| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Manoj K Pandey, Bokyung Sung, Bharat B Aggarwa. Betulinic acid suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase SHP-1 in human multiple myeloma cells. International journal of cancer. vol 127. issue 2. 2010-06-22. PMID:19937797. |
consistent with these results, overexpression of constitutive active stat3 significantly reduced the betulinic acid-induced apoptosis. |
2010-06-22 |
2023-08-12 |
human |
| Shengbing Huang, Frank A Sinicrop. Sorafenib inhibits STAT3 activation to enhance TRAIL-mediated apoptosis in human pancreatic cancer cells. Molecular cancer therapeutics. vol 9. issue 3. 2010-06-18. PMID:20197401. |
sorafenib inhibits stat3 activation to enhance trail-mediated apoptosis in human pancreatic cancer cells. |
2010-06-18 |
2023-08-12 |
human |
| Shengbing Huang, Frank A Sinicrop. Sorafenib inhibits STAT3 activation to enhance TRAIL-mediated apoptosis in human pancreatic cancer cells. Molecular cancer therapeutics. vol 9. issue 3. 2010-06-18. PMID:20197401. |
signal transducers and activators of transcription 3 (stat3) is constitutively active in human pancreatic cancer cells and can promote cell growth and apoptosis resistance that contribute to tumorigenesis. |
2010-06-18 |
2023-08-12 |
human |
| Shengbing Huang, Frank A Sinicrop. Sorafenib inhibits STAT3 activation to enhance TRAIL-mediated apoptosis in human pancreatic cancer cells. Molecular cancer therapeutics. vol 9. issue 3. 2010-06-18. PMID:20197401. |
we determined if sorafenib, a multikinase inhibitor, can induce apoptosis by targeting stat3 signaling to enhance apoptosis induction by tumor necrosis factor-related apoptosis-inducing ligand (trail). |
2010-06-18 |
2023-08-12 |
human |
| Shengbing Huang, Frank A Sinicrop. Sorafenib inhibits STAT3 activation to enhance TRAIL-mediated apoptosis in human pancreatic cancer cells. Molecular cancer therapeutics. vol 9. issue 3. 2010-06-18. PMID:20197401. |
stat3 knockdown or a dn stat3 was shown to downregulate mcl-1 and bcl-x(l) and to sensitize cells to trail-mediated apoptosis. |
2010-06-18 |
2023-08-12 |
human |
| Shengbing Huang, Frank A Sinicrop. Sorafenib inhibits STAT3 activation to enhance TRAIL-mediated apoptosis in human pancreatic cancer cells. Molecular cancer therapeutics. vol 9. issue 3. 2010-06-18. PMID:20197401. |
the suppression of stat3 by genetic means or using sorafenib was shown to downregulate mcl-1 and bcl-x(l) and to sensitize cells to trail-mediated apoptosis. |
2010-06-18 |
2023-08-12 |
human |
| Karuppaiyah Selvendiran, Shabnam Ahmed, Alex Dayton, M Lakshmi Kuppusamy, Mia Tazi, Anna Bratasz, Liyue Tong, Brian K Rivera, Tamás Kálai, Kálmán Hideg, Periannan Kuppusam. Safe and targeted anticancer efficacy of a novel class of antioxidant-conjugated difluorodiarylidenyl piperidones: differential cytotoxicity in healthy and cancer cells. Free radical biology & medicine. vol 48. issue 9. 2010-06-16. PMID:20156552. |
western blot analysis showed that the dap-induced growth arrest and apoptosis in cancer cells were mediated by inhibition of stat3 phosphorylation at the tyr705 and ser727 residues and induction of apoptotic markers of cleaved caspase-3 and parp. |
2010-06-16 |
2023-08-12 |
human |
| Hsuan-Heng Yeh, Raghavaraju Giri, Tsuey-Yu Chang, Cheng-Yang Chou, Wu-Chou Su, Hsiao-Sheng Li. Ha-ras oncogene-induced Stat3 phosphorylation enhances oncogenicity of the cell. DNA and cell biology. vol 28. issue 3. 2010-06-14. PMID:19182994. |
