| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jun Peng, Youqin Chen, Jiumao Lin, Qunchuan Zhuang, Wei Xu, Zhenfeng Hong, Thomas J Sferr. Patrinia scabiosaefolia extract suppresses proliferation and promotes apoptosis by inhibiting the STAT3 pathway in human multiple myeloma cells. Molecular medicine reports. vol 4. issue 2. 2011-07-12. PMID:21468570. |
in this study, we evaluated the effect of the ethanol extract of patrinia scabiosaefolia (eeps) on proliferation and apoptosis in human multiple myeloma u266 cells that persistently express phosphorylated stat3, and investigated the possible molecular mechanisms mediating its biological effects. |
2011-07-12 |
2023-08-12 |
human |
| Jun Peng, Youqin Chen, Jiumao Lin, Qunchuan Zhuang, Wei Xu, Zhenfeng Hong, Thomas J Sferr. Patrinia scabiosaefolia extract suppresses proliferation and promotes apoptosis by inhibiting the STAT3 pathway in human multiple myeloma cells. Molecular medicine reports. vol 4. issue 2. 2011-07-12. PMID:21468570. |
consequently, the inhibitory effect of eeps on stat3 activation resulted in the suppression of cell proliferation and the induction of cell apoptosis. |
2011-07-12 |
2023-08-12 |
human |
| Jun Peng, Youqin Chen, Jiumao Lin, Qunchuan Zhuang, Wei Xu, Zhenfeng Hong, Thomas J Sferr. Patrinia scabiosaefolia extract suppresses proliferation and promotes apoptosis by inhibiting the STAT3 pathway in human multiple myeloma cells. Molecular medicine reports. vol 4. issue 2. 2011-07-12. PMID:21468570. |
moreover, eeps treatment inhibited the expression of cyclin d1 (a promoter of cell proliferation) and bcl-2 (an inhibitor of apoptosis), two important target genes of the stat3 signaling pathway. |
2011-07-12 |
2023-08-12 |
human |
| Jun Peng, Youqin Chen, Jiumao Lin, Qunchuan Zhuang, Wei Xu, Zhenfeng Hong, Thomas J Sferr. Patrinia scabiosaefolia extract suppresses proliferation and promotes apoptosis by inhibiting the STAT3 pathway in human multiple myeloma cells. Molecular medicine reports. vol 4. issue 2. 2011-07-12. PMID:21468570. |
our findings for the first time demonstrate that patrinia scabiosaefolia inhibits proliferation and promotes the apoptosis of cancer cells via inhibition of the stat3 pathway, which may in part explain its anti-cancer activity. |
2011-07-12 |
2023-08-12 |
human |
| Huan-Chih Chiu, Ding-Li Chou, Chin-Ting Huang, Wen-Hsing Lin, Tzu-Wen Lien, Kuei-Jung Yen, John T-A Hs. Suppression of Stat3 activity sensitizes gefitinib-resistant non small cell lung cancer cells. Biochemical pharmacology. vol 81. issue 11. 2011-07-05. PMID:21406185. |
meanwhile, apoptosis activation by sirna-mediated down-regulation of stat3 in h1650 cells provides more direct evidence for the involvement of stat3 in viability maintenance of h1650 cells. |
2011-07-05 |
2023-08-12 |
Not clear |
| Ayako Matsumoto, Hajime Isomoto, Masaaki Nakayama, Junzo Hisatsune, Yoshito Nishi, Yujiro Nakashima, Kayoko Matsushima, Hisao Kurazono, Kazuhiko Nakao, Toshiya Hirayama, Shigeru Kohn. Helicobacter pylori VacA reduces the cellular expression of STAT3 and pro-survival Bcl-2 family proteins, Bcl-2 and Bcl-XL, leading to apoptosis in gastric epithelial cells. Digestive diseases and sciences. vol 56. issue 4. 2011-06-21. PMID:20927590. |
helicobacter pylori vaca reduces the cellular expression of stat3 and pro-survival bcl-2 family proteins, bcl-2 and bcl-xl, leading to apoptosis in gastric epithelial cells. |
2011-06-21 |
2023-08-12 |
Not clear |
| Stacey L Fossey, Misty D Bear, Jiayuh Lin, Chenglong Li, Eric B Schwartz, Pui-Kai Li, James R Fuchs, Joelle Fenger, William C Kisseberth, Cheryl A Londo. The novel curcumin analog FLLL32 decreases STAT3 DNA binding activity and expression, and induces apoptosis in osteosarcoma cell lines. BMC cancer. vol 11. 2011-06-21. PMID:21443800. |
the novel curcumin analog flll32 decreases stat3 dna binding activity and expression, and induces apoptosis in osteosarcoma cell lines. |
2011-06-21 |
2023-08-12 |
