| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Valentina Caldera, Marta Mellai, Laura Annovazzi, Guido Valente, Luciana Tessitore, Davide Schiffe. Stat3 expression and its correlation with proliferation and apoptosis/autophagy in gliomas. Journal of oncology. vol 2008. 2011-07-14. PMID:19421400. |
stat3 and akt did not show any correlation with apoptosis, whereas they showed an inverse correlation with beclin 1, a stimulator of autophagy, which was rarely positive in glioblastomas. |
2011-07-14 |
2023-08-12 |
Not clear |
| Charles Guo, Guanyu Yang, Kyle Khun, Xiantian Kong, David Levy, Peng Lee, Jonathan Melame. Activation of Stat3 in renal tumors. American journal of translational research. vol 1. issue 3. 2011-07-14. PMID:19956438. |
signal transducer and activator of transcription 3 (stat3) plays a vital role in signal transduction pathways that mediate transformation and inhibit apoptosis. |
2011-07-14 |
2023-08-12 |
human |
| Wolfgang Glienke, Eva Hausmann, Lothar Bergman. Downregulation of STAT3 signaling induces apoptosis but also promotes anti-apoptotic gene expression in human pancreatic cancer cell lines. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 32. issue 3. 2011-07-14. PMID:21174186. |
downregulation of stat3 signaling induces apoptosis but also promotes anti-apoptotic gene expression in human pancreatic cancer cell lines. |
2011-07-14 |
2023-08-12 |
human |
| Wolfgang Glienke, Eva Hausmann, Lothar Bergman. Downregulation of STAT3 signaling induces apoptosis but also promotes anti-apoptotic gene expression in human pancreatic cancer cell lines. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 32. issue 3. 2011-07-14. PMID:21174186. |
in pancreatic cancer, constitutive activation of stat3 contributes to oncogenesis by preventing apoptosis through upregulation of anti-apoptotic proteins. |
2011-07-14 |
2023-08-12 |
human |
| Wolfgang Glienke, Eva Hausmann, Lothar Bergman. Downregulation of STAT3 signaling induces apoptosis but also promotes anti-apoptotic gene expression in human pancreatic cancer cell lines. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 32. issue 3. 2011-07-14. PMID:21174186. |
sirna targeting stat3 was used to evaluate the role of stat3 in modulating the expression of survivin/birc5 and bcl-xl in the pancreatic cancer cell lines panc-1 and bxpc-3 and induction of apoptosis. |
2011-07-14 |
2023-08-12 |
human |
| Wolfgang Glienke, Eva Hausmann, Lothar Bergman. Downregulation of STAT3 signaling induces apoptosis but also promotes anti-apoptotic gene expression in human pancreatic cancer cell lines. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 32. issue 3. 2011-07-14. PMID:21174186. |
stat3 downregulation resulted in a decrease of cell viability in both cell lines and induced apoptosis in bxpc-3 cells. |
2011-07-14 |
2023-08-12 |
human |
| Wolfgang Glienke, Eva Hausmann, Lothar Bergman. Downregulation of STAT3 signaling induces apoptosis but also promotes anti-apoptotic gene expression in human pancreatic cancer cell lines. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 32. issue 3. 2011-07-14. PMID:21174186. |
inactivation of stat3 in pancreatic cancer cell lines induces apoptosis but also may promote the expression of anti-apoptotic genes. |
2011-07-14 |
2023-08-12 |
human |
