| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| X Li, H Miao, Y Zhang, W Li, Z Li, Y Zhou, L Zhao, Q Gu. Bone marrow microenvironment confers imatinib resistance to chronic myelogenous leukemia and oroxylin A reverses the resistance by suppressing Stat3 pathway. Archives of toxicology. vol 89. issue 1. 2015-09-04. PMID:24671465. |
after treatment of weakly toxic concentration of oroxylin a, the apoptosis of k562 cells induced by im was increased dramatically through suppressing stat3 pathway. |
2015-09-04 |
2023-08-12 |
human |
| Yuan Hu, Yin Hong, YuanJie Xu, Ping Liu, Dai-Hong Guo, Yibang Che. Inhibition of the JAK/STAT pathway with ruxolitinib overcomes cisplatin resistance in non-small-cell lung cancer NSCLC. Apoptosis : an international journal on programmed cell death. vol 19. issue 11. 2015-09-04. PMID:25213670. |
we treated five non-small-cell lung cancer cell lines with cisplatin alone or with cisplatin and jak2 inhibitor (ruxolitinib) and assessed cell viability, expression of jak2 and stat3 and cell apoptosis. |
2015-09-04 |
2023-08-13 |
human |
| Yuan-Fei Liu, Yun-Min Lu, Guo-Qiang Qu, Yuan Liu, Wei-Xiong Chen, Xiao-Hong Liao, Wu-Ming Kon. Ponicidin induces apoptosis via JAK2 and STAT3 signaling pathways in gastric carcinoma. International journal of molecular sciences. vol 16. issue 1. 2015-09-04. PMID:25588213. |
ponicidin induces apoptosis via jak2 and stat3 signaling pathways in gastric carcinoma. |
2015-09-04 |
2023-08-13 |
Not clear |
| Yuan-Fei Liu, Yun-Min Lu, Guo-Qiang Qu, Yuan Liu, Wei-Xiong Chen, Xiao-Hong Liao, Wu-Ming Kon. Ponicidin induces apoptosis via JAK2 and STAT3 signaling pathways in gastric carcinoma. International journal of molecular sciences. vol 16. issue 1. 2015-09-04. PMID:25588213. |
we therefore conclude that ponicidin exhibited significant growth inhibition of gastric carcinoma cell line mkn28 and induced apoptosis of mkn28 cells via the signaling pathway regulated by janus kinase 2 (jak2) and signal transducers and activators of transcription 3 (stat3). |
2015-09-04 |
2023-08-13 |
Not clear |
| Elena Fasanaro, Claudia Staffieri, Rocco Cappellesso, Filippo Marino, Giancarlo Ottaviano, Matteo Val, Luciano Giacomelli, Cosimo de Filippis, Edoardo Stellini, Alberto Staffieri, Gino Marion. Prognostic Significance of Serine-Phosphorylated STAT3 Expression in pT1-T2 Oral Tongue Carcinoma. Clinical and experimental otorhinolaryngology. vol 8. issue 3. 2015-09-02. PMID:26330924. |
phosphorylated (activated) stat3 (pstat3) is a regulator of numerous genes that play an essential part in the onset, development and progression of cancer; it is involved in cell proliferation and preventing apoptosis, and in invasion, angiogenesis, and the evasion of immune surveillance. |
2015-09-02 |
2023-08-13 |
Not clear |
| Dae-Hee Lee, Ki Sa Sung, David L Bartlett, Yong Tae Kwon, Yong J Le. HSP90 inhibitor NVP-AUY922 enhances TRAIL-induced apoptosis by suppressing the JAK2-STAT3-Mcl-1 signal transduction pathway in colorectal cancer cells. Cellular signalling. vol 27. issue 2. 2015-08-25. PMID:25446253. |
knock down of mcl-1, stat3 inhibitor or jak2 inhibitor synergistically enhanced trail-induced apoptosis. |
2015-08-25 |
2023-08-13 |
Not clear |
