| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xinchao Pan, Xunde Wang, Weiwei Lei, Lihua Min, Yanan Yang, Xin Wang, Jianguo Son. Nitric oxide suppresses transforming growth factor-beta1-induced epithelial-to-mesenchymal transition and apoptosis in mouse hepatocytes. Hepatology (Baltimore, Md.). vol 50. issue 5. 2009-12-03. PMID:19821529. |
no and fccp also inhibited tgf-beta1-induced stat3 activation, suggesting that signal transducer and activator of transcription 3 inactivation is involved in the no-induced effects on tgf-beta1-induced emt and apoptosis. |
2009-12-03 |
2023-08-12 |
mouse |
| Murugavel Ponnusamy, Maoyin Pang, Pavan Kumar Annamaraju, Zhu Zhang, Rujun Gong, Y Eugene Chin, Shougang Zhuan. Transglutaminase-1 protects renal epithelial cells from hydrogen peroxide-induced apoptosis through activation of STAT3 and AKT signaling pathways. American journal of physiology. Renal physiology. vol 297. issue 5. 2009-11-17. PMID:19710241. |
transglutaminase-1 protects renal epithelial cells from hydrogen peroxide-induced apoptosis through activation of stat3 and akt signaling pathways. |
2009-11-17 |
2023-08-12 |
mouse |
| Murugavel Ponnusamy, Maoyin Pang, Pavan Kumar Annamaraju, Zhu Zhang, Rujun Gong, Y Eugene Chin, Shougang Zhuan. Transglutaminase-1 protects renal epithelial cells from hydrogen peroxide-induced apoptosis through activation of STAT3 and AKT signaling pathways. American journal of physiology. Renal physiology. vol 297. issue 5. 2009-11-17. PMID:19710241. |
concurrent with rptc apoptosis, phosphorylation of akt, signal transducer and activator of transcription-3 (stat3), and glucogen synthase kinase-3beta (gsk-3beta) were observed. |
2009-11-17 |
2023-08-12 |
mouse |
| Murugavel Ponnusamy, Maoyin Pang, Pavan Kumar Annamaraju, Zhu Zhang, Rujun Gong, Y Eugene Chin, Shougang Zhuan. Transglutaminase-1 protects renal epithelial cells from hydrogen peroxide-induced apoptosis through activation of STAT3 and AKT signaling pathways. American journal of physiology. Renal physiology. vol 297. issue 5. 2009-11-17. PMID:19710241. |
furthermore, treatment with gsk-3beta inhibitors reduced h2o2-induced apoptosis and abolished the death-promoting effect of akt and stat3 inhibition. |
2009-11-17 |
2023-08-12 |
mouse |
| Charles E Egwuag. STAT3 in CD4+ T helper cell differentiation and inflammatory diseases. Cytokine. vol 47. issue 3. 2009-11-12. PMID:19648026. |
stat3 also has potent anti-inflammatory effects and regulates critical cellular processes such as, cell growth, apoptosis and transcription of inflammatory genes. |
2009-11-12 |
2023-08-12 |
Not clear |
| Elena A Goncharova, Dmitry A Goncharov, Gautam Damera, Omar Tliba, Yassine Amrani, Reynold A Panettieri, Vera P Krymskay. Signal transducer and activator of transcription 3 is required for abnormal proliferation and survival of TSC2-deficient cells: relevance to pulmonary lymphangioleiomyomatosis. Molecular pharmacology. vol 76. issue 4. 2009-11-03. PMID:19596836. |
reduction of stat3 protein levels or activity using specific small interfering rna or inhibitory peptide, respectively, decreased proliferation and induced apoptosis in tsc2-null and lamd cells and sensitized cells to growth-inhibitory and proapoptotic effects of ifn-gamma. |
2009-11-03 |
2023-08-12 |
human |
| Bao-Rang Zhu, Jian-Ming Cai, Gu-Sheng Tang, Bai-Long Li, Fu Gao, Jian-Guo Cui, Han-Chen Li. [Effects of STAT3 antisense oligonucleotide on proliferation and apoptosis of non-small cell lung cancer cell line A549]. Ai zheng = Aizheng = Chinese journal of cancer. vol 26. issue 8. 2009-10-29. PMID:17697540. |
[effects of stat3 antisense oligonucleotide on proliferation and apoptosis of non-small cell lung cancer cell line a549]. |
2009-10-29 |
2023-08-12 |
human |
| Bao-Rang Zhu, Jian-Ming Cai, Gu-Sheng Tang, Bai-Long Li, Fu Gao, Jian-Guo Cui, Han-Chen Li. [Effects of STAT3 antisense oligonucleotide on proliferation and apoptosis of non-small cell lung cancer cell line A549]. Ai zheng = Aizheng = Chinese journal of cancer. vol 26. issue 8. 2009-10-29. PMID:17697540. |
this study was to design effective antisense oligonucleotide targeting stat3 mrna, and explore its effect on the proliferation and apoptosis of human non-small cell lung cancer cell line a549. |
2009-10-29 |
2023-08-12 |
human |
| Long-Bo Gong, Xue-Lai Luo, Shuang-You Liu, De-Ding Tao, Jian-Ping Gong, Jun-Bo H. [Correlations of GRIM-19 and its target gene product STAT3 to malignancy of human colorectal carcinoma]. Ai zheng = Aizheng = Chinese journal of cancer. vol 26. issue 7. 2009-10-27. PMID:17626740. |
