| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sahdeo Prasad, Manoj K Pandey, Vivek R Yadav, Bharat B Aggarwa. Gambogic acid inhibits STAT3 phosphorylation through activation of protein tyrosine phosphatase SHP-1: potential role in proliferation and apoptosis. Cancer prevention research (Philadelphia, Pa.). vol 4. issue 7. 2011-11-15. PMID:21490133. |
deletion of the shp-1 gene by sirna suppressed the ability of ga to inhibit stat3 activation and to induce apoptosis, suggesting the critical role of shp-1 in its action. |
2011-11-15 |
2023-08-12 |
human |
| Sahdeo Prasad, Manoj K Pandey, Vivek R Yadav, Bharat B Aggarwa. Gambogic acid inhibits STAT3 phosphorylation through activation of protein tyrosine phosphatase SHP-1: potential role in proliferation and apoptosis. Cancer prevention research (Philadelphia, Pa.). vol 4. issue 7. 2011-11-15. PMID:21490133. |
overall, these results suggest that ga blocks stat3 activation, leading to suppression of tumor cell proliferation and induction of apoptosis. |
2011-11-15 |
2023-08-12 |
human |
| Hyun-Mee Oh, Cheng-Rong Yu, Nady Golestaneh, Ahjoku Amadi-Obi, Yun Sang Lee, Amarachi Eseonu, Rashid M Mahdi, Charles E Egwuag. STAT3 protein promotes T-cell survival and inhibits interleukin-2 production through up-regulation of Class O Forkhead transcription factors. The Journal of biological chemistry. vol 286. issue 35. 2011-10-25. PMID:21730069. |
it is notable that their exaggerated increase in il-2 production rendered stat3-deficient lymphocytes more susceptible to activation-induced cell death, suggesting that stat3 might protect t-cells from apoptosis by limiting their production of il-2 through up-regulation of foxo1/foxo3a expression. |
2011-10-25 |
2023-08-12 |
Not clear |
| Jingya Zhang, Yueting Zhang, Dipankar J Dutta, Azeb T Argaw, Virginie Bonnamain, Jeremy Seto, David A Braun, Andleeb Zameer, Fernand Hayot, Carolina B Lòpez, Cedric S Raine, Gareth R Joh. Proapoptotic and antiapoptotic actions of Stat1 versus Stat3 underlie neuroprotective and immunoregulatory functions of IL-11. Journal of immunology (Baltimore, Md. : 1950). vol 187. issue 3. 2011-10-24. PMID:21709156. |
in this study, we demonstrate that these effects of il-11 are mediated via differential regulation of apoptosis in oligodendrocytes versus ag-presenting dendritic cells (dcs), and are dependent on lineage-specific activity of the transcription factors stat1 versus stat3. |
2011-10-24 |
2023-08-12 |
mouse |
| Jingya Zhang, Yueting Zhang, Dipankar J Dutta, Azeb T Argaw, Virginie Bonnamain, Jeremy Seto, David A Braun, Andleeb Zameer, Fernand Hayot, Carolina B Lòpez, Cedric S Raine, Gareth R Joh. Proapoptotic and antiapoptotic actions of Stat1 versus Stat3 underlie neuroprotective and immunoregulatory functions of IL-11. Journal of immunology (Baltimore, Md. : 1950). vol 187. issue 3. 2011-10-24. PMID:21709156. |
importantly, sirna inhibition of stat1 enhanced the antiapoptotic effects of il-11 on opcs, but il-11 induced apoptosis in the presence of stat3 silencing. |
2011-10-24 |
2023-08-12 |
mouse |
| Muthu K Shanmugam, Peramaiyan Rajendran, Feng Li, Tarang Nema, Shireen Vali, Taher Abbasi, Shweta Kapoor, Ashish Sharma, Alan Prem Kumar, Paul C Ho, Kam M Hui, Gautam Seth. Ursolic acid inhibits multiple cell survival pathways leading to suppression of growth of prostate cancer xenograft in nude mice. Journal of molecular medicine (Berlin, Germany). vol 89. issue 7. 2011-10-17. PMID:21465181. |
ua also downregulated the expression of various nf-κb and stat3 regulated gene products involved in proliferation, survival, and angiogenesis and induced apoptosis in both cells lines as evidenced by dna fragmentation and annexin v staining. |
2011-10-17 |
2023-08-12 |
mouse |
| Jolyane Meloche, Roxane Paulin, Audrey Courboulin, Caroline Lambert, Marjorie Barrier, Pierre Bonnet, Malik Bisserier, Mélanie Roy, Mark A Sussman, Mohsen Agharazii, Sébastien Bonne. RAGE-dependent activation of the oncoprotein Pim1 plays a critical role in systemic vascular remodeling processes. Arteriosclerosis, thrombosis, and vascular biology. vol 31. issue 9. 2011-10-13. PMID:21680901. |
