| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiangyang Yao, Fenfen Zhu, Zhihui Zhao, Chang Liu, Lan Luo, Zhimin Yi. Arctigenin enhances chemosensitivity of cancer cells to cisplatin through inhibition of the STAT3 signaling pathway. Journal of cellular biochemistry. vol 112. issue 10. 2012-04-12. PMID:21608020. |
furthermore, the constitutive activation level of stat3 was found to be correlated to the resistance of cancer cells to cisplatin-induced apoptosis. |
2012-04-12 |
2023-08-12 |
Not clear |
| Hua Xiong, Jie Hong, Wan Du, Yan-wei Lin, Lin-lin Ren, Ying-chao Wang, Wen-yu Su, Ji-lin Wang, Yun Cui, Zhen-hua Wang, Jing-Yuan Fan. Roles of STAT3 and ZEB1 proteins in E-cadherin down-regulation and human colorectal cancer epithelial-mesenchymal transition. The Journal of biological chemistry. vol 287. issue 8. 2012-04-09. PMID:22205702. |
activation of stat3 significantly increased crc cell invasiveness and resistance to apoptosis. |
2012-04-09 |
2023-08-12 |
human |
| Peramaiyan Rajendran, Feng Li, Muthu K Shanmugam, Shireen Vali, Taher Abbasi, Shweta Kapoor, Kwang Seok Ahn, Alan Prem Kumar, Gautam Seth. Honokiol inhibits signal transducer and activator of transcription-3 signaling, proliferation, and survival of hepatocellular carcinoma cells via the protein tyrosine phosphatase SHP-1. Journal of cellular physiology. vol 227. issue 5. 2012-04-02. PMID:21792937. |
the effect of honokiol on stat3 activation, associated protein kinases, and phosphatase, stat3-regulated gene products and apoptosis was investigated using both functional proteomics tumor pathway technology platform and different hcc cell lines. |
2012-04-02 |
2023-08-12 |
Not clear |
| R C T McKenzie, C L Jones, I Tosi, J A Caesar, S J Whittaker, T J Mitchel. Constitutive activation of STAT3 in Sézary syndrome is independent of SHP-1. Leukemia. vol 26. issue 2. 2012-03-30. PMID:21818116. |
in contrast, treatment of ss tumour cells with the pan-jak inhibitor pyridone 6 led to downregulation of phosphorylated stat3 (pstat3), its target genes and induction of apoptosis. |
2012-03-30 |
2023-08-12 |
Not clear |
| Hanrui Zhang, Cuihua Zhan. Vasoprotection by dietary supplements and exercise: role of TNFα signaling. Experimental diabetes research. vol 2012. 2012-03-25. PMID:22110483. |
tnfα induces vascular inflammation, monocyte adhesion to endothelial cells, vascular oxidative stress, apoptosis, and atherogenic response and participates in the regulation of thrombosis and coagulation through multiple signaling pathways involving nfκb, sp1, activator protein 1, jnk, p38, stat3, and so forth. |
2012-03-25 |
2023-08-12 |
Not clear |
| J R Matthews, O J Sansom, A R Clark. Absolute requirement for STAT3 function in small-intestine crypt stem cell survival. Cell death and differentiation. vol 18. issue 12. 2012-03-06. PMID:21637293. |
following cre recombinase expression, apoptosis increased in stat3(fl/-) experimental crypts relative to stat3(wt/-) controls before declining. |
2012-03-06 |
2023-08-12 |
mouse |
| J R Matthews, O J Sansom, A R Clark. Absolute requirement for STAT3 function in small-intestine crypt stem cell survival. Cell death and differentiation. vol 18. issue 12. 2012-03-06. PMID:21637293. |
rapid clearance of recombined stat3(fl/-) cells involves apoptosis potentially induced by elevated c-myc in non-recombined cells and involves elevated p53 expression and caspase 3 activation. |
2012-03-06 |
2023-08-12 |
mouse |
