| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yan Liu, Aiguo Liu, Zhenghu Xu, Wenying Yu, Hong Wang, Chenglong Li, Jiayuh Li. XZH-5 inhibits STAT3 phosphorylation and causes apoptosis in human hepatocellular carcinoma cells. Apoptosis : an international journal on programmed cell death. vol 16. issue 5. 2011-08-16. PMID:21311975. |
in this study, we demonstrated that blocking stat3 phosphorylation with stat3 small molecule inhibitors sd-1029 and stattic caused apoptosis in hcc cells. |
2011-08-16 |
2023-08-12 |
human |
| Yan Liu, Aiguo Liu, Zhenghu Xu, Wenying Yu, Hong Wang, Chenglong Li, Jiayuh Li. XZH-5 inhibits STAT3 phosphorylation and causes apoptosis in human hepatocellular carcinoma cells. Apoptosis : an international journal on programmed cell death. vol 16. issue 5. 2011-08-16. PMID:21311975. |
the inhibition of stat3 in hcc cells resulted in the induction of apoptosis and reduction of colony forming ability. |
2011-08-16 |
2023-08-12 |
human |
| Sarah Ball, Chenglong Li, Pui-Kai Li, Jiayuh Li. The small molecule, LLL12, inhibits STAT3 phosphorylation and induces apoptosis in medulloblastoma and glioblastoma cells. PloS one. vol 6. issue 4. 2011-08-16. PMID:21526200. |
the small molecule, lll12, inhibits stat3 phosphorylation and induces apoptosis in medulloblastoma and glioblastoma cells. |
2011-08-16 |
2023-08-12 |
Not clear |
| Sarah Ball, Chenglong Li, Pui-Kai Li, Jiayuh Li. The small molecule, LLL12, inhibits STAT3 phosphorylation and induces apoptosis in medulloblastoma and glioblastoma cells. PloS one. vol 6. issue 4. 2011-08-16. PMID:21526200. |
lll12 was able to inhibit stat3 phosphorylation, decrease cell viability and induce apoptosis in medulloblastoma and glioblastoma cell lines with elevated levels of p-stat3 (y705). |
2011-08-16 |
2023-08-12 |
Not clear |
| Ahmed Malki, Amal Yousse. Antidiabetic drug metformin induces apoptosis in human MCF breast cancer via targeting ERK signaling. Oncology research. vol 19. issue 6. 2011-08-16. PMID:21776823. |
metformin induced apoptosis by arresting cells in g1 phase and reducing cyclin d level and increasing the expression of p21 and cyclin e. molecular and cellular studies indicated that metformin significantly elevated p53 and bax levels and reduced stat3 and bcl-2. |
2011-08-16 |
2023-08-12 |
human |
| Chen Huang, Tao Jiang, Lin Zhu, Jun Liu, Jun Cao, Ke-Jian Huang, Zheng-Jun Qi. STAT3-targeting RNA interference inhibits pancreatic cancer angiogenesis in vitro and in vivo. International journal of oncology. vol 38. issue 6. 2011-08-09. PMID:21479358. |
stat3 regulates a number of pathways important in tumorigenesis including cell cycle progression, apoptosis, tumor angiogenesis, invasion and metastasis, and tumor cell evasion of the immune system. |
2011-08-09 |
2023-08-12 |
human |
| Anna Scuto, Maciej Kujawski, Claudia Kowolik, Ludmila Krymskaya, Lin Wang, Lawrence M Weiss, David Digiusto, Hua Yu, Stephen Forman, Richard Jov. STAT3 inhibition is a therapeutic strategy for ABC-like diffuse large B-cell lymphoma. Cancer research. vol 71. issue 9. 2011-08-09. PMID:21521803. |
direct inhibition of stat3 with short hairpin rna suppressed the growth of human abc-like dlbcl in mouse models in a manner associated with apoptosis, repression of stat3 target genes, and inhibition of a tumor-promoting microenvironment. |
2011-08-09 |
2023-08-12 |
mouse |