methods/results- in vitro, freshly isolated human carotid vsmcs exposed to rage activator nε-(carboxymethyl)lysine (cml) for 48 hours had (1) activated stat3 (increased p-stat3/stat3 ratio and p-stat3 nuclear translocation); (2) increased stat3-dependent pim1 expression resulting in nfatc1 activation; and (3) increased pim1/nfat-dependent vsmc proliferation (pcna, ki67) and resistance to mitochondrial-dependent apoptosis (tmrm, annexin v, tunel). |
2011-10-13 |
2023-08-12 |
mouse |
| Edmund A Rossi, Diane L Rossi, Thomas M Cardillo, Rhona Stein, David M Goldenberg, Chien-Hsing Chan. Preclinical studies on targeted delivery of multiple IFNα2b to HLA-DR in diverse hematologic cancers. Blood. vol 118. issue 7. 2011-10-12. PMID:21680794. |
phosphorylation of stat1 was more robust and persistent than that of stat3, which may promote apoptosis. |
2011-10-12 |
2023-08-12 |
human |
| Byung Hak Kim, Yun Sook Min, Jung Sook Choi, Gyeong Hun Baeg, Young Soo Kim, Jong Wook Shin, Tae Yoon Kim, Sang Kyu Y. Benzoxathiol derivative BOT-4-one suppresses L540 lymphoma cell survival and proliferation via inhibition of JAK3/STAT3 signaling. Experimental & molecular medicine. vol 43. issue 5. 2011-10-03. PMID:21499010. |
here, we report that 2-cyclohexylimino-6-methyl-6,7-dihydro-5h-benzo [1,3]oxathiol-4-one (bot-4-one), a small molecule inhibitor of jak/stat3 signaling, induces apoptosis through inhibition of stat3 activation. |
2011-10-03 |
2023-08-12 |
human |
| Byung Hak Kim, Yun Sook Min, Jung Sook Choi, Gyeong Hun Baeg, Young Soo Kim, Jong Wook Shin, Tae Yoon Kim, Sang Kyu Y. Benzoxathiol derivative BOT-4-one suppresses L540 lymphoma cell survival and proliferation via inhibition of JAK3/STAT3 signaling. Experimental & molecular medicine. vol 43. issue 5. 2011-10-03. PMID:21499010. |
in addition, bot-4-one-treated hodgkin's lymphoma cells showed decreased cell survival and proliferation by inducing apoptosis through down-regulation of stat3 downstream target anti-apoptotic gene expression. |
2011-10-03 |
2023-08-12 |
human |
| Golla Jaya Prakash, Pankaj Suman, Diana M Morales Prieto, Udo R Markert, Satish K Gupt. Leukaemia inhibitory factor mediated proliferation of HTR-8/SVneo trophoblast cells is dependent on activation of extracellular signal-regulated kinase 1/2. Reproduction, fertility, and development. vol 23. issue 5. 2011-09-30. PMID:21635820. |
although stat3 silencing had no effect on lif-dependent proliferation of htr-8/svneo cells, it did result in an increase in cell apoptosis, which increased further upon inhibition of erk1/2 activation irrespective of lif stimulation. |
2011-09-30 |
2023-08-12 |
Not clear |
| Yi Jiang, Ze-Hong Miao, Lei Xu, Bing Yu, Jing-Xu Gong, Lin-Jiang Tong, Yi Chen, Zhao-Li Zhou, Hong-Chun Liu, Yi Wang, Yue-Wei Guo, Jian Din. Drug transporter-independent liver cancer cell killing by a marine steroid methyl spongoate via apoptosis induction. The Journal of biological chemistry. vol 286. issue 30. 2011-09-28. PMID:21659517. |
in contrast, mesp potently induced apoptosis via activation of a proapoptotic caspase cascade and relief of the suppression of antiapoptotic signal transducers and activators of transcription 3 (stat3) signaling. |
2011-09-28 |
2023-08-12 |
Not clear |
| Yi Jiang, Ze-Hong Miao, Lei Xu, Bing Yu, Jing-Xu Gong, Lin-Jiang Tong, Yi Chen, Zhao-Li Zhou, Hong-Chun Liu, Yi Wang, Yue-Wei Guo, Jian Din. Drug transporter-independent liver cancer cell killing by a marine steroid methyl spongoate via apoptosis induction. The Journal of biological chemistry. vol 286. issue 30. 2011-09-28. PMID:21659517. |
mesp inhibited the phosphorylation of stat3, a critical survival signaling factor that reduced the expression of the antiapoptotic protein x-linked inhibitor of apoptosis protein but enhanced the expression of the proapoptotic protein bax, thus promoting caspase-dependent apoptosis. |
2011-09-28 |
2023-08-12 |
Not clear |