| Toshinori Bito, Nahoko Sumita, Masashi Ashida, Arief Budiyanto, Masato Ueda, Masamitsu Ichihashi, Yoshiki Tokura, Chikako Nishigor. Inhibition of Epidermal Growth Factor Receptor and PI3K/Akt Signaling Suppresses Cell Proliferation and Survival through Regulation of Stat3 Activation in Human Cutaneous Squamous Cell Carcinoma. Journal of skin cancer. vol 2011. 2011-07-14. PMID:21197106. |
ag1478 inhibited cell proliferation and induced apoptosis of hsc-1 cells but did not inhibit the growth of normal human epidermal keratinocytes that did not show stat3 activation. |
2011-07-14 |
2023-08-12 |
human |
| Toshinori Bito, Nahoko Sumita, Masashi Ashida, Arief Budiyanto, Masato Ueda, Masamitsu Ichihashi, Yoshiki Tokura, Chikako Nishigor. Inhibition of Epidermal Growth Factor Receptor and PI3K/Akt Signaling Suppresses Cell Proliferation and Survival through Regulation of Stat3 Activation in Human Cutaneous Squamous Cell Carcinoma. Journal of skin cancer. vol 2011. 2011-07-14. PMID:21197106. |
combined treatment with the pi3k inhibitor and ag1478 strongly suppressed stat3 activity and dramatically induced apoptosis of hsc-1 cells. |
2011-07-14 |
2023-08-12 |
human |
| Jun Peng, Youqin Chen, Jiumao Lin, Qunchuan Zhuang, Wei Xu, Zhenfeng Hong, Thomas J Sferr. Patrinia scabiosaefolia extract suppresses proliferation and promotes apoptosis by inhibiting the STAT3 pathway in human multiple myeloma cells. Molecular medicine reports. vol 4. issue 2. 2011-07-12. PMID:21468570. |
patrinia scabiosaefolia extract suppresses proliferation and promotes apoptosis by inhibiting the stat3 pathway in human multiple myeloma cells. |
2011-07-12 |
2023-08-12 |
human |
| Jun Peng, Youqin Chen, Jiumao Lin, Qunchuan Zhuang, Wei Xu, Zhenfeng Hong, Thomas J Sferr. Patrinia scabiosaefolia extract suppresses proliferation and promotes apoptosis by inhibiting the STAT3 pathway in human multiple myeloma cells. Molecular medicine reports. vol 4. issue 2. 2011-07-12. PMID:21468570. |
in this study, we evaluated the effect of the ethanol extract of patrinia scabiosaefolia (eeps) on proliferation and apoptosis in human multiple myeloma u266 cells that persistently express phosphorylated stat3, and investigated the possible molecular mechanisms mediating its biological effects. |
2011-07-12 |
2023-08-12 |
human |
| Jun Peng, Youqin Chen, Jiumao Lin, Qunchuan Zhuang, Wei Xu, Zhenfeng Hong, Thomas J Sferr. Patrinia scabiosaefolia extract suppresses proliferation and promotes apoptosis by inhibiting the STAT3 pathway in human multiple myeloma cells. Molecular medicine reports. vol 4. issue 2. 2011-07-12. PMID:21468570. |
consequently, the inhibitory effect of eeps on stat3 activation resulted in the suppression of cell proliferation and the induction of cell apoptosis. |
2011-07-12 |
2023-08-12 |
human |
| Jun Peng, Youqin Chen, Jiumao Lin, Qunchuan Zhuang, Wei Xu, Zhenfeng Hong, Thomas J Sferr. Patrinia scabiosaefolia extract suppresses proliferation and promotes apoptosis by inhibiting the STAT3 pathway in human multiple myeloma cells. Molecular medicine reports. vol 4. issue 2. 2011-07-12. PMID:21468570. |
moreover, eeps treatment inhibited the expression of cyclin d1 (a promoter of cell proliferation) and bcl-2 (an inhibitor of apoptosis), two important target genes of the stat3 signaling pathway. |
2011-07-12 |
2023-08-12 |
human |
