| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ganchimeg Ishdorj, James B Johnston, Spencer B Gibso. Inhibition of constitutive activation of STAT3 by curcurbitacin-I (JSI-124) sensitized human B-leukemia cells to apoptosis. Molecular cancer therapeutics. vol 9. issue 12. 2011-03-28. PMID:21159613. |
jsi-124 potently induces apoptosis in 3 b-leukemia cell lines (bjab, i-83, and nalm-6) and in primary cll cells and was associated with a reduction in serine 727 phosphorylation of stat3. |
2011-03-28 |
2023-08-12 |
human |
| Ganchimeg Ishdorj, James B Johnston, Spencer B Gibso. Inhibition of constitutive activation of STAT3 by curcurbitacin-I (JSI-124) sensitized human B-leukemia cells to apoptosis. Molecular cancer therapeutics. vol 9. issue 12. 2011-03-28. PMID:21159613. |
similarly, knockdown of stat3 expression induced apoptosis in these leukemia cells. |
2011-03-28 |
2023-08-12 |
human |
| Ganchimeg Ishdorj, James B Johnston, Spencer B Gibso. Inhibition of constitutive activation of STAT3 by curcurbitacin-I (JSI-124) sensitized human B-leukemia cells to apoptosis. Molecular cancer therapeutics. vol 9. issue 12. 2011-03-28. PMID:21159613. |
in addition, we found that jsi-124 and knockdown of stat3 decreased antiapoptotic protein xiap expression and overexpression of xiap blocked jsi-124-induced apoptosis. |
2011-03-28 |
2023-08-12 |
human |
| Ganchimeg Ishdorj, James B Johnston, Spencer B Gibso. Inhibition of constitutive activation of STAT3 by curcurbitacin-I (JSI-124) sensitized human B-leukemia cells to apoptosis. Molecular cancer therapeutics. vol 9. issue 12. 2011-03-28. PMID:21159613. |
thus, we present here for the first time that jsi-124 induced suppression of serine 727 phosphorylation of stat3, leading to apoptosis and cell-cycle arrest through alterations in gene transcription in b-leukemia cells. |
2011-03-28 |
2023-08-12 |
human |
| H Zhang, D Zhang, X Luan, G Xie, X Pa. Inhibition of the signal transducers and activators of transcription (STAT) 3 signalling pathway by AG490 in laryngeal carcinoma cells. The Journal of international medical research. vol 38. issue 5. 2011-03-10. PMID:21309481. |
this study showed that ag490 significantly inhibited proliferation and induced apoptosis of laryngeal carcinoma cells through down-regulation of stat3 and survivin, suggesting a potential target for laryngeal carcinoma treatment. |
2011-03-10 |
2023-08-12 |
human |
| Aya Nakaya, Morihiko Sagawa, Akihiro Muto, Hideo Uchida, Yasuo Ikeda, Masahiro Kizak. The gold compound auranofin induces apoptosis of human multiple myeloma cells through both down-regulation of STAT3 and inhibition of NF-κB activity. Leukemia research. vol 35. issue 2. 2011-03-09. PMID:20542334. |
the gold compound auranofin induces apoptosis of human multiple myeloma cells through both down-regulation of stat3 and inhibition of nf-κb activity. |
2011-03-09 |
2023-08-12 |
human |
| Wei Zhao, Tao Zhang, Bingqian Qu, Xingxin Wu, Xu Zhu, Fanyu Meng, Yanhong Gu, Yongqian Shu, Yan Shen, Yang Sun, Qiang X. Sorafenib induces apoptosis in HL60 cells by inhibiting Src kinase-mediated STAT3 phosphorylation. Anti-cancer drugs. vol 22. issue 1. 2011-03-04. PMID:20881478. |
sorafenib induces apoptosis in hl60 cells by inhibiting src kinase-mediated stat3 phosphorylation. |
2011-03-04 |
2023-08-12 |
human |
