| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rong Tian, You Li, Mei Ga. Shikonin causes cell-cycle arrest and induces apoptosis by regulating the EGFR-NF-κB signalling pathway in human epidermoid carcinoma A431 cells. Bioscience reports. vol 35. issue 2. 2016-01-25. PMID:25720435. |
then, the nf-κb inhibitors such as bay11-7082, sn50, helenalin and the egfr inhibitor ag1478 and its downstream inhibitor such as pi3k inhibitor ly294002 and stat3 inhibitor stattic dramatically blocked egf-reversed decreases in cell viability and increases in apoptosis induced by shikonin. |
2016-01-25 |
2023-08-13 |
human |
| Meixian Xiang, Hanwen Su, Zongguo Hong, Tianming Yang, Guangwen Sh. Chemical composition of total flavonoids from Polygonum amplexicaule and their pro-apoptotic effect on hepatocellular carcinoma cells: Potential roles of suppressing STAT3 signaling. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 80. 2016-01-25. PMID:25754378. |
suppressing stat3 signaling is implicated in tfpa-mediated hcc cell apoptosis. |
2016-01-25 |
2023-08-13 |
mouse |
| Sichu Liu, Qi Shen, Yu Chen, Chengwu Zeng, Changshu Cao, Lijian Yang, Shaohua Chen, Xiuli Wu, Bo Li, Yangqiu L. Alteration of gene expression profile following PPP2R5C knockdown may be associated with proliferation suppression and increased apoptosis of K562 cells. Journal of hematology & oncology. vol 8. 2016-01-19. PMID:25888193. |
we propose that the mechanism for proliferation inhibition and increased apoptosis of k562 cells following ppp2r5c suppression may be related to the alteration of expression profiles of braf, akt2, akt3, nfkb2 and stat3 genes. |
2016-01-19 |
2023-08-13 |
Not clear |
| Xiaoyun Dai, Kwang Seok Ahn, Chulwon Kim, Kodappully Sivaraman Siveen, Tina H Ong, Muthu K Shanmugam, Feng Li, Jizhong Shi, Alan Prem Kumar, Ling Zhi Wang, Boon Cher Goh, Junji Magae, Kam M Hui, Gautam Seth. Ascochlorin, an isoprenoid antibiotic inhibits growth and invasion of hepatocellular carcinoma by targeting STAT3 signaling cascade through the induction of PIAS3. Molecular oncology. vol 9. issue 4. 2016-01-05. PMID:25624051. |
deletion of pias3 gene by sirna abolished the ability of asc to inhibit stat3 activation and induce apoptosis in hcc cells. |
2016-01-05 |
2023-08-13 |
mouse |
| Matteo Santoni, Francesco Massari, Marzia Del Re, Chiara Ciccarese, Francesco Piva, Giovanni Principato, Rodolfo Montironi, Daniele Santini, Romano Danesi, Giampaolo Tortora, Stefano Cascin. Investigational therapies targeting signal transducer and activator of transcription 3 for the treatment of cancer. Expert opinion on investigational drugs. vol 24. issue 6. 2016-01-04. PMID:25746129. |
signal transducer and activator of transcription 3 (stat3) mediates the expression of a variety of genes in response to cell stimuli and thus plays a key role in several cellular processes such as cell growth and apoptosis. |
2016-01-04 |
2023-08-13 |
Not clear |
| Changxiao Ye, Wei Zhao, Minghui Li, Junlong Zhuang, Xiang Yan, Qun Lu, Cunjie Chang, Xiaojing Huang, Ji Zhou, Bingxian Xie, Zhen Zhang, Xin Yao, Jun Yan, Hongqian Gu. δ-tocotrienol induces human bladder cancer cell growth arrest, apoptosis and chemosensitization through inhibition of STAT3 pathway. PloS one. vol 10. issue 4. 2016-01-04. PMID:25849286. |
δ-tocotrienol induces human bladder cancer cell growth arrest, apoptosis and chemosensitization through inhibition of stat3 pathway. |
2016-01-04 |
2023-08-13 |
human |
| Alejandro D Hofmann, Toshiaki Takahashi, Johannes Duess, Jan-Hendrik Gosemann, Prem Pur. Increased expression of activated pSTAT3 and PIM-1 in the pulmonary vasculature of experimental congenital diaphragmatic hernia. Journal of pediatric surgery. vol 50. issue 6. 2015-12-28. PMID:25812446. |