| X H Wang, B R Liu, B Qu, H Xing, S L Gao, J M Yin, X F Wang, Y Q Chen. Silencing STAT3 may inhibit cell growth through regulating signaling pathway, telomerase, cell cycle, apoptosis and angiogenesis in hepatocellular carcinoma: potential uses for gene therapy. Neoplasma. vol 58. issue 2. 2011-08-04. PMID:21275467. |
silencing stat3 may inhibit cell growth through regulating signaling pathway, telomerase, cell cycle, apoptosis and angiogenesis in hepatocellular carcinoma: potential uses for gene therapy. |
2011-08-04 |
2023-08-12 |
Not clear |
| X H Wang, B R Liu, B Qu, H Xing, S L Gao, J M Yin, X F Wang, Y Q Chen. Silencing STAT3 may inhibit cell growth through regulating signaling pathway, telomerase, cell cycle, apoptosis and angiogenesis in hepatocellular carcinoma: potential uses for gene therapy. Neoplasma. vol 58. issue 2. 2011-08-04. PMID:21275467. |
the genesis and development of hepatocellular carcinoma (hcc) is related to the abnormity of signaling pathway, telomerase, cell cycle, apoptosis, angiogenesis, and others, in which stat3 signaling pathway plays a key role. |
2011-08-04 |
2023-08-12 |
Not clear |
| X H Wang, B R Liu, B Qu, H Xing, S L Gao, J M Yin, X F Wang, Y Q Chen. Silencing STAT3 may inhibit cell growth through regulating signaling pathway, telomerase, cell cycle, apoptosis and angiogenesis in hepatocellular carcinoma: potential uses for gene therapy. Neoplasma. vol 58. issue 2. 2011-08-04. PMID:21275467. |
the results demonstrated that stat3 signaling pathway may participate in hcc genesis and development through regulating the protein expression of other signaling pathway, telomerase, apoptosis, cell cycle and angiogenesis; thereby, blockade of the stat3 pathway represents a potential strategy for future treatment. |
2011-08-04 |
2023-08-12 |
Not clear |
| Mark Luedde, Saskia Spaich, Hans-Joerg Hippe, Sebastian Busch, Rainer Will, Issam Abu-Taha, Tilman Klein, Christian Kuhn, Derk Frank, Hugo A Katus, Norbert Fre. Affixin (β-parvin) promotes cardioprotective signaling via STAT3 activation. Journal of molecular and cellular cardiology. vol 50. issue 5. 2011-08-03. PMID:21295579. |
consistent with stat3 activation, overexpression of affixin also protected cardiomyocytes from doxorubicin-induced apoptosis. |
2011-08-03 |
2023-08-12 |
rat |
| Mark Luedde, Saskia Spaich, Hans-Joerg Hippe, Sebastian Busch, Rainer Will, Issam Abu-Taha, Tilman Klein, Christian Kuhn, Derk Frank, Hugo A Katus, Norbert Fre. Affixin (β-parvin) promotes cardioprotective signaling via STAT3 activation. Journal of molecular and cellular cardiology. vol 50. issue 5. 2011-08-03. PMID:21295579. |
in conclusion, we demonstrate that affixin activates stat3 in cardiomyocytes and promotes characteristic stat3-related effects such as hypertrophy, protection against apoptosis, and angiogenesis. |
2011-08-03 |
2023-08-12 |
rat |
| Tadashi Ashizawa, Haruo Miyata, Hidee Ishii, Chie Oshita, Kenji Matsuno, Yoshiaki Masuda, Toshio Furuya, Tadashi Okawara, Masami Otsuka, Naohisa Ogo, Akira Asai, Yasuto Akiyam. Antitumor activity of a novel small molecule STAT3 inhibitor against a human lymphoma cell line with high STAT3 activation. International journal of oncology. vol 38. issue 5. 2011-08-03. PMID:21369699. |
stx-0119 suppressed the growth of scc3 cells, a human lymphoma cell line with highly activated stat3, through apoptosis and down-regulation of stat3 targets such as c-myc, cyclin d1, survivin and bcl-xl. |
2011-08-03 |
2023-08-12 |
mouse |
