros Skaltsounis, Richard Jov. A novel 7-bromoindirubin with potent anticancer activity suppresses survival of human melanoma cells associated with inhibition of STAT3 and Akt signaling. Cancer biology & therapy. vol 13. issue 13. 2013-07-03. PMID:22895078. |
here, we show that mls-2438 inhibits viability and induces apoptosis of human melanoma cells associated with inhibition of stat3 and akt signaling. |
2013-07-03 |
2023-08-12 |
mouse |
| Bingshan Wu, Hui Yao, Shanshan Wang, Ruxiang X. DAPK1 modulates a curcumin-induced G2/M arrest and apoptosis by regulating STAT3, NF-κB, and caspase-3 activation. Biochemical and biophysical research communications. vol 434. issue 1. 2013-07-03. PMID:23545262. |
dapk1 modulates a curcumin-induced g2/m arrest and apoptosis by regulating stat3, nf-κb, and caspase-3 activation. |
2013-07-03 |
2023-08-12 |
Not clear |
| Jinsil Jang, Soo-Jin Jeong, Hee-Young Kwon, Ji Hoon Jung, Eun Jung Sohn, Hyo-Jung Lee, Ji-Hyun Kim, Sun-Hee Kim, Jin Hyoung Kim, Sung-Hoon Ki. Decursin and Doxorubicin Are in Synergy for the Induction of Apoptosis via STAT3 and/or mTOR Pathways in Human Multiple Myeloma Cells. Evidence-based complementary and alternative medicine : eCAM. vol 2013. 2013-07-03. PMID:23818927. |
decursin and doxorubicin are in synergy for the induction of apoptosis via stat3 and/or mtor pathways in human multiple myeloma cells. |
2013-07-03 |
2023-08-12 |
human |
| María Carmen Cénit, Norberto Ortego-Centeno, Enrique Raya, José L Callejas, Francisco J García-Hernandez, María Jesús Castillo-Palma, J L Fernandez-Sueiro, Cesar Magro, Roser Solans, Santos Castañeda, Maite Camps, Ana Hidalgo, Gerard Espinosa, Miguel A González-Gay, M F González-Escribano, Javier Martí. Influence of the STAT3 genetic variants in the susceptibility to psoriatic arthritis and Behcet's disease. Human immunology. vol 74. issue 2. 2013-06-27. PMID:23127549. |
signal-transducer and activator of transcription protein 3 (stat3) gene encodes a transducer and transcription factor that plays an important role in many cellular processes such as cell growth, apoptosis and immune response. |
2013-06-27 |
2023-08-12 |
Not clear |
| Ilona Bednarek, Daniel Sypniewski, Natalia Gawlik, Anna Galilejczyk, Karol Gorau. The efficiency of silencing expression of the gene coding STAT3 transcriptional factor and susceptibility of bladder cancer cells to apoptosis. Contemporary oncology (Poznan, Poland). vol 16. issue 4. 2013-06-24. PMID:23788901. |
the efficiency of silencing expression of the gene coding stat3 transcriptional factor and susceptibility of bladder cancer cells to apoptosis. |
2013-06-24 |
2023-08-12 |
Not clear |
| Ilona Bednarek, Daniel Sypniewski, Natalia Gawlik, Anna Galilejczyk, Karol Gorau. The efficiency of silencing expression of the gene coding STAT3 transcriptional factor and susceptibility of bladder cancer cells to apoptosis. Contemporary oncology (Poznan, Poland). vol 16. issue 4. 2013-06-24. PMID:23788901. |
the main goal of the study was to verify the effectiveness of stat3 gene silencing and its influence on cell proliferation and activation of apoptosis in bladder cancer cells. |
2013-06-24 |
2023-08-12 |
Not clear |
| Lina Y Dimberg, Anna Dimberg, Karolina Ivarsson, Mårten Fryknäs, Linda Rickardson, Gerard Tobin, Simon Ekman, Rolf Larsson, Urban Gullberg, Kenneth Nilsson, Fredrik Öberg, Helena Jernberg Wiklun. Stat1 activation attenuates IL-6 induced Stat3 activity but does not alter apoptosis sensitivity in multiple myeloma. BMC cancer. vol 12. 2013-06-17. PMID:22838736. |
stat1 activation attenuates il-6 induced stat3 activity but does not alter apoptosis sensitivity in multiple myeloma. |
2013-06-17 |
2023-08-12 |
Not clear |
| Lina Y Dimberg, Anna Dimberg, Karolina Ivarsson, Mårten Fryknäs, Linda Rickardson, Gerard Tobin, Simon Ekman, Rolf Larsson, Urban Gullberg, Kenneth Nilsson, Fredrik Öberg, Helena Jernberg Wiklun. Stat1 activation attenuates IL-6 induced Stat3 activity but does not alter apoptosis sensitivity in multiple myeloma. BMC cancer. vol 12. 2013-06-17. PMID:22838736. |
conversely, il-6 induction of stat3 is known to confer resistance to apoptosis in mm. |
2013-06-17 |
2023-08-12 |
Not clear |
| Sebastian Michels, Marcel Trautmann, Elisabeth Sievers, Dagmar Kindler, Sebastian Huss, Marcus Renner, Nicolaus Friedrichs, Jutta Kirfel, Susanne Steiner, Elmar Endl, Peter Wurst, Lukas Heukamp, Roland Penzel, Olle Larsson, Akira Kawai, Shinya Tanaka, Hiroshi Sonobe, Peter Schirmacher, Gunhild Mechtersheimer, Eva Wardelmann, Reinhard Büttner, Wolfgang Hartman. SRC signaling is crucial in the growth of synovial sarcoma cells. Cancer research. vol 73. issue 8. 2013-06-12. PMID:23580575. |