ha-ras-induced stat3 phosphorylation at serine-727 plays a pivotal role in transcriptional activation of cyclin d1 and suppression of cell apoptosis. |
2010-06-14 |
2023-08-12 |
mouse |
| Tan Li, Wei Wang, Hong Chen, Tong Li, Lu Y. Evaluation of anti-leukemia effect of resveratrol by modulating STAT3 signaling. International immunopharmacology. vol 10. issue 1. 2010-06-14. PMID:19796711. |
our data indicate that resveratrol contributes to inhibiting growth, inducing apoptosis and cell cycle arrest in the three leukemia cell lines (jurkat, sup-b15, and kasumi-1), and reducing the phosphorylation of stat3, meanwhile modulating the expression of bcl-2 and bax. |
2010-06-14 |
2023-08-12 |
mouse |
| Jun Wan, Amy K Y Fu, Fanny C F Ip, Ho-Keung Ng, Jacques Hugon, Guylène Page, Jerry H Wang, Kwok-On Lai, Zhenguo Wu, Nancy Y I. Tyk2/STAT3 signaling mediates beta-amyloid-induced neuronal cell death: implications in Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 20. 2010-06-04. PMID:20484629. |
importantly, reduction of either the expression or activation of stat3 markedly attenuates abeta-induced neuronal apoptosis, suggesting that stat3 activation contributes to neuronal death after abeta exposure. |
2010-06-04 |
2023-08-12 |
mouse |
| Andrzej Wincewicz, Mariusz Koda, Mariola Sulkowska, Luiza Kanczuga-Koda, Dominik Wincewicz, Stanislaw Sulkowsk. STAT3 and hypoxia induced proteins--HIF-1alpha, EPO and EPOR in relation with Bax and Bcl-xL in nodal metastases of ductal breast cancers. Folia histochemica et cytobiologica. vol 47. issue 3. 2010-05-24. PMID:20164027. |
our present study was focused on immunohistochemical evaluation of stat3, hif-1alpha, epo and epor in relation to apoptosis regulators, bax and bcl-xl in 39 metastases of ductal breast cancers to lymph nodes. |
2010-05-24 |
2023-08-12 |
Not clear |
| Apar Kishor Gant. Epidermal growth factor receptor signaling in nonsmall cell lung cancer. Cancer investigation. vol 28. issue 5. 2010-05-14. PMID:20073576. |
egfr function is dysregulated in various malignancies including nonsmall cell lung cancer (nsclc) leading to activation of several signal transduction pathways including k-ras, pik3, and stat3 and stat5, that promote cell cycle progression, proliferation, invasion, angiogenesis, and inhibit apoptosis. |
2010-05-14 |
2023-08-12 |
Not clear |
| Young-Kwang Yoon, Hwang-Phill Kim, Sae-Won Han, Do Youn Oh, Seock-Ah Im, Yung-Jue Bang, Tae-You Ki. KRAS mutant lung cancer cells are differentially responsive to MEK inhibitor due to AKT or STAT3 activation: implication for combinatorial approach. Molecular carcinogenesis. vol 49. issue 4. 2010-05-12. PMID:20358631. |
combined stat3 inhibition by a jak2 inhibitor or gene knockdown with mek inhibition blocked stat3 activation, synergistically suppressed cell growth, and induced apoptosis in comutant cells. |
2010-05-12 |
2023-08-12 |
Not clear |
| L-M Liu, J-X Zhang, X-P Wang, H-X Guo, H Deng, J Lu. Pim-3 protects against hepatic failure in D-galactosamine (D-GalN)-sensitized rats. European journal of clinical investigation. vol 40. issue 2. 2010-05-11. PMID:20039932. |