| Tadashi Ashizawa, Haruo Miyata, Hidee Ishii, Chie Oshita, Kenji Matsuno, Yoshiaki Masuda, Toshio Furuya, Tadashi Okawara, Masami Otsuka, Naohisa Ogo, Akira Asai, Yasuto Akiyam. Antitumor activity of a novel small molecule STAT3 inhibitor against a human lymphoma cell line with high STAT3 activation. International journal of oncology. vol 38. issue 5. 2011-08-03. PMID:21369699. |
stx-0119 demonstrated potent antitumor effects in vivo in scc3-bearing nude mice by way of the down-regulation of stat3 target genes and induction of apoptosis in the tumors. |
2011-08-03 |
2023-08-12 |
mouse |
| Paul A Johnston, Jennifer R Grandi. STAT3 signaling: anticancer strategies and challenges. Molecular interventions. vol 11. issue 1. 2011-07-29. PMID:21441118. |
stat3 modulates the transcription of a variety of genes involved in the regulation of critical functions, including cell differentiation, proliferation, apoptosis, angiogenesis, metastasis, and immune responses. |
2011-07-29 |
2023-08-12 |
human |
| Shenxian Qian, George Somlo, Bingsen Zhou, Yun Ye. Therapeutic effects of thalidomide in myeloma are associated with the expression of fibroblast growth factor receptor 3. Therapeutics and clinical risk management. vol 1. issue 3. 2011-07-14. PMID:18360564. |
further results suggested that thal inhibition of dna synthesis, induction of apoptosis, and down-regulation of vegf and il-6 might be dependent on fgfr3-associated signal transduction of the erk and stat3 phosphorylation pathway. |
2011-07-14 |
2023-08-12 |
human |
| Ana Moran, Ayse Akcan Arikan, Mary-Ann A Mastrangelo, Yong Wu, Bi Yu, Valeria Poli, David J Tweard. Prevention of trauma and hemorrhagic shock-mediated liver apoptosis by activation of stat3alpha. International journal of clinical and experimental medicine. vol 1. issue 3. 2011-07-14. PMID:18997875. |
we established that il-6 administration at the start of resuscitation is capable of completely reversing liver apoptosis and is associated with increased stat3 activation. |
2011-07-14 |
2023-08-12 |
Not clear |
| Ana Moran, Ayse Akcan Arikan, Mary-Ann A Mastrangelo, Yong Wu, Bi Yu, Valeria Poli, David J Tweard. Prevention of trauma and hemorrhagic shock-mediated liver apoptosis by activation of stat3alpha. International journal of clinical and experimental medicine. vol 1. issue 3. 2011-07-14. PMID:18997875. |
pharmacological inhibition of stat3 activity within the liver blocked the ability of il-6 to prevent liver apoptosis and to normalize the trauma/hs- induced liver apoptosis transcriptome. |
2011-07-14 |
2023-08-12 |
Not clear |
| Ana Moran, Ayse Akcan Arikan, Mary-Ann A Mastrangelo, Yong Wu, Bi Yu, Valeria Poli, David J Tweard. Prevention of trauma and hemorrhagic shock-mediated liver apoptosis by activation of stat3alpha. International journal of clinical and experimental medicine. vol 1. issue 3. 2011-07-14. PMID:18997875. |
genetic deletion of a stat3beta, a naturally occurring, dominant-negative isoform of the stat3, attenuated trauma/hs-induced liver apoptosis, confirming a role for stat3, especially stat3alpha, in preventing trauma/hs-mediated liver apoptosis. |
2011-07-14 |
2023-08-12 |
Not clear |
| Valentina Caldera, Marta Mellai, Laura Annovazzi, Guido Valente, Luciana Tessitore, Davide Schiffe. Stat3 expression and its correlation with proliferation and apoptosis/autophagy in gliomas. Journal of oncology. vol 2008. 2011-07-14. PMID:19421400. |
the goal of the study was to investigate whether activated stat3 (phospho-stat3) levels correlated with cell proliferation, apoptosis, and autophagy. |
2011-07-14 |
2023-08-12 |
Not clear |