| Yongzhi Wang, Lingchao Chen, Zhaoshi Bao, Shouwei Li, Gan You, Wei Yan, Zhendong Shi, Yanwei Liu, Pei Yang, Wei Zhang, Lei Han, Chunsheng Kang, Tao Jian. Inhibition of STAT3 reverses alkylator resistance through modulation of the AKT and β-catenin signaling pathways. Oncology reports. vol 26. issue 5. 2012-03-01. PMID:21887474. |
inhibition of stat3 dramatically decreased the ic50 of tmz, increasing tmz-induced apoptosis while up-regulating expression of bcl-2 and down-regulating expression of bax. |
2012-03-01 |
2023-08-12 |
human |
| Shuling Huang, Min Chen, Yonghua Shen, Weidong Shen, Huimin Guo, Qian Gao, Xiaoping Zo. Inhibition of activated Stat3 reverses drug resistance to chemotherapeutic agents in gastric cancer cells. Cancer letters. vol 315. issue 2. 2012-02-13. PMID:22104727. |
inhibition of stat3 function resulted in significant decreases in cisplatin resistance and enhanced apoptosis in drug resistant cells. |
2012-02-13 |
2023-08-12 |
human |
| Jin-fang Zhang, Ming-liang He, Wei-ming Fu, Hua Wang, Lian-zhou Chen, Xiao Zhu, Ying Chen, Dan Xie, Paul Lai, Gong Chen, Gang Lu, Marie C M Lin, Hsiang-fu Kun. Primate-specific microRNA-637 inhibits tumorigenesis in hepatocellular carcinoma by disrupting signal transducer and activator of transcription 3 signaling. Hepatology (Baltimore, Md.). vol 54. issue 6. 2012-02-07. PMID:21809363. |
the transcription factor, signal transducer and activator of transcription 3 (stat3), is constitutively activated in multiple tumors, and aberrant stat3 activation is linked to the promotion of growth and desensitization of apoptosis. |
2012-02-07 |
2023-08-12 |
mouse |
| Heng-Chao Yu, Hong-Yan Qin, Fei He, Lin Wang, Wei Fu, Dong Liu, Feng-Cheng Guo, Liang Liang, Ke-Feng Dou, Hua Ha. Canonical notch pathway protects hepatocytes from ischemia/reperfusion injury in mice by repressing reactive oxygen species production through JAK2/STAT3 signaling. Hepatology (Baltimore, Md.). vol 54. issue 3. 2012-02-06. PMID:21633967. |
notch signal blockade resulted in down-regulation of hes5, leading to reduced formation of the hes5-stat3 complex and hypophosphorylation of stat3, which further attenuated manganese superoxide dismutase (mnsod) expression and increased ros and apoptosis. |
2012-02-06 |
2023-08-12 |
mouse |
| Heng-Chao Yu, Hong-Yan Qin, Fei He, Lin Wang, Wei Fu, Dong Liu, Feng-Cheng Guo, Liang Liang, Ke-Feng Dou, Hua Ha. Canonical notch pathway protects hepatocytes from ischemia/reperfusion injury in mice by repressing reactive oxygen species production through JAK2/STAT3 signaling. Hepatology (Baltimore, Md.). vol 54. issue 3. 2012-02-06. PMID:21633967. |
indeed, overexpression of a constitutively active stat3 rescued mnsod expression and i/r injury-induced apoptosis in the absence of notch signaling. |
2012-02-06 |
2023-08-12 |
mouse |
| Heng-Chao Yu, Hong-Yan Qin, Fei He, Lin Wang, Wei Fu, Dong Liu, Feng-Cheng Guo, Liang Liang, Ke-Feng Dou, Hua Ha. Canonical notch pathway protects hepatocytes from ischemia/reperfusion injury in mice by repressing reactive oxygen species production through JAK2/STAT3 signaling. Hepatology (Baltimore, Md.). vol 54. issue 3. 2012-02-06. PMID:21633967. |
finally, forced notch activation by ligand stimulation or hes5 overexpression reduced intracellular ros and protected hepatocytes from apoptosis after i/r injury through the activation of stat3 and mnsod expression. |
2012-02-06 |
2023-08-12 |
mouse |
| Sanjiv Dhingra, Ashim K Bagchi, Ana L Ludke, Anita K Sharma, Pawan K Singa. Akt regulates IL-10 mediated suppression of TNFα-induced cardiomyocyte apoptosis by upregulating Stat3 phosphorylation. PloS one. vol 6. issue 9. 2012-02-03. PMID:21949832. |