| Jeffrey A Poynter, Jeremy L Herrmann, Mariuxi C Manukyan, Yue Wang, Aaron M Abarbanell, Brent R Weil, Benjamin D Brewster, Daniel R Meldru. Intracoronary mesenchymal stem cells promote postischemic myocardial functional recovery, decrease inflammation, and reduce apoptosis via a signal transducer and activator of transcription 3 mechanism. Journal of the American College of Surgeons. vol 213. issue 2. 2011-09-27. PMID:21546276. |
signal transducer and activator of transcription 3 (stat3) regulates myocardial apoptosis, cellular proliferation, and the immune response after ischemia/reperfusion (i/r). |
2011-09-27 |
2023-08-12 |
Not clear |
| Lucy Liu, Sangkil Nam, Yan Tian, Fan Yang, Jun Wu, Yan Wang, Anna Scuto, Panos Polychronopoulos, Prokopios Magiatis, Leandros Skaltsounis, Richard Jov. 6-Bromoindirubin-3'-oxime inhibits JAK/STAT3 signaling and induces apoptosis of human melanoma cells. Cancer research. vol 71. issue 11. 2011-09-20. PMID:21610112. |
apoptosis of human melanoma cells induced by 6bio was associated with reduced phosphorylation of jaks and stat3 in both dose- and time-dependent manners. |
2011-09-20 |
2023-08-12 |
mouse |
| Lucy Liu, Sangkil Nam, Yan Tian, Fan Yang, Jun Wu, Yan Wang, Anna Scuto, Panos Polychronopoulos, Prokopios Magiatis, Leandros Skaltsounis, Richard Jov. 6-Bromoindirubin-3'-oxime inhibits JAK/STAT3 signaling and induces apoptosis of human melanoma cells. Cancer research. vol 71. issue 11. 2011-09-20. PMID:21610112. |
taken together, these results show that 6bio is a novel pan-jak inhibitor that can selectively inhibit stat3 signaling and induces tumor cell apoptosis. |
2011-09-20 |
2023-08-12 |
mouse |
| W Okamoto, I Okamoto, T Arao, K Yanagihara, K Nishio, K Nakagaw. Differential roles of STAT3 depending on the mechanism of STAT3 activation in gastric cancer cells. British journal of cancer. vol 105. issue 3. 2011-09-16. PMID:21730976. |
signal transducer and activator of transcription 3 (stat3) is a transcription factor that is activated in response to growth factors and cytokines, and which contributes to the regulation of cell proliferation, apoptosis, and motility in many human tumour types. |
2011-09-16 |
2023-08-12 |
human |
| Ralf Buettner, Renzo Corzano, Rumana Rashid, Jianping Lin, Maheswari Senthil, Michael Hedvat, Anne Schroeder, Allen Mao, Andreas Herrmann, John Yim, Hongzhi Li, Yate-Ching Yuan, Kenichi Yakushijin, Fumiko Yakushijin, Nagarajan Vaidehi, Roger Moore, Gabriel Gugiu, Terry D Lee, Richard Yip, Yuan Chen, Richard Jove, David Horne, John C William. Alkylation of cysteine 468 in Stat3 defines a novel site for therapeutic development. ACS chemical biology. vol 6. issue 5. 2011-09-06. PMID:21226522. |
inhibition of stat3 signaling pathways suppresses cell survival signals and leads to apoptosis in cancer cells, suggesting direct inhibition of stat3 function is a viable therapeutic approach. |
2011-09-06 |
2023-08-12 |
mouse |
| Aiguo Liu, Yan Liu, Zhenghu Xu, Wenying Yu, Hong Wang, Chenglong Li, Jiayuh Li. Novel small molecule, XZH-5, inhibits constitutive and interleukin-6-induced STAT3 phosphorylation in human rhabdomyosarcoma cells. Cancer science. vol 102. issue 7. 2011-08-26. PMID:21435102. |
we also demonstrated that inhibition of the stat3 pathway led to apoptosis in human rhabdomyosarcoma cells. |
2011-08-26 |
2023-08-12 |
human |
| Aiguo Liu, Yan Liu, Zhenghu Xu, Wenying Yu, Hong Wang, Chenglong Li, Jiayuh Li. Novel small molecule, XZH-5, inhibits constitutive and interleukin-6-induced STAT3 phosphorylation in human rhabdomyosarcoma cells. Cancer science. vol 102. issue 7. 2011-08-26. PMID:21435102. |
the inhibition of stat3 by xzh-5 was confirmed by the inhibition of stat3 dna binding ability and the downregulation of stat3 downstream genes, such as bcl-2, bcl-xl, cyclin d1 and survivin; we also demonstrated that blockade of stat3 phosphorylation in human rhabdomyosarcoma cells with xzh-5 caused apoptosis and suppressed colony-forming ability and cell migration. |
2011-08-26 |
2023-08-12 |
human |