| Wei Zhao, Tao Zhang, Bingqian Qu, Xingxin Wu, Xu Zhu, Fanyu Meng, Yanhong Gu, Yongqian Shu, Yan Shen, Yang Sun, Qiang X. Sorafenib induces apoptosis in HL60 cells by inhibiting Src kinase-mediated STAT3 phosphorylation. Anti-cancer drugs. vol 22. issue 1. 2011-03-04. PMID:20881478. |
signal transducer and activator of transcription 3 (stat3) is constitutively active in approximately 50% of acute myeloid leukemia (aml) cases and mediates multiple cellular processes including cell resistance to apoptosis. |
2011-03-04 |
2023-08-12 |
human |
| Wei Zhao, Tao Zhang, Bingqian Qu, Xingxin Wu, Xu Zhu, Fanyu Meng, Yanhong Gu, Yongqian Shu, Yan Shen, Yang Sun, Qiang X. Sorafenib induces apoptosis in HL60 cells by inhibiting Src kinase-mediated STAT3 phosphorylation. Anti-cancer drugs. vol 22. issue 1. 2011-03-04. PMID:20881478. |
inhibition of constitutively active stat3 has been shown to induce aml cell apoptosis. |
2011-03-04 |
2023-08-12 |
human |
| Wei Zhao, Tao Zhang, Bingqian Qu, Xingxin Wu, Xu Zhu, Fanyu Meng, Yanhong Gu, Yongqian Shu, Yan Shen, Yang Sun, Qiang X. Sorafenib induces apoptosis in HL60 cells by inhibiting Src kinase-mediated STAT3 phosphorylation. Anti-cancer drugs. vol 22. issue 1. 2011-03-04. PMID:20881478. |
taken together, our study indicates that sorafenib blocks src kinase-mediated stat3 phosphorylation and decreases the expression of apoptosis regulatory proteins mcl-1 and bcl-2, which are associated with increased apoptosis in hl60 cells. |
2011-03-04 |
2023-08-12 |
human |
| Yi-Wei Chen, Kuan-Hsuan Chen, Pin-I Huang, Yu-Chih Chen, Guang-Yu Chiou, Wen-Liang Lo, Ling-Ming Tseng, Han-Sui Hsu, Kuo-Wei Chang, Shih-Hwa Chio. Cucurbitacin I suppressed stem-like property and enhanced radiation-induced apoptosis in head and neck squamous carcinoma--derived CD44(+)ALDH1(+) cells. Molecular cancer therapeutics. vol 9. issue 11. 2011-02-28. PMID:21062915. |
notably, 150 nmol/l cucurbitacin i effectively blocked stat3 signaling and downstream survivin and bcl-2 expression, and it induced apoptosis in hnscc-cd44(+)aldh1(+). |
2011-02-28 |
2023-08-12 |
mouse |
| Vikas Kumar Srivastava, Rishi Kumar Gara, M L B Bhatt, D P Sahu, Durga Prasad Mishr. Centchroman inhibits proliferation of head and neck cancer cells through the modulation of PI3K/mTOR pathway. Biochemical and biophysical research communications. vol 404. issue 1. 2011-02-14. PMID:21094138. |
further studies showed that cc treatment induced apoptosis, inhibited akt/mtor and signal transducers and activators of transcription protein 3 (stat3) signaling, altered proteins associated with cell cycle regulation and dna damage and inhibited colony forming efficiency of hnscc cells. |
2011-02-14 |
2023-08-12 |
Not clear |
| Wei Zhao, Soumya Jaganathan, James Turkso. A cell-permeable Stat3 SH2 domain mimetic inhibits Stat3 activation and induces antitumor cell effects in vitro. The Journal of biological chemistry. vol 285. issue 46. 2011-02-09. PMID:20807764. |
significantly, treatment with spi of human breast, pancreatic, prostate, and non-small cell lung cancer cells harboring constitutively active stat3 induced extensive morphology changes, associated with viability loss and apoptosis. |
2011-02-09 |
2023-08-12 |
human |
| Xiaoguang Chen, Cunshuan Xu, Fuchun Zhang, Ji M. Microarray approach reveals the relevance of interferon signaling pathways with rat liver restoration post 2/3 hepatectomy at cellular level. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. vol 30. issue 7. 2011-02-04. PMID:20626293. |