| Jun Peng, Youqin Chen, Jiumao Lin, Qunchuan Zhuang, Wei Xu, Zhenfeng Hong, Thomas J Sferr. Patrinia scabiosaefolia extract suppresses proliferation and promotes apoptosis by inhibiting the STAT3 pathway in human multiple myeloma cells. Molecular medicine reports. vol 4. issue 2. 2011-07-12. PMID:21468570. |
our findings for the first time demonstrate that patrinia scabiosaefolia inhibits proliferation and promotes the apoptosis of cancer cells via inhibition of the stat3 pathway, which may in part explain its anti-cancer activity. |
2011-07-12 |
2023-08-12 |
human |
| Huan-Chih Chiu, Ding-Li Chou, Chin-Ting Huang, Wen-Hsing Lin, Tzu-Wen Lien, Kuei-Jung Yen, John T-A Hs. Suppression of Stat3 activity sensitizes gefitinib-resistant non small cell lung cancer cells. Biochemical pharmacology. vol 81. issue 11. 2011-07-05. PMID:21406185. |
meanwhile, apoptosis activation by sirna-mediated down-regulation of stat3 in h1650 cells provides more direct evidence for the involvement of stat3 in viability maintenance of h1650 cells. |
2011-07-05 |
2023-08-12 |
Not clear |
| Ayako Matsumoto, Hajime Isomoto, Masaaki Nakayama, Junzo Hisatsune, Yoshito Nishi, Yujiro Nakashima, Kayoko Matsushima, Hisao Kurazono, Kazuhiko Nakao, Toshiya Hirayama, Shigeru Kohn. Helicobacter pylori VacA reduces the cellular expression of STAT3 and pro-survival Bcl-2 family proteins, Bcl-2 and Bcl-XL, leading to apoptosis in gastric epithelial cells. Digestive diseases and sciences. vol 56. issue 4. 2011-06-21. PMID:20927590. |
helicobacter pylori vaca reduces the cellular expression of stat3 and pro-survival bcl-2 family proteins, bcl-2 and bcl-xl, leading to apoptosis in gastric epithelial cells. |
2011-06-21 |
2023-08-12 |
Not clear |
| Stacey L Fossey, Misty D Bear, Jiayuh Lin, Chenglong Li, Eric B Schwartz, Pui-Kai Li, James R Fuchs, Joelle Fenger, William C Kisseberth, Cheryl A Londo. The novel curcumin analog FLLL32 decreases STAT3 DNA binding activity and expression, and induces apoptosis in osteosarcoma cell lines. BMC cancer. vol 11. 2011-06-21. PMID:21443800. |
the novel curcumin analog flll32 decreases stat3 dna binding activity and expression, and induces apoptosis in osteosarcoma cell lines. |
2011-06-21 |
2023-08-12 |
human |
| Haili Lü, Qiuhang Zhang, Bo Ya. [Apoptosis of laryngeal carcinoma cells induced by antisense oligodeoxynucleotides complementary Stat3 in vitro]. Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery. vol 22. issue 21. 2011-06-16. PMID:19157144. |
[apoptosis of laryngeal carcinoma cells induced by antisense oligodeoxynucleotides complementary stat3 in vitro]. |
2011-06-16 |
2023-08-12 |
Not clear |
| Haili Lü, Qiuhang Zhang, Bo Ya. [Apoptosis of laryngeal carcinoma cells induced by antisense oligodeoxynucleotides complementary Stat3 in vitro]. Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery. vol 22. issue 21. 2011-06-16. PMID:19157144. |
to study the effects of oligodeoxynucleotides complementary stat3 on apoptosis in laryngeal carcinoma hep-2 cell. |
2011-06-16 |
2023-08-12 |
Not clear |
| Dae Joon Kim, Michel L Tremblay, John Digiovann. Protein tyrosine phosphatases, TC-PTP, SHP1, and SHP2, cooperate in rapid dephosphorylation of Stat3 in keratinocytes following UVB irradiation. PloS one. vol 5. issue 4. 2011-06-16. PMID:20421975. |
treatment with na(3)vo(4) desensitized keratinocytes to uvb-induced apoptosis with the recovery of phosphorylated stat3 protein levels, implying that a protein tyrosine phosphatase (ptp) is involved in this mechanism. |
2011-06-16 |
2023-08-12 |
mouse |