| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chun-Yu Liu, Jung-Chen Su, Mei-Huei Ni, Ling-Ming Tseng, Pei-Yi Chu, Duen-Shian Wang, Wei-Tien Tai, Yuan-Ping Kao, Man-Hsin Hung, Chung-Wai Shiau, Kuen-Feng Che. Obatoclax analog SC-2001 inhibits STAT3 phosphorylation through enhancing SHP-1 expression and induces apoptosis in human breast cancer cells. Breast cancer research and treatment. vol 146. issue 1. 2015-08-18. PMID:24903225. |
obatoclax analog sc-2001 inhibits stat3 phosphorylation through enhancing shp-1 expression and induces apoptosis in human breast cancer cells. |
2015-08-18 |
2023-08-13 |
mouse |
| Chun-Yu Liu, Jung-Chen Su, Mei-Huei Ni, Ling-Ming Tseng, Pei-Yi Chu, Duen-Shian Wang, Wei-Tien Tai, Yuan-Ping Kao, Man-Hsin Hung, Chung-Wai Shiau, Kuen-Feng Che. Obatoclax analog SC-2001 inhibits STAT3 phosphorylation through enhancing SHP-1 expression and induces apoptosis in human breast cancer cells. Breast cancer research and treatment. vol 146. issue 1. 2015-08-18. PMID:24903225. |
over-expression of stat3 in mda-mb-468 cells protected cells from sc-2001-induced apoptosis. |
2015-08-18 |
2023-08-13 |
mouse |
| Chun-Yu Liu, Jung-Chen Su, Mei-Huei Ni, Ling-Ming Tseng, Pei-Yi Chu, Duen-Shian Wang, Wei-Tien Tai, Yuan-Ping Kao, Man-Hsin Hung, Chung-Wai Shiau, Kuen-Feng Che. Obatoclax analog SC-2001 inhibits STAT3 phosphorylation through enhancing SHP-1 expression and induces apoptosis in human breast cancer cells. Breast cancer research and treatment. vol 146. issue 1. 2015-08-18. PMID:24903225. |
sc-2001 induced apoptosis in breast cancer cells, an effect that was mediated by rfx-1 upregulated shp-1 expression and shp-1-dependent stat3 inactivation. |
2015-08-18 |
2023-08-13 |
mouse |
| Hesheng Ou, Yumei Li, Min Kan. Activation of miR-21 by STAT3 induces proliferation and suppresses apoptosis in nasopharyngeal carcinoma by targeting PTEN gene. PloS one. vol 9. issue 11. 2015-08-18. PMID:25365510. |
activation of mir-21 by stat3 induces proliferation and suppresses apoptosis in nasopharyngeal carcinoma by targeting pten gene. |
2015-08-18 |
2023-08-13 |
human |
| Hesheng Ou, Yumei Li, Min Kan. Activation of miR-21 by STAT3 induces proliferation and suppresses apoptosis in nasopharyngeal carcinoma by targeting PTEN gene. PloS one. vol 9. issue 11. 2015-08-18. PMID:25365510. |
mir-21, activated by stat3, induced proliferation and suppressed apoptosis in npc by targeting pten-akt pathway. |
2015-08-18 |
2023-08-13 |
human |
| Man-Hsin Hung, Wei-Tien Tai, Chung-Wai Shiau, Kuen-Feng Che. Downregulation of signal transducer and activator of transcription 3 by sorafenib: a novel mechanism for hepatocellular carcinoma therapy. World journal of gastroenterology. vol 20. issue 41. 2015-08-10. PMID:25386075. |
this phosphatase negatively regulates stat3 activity, which leads to the subsequent apoptosis of cancer cells. |
2015-08-10 |
2023-08-13 |
Not clear |
| Akhilesh K Singh, Ahmet Eken, Mallory Fry, Estelle Bettelli, Mohamed Oukk. DOCK8 regulates protective immunity by controlling the function and survival of RORγt+ ILCs. Nature communications. vol 5. 2015-08-04. PMID:25091235. |
furthermore, dock8-deficient rorγt(+) ilcs are less responsive to il-7 mediated signalling, more prone to apoptosis and produce less il-22 due to a defect in il-23-mediated stat3 phosphorylation. |
