| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lan V Pham, Archito T Tamayo, Changping Li, William Bornmann, Waldemar Priebe, Richard J For. Degrasyn potentiates the antitumor effects of bortezomib in mantle cell lymphoma cells in vitro and in vivo: therapeutic implications. Molecular cancer therapeutics. vol 9. issue 7. 2010-11-04. PMID:20606045. |
the apoptosis in these cells was correlated with the downregulation of constitutive nf-kappab and phosphorylated stat3 activation, leading to the inhibition of c-myc, cyclin d1, and bcl-2 protein expression and the upregulation of bax protein expression. |
2010-11-04 |
2023-08-12 |
mouse |
| Anurima Majumder, Lakshmanan Govindasamy, Andrew Magis, Róbert Kiss, Tímea Polgár, Rebekah Baskin, Robert W Allan, Mavis Agbandje-McKenna, Gary W Reuther, György M Keseru, Kirpal S Bisht, Peter P Sayesk. Structure-function correlation of G6, a novel small molecule inhibitor of Jak2: indispensability of the stilbenoid core. The Journal of biological chemistry. vol 285. issue 41. 2010-11-04. PMID:20667821. |
they also inhibited phosphorylation of jak2, stat3, and stat5 proteins within cells, resulting in higher levels of apoptosis via the intrinsic apoptotic pathway. |
2010-11-04 |
2023-08-12 |
human |
| Joo Eun Jung, Gab Seok Kim, Hai Chen, Carolina M Maier, Purnima Narasimhan, Yun Seon Song, Kuniyasu Niizuma, Masataka Katsu, Nobuya Okami, Hideyuki Yoshioka, Hiroyuki Sakata, Christina E Goeders, Pak H Cha. Reperfusion and neurovascular dysfunction in stroke: from basic mechanisms to potential strategies for neuroprotection. Molecular neurobiology. vol 41. issue 2-3. 2010-10-08. PMID:20157789. |
during reperfusion, activation of stat3 and its recruitment into the sod2 gene were blocked, resulting in increased oxidative stress and neuronal apoptosis. |
2010-10-08 |
2023-08-12 |
mouse |
| Mi-Ae Lyu, Bokyung Sung, Lawrence H Cheung, John W Marks, Bharat B Aggarwal, Ricardo C T Aguiar, Michael G Rosenblu. The rGel/BLyS fusion toxin inhibits STAT3 signaling via down-regulation of interleukin-6 receptor in diffuse large B-cell lymphoma. Biochemical pharmacology. vol 80. issue 9. 2010-10-06. PMID:20654581. |
inhibition of il-6r-mediated stat3 signaling by rgel/blys led to growth inhibition, triggered accumulation of cells in the sub-g(1) phase of the cell cycle, and induced apoptosis. |
2010-10-06 |
2023-08-12 |
human |
| Ling-di Ma, Min Zhou, Shi-hong Wen, Cheng Ni, Li-jia Jiang, Jing Fan, Lei Xi. Effects of STAT3 silencing on fate of chronic myelogenous leukemia K562 cells. Leukemia & lymphoma. vol 51. issue 7. 2010-09-30. PMID:20497005. |
knockdown of stat3 by stat3 sirna caused a decrease in stat3 protein level, inhibition of growth and proliferation, cell cycle blockade, visible morphologic changes, and induction of apoptosis in k562 cells. |
2010-09-30 |
2023-08-12 |
human |
| Guang-Hui Li, Hong Wei, Sheng-Qing Lv, Hua Ji, Dong-Lin Wan. Knockdown of STAT3 expression by RNAi suppresses growth and induces apoptosis and differentiation in glioblastoma stem cells. International journal of oncology. vol 37. issue 1. 2010-09-27. PMID:20514402. |
knockdown of stat3 expression by rnai suppresses growth and induces apoptosis and differentiation in glioblastoma stem cells. |
2010-09-27 |
2023-08-12 |
human |
| Guang-Hui Li, Hong Wei, Sheng-Qing Lv, Hua Ji, Dong-Lin Wan. Knockdown of STAT3 expression by RNAi suppresses growth and induces apoptosis and differentiation in glioblastoma stem cells. International journal of oncology. vol 37. issue 1. 2010-09-27. PMID:20514402. |