human |
| Haili Lü, Qiuhang Zhang, Bo Ya. [Apoptosis of laryngeal carcinoma cells induced by antisense oligodeoxynucleotides complementary Stat3 in vitro]. Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery. vol 22. issue 21. 2011-06-16. PMID:19157144. |
[apoptosis of laryngeal carcinoma cells induced by antisense oligodeoxynucleotides complementary stat3 in vitro]. |
2011-06-16 |
2023-08-12 |
Not clear |
| Haili Lü, Qiuhang Zhang, Bo Ya. [Apoptosis of laryngeal carcinoma cells induced by antisense oligodeoxynucleotides complementary Stat3 in vitro]. Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery. vol 22. issue 21. 2011-06-16. PMID:19157144. |
to study the effects of oligodeoxynucleotides complementary stat3 on apoptosis in laryngeal carcinoma hep-2 cell. |
2011-06-16 |
2023-08-12 |
Not clear |
| Dae Joon Kim, Michel L Tremblay, John Digiovann. Protein tyrosine phosphatases, TC-PTP, SHP1, and SHP2, cooperate in rapid dephosphorylation of Stat3 in keratinocytes following UVB irradiation. PloS one. vol 5. issue 4. 2011-06-16. PMID:20421975. |
treatment with na(3)vo(4) desensitized keratinocytes to uvb-induced apoptosis with the recovery of phosphorylated stat3 protein levels, implying that a protein tyrosine phosphatase (ptp) is involved in this mechanism. |
2011-06-16 |
2023-08-12 |
mouse |
| Kanji Yamaguchi, Yoshito Itoh, Chihiro Yokomizo, Takeshi Nishimura, Toshihisa Niimi, Atsushi Umemura, Hideki Fujii, Takeshi Okanoue, Toshikazu Yoshikaw. Blockade of IL-6 signaling exacerbates liver injury and suppresses antiapoptotic gene expression in methionine choline-deficient diet-fed db/db mice. Laboratory investigation; a journal of technical methods and pathology. vol 91. issue 4. 2011-06-01. PMID:21321532. |
mr16-1 treatment of mcd diet-fed db/db mice further repressed stat3 activities and expression of stat3-related antiapoptotic genes, such as bcl-2 and ref-1, but increased plasma-free fatty acid and hepatic markers of lipid peroxidation/oxidant stress, leading to increased liver injury, hepatocyte apoptosis and liver fibrosis. |
2011-06-01 |
2023-08-12 |
mouse |
| Kanji Yamaguchi, Yoshito Itoh, Chihiro Yokomizo, Takeshi Nishimura, Toshihisa Niimi, Atsushi Umemura, Hideki Fujii, Takeshi Okanoue, Toshikazu Yoshikaw. Blockade of IL-6 signaling exacerbates liver injury and suppresses antiapoptotic gene expression in methionine choline-deficient diet-fed db/db mice. Laboratory investigation; a journal of technical methods and pathology. vol 91. issue 4. 2011-06-01. PMID:21321532. |
although 'moderate' blockade of enhanced il-6-stat3 signaling may be beneficial in nash, as we reported previously, these findings demonstrate that a profound defect in stat3 activation is detrimental in terms of liver injury, hepatocyte apoptosis and liver fibrosis, indicating the hepato-protective role of il-6 signaling in this severe nash model. |
2011-06-01 |
2023-08-12 |
mouse |
| Minoru Shigekawa, Tetsuo Takehara, Takahiro Kodama, Hayato Hikita, Satoshi Shimizu, Wei Li, Takuya Miyagi, Atsushi Hosui, Tomohide Tatsumi, Hisashi Ishida, Tatsuya Kanto, Naoki Hiramatsu, Norio Hayash. Involvement of STAT3-regulated hepatic soluble factors in attenuation of stellate cell activity and liver fibrogenesis in mice. Biochemical and biophysical research communications. vol 406. issue 4. 2011-05-24. PMID:21356197. |
glycoprotein 130 (gp130)/signal transducer and activator of transcription 3 (stat3) signaling in hepatocytes controls a variety of physiological and pathological processes including liver regeneration, apoptosis resistance and metabolism. |
2011-05-24 |
2023-08-12 |
mouse |
| Su Hui Yang, Daulat Bikram Khadka, Suk Hee Cho, Hye-Kyung Ju, Kwang Youl Lee, Ho Jae Han, Kyung-Tae Lee, Won-Jea Ch. Virtual screening and synthesis of quinazolines as novel JAK2 inhibitors. Bioorganic & medicinal chemistry. vol 19. issue 2. 2011-05-03. PMID:21185195. |
