| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L-J Liu, K-H Leung, D S-H Chan, Y-T Wang, D-L Ma, C-H Leun. Identification of a natural product-like STAT3 dimerization inhibitor by structure-based virtual screening. Cell death & disease. vol 5. 2015-02-12. PMID:24922077. |
stat3 regulates a variety of genes involved with cell proliferation, differentiation, apoptosis, angiogenesis, metastasis, inflammation, and immunity. |
2015-02-12 |
2023-08-13 |
Not clear |
| Guangwen Shu, Jing Yang, Wenhao Zhao, Chan Xu, Zongguo Hong, Zhinan Mei, Xinzhou Yan. Kurarinol induces hepatocellular carcinoma cell apoptosis through suppressing cellular signal transducer and activator of transcription 3 signaling. Toxicology and applied pharmacology. vol 281. issue 2. 2015-02-06. PMID:24997323. |
suppression of stat3 signaling is involved in kurarinol-induced hcc cell apoptosis. |
2015-02-06 |
2023-08-13 |
mouse |
| Guangwen Shu, Jing Yang, Wenhao Zhao, Chan Xu, Zongguo Hong, Zhinan Mei, Xinzhou Yan. Kurarinol induces hepatocellular carcinoma cell apoptosis through suppressing cellular signal transducer and activator of transcription 3 signaling. Toxicology and applied pharmacology. vol 281. issue 2. 2015-02-06. PMID:24997323. |
suppressing stat3 signaling is implicated in kurarinol-mediated hcc cell apoptosis. |
2015-02-06 |
2023-08-13 |
mouse |
| Sung-Lyul Lim, Sang-Yoon Park, Sukmin Kang, Dain Park, Sung-Hoon Kim, Jae-Young Um, Hyeung-Jin Jang, Jun-Hee Lee, Chul-Ho Jeong, Jung-Hee Jang, Kwang Seok Ahn, Seok-Geun Le. Morusin induces cell death through inactivating STAT3 signaling in prostate cancer cells. American journal of cancer research. vol 5. issue 1. 2015-01-28. PMID:25628938. |
in addition, morusin down-regulated expression of stat3 target genes encoding bcl-xl, bcl-2, survivin, c-myc and cyclin d1, which are involved in regulation of apoptosis and cell cycle. |
2015-01-28 |
2023-08-13 |
human |
| Sung-Lyul Lim, Sang-Yoon Park, Sukmin Kang, Dain Park, Sung-Hoon Kim, Jae-Young Um, Hyeung-Jin Jang, Jun-Hee Lee, Chul-Ho Jeong, Jung-Hee Jang, Kwang Seok Ahn, Seok-Geun Le. Morusin induces cell death through inactivating STAT3 signaling in prostate cancer cells. American journal of cancer research. vol 5. issue 1. 2015-01-28. PMID:25628938. |
furthermore, morusin induced apoptosis in human prostate cancer cells by reducing stat3 activity. |
2015-01-28 |
2023-08-13 |
human |
| Sung-Lyul Lim, Sang-Yoon Park, Sukmin Kang, Dain Park, Sung-Hoon Kim, Jae-Young Um, Hyeung-Jin Jang, Jun-Hee Lee, Chul-Ho Jeong, Jung-Hee Jang, Kwang Seok Ahn, Seok-Geun Le. Morusin induces cell death through inactivating STAT3 signaling in prostate cancer cells. American journal of cancer research. vol 5. issue 1. 2015-01-28. PMID:25628938. |
taken together, these results suggest that morusin could be a potentially therapeutic agent for prostate cancer by reducing stat3 activity and inducing apoptosis. |
2015-01-28 |
2023-08-13 |
human |
| Louise M Judd, Treve R Menheniott, Hui Ling, Cameron B Jackson, Meegan Howlett, Anastasia Kalantzis, Waldemar Priebe, Andrew S Girau. Inhibition of the JAK2/STAT3 pathway reduces gastric cancer growth in vitro and in vivo. PloS one. vol 9. issue 5. 2015-01-23. PMID:24804649. |
signal transducer and activator of transcription-3 (stat3) is constitutively activated in many cancers where it promotes growth, inflammation, angiogenesis and inhibits apoptosis. |
2015-01-23 |
2023-08-13 |
mouse |