treatment of synovial sarcoma cells with dasatinib led to apoptosis and inhibition of cellular proliferation, associated with reduced phosphorylation of fak (ptk2), stat3, igf-ir, and akt. |
2013-06-12 |
2023-08-12 |
mouse |
| L Liu, W Li, X Wei, Q Cui, W Lou, G Wang, X Hu, C Qia. Potent antitumor activity of oncolytic adenovirus-mediated SOCS1 for hepatocellular carcinoma. Gene therapy. vol 20. issue 1. 2013-06-11. PMID:22318090. |
signal transducer and activator of transcription 3 (stat3) is constitutively activated in diverse cancers, which contributes to the proliferation and survival of cancer cells by upregulating apoptosis inhibitors and cell cycle regulators. |
2013-06-11 |
2023-08-12 |
Not clear |
| Q Li, X H Yang, F Xu, C Sharma, H-X Wang, K Knoblich, I Rabinovitz, S R Granter, M E Hemle. Tetraspanin CD151 plays a key role in skin squamous cell carcinoma. Oncogene. vol 32. issue 14. 2013-05-23. PMID:22824799. |
cd151 support of keratinocyte survival and proliferation may depend on activation of transcription factor stat3 (signal transducers and activators of transcription), a regulator of cell proliferation and apoptosis. |
2013-05-23 |
2023-08-12 |
mouse |
| Jin Fu, Dan Chen, Bo Zhao, Zhihui Zhao, Jiahong Zhou, Yimiao Xu, Yinqiang Xin, Chang Liu, Lan Luo, Zhimin Yi. Luteolin induces carcinoma cell apoptosis through binding Hsp90 to suppress constitutive activation of STAT3. PloS one. vol 7. issue 11. 2013-05-23. PMID:23145121. |
luteolin induces carcinoma cell apoptosis through binding hsp90 to suppress constitutive activation of stat3. |
2013-05-23 |
2023-08-12 |
human |
| Juncheng Wei, Yanzhi Yuan, Chaozhi Jin, Hui Chen, Ling Leng, Fuchu He, Jian Wan. The ubiquitin ligase TRAF6 negatively regulates the JAK-STAT signaling pathway by binding to STAT3 and mediating its ubiquitination. PloS one. vol 7. issue 11. 2013-05-22. PMID:23185365. |
stat3 is a key transcription factor that mediates various cellular and organismal processes, such as cell growth, apoptosis, immune response and cancer. |
2013-05-22 |
2023-08-12 |
Not clear |
| Chi-Keung Wan, Jangsuk Oh, Peng Li, Erin E West, Elizabeth A Wong, Allison B Andraski, Rosanne Spolski, Zu-Xi Yu, Jianping He, Brian L Kelsall, Warren J Leonar. The cytokines IL-21 and GM-CSF have opposing regulatory roles in the apoptosis of conventional dendritic cells. Immunity. vol 38. issue 3. 2013-05-17. PMID:23453633. |
here we show that il-21 induced apoptosis of conventional dendritic cells (cdcs) via stat3 and bim, and this was inhibited by granulocyte-macrophage colony-stimulating factor (gm-csf). |
2013-05-17 |
2023-08-12 |
mouse |
| Shreeram C Nallar, Sudhakar Kalakonda, Daniel J Lindner, Robert R Lorenz, Eric Lamarre, Xiao Weihua, Dhananjaya V Kalvakolan. Tumor-derived mutations in the gene associated with retinoid interferon-induced mortality (GRIM-19) disrupt its anti-signal transducer and activator of transcription 3 (STAT3) activity and promote oncogenesis. The Journal of biological chemistry. vol 288. issue 11. 2013-05-14. PMID:23386605. |
constitutive activation of stat3 imparts resistance to apoptosis, promotes cell proliferation, and induces de novo micro-angiogenesis, three of the six cardinal hallmarks of a typical cancer cell. |
2013-05-14 |
2023-08-12 |
human |
| Bora Oh, Tae Y Kim, Hyun J Min, Miyoung Kim, Myung S Kang, Ji Y Huh, Youngsoo Kim, Dong S Le. Synergistic killing effect of imatinib and simvastatin on imatinib-resistant chronic myelogenous leukemia cells. Anti-cancer drugs. vol 24. issue 1. 2013-05-09. PMID:23075630. |
mechanisms of killing were an induction of apoptosis and cell cycle arrest, through inhibition of tyrosine phosphorylation, and activated stat5 and stat3. |
2013-05-09 |
2023-08-12 |
mouse |
| Joana P Couto, Ana Almeida, Laura Daly, Manuel Sobrinho-Simões, Jacqueline F Bromberg, Paula Soare. AZD1480 blocks growth and tumorigenesis of RET- activated thyroid cancer cell lines. PloS one. vol 7. issue 10. 2013-05-07. PMID:23056499. |
this inhibitor led to growth inhibition and/or apoptosis of the thyroid cancer cell lines in vitro, as well as to tumor regression of tpc-1 xenografts, where it efficiently blocked stat3 activation in tumor and stromal cells. |
2013-05-07 |
2023-08-12 |
Not clear |