| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gerardo G Mackenzie, Liqun Huang, Ninche Alston, Nengtai Ouyang, Kvetoslava Vrankova, George Mattheolabakis, Panayiotis P Constantinides, Basil Riga. Targeting mitochondrial STAT3 with the novel phospho-valproic acid (MDC-1112) inhibits pancreatic cancer growth in mice. PloS one. vol 8. issue 5. 2013-11-26. PMID:23650499. |
p-v also reduced stat3 levels in the mitochondria by preventing its translocation from the cytosol, and enhanced the mitochondrial levels of reactive oxygen species, which triggered apoptosis. |
2013-11-26 |
2023-08-12 |
mouse |
| Brent D G Page, Danielle C Croucher, Zhi Hua Li, Sina Haftchenary, Victor H Jimenez-Zepeda, Jennifer Atkinson, Paul A Spagnuolo, Yoong Lim Wong, Robert Colaguori, Andrew M Lewis, Aaron D Schimmer, Suzanne Trudel, Patrick T Gunnin. Inhibiting aberrant signal transducer and activator of transcription protein activation with tetrapodal, small molecule Src homology 2 domain binders: promising agents against multiple myeloma. Journal of medicinal chemistry. vol 56. issue 18. 2013-11-26. PMID:23968501. |
these compounds showed high-affinity binding to stat3's sh2 domain, inhibited intracellular stat3 phosphorylation, and induced apoptosis in mm cell lines at low micromolar concentrations. |
2013-11-26 |
2023-08-12 |
Not clear |
| Pei Liang, Suk Hang Cheng, Chi Keung Cheng, Kin Mang Lau, Shek Ying Lin, Eudora Y D Chow, Natalie P H Chan, Rosalina K L Ip, Raymond S M Wong, Margaret H L N. Platelet factor 4 induces cell apoptosis by inhibition of STAT3 via up-regulation of SOCS3 expression in multiple myeloma. Haematologica. vol 98. issue 2. 2013-11-25. PMID:22929979. |
platelet factor 4 induces cell apoptosis by inhibition of stat3 via up-regulation of socs3 expression in multiple myeloma. |
2013-11-25 |
2023-08-12 |
mouse |
| Pei Liang, Suk Hang Cheng, Chi Keung Cheng, Kin Mang Lau, Shek Ying Lin, Eudora Y D Chow, Natalie P H Chan, Rosalina K L Ip, Raymond S M Wong, Margaret H L N. Platelet factor 4 induces cell apoptosis by inhibition of STAT3 via up-regulation of SOCS3 expression in multiple myeloma. Haematologica. vol 98. issue 2. 2013-11-25. PMID:22929979. |
knockdown of lrp1, a putative pf4 receptor, could also abolish pf4-induced apoptosis and stat3 inhibition. |
2013-11-25 |
2023-08-12 |
mouse |
| Pei Liang, Suk Hang Cheng, Chi Keung Cheng, Kin Mang Lau, Shek Ying Lin, Eudora Y D Chow, Natalie P H Chan, Rosalina K L Ip, Raymond S M Wong, Margaret H L N. Platelet factor 4 induces cell apoptosis by inhibition of STAT3 via up-regulation of SOCS3 expression in multiple myeloma. Haematologica. vol 98. issue 2. 2013-11-25. PMID:22929979. |
immunostaining of rabbit bone xenografts from pf4-treated mice showed induction of apoptosis of myeloma cells and inhibition of angiogenesis, which was associated with suppression of stat3 activity. |
2013-11-25 |
2023-08-12 |
mouse |
| Huizhen Nie, Qingzhen Cao, Lei Zhu, Yuehua Gong, Jianren Gu, Zuping H. Acetylcholine acts on androgen receptor to promote the migration and invasion but inhibit the apoptosis of human hepatocarcinoma. PloS one. vol 8. issue 4. 2013-11-11. PMID:23620780. |
collectively, these data suggest that ach activates stat3 and akt pathways and acts on ar to promote the migration and invasion but inhibit the apoptosis of hcc cells. |
2013-11-11 |
2023-08-12 |
human |
| Soon Re Kim, Hye Sook Seo, Han-Seok Choi, Sung-Gook Cho, Yong Kuk Kim, Eun Hee Hong, Yong Cheol Shin, Seong-Gyu K. Trichosanthes kirilowii Ethanol Extract and Cucurbitacin D Inhibit Cell Growth and Induce Apoptosis through Inhibition of STAT3 Activity in Breast Cancer Cells. Evidence-based complementary and alternative medicine : eCAM. vol 2013. 2013-11-06. PMID:24194785. |