stat3 plays a key role in proliferation, apoptosis and differentiation in embryonic stem cells and several cancer types. |
2010-09-27 |
2023-08-12 |
human |
| Guang-Hui Li, Hong Wei, Sheng-Qing Lv, Hua Ji, Dong-Lin Wan. Knockdown of STAT3 expression by RNAi suppresses growth and induces apoptosis and differentiation in glioblastoma stem cells. International journal of oncology. vol 37. issue 1. 2010-09-27. PMID:20514402. |
knockdown of stat3 induces apoptosis and reduces significantly expression of bcl-2 and cyclin-d in human primary gscs, whereas no significance was achieved in bax and caspase-3 expression. |
2010-09-27 |
2023-08-12 |
human |
| Guang-Hui Li, Hong Wei, Sheng-Qing Lv, Hua Ji, Dong-Lin Wan. Knockdown of STAT3 expression by RNAi suppresses growth and induces apoptosis and differentiation in glioblastoma stem cells. International journal of oncology. vol 37. issue 1. 2010-09-27. PMID:20514402. |
together, these studies suggest that stat3 is an important target for human gscs in regulation of gscs growth, apoptosis, differentiation and tumorigenic potential. |
2010-09-27 |
2023-08-12 |
human |
| Yan Liu, Pui-Kai Li, Chenglong Li, Jiayuh Li. Inhibition of STAT3 signaling blocks the anti-apoptotic activity of IL-6 in human liver cancer cells. The Journal of biological chemistry. vol 285. issue 35. 2010-09-17. PMID:20562100. |
targeting stat3 with stat3 sirna reduced the protection of il-6 against doxorubicin-induced apoptosis, indicating that stat3 signaling contributed to the anti-apoptotic effect of il-6. |
2010-09-17 |
2023-08-12 |
human |
| Dongmei Wang, Yiran Zhou, Weiwei Lei, Kehua Zhang, Jian Shi, Ying Hu, Guangwen Shu, Jianguo Son. Signal transducer and activator of transcription 3 (STAT3) regulates adipocyte differentiation via peroxisome-proliferator-activated receptor gamma (PPARgamma). Biology of the cell. vol 102. issue 1. 2010-09-09. PMID:19566485. |
stat3 (signal transducer and activator of transcription 3) is an important transcription factor involved in many biological events, including apoptosis, tumorigenesis, angiogenesis and epithelial-to-mesenchymal transition. |
2010-09-09 |
2023-08-12 |
Not clear |
| Hiroto Ueba, Michael Brines, Michael Yamin, Tomio Umemoto, Junya Ako, Shin-ichi Momomura, Anthony Cerami, Masanobu Kawakam. Cardioprotection by a nonerythropoietic, tissue-protective peptide mimicking the 3D structure of erythropoietin. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 32. 2010-09-07. PMID:20660739. |
in cultured neonatal rat cardiomyocytes, hbsp clearly inhibited apoptosis (approximately 80%) induced by tnf-alpha, which was comparable with the effect of epo, and activated critical signaling pathways of cell survival, including akt, erk1/2, and stat3. |
2010-09-07 |
2023-08-12 |
rat |
| Zu-Yin Yu, Rui Huang, He Xiao, Wen-Feng Sun, Ya-Jun Shan, Bo Wang, Ting-Ting Zhao, Bo Dong, Zhen-Hu Zhao, Xiao-Lan Liu, Sheng-Qi Wang, Ri-Fang Yang, Qing-Liang Luo, Yu-Wen Con. Fluacrypyrim, a novel STAT3 activation inhibitor, induces cell cycle arrest and apoptosis in cancer cells harboring constitutively-active STAT3. International journal of cancer. vol 127. issue 6. 2010-08-24. PMID:20087863. |
fluacrypyrim, a novel stat3 activation inhibitor, induces cell cycle arrest and apoptosis in cancer cells harboring constitutively-active stat3. |
2010-08-24 |
2023-08-12 |
Not clear |