moreover, 5p showed a positive correlation between jak2 inhibition and cytotoxicity; 5p treatment in ht-29 cells strongly inhibited jak2 activation and subsequent stat3 phosphorylation, reduced anti-apoptotic protein levels, and finally induced apoptosis. |
2011-05-03 |
2023-08-12 |
mouse |
| Sun-Hee Kim, Kwang Seok Ahn, Soo-Jin Jeong, Tae-Rin Kwon, Ji Hoon Jung, Sun-Mi Yun, Ihn Han, Seok-Geun Lee, Dae Keun Kim, Minkyung Kang, Chang-Yan Chen, Jung Weon Lee, Sung-Hoon Ki. Janus activated kinase 2/signal transducer and activator of transcription 3 pathway mediates icariside II-induced apoptosis in U266 multiple myeloma cells. European journal of pharmacology. vol 654. issue 1. 2011-04-25. PMID:21172343. |
to analyze the effects on signal transducer and activator of transcription 3 (stat3) signaling and apoptosis, u266 multiple myeloma cells were treated with icariside ii and performed western blotting, electrophoretic mobility gel shift assay (emsa), rt-pcr, proliferation assay, cell cycle analysis and terminal deoxynucleotidyl transferase dutp nick end labeling (tunel) assay. |
2011-04-25 |
2023-08-12 |
human |
| Sun-Hee Kim, Kwang Seok Ahn, Soo-Jin Jeong, Tae-Rin Kwon, Ji Hoon Jung, Sun-Mi Yun, Ihn Han, Seok-Geun Lee, Dae Keun Kim, Minkyung Kang, Chang-Yan Chen, Jung Weon Lee, Sung-Hoon Ki. Janus activated kinase 2/signal transducer and activator of transcription 3 pathway mediates icariside II-induced apoptosis in U266 multiple myeloma cells. European journal of pharmacology. vol 654. issue 1. 2011-04-25. PMID:21172343. |
pervanadate reversed the icariside ii-mediated stat3 inactivation and also blocked the cleavages of caspase-3 and parp, suggesting involvement of stat3 pathway in icariside ii-induced apoptosis. |
2011-04-25 |
2023-08-12 |
human |
| Hui Ying Zhang, Qiuyang Zhang, Xi Zhang, Chunhua Yu, Xiaofang Huo, Edaire Cheng, David H Wang, Stuart J Spechler, Rhonda F Souz. Cancer-related inflammation and Barrett's carcinogenesis: interleukin-6 and STAT3 mediate apoptotic resistance in transformed Barrett's cells. American journal of physiology. Gastrointestinal and liver physiology. vol 300. issue 3. 2011-04-21. PMID:21148399. |
we also used small interfering rnas (sirnas) to stat3 and mcl-1 to assess effects of stat3 pathway inhibition on apoptosis. |
2011-04-21 |
2023-08-12 |
human |
| Hui Ying Zhang, Qiuyang Zhang, Xi Zhang, Chunhua Yu, Xiaofang Huo, Edaire Cheng, David H Wang, Stuart J Spechler, Rhonda F Souz. Cancer-related inflammation and Barrett's carcinogenesis: interleukin-6 and STAT3 mediate apoptotic resistance in transformed Barrett's cells. American journal of physiology. Gastrointestinal and liver physiology. vol 300. issue 3. 2011-04-21. PMID:21148399. |
in transformed barrett's cells, rates of apoptosis following exposure to deoxycholic acid were significantly increased by transfection with sirnas for stat3 and mcl-1. |
2011-04-21 |
2023-08-12 |
human |
| Zhenlian Wang, Feijun Luo, Lili Li, Lifang Yang, Duosha Hu, Xiaoqian Ma, Zhongxin Lu, Lunquan Sun, Ya Ca. STAT3 activation induced by Epstein-Barr virus latent membrane protein1 causes vascular endothelial growth factor expression and cellular invasiveness via JAK3 And ERK signaling. European journal of cancer (Oxford, England : 1990). vol 46. issue 16. 2011-03-28. PMID:20709526. |
signal transducer and activator of transcription 3 (stat3) is a master transcriptional regulator in proliferation and apoptosis and is newly implicated in angiogenesis and invasiveness, which, in turn, are likely to contribute to the highly invasive character of npc. |
2011-03-28 |
2023-08-12 |
human |
| Ganchimeg Ishdorj, James B Johnston, Spencer B Gibso. Inhibition of constitutive activation of STAT3 by curcurbitacin-I (JSI-124) sensitized human B-leukemia cells to apoptosis. Molecular cancer therapeutics. vol 9. issue 12. 2011-03-28. PMID:21159613. |
inhibition of constitutive activation of stat3 by curcurbitacin-i (jsi-124) sensitized human b-leukemia cells to apoptosis. |
2011-03-28 |
2023-08-12 |
human |