| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elena Butturini, Alessandra Carcereri de Prati, Giulia Chiavegato, Antonella Rigo, Elisabetta Cavalieri, Elena Darra, Sofia Mariott. Mild oxidative stress induces S-glutathionylation of STAT3 and enhances chemosensitivity of tumoural cells to chemotherapeutic drugs. Free radical biology & medicine. vol 65. 2014-09-02. PMID:24095958. |
stat3 is a transcription factor constitutively activated in a variety of cancers that has a critical role in the inhibition of apoptosis and induction of chemoresistance. |
2014-09-02 |
2023-08-12 |
Not clear |
| Elena Butturini, Alessandra Carcereri de Prati, Giulia Chiavegato, Antonella Rigo, Elisabetta Cavalieri, Elena Darra, Sofia Mariott. Mild oxidative stress induces S-glutathionylation of STAT3 and enhances chemosensitivity of tumoural cells to chemotherapeutic drugs. Free radical biology & medicine. vol 65. 2014-09-02. PMID:24095958. |
inhibition of the stat3 signaling pathway suppresses cell survival signals and leads to apoptosis in cancer cells, suggesting that direct inhibition of stat3 function is a viable therapeutic approach. |
2014-09-02 |
2023-08-12 |
Not clear |
| Yonghe Li, Pui-Kai Li, Michael J Roberts, Rebecca C Arend, Rajeev S Samant, Donald J Buchsbau. Multi-targeted therapy of cancer by niclosamide: A new application for an old drug. Cancer letters. vol 349. issue 1. 2014-08-28. PMID:24732808. |
niclosamide not only inhibits the wnt/β-catenin, mtorc1, stat3, nf-κb and notch signaling pathways, but also targets mitochondria in cancer cells to induce cell cycle arrest, growth inhibition and apoptosis. |
2014-08-28 |
2023-08-13 |
Not clear |
| Henrike K Resemann, Christine J Watson, Bethan Lloyd-Lewi. The Stat3 paradox: a killer and an oncogene. Molecular and cellular endocrinology. vol 382. issue 1. 2014-08-26. PMID:23827176. |
stat3 induces transcriptional activation of genes involved in the inflammatory response, and in seemingly contradictory cellular events such as apoptosis, differentiation and stem cell maintenance. |
2014-08-26 |
2023-08-12 |
Not clear |
| Anita C G Chua, Borut R S Klopcic, Desiree S Ho, S Kristine Fu, Cynthia H Forrest, Kevin D Croft, John K Olynyk, Ian C Lawrance, Debbie Trinde. Dietary iron enhances colonic inflammation and IL-6/IL-11-Stat3 signaling promoting colonic tumor development in mice. PloS one. vol 8. issue 11. 2014-08-26. PMID:24223168. |
intestinal inflammation and tumor development were assessed by endoscopy and histology, gene expression by real-time pcr, stat3 phosphorylation by immunoblot, cytokines by elisa and apoptosis by tunel assay. |
2014-08-26 |
2023-08-12 |
mouse |
| Carolina Hoyo-Becerra, Anastasia Huebener, Martin Trippler, Melanie Lutterbeck, Zijian J Liu, Kurt Truebner, Thomas Bajanowski, Guido Gerken, Dirk M Hermann, Joerg F Schlaa. Concomitant interferon alpha stimulation and TLR3 activation induces neuronal expression of depression-related genes that are elevated in the brain of suicidal persons. PloS one. vol 8. issue 12. 2014-08-25. PMID:24391741. |
using cultured mouse hippocampal and prefrontal neurons we show that costimulation with murine ifn (mifn) and the tlr3 agonist poly(i:c) promotes the expression of the described driis, at the same time inducing pro-inflammatory cytokine expression through stat1 and stat3 activation, promoting neuronal apoptosis. |
2014-08-25 |
2023-08-12 |
mouse |
| Hye-Sook Seo, Jin Mo Ku, Han-Seok Choi, Jong-Kyu Woo, Bo-Hyoung Jang, Yong Cheol Shin, Seong-Gyu K. Induction of caspase-dependent apoptosis by apigenin by inhibiting STAT3 signaling in HER2-overexpressing MDA-MB-453 breast cancer cells. Anticancer research. vol 34. issue 6. 2014-08-21. PMID:24922650. |