| Hong Chai, Annie Z Luo, Priya Weerasinghe, Robert E Brow. Sorafenib downregulates ERK/Akt and STAT3 survival pathways and induces apoptosis in a human neuroblastoma cell line. International journal of clinical and experimental pathology. vol 3. issue 4. 2010-08-20. PMID:20490331. |
sorafenib downregulates erk/akt and stat3 survival pathways and induces apoptosis in a human neuroblastoma cell line. |
2010-08-20 |
2023-08-12 |
human |
| Hong Chai, Annie Z Luo, Priya Weerasinghe, Robert E Brow. Sorafenib downregulates ERK/Akt and STAT3 survival pathways and induces apoptosis in a human neuroblastoma cell line. International journal of clinical and experimental pathology. vol 3. issue 4. 2010-08-20. PMID:20490331. |
sorafenib is a multikinase inhibitor that also inhibits stat3 signaling and induces apoptosis. |
2010-08-20 |
2023-08-12 |
human |
| Keinosuke Ryu, Michiro Susa, Edwin Choy, Cao Yang, Francis J Hornicek, Henry J Mankin, Zhenfeng Dua. Oleanane triterpenoid CDDO-Me induces apoptosis in multidrug resistant osteosarcoma cells through inhibition of Stat3 pathway. BMC cancer. vol 10. 2010-08-16. PMID:20459702. |
oleanane triterpenoid cddo-me induces apoptosis in multidrug resistant osteosarcoma cells through inhibition of stat3 pathway. |
2010-08-16 |
2023-08-12 |
Not clear |
| Muneyuk Masuda, T Wakasaki, Masumi Suzui, Satoshi Toh, Andrew K Joe, I B Weinstei. Stat3 orchestrates tumor development and progression: the Achilles' heel of head and neck cancers? Current cancer drug targets. vol 10. issue 1. 2010-08-04. PMID:20088788. |
in this context, an increasing number of preclinical studies have demonstrated that the signal transducers and activators of transcription 3 (stat3) transcription factor plays critical roles in the development and progression of a variety of tumors including hnscc, by regulating cell proliferation, cell cycle progression, apoptosis, angiogenesis, immune evasion, epithelial-mesenchymal transition (emt) and through effects in cancer stem cells. |
2010-08-04 |
2023-08-12 |
Not clear |
| Ana Moran, Anna I Tsimelzon, Mary-Ann A Mastrangelo, Yong Wu, Bi Yu, Susan G Hilsenbeck, Valeria Poli, David J Tweard. Prevention of trauma/hemorrhagic shock-induced lung apoptosis by IL-6-mediated activation of Stat3. Clinical and translational science. vol 2. issue 1. 2010-07-30. PMID:20443866. |
prevention of trauma/hemorrhagic shock-induced lung apoptosis by il-6-mediated activation of stat3. |
2010-07-30 |
2023-08-12 |
mouse |
| Ana Moran, Anna I Tsimelzon, Mary-Ann A Mastrangelo, Yong Wu, Bi Yu, Susan G Hilsenbeck, Valeria Poli, David J Tweard. Prevention of trauma/hemorrhagic shock-induced lung apoptosis by IL-6-mediated activation of Stat3. Clinical and translational science. vol 2. issue 1. 2010-07-30. PMID:20443866. |
to determine if aec apoptosis is a key contributor to ali following t/hs and whether or not signal transducer and activator of translation (stat)3 activation can prevent it, rats were pretreated with a stat3 inhibitor or placebo and subjected to t/hs or sham protocol and resuscitated without or with interleukin (il)-6. |
2010-07-30 |
2023-08-12 |
mouse |
| Ana Moran, Anna I Tsimelzon, Mary-Ann A Mastrangelo, Yong Wu, Bi Yu, Susan G Hilsenbeck, Valeria Poli, David J Tweard. Prevention of trauma/hemorrhagic shock-induced lung apoptosis by IL-6-mediated activation of Stat3. Clinical and translational science. vol 2. issue 1. 2010-07-30. PMID:20443866. |
il-6 treatment stimulated lung stat3 activation and prevented aec apoptosis. |
2010-07-30 |
2023-08-12 |
mouse |