2015-08-04 |
2023-08-13 |
mouse |
| Kuen-Feng Chen, Wei-Tien Tai, Jui-Wen Huang, Cheng-Yi Hsu, Wei-Lin Chen, Ann-Lii Cheng, Pei-Jer Chen, Chung-Wai Shia. Sorafenib derivatives induce apoptosis through inhibition of STAT3 independent of Raf. European journal of medicinal chemistry. vol 46. issue 7. 2015-07-15. PMID:21531053. |
sorafenib derivatives induce apoptosis through inhibition of stat3 independent of raf. |
2015-07-15 |
2023-08-12 |
human |
| Wei-Tien Tai, Pei-Yi Chu, Chung-Wai Shiau, Yao-Li Chen, Yong-Shi Li, Man-Hsin Hung, Li-Ju Chen, Pei-Lung Chen, Jung-Chen Su, Ping-Yi Lin, Hui-Chuan Yu, Kuen-Feng Che. STAT3 mediates regorafenib-induced apoptosis in hepatocellular carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 20. issue 22. 2015-07-09. PMID:25248379. |
stat3 mediates regorafenib-induced apoptosis in hepatocellular carcinoma. |
2015-07-09 |
2023-08-13 |
Not clear |
| Lin Yang, Siqi Han, Yong Su. An IL6-STAT3 loop mediates resistance to PI3K inhibitors by inducing epithelial-mesenchymal transition and cancer stem cell expansion in human breast cancer cells. Biochemical and biophysical research communications. vol 453. issue 3. 2015-07-08. PMID:25285632. |
pharmacological inhibition of stat3 disrupted the il6-stat3 signaling and overcome resistance to pi3k inhibitors partially due to increased apoptosis induction. |
2015-07-08 |
2023-08-13 |
human |
| Stefan W Ryter, Augustine M K Choi, Hong Pyo Ki. Profibrogenic phenotype in caveolin-1 deficiency via differential regulation of STAT-1/3 proteins. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 92. issue 5. 2015-07-07. PMID:25263949. |
stat1 can inhibit cell growth and promote apoptosis while stat3 inhibits apoptosis. |
2015-07-07 |
2023-08-13 |
human |
| C Capron, K Jondeau, L Casetti, V Jalbert, C Costa, E Verhoeyen, E Verhoyen, J M Massé, P Coppo, M C Béné, P Bourdoncle, E Cramer-Bordé, I Dusanter-Four. Viability and stress protection of chronic lymphoid leukemia cells involves overactivation of mitochondrial phosphoSTAT3Ser727. Cell death & disease. vol 5. 2015-07-07. PMID:25299776. |
furthermore, stat3 activity contributes to the resistance to apoptosis of cll, but not normal b cells, in vitro. |
2015-07-07 |
2023-08-13 |
Not clear |
| Anup S Pathania, Suresh Kumar, Santosh K Guru, Shashi Bhushan, Parduman R Sharma, Sravan K Aithagani, Parvinder P Singh, Ram A Vishwakarma, Ajay Kumar, Fayaz Mali. The synthetic tryptanthrin analogue suppresses STAT3 signaling and induces caspase dependent apoptosis via ERK up regulation in human leukemia HL-60 cells. PloS one. vol 9. issue 11. 2015-07-07. PMID:25383546. |
the synthetic tryptanthrin analogue suppresses stat3 signaling and induces caspase dependent apoptosis via erk up regulation in human leukemia hl-60 cells. |
2015-07-07 |
2023-08-13 |
human |
| Anup S Pathania, Suresh Kumar, Santosh K Guru, Shashi Bhushan, Parduman R Sharma, Sravan K Aithagani, Parvinder P Singh, Ram A Vishwakarma, Ajay Kumar, Fayaz Mali. The synthetic tryptanthrin analogue suppresses STAT3 signaling and induces caspase dependent apoptosis via ERK up regulation in human leukemia HL-60 cells. PloS one. vol 9. issue 11. 2015-07-07. PMID:25383546. |