| Louise M Judd, Treve R Menheniott, Hui Ling, Cameron B Jackson, Meegan Howlett, Anastasia Kalantzis, Waldemar Priebe, Andrew S Girau. Inhibition of the JAK2/STAT3 pathway reduces gastric cancer growth in vitro and in vivo. PloS one. vol 9. issue 5. 2015-01-23. PMID:24804649. |
here we show that treatment of human ags gastric cancer cells with the janus kinase (jak) inhibitor wp1066 dose-, and time-dependently inhibits stat3 phosphorylation, in conjunction with reduced jak2 phosphorylation, reduced proliferation and increased apoptosis. |
2015-01-23 |
2023-08-13 |
mouse |
| Louise M Judd, Treve R Menheniott, Hui Ling, Cameron B Jackson, Meegan Howlett, Anastasia Kalantzis, Waldemar Priebe, Andrew S Girau. Inhibition of the JAK2/STAT3 pathway reduces gastric cancer growth in vitro and in vivo. PloS one. vol 9. issue 5. 2015-01-23. PMID:24804649. |
these results show that wp1066 can block proliferation, reduce inflammation and induce apoptosis in gastric tumour cells by inhibiting stat3 phosphorylation, and that many cytokines and growth factors that promote gastric tumour growth are regulated by stat3-dependent mechanisms. |
2015-01-23 |
2023-08-13 |
mouse |
| Hikmat Assi, Jaclyn Espinosa, Sarah Suprise, Michael Sofroniew, Robert Doherty, Daniel Zamler, Pedro R Lowenstein, Maria G Castr. Assessing the role of STAT3 in DC differentiation and autologous DC immunotherapy in mouse models of GBM. PloS one. vol 9. issue 5. 2015-01-23. PMID:24806510. |
as a transcription factor and oncogene, stat3 promotes the expression of genes which allow tumor cells to proliferate, migrate and evade apoptosis. |
2015-01-23 |
2023-08-13 |
mouse |
| Yao Wang, Gao-Xiang Zhao, Li-Hui Xu, Kun-Peng Liu, Hao Pan, Jian He, Ji-Ye Cai, Dong-Yun Ouyang, Xian-Hui H. Cucurbitacin IIb exhibits anti-inflammatory activity through modulating multiple cellular behaviors of mouse lymphocytes. PloS one. vol 9. issue 2. 2015-01-22. PMID:24587010. |
in addition, cuiib downregulated con a-induced stat3 phosphorylation and increased cell apoptosis. |
2015-01-22 |
2023-08-12 |
mouse |
| Mo-Li Wu, Hong Li, Li-Jun Yu, Xiao-Yan Chen, Qing-You Kong, Xue Song, Xiao-Hong Shu, Jia Li. Short-term resveratrol exposure causes in vitro and in vivo growth inhibition and apoptosis of bladder cancer cells. PloS one. vol 9. issue 2. 2015-01-22. PMID:24587049. |
the results revealed that 2 h 150 µm or 200 µm resveratrol treatment leaded to remarkable s phase arrest and apoptosis at 72 h time-point, accompanied with attenuated phosphorylation, nuclear translocation and transcription of stat3, down-regulation of stat3 downstream genes (survivin, cyclind1, c-myc and vegf) and nuclear translocations of sirt1 and p53. |
2015-01-22 |
2023-08-12 |
mouse |
| Mo-Li Wu, Hong Li, Li-Jun Yu, Xiao-Yan Chen, Qing-You Kong, Xue Song, Xiao-Hong Shu, Jia Li. Short-term resveratrol exposure causes in vitro and in vivo growth inhibition and apoptosis of bladder cancer cells. PloS one. vol 9. issue 2. 2015-01-22. PMID:24587049. |
the efficacy and safety of resveratrol instillation were proved by the findings from nude mouse orthotopic xenograft models, because this treatment caused growth suppression, distinctive apoptosis and stat3 inactivation of the transplanted tumors without affecting normal urothelium. |
2015-01-22 |
2023-08-12 |
mouse |
| Saad Yousuf, MeiLi Duan, Erika L Moen, Sam Cross-Knorr, Kate Brilliant, Benjamin Bonavida, Theresa LaValle, Kam C Yeung, Fahd Al-Mulla, Eugene Chin, Devasis Chatterje. Raf kinase inhibitor protein (RKIP) blocks signal transducer and activator of transcription 3 (STAT3) activation in breast and prostate cancer. PloS one. vol 9. issue 3. 2015-01-20. PMID:24658061. |