induction of caspase-dependent apoptosis by apigenin by inhibiting stat3 signaling in her2-overexpressing mda-mb-453 breast cancer cells. |
2014-08-21 |
2023-08-13 |
Not clear |
| Aruljothi Subramaniam, Muthu K Shanmugam, Tina H Ong, Feng Li, Ekambaram Perumal, Luxi Chen, Shireen Vali, Taher Abbasi, Shweta Kapoor, Kwang Seok Ahn, Alan Prem Kumar, Kam M Hui, Gautam Seth. Emodin inhibits growth and induces apoptosis in an orthotopic hepatocellular carcinoma model by blocking activation of STAT3. British journal of pharmacology. vol 170. issue 4. 2014-08-19. PMID:23848338. |
emodin inhibits growth and induces apoptosis in an orthotopic hepatocellular carcinoma model by blocking activation of stat3. |
2014-08-19 |
2023-08-12 |
Not clear |
| Uri Rozovski, Ji Yuan Wu, David M Harris, Zhiming Liu, Ping Li, Inbal Hazan-Halevy, Alessandra Ferrajoli, Jan A Burger, Susan O'Brien, Nitin Jain, Srdan Verstovsek, William G Wierda, Michael J Keating, Zeev Estro. Stimulation of the B-cell receptor activates the JAK2/STAT3 signaling pathway in chronic lymphocytic leukemia cells. Blood. vol 123. issue 24. 2014-08-12. PMID:24778152. |
incubation of cll cells with the jak1/2 inhibitor ruxolitinib inhibited igm-induced stat3 phosphorylation and induced apoptosis of igm-stimulated but not unstimulated cll cells in a dose- and time-dependent manner. |
2014-08-12 |
2023-08-13 |
Not clear |
| Xiaoxia Sun, Qiangjun Sui, Cai Zhang, Zhigang Tian, Jian Zhan. Targeting blockage of STAT3 in hepatocellular carcinoma cells augments NK cell functions via reverse hepatocellular carcinoma-induced immune suppression. Molecular cancer therapeutics. vol 12. issue 12. 2014-08-04. PMID:24107450. |
stat3 is an important transcriptional factor for cell growth, differentiation, and apoptosis. |
2014-08-04 |
2023-08-12 |
human |
| Janakiram Reddy Vangala, Srikanth Dudem, Nishant Jain, Shasi V Kalivend. Regulation of PSMB5 protein and β subunits of mammalian proteasome by constitutively activated signal transducer and activator of transcription 3 (STAT3): potential role in bortezomib-mediated anticancer therapy. The Journal of biological chemistry. vol 289. issue 18. 2014-08-02. PMID:24627483. |
combined treatments with bortezomib and inhibitor of stat3 abrogated proteasome activity and enhanced cellular apoptosis. |
2014-08-02 |
2023-08-12 |
Not clear |
| Peng Zhang, Hong Li, Bin Yang, Fan Yang, Lin-Lin Zhang, Qing-You Kong, Xiao-Yan Chen, Mo-Li Wu, Jia Li. Biological significance and therapeutic implication of resveratrol-inhibited Wnt, Notch and STAT3 signaling in cervical cancer cells. Genes & cancer. vol 5. issue 5-6. 2014-07-25. PMID:25061499. |
the results revealed that hela and siha cells treated by 100μm resveratrol showed extensive apoptosis, accompanied with suppression of stat3, notch and wnt activations. |
2014-07-25 |
2023-08-13 |
human |
| Peng Zhang, Hong Li, Bin Yang, Fan Yang, Lin-Lin Zhang, Qing-You Kong, Xiao-Yan Chen, Mo-Li Wu, Jia Li. Biological significance and therapeutic implication of resveratrol-inhibited Wnt, Notch and STAT3 signaling in cervical cancer cells. Genes & cancer. vol 5. issue 5-6. 2014-07-25. PMID:25061499. |
our results thus demonstrate that stat3, wnt and notch signaling are frequently co-activated in human cc cells and specimens and resveratrol can concurrently inhibit those signaling activations and meanwhile lead cervical squamous cell carcinoma and adenocarcinoma cells to growth arrest and apoptosis. |
2014-07-25 |
2023-08-13 |
human |
| Peng Zhang, Hong Li, Bin Yang, Fan Yang, Lin-Lin Zhang, Qing-You Kong, Xiao-Yan Chen, Mo-Li Wu, Jia Li. Biological significance and therapeutic implication of resveratrol-inhibited Wnt, Notch and STAT3 signaling in cervical cancer cells. Genes & cancer. vol 5. issue 5-6. 2014-07-25. PMID:25061499. |