pim-3, a hepatic growth stimulator, belongs to the serine/threonine kinase pim-family that has been implicated in gp130-mediated induction of cell proliferation, protection from apoptosis downstream of signal transducer and activator of transcription 3 (stat3) and vascular endothelial growth factor-a-dependent vasculogenesis and angiogenesis, thus is suggested to possibly play a role in the tissue repair of fhf. |
2010-05-11 |
2023-08-12 |
rat |
| Li Lin, Brian Hutzen, Pui-Kai Li, Sarah Ball, Mingxin Zuo, Stephanie DeAngelis, Elizabeth Foust, Matthew Sobo, Lauren Friedman, Deepak Bhasin, Ling Cen, Chenglong Li, Jiayuh Li. A novel small molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells. Neoplasia (New York, N.Y.). vol 12. issue 1. 2010-05-10. PMID:20072652. |
lll12 was found to inhibit stat3 phosphorylation (tyrosine 705) and induce apoptosis as indicated by the increases of cleaved caspase-3 and poly (adp-ribose) polymerase in various breast, pancreatic, and glioblastoma cancer cell lines expressing elevated levels of stat3 phosphorylation. |
2010-05-10 |
2023-08-12 |
mouse |
| Soumya Jaganathan, Peibin Yue, James Turkso. Enhanced sensitivity of pancreatic cancer cells to concurrent inhibition of aberrant signal transducer and activator of transcription 3 and epidermal growth factor receptor or Src. The Journal of pharmacology and experimental therapeutics. vol 333. issue 2. 2010-05-10. PMID:20100905. |
by contrast, the concurrent inhibition of stat3 and egfr or src induced greater viability loss and apoptosis and decreased the migration/invasion of pancreatic cancer cells in vitro. |
2010-05-10 |
2023-08-12 |
human |
| Fatih M Uckun, Sanjive Qazi, Hong Ma, Lisa Tuel-Ahlgren, Zahide Oze. STAT3 is a substrate of SYK tyrosine kinase in B-lineage leukemia/lymphoma cells exposed to oxidative stress. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 7. 2010-05-10. PMID:20133729. |
these results provide evidence for the existence of a novel mode of cytokine-independent cross-talk that operates between syk and stat3 pathways and regulates apoptosis during os. |
2010-05-10 |
2023-08-12 |
human |
| Fatih M Uckun, Sanjive Qazi, Hong Ma, Lisa Tuel-Ahlgren, Zahide Oze. STAT3 is a substrate of SYK tyrosine kinase in B-lineage leukemia/lymphoma cells exposed to oxidative stress. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 7. 2010-05-10. PMID:20133729. |
notably, inhibition of syk with a small molecule drug candidate prevents os-induced activation of stat3 and overcomes the resistance of human b-lineage leukemia/lymphoma cells to os-induced apoptosis. |
2010-05-10 |
2023-08-12 |
human |
| E V Mitiushova, N D Aksenov, I I Marakhov. [Specific function of STAT5 in regulation of proliferation of chronic leukemia K562 cells: inhibitory effect of WHI-P131]. Tsitologiia. vol 52. issue 2. 2010-05-10. PMID:20352702. |
thus, our findings indicate a preferential role for stat5 (not constitutively active stat3) in proliferation of leukemia to other jak drugs which stimulate apoptosis and decrease proliferation, whi-p131 prevents k562 cells growth by arresting in g2/m phases of cell cycle. |
2010-05-10 |
2023-08-12 |
Not clear |
| Fuxue Chen, Yaming Xu, Youqun Luo, Da Zheng, Yichao Song, Kangkang Yu, Hong Li, Li Zhang, Weiwei Zhong, Yonghua J. Down-regulation of Stat3 decreases invasion activity and induces apoptosis of human glioma cells. Journal of molecular neuroscience : MN. vol 40. issue 3. 2010-05-07. PMID:20069389. |
down-regulation of stat3 decreases invasion activity and induces apoptosis of human glioma cells. |
2010-05-07 |
2023-08-12 |
human |