rkip synergizes with mtis to induce apoptosis and inhibit stat3 activation of breast and prostate cancer cells. |
2015-01-20 |
2023-08-12 |
Not clear |
| Kaijie Wu, Zhongyun Ning, Jiancheng Zhou, Bin Wang, Jinhai Fan, Jianning Zhu, Yang Gao, Xinyang Wang, Jer-Tsong Hsieh, Dalin H. 2'-hydroxyflavanone inhibits prostate tumor growth through inactivation of AKT/STAT3 signaling and induction of cell apoptosis. Oncology reports. vol 32. issue 1. 2015-01-14. PMID:24859932. |
mechanistically, besides its known inhibitory effects on aldo‑keto reductase activity and de novo androgen synthesis, 2hf also markedly suppressed akt phosphorylation, signal transducer and activator of transcription-3 (stat3) phosphorylation and transactivation subsequently regulating the expression of members of the bcl-2 family (i.e., mcl-1, bcl-2 and bax) and modulating caspase-mediated cell apoptosis. |
2015-01-14 |
2023-08-13 |
Not clear |
| Leslie van der Fits, Jacoba J Out-Luiting, Cornelis P Tensen, Willem H Zoutman, Maarten H Vermee. Exploring the IL-21-STAT3 axis as therapeutic target for Sézary syndrome. The Journal of investigative dermatology. vol 134. issue 10. 2015-01-13. PMID:24756111. |
sézary cells underwent apoptosis when incubated with stattic, a selective stat3 inhibitor. |
2015-01-13 |
2023-08-13 |
Not clear |
| Leslie van der Fits, Jacoba J Out-Luiting, Cornelis P Tensen, Willem H Zoutman, Maarten H Vermee. Exploring the IL-21-STAT3 axis as therapeutic target for Sézary syndrome. The Journal of investigative dermatology. vol 134. issue 10. 2015-01-13. PMID:24756111. |
thus, specific inhibition of stat3 is highly efficient in the induction of apoptosis of sézary cells, likely mediated via the regulation of (proto)oncogenes. |
2015-01-13 |
2023-08-13 |
Not clear |
| Leslie van der Fits, Jacoba J Out-Luiting, Cornelis P Tensen, Willem H Zoutman, Maarten H Vermee. Exploring the IL-21-STAT3 axis as therapeutic target for Sézary syndrome. The Journal of investigative dermatology. vol 134. issue 10. 2015-01-13. PMID:24756111. |
in contrast, blocking il-21 alone seems insufficient to affect stat3 activation, cell proliferation, or apoptosis. |
2015-01-13 |
2023-08-13 |
Not clear |
| Yan Zhou, Qing Tang, Shunyu Zhao, Fang Zhang, Liuning Li, WanYin Wu, ZhiYu Wang, Swei Han. Targeting signal transducer and activator of transcription 3 contributes to the solamargine-inhibited growth and -induced apoptosis of human lung cancer cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 8. 2015-01-13. PMID:24845028. |
collectively, our results show that sm inhibits proliferation and induces apoptosis in lung cancer cells through p38 mapk-mediated suppression of phosphorylation and protein expression of stat3, followed by inducing stat3 downstream effector p21. |
2015-01-13 |
2023-08-13 |
human |
| Marcin Kruczyk, Piotr Przanowski, Michal Dabrowski, Karolina Swiatek-Machado, Jakub Mieczkowski, Ola Wallerman, Anna Ronowicz, Arkadiusz Piotrowski, Claes Wadelius, Bozena Kaminska, Jan Komorowsk. Integration of genome-wide of Stat3 binding and epigenetic modification mapping with transcriptome reveals novel Stat3 target genes in glioma cells. Biochimica et biophysica acta. vol 1839. issue 11. 2015-01-13. PMID:25111868. |
signal transducer and activator of transcription 3 (stat3) is constitutively activated in many human tumors, including gliomas, and regulates the expression of genes implicated in proliferation, survival, apoptosis, angiogenesis and immune regulation. |
2015-01-13 |
2023-08-13 |
human |