stat3 signaling is more critical for cc cells and is the major target of resveratrol because selective inhibition of stat3 rather than wnt or notch activation commits siha and hela cells to apoptosis. |
2014-07-25 |
2023-08-13 |
human |
| Kellie S Rath, Shan K Naidu, Pushpa Lata, Hemant K Bid, Brian K Rivera, Georgia A McCann, Brent J Tierney, Adam C Elnaggar, Veronica Bravo, Gustavo Leone, Peter Houghton, Kálmán Hideg, Periannan Kuppusamy, David E Cohn, Karuppaiyah Selvendira. HO-3867, a safe STAT3 inhibitor, is selectively cytotoxic to ovarian cancer. Cancer research. vol 74. issue 8. 2014-07-24. PMID:24590057. |
rnai attenuation experiments confirmed the requirement of stat3 for ho-3867-mediated apoptosis in ovarian cancer cells. |
2014-07-24 |
2023-08-12 |
human |
| Ji Hoon Jung, Soo-Jin Jeong, Ji-Hyun Kim, Sung-Ki Jung, Deok-Beom Jung, Duckgu Lee, Eun Jung Sohn, Miyong Yun, Hyo-Jung Lee, Hyo-Jeong Lee, Sung-Hoon Ki. Inactivation of HDAC3 and STAT3 is critically involved in 1-stearoyl-sn-glycero-3-phosphocholine-induced apoptosis in chronic myelogenous leukemia K562 cells. Cell biochemistry and biophysics. vol 67. issue 3. 2014-07-15. PMID:23729004. |
inactivation of hdac3 and stat3 is critically involved in 1-stearoyl-sn-glycero-3-phosphocholine-induced apoptosis in chronic myelogenous leukemia k562 cells. |
2014-07-15 |
2023-08-12 |
Not clear |
| Ji Hoon Jung, Soo-Jin Jeong, Ji-Hyun Kim, Sung-Ki Jung, Deok-Beom Jung, Duckgu Lee, Eun Jung Sohn, Miyong Yun, Hyo-Jung Lee, Hyo-Jeong Lee, Sung-Hoon Ki. Inactivation of HDAC3 and STAT3 is critically involved in 1-stearoyl-sn-glycero-3-phosphocholine-induced apoptosis in chronic myelogenous leukemia K562 cells. Cell biochemistry and biophysics. vol 67. issue 3. 2014-07-15. PMID:23729004. |
consistently, silencing shp-1 and pervanadate, an inhibitor of protein tyrosine phosphatase, reversed inactivation of hdac and stat3, cleavages of caspase 3 and poly (adp-ribose) polymerase in lpc-induced apoptosis. |
2014-07-15 |
2023-08-12 |
Not clear |
| Ji Hoon Jung, Soo-Jin Jeong, Ji-Hyun Kim, Sung-Ki Jung, Deok-Beom Jung, Duckgu Lee, Eun Jung Sohn, Miyong Yun, Hyo-Jung Lee, Hyo-Jeong Lee, Sung-Hoon Ki. Inactivation of HDAC3 and STAT3 is critically involved in 1-stearoyl-sn-glycero-3-phosphocholine-induced apoptosis in chronic myelogenous leukemia K562 cells. Cell biochemistry and biophysics. vol 67. issue 3. 2014-07-15. PMID:23729004. |
overall, our findings indicate that inactivation of stat3 and hdac mediates lpc-induced apoptosis in cml k562 cells. |
2014-07-15 |
2023-08-12 |
Not clear |
| Wei-Ye Shi, Chang-Yan Che, Li Li. Human interleukin 23 receptor induces cell apoptosis in mammalian cells by intrinsic mitochondrial pathway associated with the down-regulation of RAS/mitogen-activated protein kinase and signal transducers and activators of transcription factor 3 signaling pathways. International journal of molecular sciences. vol 14. issue 12. 2014-07-15. PMID:24351840. |
therefore, our data strongly indicates that il-23r is able to induce cell apoptosis by activating the intrinsic mitochondrial pathways associated with the inhibition in ras/mapk and stat3 activations in mammalian cells. |
2014-07-15 |
2023-08-12 |
human |
| Remi Fagard, Valeri Metelev, Inès Souissi, Fanny Baran-Marsza. STAT3 inhibitors for cancer therapy: Have all roads been explored? JAK-STAT. vol 2. issue 1. 2014-06-24. PMID:24058788. |
yet, there is still only a small number of stat3 direct inhibitors; in addition, the high similarity of stat3 with stat1, another stat family member mostly oriented toward apoptosis, cell death and defense against pathogens, requires that stat3-inhibitors have no effect on stat1. |
2014-06-24 |
2023-08-12 |
Not clear |