| Chun-Yu Liu, Jung-Chen Su, Mei-Huei Ni, Ling-Ming Tseng, Pei-Yi Chu, Duen-Shian Wang, Wei-Tien Tai, Yuan-Ping Kao, Man-Hsin Hung, Chung-Wai Shiau, Kuen-Feng Che. Obatoclax analog SC-2001 inhibits STAT3 phosphorylation through enhancing SHP-1 expression and induces apoptosis in human breast cancer cells. Breast cancer research and treatment. vol 146. issue 1. 2015-08-18. PMID:24903225. |
obatoclax analog sc-2001 inhibits stat3 phosphorylation through enhancing shp-1 expression and induces apoptosis in human breast cancer cells. |
2015-08-18 |
2023-08-13 |
mouse |
| Chun-Yu Liu, Jung-Chen Su, Mei-Huei Ni, Ling-Ming Tseng, Pei-Yi Chu, Duen-Shian Wang, Wei-Tien Tai, Yuan-Ping Kao, Man-Hsin Hung, Chung-Wai Shiau, Kuen-Feng Che. Obatoclax analog SC-2001 inhibits STAT3 phosphorylation through enhancing SHP-1 expression and induces apoptosis in human breast cancer cells. Breast cancer research and treatment. vol 146. issue 1. 2015-08-18. PMID:24903225. |
over-expression of stat3 in mda-mb-468 cells protected cells from sc-2001-induced apoptosis. |
2015-08-18 |
2023-08-13 |
mouse |
| Chun-Yu Liu, Jung-Chen Su, Mei-Huei Ni, Ling-Ming Tseng, Pei-Yi Chu, Duen-Shian Wang, Wei-Tien Tai, Yuan-Ping Kao, Man-Hsin Hung, Chung-Wai Shiau, Kuen-Feng Che. Obatoclax analog SC-2001 inhibits STAT3 phosphorylation through enhancing SHP-1 expression and induces apoptosis in human breast cancer cells. Breast cancer research and treatment. vol 146. issue 1. 2015-08-18. PMID:24903225. |
sc-2001 induced apoptosis in breast cancer cells, an effect that was mediated by rfx-1 upregulated shp-1 expression and shp-1-dependent stat3 inactivation. |
2015-08-18 |
2023-08-13 |
mouse |
| Hesheng Ou, Yumei Li, Min Kan. Activation of miR-21 by STAT3 induces proliferation and suppresses apoptosis in nasopharyngeal carcinoma by targeting PTEN gene. PloS one. vol 9. issue 11. 2015-08-18. PMID:25365510. |
activation of mir-21 by stat3 induces proliferation and suppresses apoptosis in nasopharyngeal carcinoma by targeting pten gene. |
2015-08-18 |
2023-08-13 |
human |
| Hesheng Ou, Yumei Li, Min Kan. Activation of miR-21 by STAT3 induces proliferation and suppresses apoptosis in nasopharyngeal carcinoma by targeting PTEN gene. PloS one. vol 9. issue 11. 2015-08-18. PMID:25365510. |
mir-21, activated by stat3, induced proliferation and suppressed apoptosis in npc by targeting pten-akt pathway. |
2015-08-18 |
2023-08-13 |
human |
| Man-Hsin Hung, Wei-Tien Tai, Chung-Wai Shiau, Kuen-Feng Che. Downregulation of signal transducer and activator of transcription 3 by sorafenib: a novel mechanism for hepatocellular carcinoma therapy. World journal of gastroenterology. vol 20. issue 41. 2015-08-10. PMID:25386075. |
this phosphatase negatively regulates stat3 activity, which leads to the subsequent apoptosis of cancer cells. |
2015-08-10 |
2023-08-13 |
Not clear |
| Akhilesh K Singh, Ahmet Eken, Mallory Fry, Estelle Bettelli, Mohamed Oukk. DOCK8 regulates protective immunity by controlling the function and survival of RORγt+ ILCs. Nature communications. vol 5. 2015-08-04. PMID:25091235. |
furthermore, dock8-deficient rorγt(+) ilcs are less responsive to il-7 mediated signalling, more prone to apoptosis and produce less il-22 due to a defect in il-23-mediated stat3 phosphorylation. |
2015-08-04 |
2023-08-13 |
mouse |