trichosanthes kirilowii ethanol extract and cucurbitacin d inhibit cell growth and induce apoptosis through inhibition of stat3 activity in breast cancer cells. |
2013-11-06 |
2023-08-12 |
human |
| Soon Re Kim, Hye Sook Seo, Han-Seok Choi, Sung-Gook Cho, Yong Kuk Kim, Eun Hee Hong, Yong Cheol Shin, Seong-Gyu K. Trichosanthes kirilowii Ethanol Extract and Cucurbitacin D Inhibit Cell Growth and Induce Apoptosis through Inhibition of STAT3 Activity in Breast Cancer Cells. Evidence-based complementary and alternative medicine : eCAM. vol 2013. 2013-11-06. PMID:24194785. |
in the present study, we tested whether trichosanthes kirilowii ethanol extract (tke) or cud suppresses cell growth and induces apoptosis through inhibition of stat3 activity in breast cancer cells. |
2013-11-06 |
2023-08-12 |
human |
| Soon Re Kim, Hye Sook Seo, Han-Seok Choi, Sung-Gook Cho, Yong Kuk Kim, Eun Hee Hong, Yong Cheol Shin, Seong-Gyu K. Trichosanthes kirilowii Ethanol Extract and Cucurbitacin D Inhibit Cell Growth and Induce Apoptosis through Inhibition of STAT3 Activity in Breast Cancer Cells. Evidence-based complementary and alternative medicine : eCAM. vol 2013. 2013-11-06. PMID:24194785. |
we found that both tke and cud suppressed proliferation and induced apoptosis and g2/m cell cycle arrest in mda-mb-231 breast cancer cells by inhibiting stat3 phosphorylation. |
2013-11-06 |
2023-08-12 |
human |
| Soon Re Kim, Hye Sook Seo, Han-Seok Choi, Sung-Gook Cho, Yong Kuk Kim, Eun Hee Hong, Yong Cheol Shin, Seong-Gyu K. Trichosanthes kirilowii Ethanol Extract and Cucurbitacin D Inhibit Cell Growth and Induce Apoptosis through Inhibition of STAT3 Activity in Breast Cancer Cells. Evidence-based complementary and alternative medicine : eCAM. vol 2013. 2013-11-06. PMID:24194785. |
taken together, our results indicate that tke and its derived compound, cud, could be potent therapeutic agents for breast cancer, blocking tumor cell proliferation and inducing apoptosis through suppression of stat3 activity. |
2013-11-06 |
2023-08-12 |
human |
| Ping He, Dan Zhang, Hong Li, Xu Yang, Detian Li, Yongzhen Zhai, Li Ma, Guohe Fen. Hepatitis B virus X protein modulates apoptosis in human renal proximal tubular epithelial cells by activating the JAK2/STAT3 signaling pathway. International journal of molecular medicine. vol 31. issue 5. 2013-10-29. PMID:23483208. |
hbx, p-stat3 and stat3 levels in nephridial tissues were determined by immunohistochemical assay, and a correlation analysis between hbx expression levels and apoptosis index in nephridial tissues was conducted. |
2013-10-29 |
2023-08-12 |
human |
| Guo-Qing Bao, Bai-Yong Shen, Chun-Peng Pan, Ya-Jing Zhang, Min-Min Shi, Cheng-Hong Pen. Andrographolide causes apoptosis via inactivation of STAT3 and Akt and potentiates antitumor activity of gemcitabine in pancreatic cancer. Toxicology letters. vol 222. issue 1. 2013-10-29. PMID:23845849. |
andrographolide causes apoptosis via inactivation of stat3 and akt and potentiates antitumor activity of gemcitabine in pancreatic cancer. |
2013-10-29 |
2023-08-12 |
human |
| Guo-Qing Bao, Bai-Yong Shen, Chun-Peng Pan, Ya-Jing Zhang, Min-Min Shi, Cheng-Hong Pen. Andrographolide causes apoptosis via inactivation of STAT3 and Akt and potentiates antitumor activity of gemcitabine in pancreatic cancer. Toxicology letters. vol 222. issue 1. 2013-10-29. PMID:23845849. |
interestingly, andro induces cell cycle arrest and apoptosis of pancreatic cancer cells by inhibiting stat3 and akt activation, upregulating the expression of p21(waf1) and bax, and downregulating the expression of cyclind1, cycline, survivin, x-iap and bcl-2. |