akt regulates il-10 mediated suppression of tnfα-induced cardiomyocyte apoptosis by upregulating stat3 phosphorylation. |
2012-02-03 |
2023-08-12 |
Not clear |
| Seong-Kyu Kim, Ki-Yeun Park, Wern-Chan Yoon, Sung-Hoon Park, Kwan-Kyu Park, Dae-Hyun Yoo, Jung-Yoon Cho. Melittin enhances apoptosis through suppression of IL-6/sIL-6R complex-induced NF-κB and STAT3 activation and Bcl-2 expression for human fibroblast-like synoviocytes in rheumatoid arthritis. Joint bone spine. vol 78. issue 5. 2012-01-31. PMID:21354845. |
melittin enhances apoptosis through suppression of il-6/sil-6r complex-induced nf-κb and stat3 activation and bcl-2 expression for human fibroblast-like synoviocytes in rheumatoid arthritis. |
2012-01-31 |
2023-08-12 |
human |
| Jinbing Zhao, Guangzhao Li, Yang Zhang, Xingfen Su, Chunhua Han. The potential role of JAK2/STAT3 pathway on the anti-apoptotic effect of recombinant human erythropoietin (rhEPO) after experimental traumatic brain injury of rats. Cytokine. vol 56. issue 2. 2012-01-30. PMID:21843949. |
as a result, we found that tbi could activate jak2 and stat3, and increase cell apoptosis in pericontusional cortex. |
2012-01-30 |
2023-08-12 |
human |
| Nicodemus Mautsa, Earl Prinsloo, Özlem Tastan Bishop, Gregory L Blatc. The PINIT domain of PIAS3: structure-function analysis of its interaction with STAT3. Journal of molecular recognition : JMR. vol 24. issue 5. 2012-01-26. PMID:21812053. |
the protein inhibitor of activated signal transducer and activator of transcription 3 (pias3) regulates the transcriptional activity of signal transducer and activator of transcription 3 (stat3) which regulates transcription of genes involved in cell growth, proliferation and apoptosis. |
2012-01-26 |
2023-08-12 |
Not clear |
| Jun Liu, Xinnv Xu, Xuequan Feng, Biao Zhang, Jinhuan Wan. Adenovirus-mediated delivery of bFGF small interfering RNA reduces STAT3 phosphorylation and induces the depolarization of mitochondria and apoptosis in glioma cells U251. Journal of experimental & clinical cancer research : CR. vol 30. 2012-01-17. PMID:21906308. |
adenovirus-mediated delivery of bfgf small interfering rna reduces stat3 phosphorylation and induces the depolarization of mitochondria and apoptosis in glioma cells u251. |
2012-01-17 |
2023-08-12 |
human |
| Jun Liu, Xinnv Xu, Xuequan Feng, Biao Zhang, Jinhuan Wan. Adenovirus-mediated delivery of bFGF small interfering RNA reduces STAT3 phosphorylation and induces the depolarization of mitochondria and apoptosis in glioma cells U251. Journal of experimental & clinical cancer research : CR. vol 30. 2012-01-17. PMID:21906308. |
therefore, we hypothesized that the proliferation inhibition and apoptosis induction by ad-bfgf-sirna may result from the interruption of stat3 phosphorylation. |
2012-01-17 |
2023-08-12 |
human |
| Jun Liu, Xinnv Xu, Xuequan Feng, Biao Zhang, Jinhuan Wan. Adenovirus-mediated delivery of bFGF small interfering RNA reduces STAT3 phosphorylation and induces the depolarization of mitochondria and apoptosis in glioma cells U251. Journal of experimental & clinical cancer research : CR. vol 30. 2012-01-17. PMID:21906308. |
in the current study, we found that in glioma cells u251, ad-bfgf-sirna impedes the activation of erk1/2 and jak2, but not src, decreases il-6 secretion, reduces stat3 phosphorylation, decreases the levels of downstream molecules cyclind1 and bcl-xl, and ultimately results in the collapse of mitochondrial membrane potentials as well as the induction of mitochondrial-related apoptosis. |
2012-01-17 |
2023-08-12 |
human |