| Kuen-Feng Chen, Wei-Tien Tai, Jui-Wen Huang, Cheng-Yi Hsu, Wei-Lin Chen, Ann-Lii Cheng, Pei-Jer Chen, Chung-Wai Shia. Sorafenib derivatives induce apoptosis through inhibition of STAT3 independent of Raf. European journal of medicinal chemistry. vol 46. issue 7. 2015-07-15. PMID:21531053. |
sorafenib derivatives induce apoptosis through inhibition of stat3 independent of raf. |
2015-07-15 |
2023-08-12 |
human |
| Wei-Tien Tai, Pei-Yi Chu, Chung-Wai Shiau, Yao-Li Chen, Yong-Shi Li, Man-Hsin Hung, Li-Ju Chen, Pei-Lung Chen, Jung-Chen Su, Ping-Yi Lin, Hui-Chuan Yu, Kuen-Feng Che. STAT3 mediates regorafenib-induced apoptosis in hepatocellular carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 20. issue 22. 2015-07-09. PMID:25248379. |
stat3 mediates regorafenib-induced apoptosis in hepatocellular carcinoma. |
2015-07-09 |
2023-08-13 |
Not clear |
| Lin Yang, Siqi Han, Yong Su. An IL6-STAT3 loop mediates resistance to PI3K inhibitors by inducing epithelial-mesenchymal transition and cancer stem cell expansion in human breast cancer cells. Biochemical and biophysical research communications. vol 453. issue 3. 2015-07-08. PMID:25285632. |
pharmacological inhibition of stat3 disrupted the il6-stat3 signaling and overcome resistance to pi3k inhibitors partially due to increased apoptosis induction. |
2015-07-08 |
2023-08-13 |
human |
| Stefan W Ryter, Augustine M K Choi, Hong Pyo Ki. Profibrogenic phenotype in caveolin-1 deficiency via differential regulation of STAT-1/3 proteins. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 92. issue 5. 2015-07-07. PMID:25263949. |
stat1 can inhibit cell growth and promote apoptosis while stat3 inhibits apoptosis. |
2015-07-07 |
2023-08-13 |
human |
| C Capron, K Jondeau, L Casetti, V Jalbert, C Costa, E Verhoeyen, E Verhoyen, J M Massé, P Coppo, M C Béné, P Bourdoncle, E Cramer-Bordé, I Dusanter-Four. Viability and stress protection of chronic lymphoid leukemia cells involves overactivation of mitochondrial phosphoSTAT3Ser727. Cell death & disease. vol 5. 2015-07-07. PMID:25299776. |
furthermore, stat3 activity contributes to the resistance to apoptosis of cll, but not normal b cells, in vitro. |
2015-07-07 |
2023-08-13 |
Not clear |
| Anup S Pathania, Suresh Kumar, Santosh K Guru, Shashi Bhushan, Parduman R Sharma, Sravan K Aithagani, Parvinder P Singh, Ram A Vishwakarma, Ajay Kumar, Fayaz Mali. The synthetic tryptanthrin analogue suppresses STAT3 signaling and induces caspase dependent apoptosis via ERK up regulation in human leukemia HL-60 cells. PloS one. vol 9. issue 11. 2015-07-07. PMID:25383546. |
the synthetic tryptanthrin analogue suppresses stat3 signaling and induces caspase dependent apoptosis via erk up regulation in human leukemia hl-60 cells. |
2015-07-07 |
2023-08-13 |
human |
| Anup S Pathania, Suresh Kumar, Santosh K Guru, Shashi Bhushan, Parduman R Sharma, Sravan K Aithagani, Parvinder P Singh, Ram A Vishwakarma, Ajay Kumar, Fayaz Mali. The synthetic tryptanthrin analogue suppresses STAT3 signaling and induces caspase dependent apoptosis via ERK up regulation in human leukemia HL-60 cells. PloS one. vol 9. issue 11. 2015-07-07. PMID:25383546. |
it was found that tbr primarily targets stat3 and erk signaling during the induction of apoptosis in several human leukemia cell lines. |
2015-07-07 |
2023-08-13 |
human |