2013-10-29 |
2023-08-12 |
human |
| Guo-Qing Bao, Bai-Yong Shen, Chun-Peng Pan, Ya-Jing Zhang, Min-Min Shi, Cheng-Hong Pen. Andrographolide causes apoptosis via inactivation of STAT3 and Akt and potentiates antitumor activity of gemcitabine in pancreatic cancer. Toxicology letters. vol 222. issue 1. 2013-10-29. PMID:23845849. |
the mechanistic study demonstrates that this synergistic effect is also dependent on the inhibition of stat3 and akt activations which subsequently regulates the pathways involved in the apoptosis and cell cycle arrest. |
2013-10-29 |
2023-08-12 |
human |
| Shuang Yan, Zhijie Li, Carol J Thiel. Inhibition of STAT3 with orally active JAK inhibitor, AZD1480, decreases tumor growth in Neuroblastoma and Pediatric Sarcomas In vitro and In vivo. Oncotarget. vol 4. issue 3. 2013-10-25. PMID:23531921. |
azd1480 induces cell growth inhibition and caspase-dependent apoptosis in vitro and decreases expression of stat3 target genes, including cell cycle regulators cyclind1, 3 and cdc25a, anti-apoptotic genes bcl-2 and survivin, the metastasis-related factor timp-1 and c-myc. |
2013-10-25 |
2023-08-12 |
mouse |
| A Scuto, M Kirschbaum, R Buettner, M Kujawski, J M Cermak, P Atadja, R Jov. SIRT1 activation enhances HDAC inhibition-mediated upregulation of GADD45G by repressing the binding of NF-κB/STAT3 complex to its promoter in malignant lymphoid cells. Cell death & disease. vol 4. 2013-10-23. PMID:23681230. |
srt501 and srt2183 induced growth arrest and apoptosis, concomitant with deacetylation of stat3 and nf-κb, and reduction of c-myc protein levels. |
2013-10-23 |
2023-08-12 |
Not clear |
| Y Jia, Y-H Lue, R Swerdloff, K-W Lee, L J Cobb, P Cohen, C Wan. The cytoprotective peptide humanin is induced and neutralizes Bax after pro-apoptotic stress in the rat testis. Andrology. vol 1. issue 4. 2013-10-21. PMID:23686888. |
we deduced that the cytoprotective action of synthetic hn on gnrh-a-induced germ cell apoptosis was mediated by attenuating p38 mitogen-activated protein kinase activity and increasing stat3 phosphorylation. |
2013-10-21 |
2023-08-12 |
rat |
| Haijun Chen, Zhengduo Yang, Chunyong Ding, Lili Chu, Yusong Zhang, Kristin Terry, Huiling Liu, Qiang Shen, Jia Zho. Fragment-based drug design and identification of HJC0123, a novel orally bioavailable STAT3 inhibitor for cancer therapy. European journal of medicinal chemistry. vol 62. 2013-10-17. PMID:23416191. |
the most potent compound 5 (hjc0123) has demonstrated to inhibit stat3 promoter activity, downregulate phosphorylation of stat3, increase the expression of cleaved caspase-3, inhibit cell cycle progression and promote apoptosis in breast and pancreatic cancer cells with low micromolar to nanomolar ic50 values. |
2013-10-17 |
2023-08-12 |
human |
| Naoki Kaneko, Aya Kita, Kentaro Yamanaka, Masamichi Mor. Combination of YM155, a survivin suppressant with a STAT3 inhibitor: a new strategy to treat diffuse large B-cell lymphoma. Leukemia research. vol 37. issue 9. 2013-10-17. PMID:23746965. |
ym155 synergistically enhanced stat3 inhibitors (ag490 and sta-21)-induced apoptosis in dlbcl cell lines. |
2013-10-17 |
2023-08-12 |
Not clear |
| Patrick Geraghty, Anne E Wyman, Itsaso Garcia-Arcos, Abdoulaye J Dabo, Sonya Gadhvi, Robert Foronj. STAT3 modulates cigarette smoke-induced inflammation and protease expression. Frontiers in physiology. vol 4. 2013-10-08. PMID:24101903. |
signal transducer and activator of transcription-3 (stat3) regulates inflammation, apoptosis, and protease expression, which are critical processes associated with airway injury and lung tissue destruction. |
2013-10-08 |
2023-08-12 |
mouse |