in human ph activated stat3 (pstat3) was shown to directly trigger expression of the provirus integration site for moloney murine leukemia virus (pim-1), which promotes proliferation and resistance to apoptosis in smcs. |
2015-12-28 |
2023-08-13 |
human |
| Miyong Yun, Duckgue Lee, Moon-Nyeo Park, Eun-Ok Kim, Eun Jung Sohn, Byung-Mog Kwon, Sung-Hoon Ki. Cinnamaldehyde derivative (CB-PIC) sensitizes chemo-resistant cancer cells to drug-induced apoptosis via suppression of MDR1 and its upstream STAT3 and AKT signalling. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 35. issue 5. 2015-12-28. PMID:25833196. |
cinnamaldehyde derivative (cb-pic) sensitizes chemo-resistant cancer cells to drug-induced apoptosis via suppression of mdr1 and its upstream stat3 and akt signalling. |
2015-12-28 |
2023-08-13 |
Not clear |
| Hongsheng Lu, Xuequan Cao, Qi Chen, Lanxi Chen, Lili Chen, Meifu Ga. The expression and role of MEKK3 in renal clear cell carcinoma. Anatomical record (Hoboken, N.J. : 2007). vol 298. issue 4. 2015-12-17. PMID:25388155. |
to explore the relationship between mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase 3(mekk3) and cell apoptosis, clinicopathology, and prognosis, we characterize the expression of mekk3, survivin and stat3 in renal clear cell carcinoma (rccc). |
2015-12-17 |
2023-08-13 |
Not clear |
| Aziz Zaanan, Koichi Okamoto, Hisato Kawakami, Khashayarsha Khazaie, Shengbing Huang, Frank A Sinicrop. The Mutant KRAS Gene Up-regulates BCL-XL Protein via STAT3 to Confer Apoptosis Resistance That Is Reversed by BIM Protein Induction and BCL-XL Antagonism. The Journal of biological chemistry. vol 290. issue 39. 2015-12-17. PMID:26245900. |
the mutant kras gene up-regulates bcl-xl protein via stat3 to confer apoptosis resistance that is reversed by bim protein induction and bcl-xl antagonism. |
2015-12-17 |
2023-08-13 |
Not clear |
| Aziz Zaanan, Koichi Okamoto, Hisato Kawakami, Khashayarsha Khazaie, Shengbing Huang, Frank A Sinicrop. The Mutant KRAS Gene Up-regulates BCL-XL Protein via STAT3 to Confer Apoptosis Resistance That Is Reversed by BIM Protein Induction and BCL-XL Antagonism. The Journal of biological chemistry. vol 290. issue 39. 2015-12-17. PMID:26245900. |
these data suggest that bcl-xl up-regulation by stat3 contributes to mutant kras-mediated apoptosis resistance. |
2015-12-17 |
2023-08-13 |
Not clear |
| Zhan Zhang, Xiaoqian Yang, Linlin Zhang, Zhenfeng Duan, Liting Jia, Peng Wang, Ying Shi, Ying Li, Junjun Ga. Decreased expression and activation of Stat3 in severe preeclampsia. Journal of molecular histology. vol 46. issue 2. 2015-12-14. PMID:25752465. |
decreased stat3 expression and activation may play an important role in the pathogenesis of pe through regulation of the transcription of the stat3 targeted genes survivin and mmp-2 to modulate apoptosis and invasion of placental trophoblastic cells. |
2015-12-14 |
2023-08-13 |
Not clear |
| Muthu K Shanmugam, Peramaiyan Rajendran, Feng Li, Chulwon Kim, Sakshi Sikka, Kodappully Sivaraman Siveen, Alan Prem Kumar, Kwang Seok Ahn, Gautam Seth. Abrogation of STAT3 signaling cascade by zerumbone inhibits proliferation and induces apoptosis in renal cell carcinoma xenograft mouse model. Molecular carcinogenesis. vol 54. issue 10. 2015-12-07. PMID:24797723. |
abrogation of stat3 signaling cascade by zerumbone inhibits proliferation and induces apoptosis in renal cell carcinoma xenograft mouse model. |
2015-12-07 |
2023-08-13 |
mouse |
| Muthu K Shanmugam, Peramaiyan Rajendran, Feng Li, Chulwon Kim, Sakshi Sikka, Kodappully Sivaraman Siveen, Alan Prem Kumar, Kwang Seok Ahn, Gautam Seth. Abrogation of STAT3 signaling cascade by zerumbone inhibits proliferation and induces apoptosis in renal cell carcinoma xenograft mouse model. Molecular carcinogenesis. vol 54. issue 10. 2015-12-07. PMID:24797723. |