it was found that tbr primarily targets stat3 and erk signaling during the induction of apoptosis in several human leukemia cell lines. |
2015-07-07 |
2023-08-13 |
human |
| Songyang Liu, Wei Zhang, Kai Liu, Yingchao Wang, Bai Ji, Yahui Li. Synergistic effects of co-expression plasmid‑based ADAM10-specific siRNA and GRIM-19 on hepatocellular carcinoma in vitro and in vivo. Oncology reports. vol 32. issue 6. 2015-06-26. PMID:25242535. |
gene associated with retinoid-interferon-induced mortality 19 (grim-19), a signal transducer and activator of transcription 3 (stat3)-inhibitory protein, was identified as a potential tumor suppressor associated with growth inhibition and cell apoptosis. |
2015-06-26 |
2023-08-13 |
mouse |
| Zhiqiang Han, Xiaoli Wang, Liang Ma, Lijuan Chen, Min Xiao, Liang Huang, Yang Cao, Jian Bai, Ding Ma, Jianfeng Zhou, Zhenya Hon. Inhibition of STAT3 signaling targets both tumor-initiating and differentiated cell populations in prostate cancer. Oncotarget. vol 5. issue 18. 2015-06-25. PMID:25261365. |
in this study we show that the stat3 small molecule inhibitor stattic caused s-phase accumulation at low-dose levels and led to massive apoptosis at a relatively high-dose level in prostate cancer cells. |
2015-06-25 |
2023-08-13 |
human |
| Guangchao Li, Likun Zhao, Wei Li, Kexing Fan, Weizhu Qian, Sheng Hou, Hao Wang, Jianxin Dai, Huafeng Wei, Yajun Gu. Feedback activation of STAT3 mediates trastuzumab resistance via upregulation of MUC1 and MUC4 expression. Oncotarget. vol 5. issue 18. 2015-06-25. PMID:25327561. |
genetic or pharmacological inhibition of stat3 disrupted stat3-dependent positive feedback loop and recovered the trastuzumab sensitivity partially due to increased apoptosis induction. |
2015-06-25 |
2023-08-13 |
Not clear |
| Valeria Poli, Annalisa Camporeal. STAT3-Mediated Metabolic Reprograming in Cellular Transformation and Implications for Drug Resistance. Frontiers in oncology. vol 5. 2015-06-24. PMID:26106584. |
stat3 can, however, also localize to mitochondria, where its serine-phosphorylated (s-p) form preserves mitochondrial oxidative phosphorylation and controls the opening of the mitochondrial permeability transition pore, also promoting survival and resistance to apoptosis in response to specific signals/oncogenes such as ras. |
2015-06-24 |
2023-08-13 |
Not clear |
| U Bharadwaj, T K Eckols, M Kolosov, M M Kasembeli, A Adam, D Torres, X Zhang, L E Dobrolecki, W Wei, M T Lewis, B Dave, J C Chang, M D Landis, C J Creighton, M A Mancini, D J Tweard. Drug-repositioning screening identified piperlongumine as a direct STAT3 inhibitor with potent activity against breast cancer. Oncogene. vol 34. issue 11. 2015-06-19. PMID:24681959. |
pl inhibited anchorage-independent and anchorage-dependent growth of multiple breast cancer cell lines having increased pstat3 or total stat3, and induced apoptosis. |
2015-06-19 |
2023-08-12 |
mouse |
| Meng Zhang, Zhi-Gang Bian, Yi Zhang, Jia-He Wang, Liang Kan, Xin Wang, Hui-Yan Niu, Ping H. Cucurbitacin B inhibits proliferation and induces apoptosis via STAT3 pathway inhibition in A549 lung cancer cells. Molecular medicine reports. vol 10. issue 6. 2015-06-19. PMID:25242136. |
cucurbitacin b inhibits proliferation and induces apoptosis via stat3 pathway inhibition in a549 lung cancer cells. |
2015-06-19 |
2023-08-13 |
Not clear |