it is inferred that stat3, in contrast to stat1, seemingly takes a more active role in ifn-alpha1-mediated jak/stat pathway in hepatocyte; ifn-beta1-mediated p38 mapk pathway possibly to some extent affects inflammation and apoptosis of biliary epithelial cell during liver regeneration; ifn-gamma-induced jak/stat pathway may be associated with the attenuated apoptosis induction in hsc, kc, and dc. |
2011-02-04 |
2023-08-12 |
rat |
| Jun-Ge Wang, Xiao-Ming Li, Ying-Hui Chen, Xiu-Ying L. [Molecular mechanisms involved in regulation of proliferation and apoptosis by STAT3 antisense oligonucleotide and chemotherapy in laryngeal cancer cells]. Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery. vol 42. issue 3. 2011-02-03. PMID:17633284. |
[molecular mechanisms involved in regulation of proliferation and apoptosis by stat3 antisense oligonucleotide and chemotherapy in laryngeal cancer cells]. |
2011-02-03 |
2023-08-12 |
Not clear |
| Yan Liu, James Fuchs, Chenglong Li, Jiayuh Li. IL-6, a risk factor for hepatocellular carcinoma: FLLL32 inhibits IL-6-induced STAT3 phosphorylation in human hepatocellular cancer cells. Cell cycle (Georgetown, Tex.). vol 9. issue 17. 2011-01-24. PMID:20818158. |
stat3 is major pathway to mediate signal from il-6 to the nucleus, where different genes associated with proliferation and apoptosis are regulated. |
2011-01-24 |
2023-08-12 |
human |
| M Tsutsui, H Yasuda, H Suto, H Imai, Y Isobe, M Sasaki, Y Kojima, K Oshimi, K Sugimot. Frequent STAT3 activation is associated with Mcl-1 expression in nasal NK-cell lymphoma. International journal of laboratory hematology. vol 32. issue 4. 2011-01-14. PMID:19968719. |
effects of stat3 inhibitor ag490 on nk-ys cell line were analyzed by western blotting and flow cytometric apoptosis assay. |
2011-01-14 |
2023-08-12 |
Not clear |
| M Tsutsui, H Yasuda, H Suto, H Imai, Y Isobe, M Sasaki, Y Kojima, K Oshimi, K Sugimot. Frequent STAT3 activation is associated with Mcl-1 expression in nasal NK-cell lymphoma. International journal of laboratory hematology. vol 32. issue 4. 2011-01-14. PMID:19968719. |
inhibition of stat3 activation by jak inhibitor ag490 decreased mcl-1 expression and induced apoptosis in stat3-active nk-ys cells. |
2011-01-14 |
2023-08-12 |
Not clear |
| Lifang Yang, Zhongxin Lu, Xiaoqian Ma, Ya Cao, Lun-Quan Su. A therapeutic approach to nasopharyngeal carcinomas by DNAzymes targeting EBV LMP-1 gene. Molecules (Basel, Switzerland). vol 15. issue 9. 2011-01-04. PMID:20877211. |
dz1 could significantly down-regulate the expression of lmp1 in npc cells, inhibit cell proliferation, metastasis, promote apoptosis and enhance radiosensitivity of npc through interfering signal pathways which are abnormally activated by lmp1, including nf-κb, ap-1 and stat3 signal pathways. |
2011-01-04 |
2023-08-12 |
Not clear |
| Paola Y Bertucci, Ana Quaglino, Andrea G Pozzi, Edith C Kordon, Adali Pecc. Glucocorticoid-induced impairment of mammary gland involution is associated with STAT5 and STAT3 signaling modulation. Endocrinology. vol 151. issue 12. 2011-01-04. PMID:20881248. |
during involution, stat3 activation mediates epithelial cell apoptosis and mammary gland remodeling. |
2011-01-04 |
2023-08-12 |
mouse |