the pharmacological effect of zerumbone on stat3 activation, associated protein kinases and phosphatase, and apoptosis was investigated using both rcc cell lines and xenograft mouse model. |
2015-12-07 |
2023-08-13 |
mouse |
| Yonghua Bao, Zhiguo Chen, Yongchen Guo, Yansheng Feng, Zexin Li, Wenliang Han, Jianguo Wang, Weixing Zhao, Yunjuan Jiao, Kai Li, Qian Wang, Jiaqi Wang, Huijuan Zhang, Liang Wang, Wancai Yan. Tumor suppressor microRNA-27a in colorectal carcinogenesis and progression by targeting SGPP1 and Smad2. PloS one. vol 9. issue 8. 2015-11-23. PMID:25166914. |
taken together, this study has revealed mir-27a as a tumor suppressor and has identified sgpp1 and smad2 as novel targets of mir-27a, linking to stat3 for regulating cancer cell proliferation, apoptosis and migration in colorectal cancer. |
2015-11-23 |
2023-08-13 |
mouse |
| Izabella T Silva, Annelise Carvalho, Karen L Lang, Sabine E Dudek, Dörthe Masemann, Fernando J Durán, Miguel S B Caro, Ulf R Rapp, Viktor Wixler, Eloir P Schenkel, Cláudia M O Simões, Stephan Ludwi. In vitro and in vivo antitumor activity of a novel semisynthetic derivative of cucurbitacin B. PloS one. vol 10. issue 2. 2015-11-20. PMID:25674792. |
dace arrested the cell cycle of lung epithelial cells at the g2/m phase and induced cell apoptosis by interfering with egfr activation and its downstream signaling, including akt, erk, and stat3. |
2015-11-20 |
2023-08-13 |
mouse |
| Qiaoyan Cai, Jiumao Lin, Lihui Wei, Ling Zhang, Lili Wang, Youzhi Zhan, Jianwei Zeng, Wei Xu, Aling Shen, Zhenfeng Hong, Jun Pen. Hedyotis diffusa Willd inhibits colorectal cancer growth in vivo via inhibition of STAT3 signaling pathway. International journal of molecular sciences. vol 13. issue 5. 2015-10-26. PMID:22754353. |
in addition, eehdw treatment suppressed stat3 phosphorylation in tumor tissues, which in turn resulted in the promotion of cancer cell apoptosis and inhibition of proliferation. |
2015-10-26 |
2023-08-12 |
mouse |
| Devan Prabhavathy, Bandaru Niranjana Prabhakar, Devarajan Karunagara. HPV16 E2-mediated potentiation of NF-κB activation induced by TNF-α involves parallel activation of STAT3 with a reduction in E2-induced apoptosis. Molecular and cellular biochemistry. vol 394. issue 1-2. 2015-10-26. PMID:24833467. |
hpv16 e2-mediated potentiation of nf-κb activation induced by tnf-α involves parallel activation of stat3 with a reduction in e2-induced apoptosis. |
2015-10-26 |
2023-08-13 |
human |
| Devan Prabhavathy, Bandaru Niranjana Prabhakar, Devarajan Karunagara. HPV16 E2-mediated potentiation of NF-κB activation induced by TNF-α involves parallel activation of STAT3 with a reduction in E2-induced apoptosis. Molecular and cellular biochemistry. vol 394. issue 1-2. 2015-10-26. PMID:24833467. |
inhibition of stat3 activation enhanced e2-induced apoptosis, whereas parallel activation of nf-κb and stat3 by the combined action of e2 and tnf-α increased the expression of their common targets, cyclin-d1, c-myc, survivin, and bcl-2, leading to a decrease in e2-induced apoptosis (viability and cell cycle). |
2015-10-26 |
2023-08-13 |
human |
| Yubao Zhang, Xia Ren, Meiyan Shi, Zheng Jiang, Hengxiao Wang, Qinghong Su, Qinglin Liu, Gang Li, Guosheng Jian. Downregulation of STAT3 and activation of MAPK are involved in the induction of apoptosis by HNK in glioblastoma cell line U87. Oncology reports. vol 32. issue 5. 2015-10-26. PMID:25175884. |
downregulation of stat3 and activation of mapk are involved in the induction of apoptosis by hnk in glioblastoma cell line u87. |
2015-10-26 |
2023-08-13 |
human |