stat3 and its pathway are involved in modulating cell proliferation, apoptosis, differentiation, and mediating malignant transformation of cells. |
2009-10-27 |
2023-08-12 |
human |
| Xing-Hui Shen, Young-Joon Han, Ding-Xiao Zhang, Xiang-Shun Cui, Nam-Hyung Ki. A link between the interleukin-6/Stat3 anti-apoptotic pathway and microRNA-21 in preimplantation mouse embryos. Molecular reproduction and development. vol 76. issue 9. 2009-10-19. PMID:19437447. |
signal transducers and activators of transcription-3 (stat3) plays a central role in interleukin-6 (il-6)-mediated cell proliferation by inhibiting apoptosis in a variety of cell types. |
2009-10-19 |
2023-08-12 |
mouse |
| Xing-Hui Shen, Young-Joon Han, Ding-Xiao Zhang, Xiang-Shun Cui, Nam-Hyung Ki. A link between the interleukin-6/Stat3 anti-apoptotic pathway and microRNA-21 in preimplantation mouse embryos. Molecular reproduction and development. vol 76. issue 9. 2009-10-19. PMID:19437447. |
in order to determine whether the il-6 induced stat3 anti-apoptosis pathway is linked with mirna-21, we first determined the effects of recombinant mouse il-6 on stat3 expression, mouse embryo viability, and the mrna levels of apoptosis related genes and mirna-21 during mouse embryo development in vitro. |
2009-10-19 |
2023-08-12 |
mouse |
| Xing-Hui Shen, Young-Joon Han, Ding-Xiao Zhang, Xiang-Shun Cui, Nam-Hyung Ki. A link between the interleukin-6/Stat3 anti-apoptotic pathway and microRNA-21 in preimplantation mouse embryos. Molecular reproduction and development. vol 76. issue 9. 2009-10-19. PMID:19437447. |
these results suggest that the induction of the stat3 anti-apoptotic pathway by il-6 is linked to mirna-21 expression, which possibly results in the regulation of cell apoptosis in early mouse embryo development. |
2009-10-19 |
2023-08-12 |
mouse |
| Jennifer Dourlat, Wang-Qing Liu, Florence Sancier, Thomas Edmonds, Perayot Pamonsinlapatham, Francisco Cruzalegui, Christiane Garba. A novel non-phosphorylated potential antitumoral peptide inhibits STAT3 biological activity. Biochimie. vol 91. issue 8. 2009-10-13. PMID:19470402. |
further biological evaluation using a stat3-dependent cell line demonstrated that its antennapedia-vectorized form p1a interacted with stat3 within the cell, resulting in a significant effect on cell proliferation and expression of cell cycle and apoptosis regulators controlled by stat3. |
2009-10-13 |
2023-08-12 |
Not clear |
| Ying Wang, Xiuquan Ma, Shousheng Yan, Shensi Shen, Huiling Zhu, Yuan Gu, Hongbing Wang, Guowei Qin, Qiang Y. 17-hydroxy-jolkinolide B inhibits signal transducers and activators of transcription 3 signaling by covalently cross-linking Janus kinases and induces apoptosis of human cancer cells. Cancer research. vol 69. issue 18. 2009-10-07. PMID:19706767. |
finally, we show that hjb inhibits growth and induces apoptosis of tumor cells, particularly those tumor cells with constitutively activated stat3. |
2009-10-07 |
2023-08-12 |
human |
| Karuppaiyah Selvendiran, Anna Bratasz, M Lakshmi Kuppusamy, Mia F Tazi, Brian K Rivera, Periannan Kuppusam. Hypoxia induces chemoresistance in ovarian cancer cells by activation of signal transducer and activator of transcription 3. International journal of cancer. vol 125. issue 9. 2009-09-15. PMID:19623660. |
inhibition of stat3 by ag490 followed by treatment with cisplatin or taxol resulted in a significant increase in apoptosis suggesting that hypoxia-induced stat3 activation is responsible for chemoresistance. |
2009-09-15 |
2023-08-12 |
mouse |
| Amy Kluge, Snehal Dabir, Jeffrey Kern, David Nethery, Balazs Halmos, Patrick Ma, Afshin Dowlat. Cooperative interaction between protein inhibitor of activated signal transducer and activator of transcription-3 with epidermal growth factor receptor blockade in lung cancer. International journal of cancer. vol 125. issue 7. 2009-08-28. PMID:19569236. |
inhibition of stat3 results in nsclc growth inhibition and apoptosis. |
2009-08-28 |
2023-08-12 |
Not clear |
| Zhihao Wu, Xiaoai Zhang, Juntao Yang, Guangzhou Wu, Ying Zhang, Yanzhi Yuan, Chaozhi Jin, Zhijie Chang, Jian Wang, Xiaoming Yang, Fuchu H. Nuclear protein IkappaB-zeta inhibits the activity of STAT3. Biochemical and biophysical research communications. vol 387. issue 2. 2009-08-20. PMID:19595668. |
stat3 (signal transducer and activator of transcription 3) is a key transcription factor of the jak-stat (janus kinase/signal transducer and activator of transcription) pathway that regulates cell proliferation and apoptosis. |
2009-08-20 |
2023-08-12 |
Not clear |
| Zhihao Wu, Xiaoai Zhang, Juntao Yang, Guangzhou Wu, Ying Zhang, Yanzhi Yuan, Chaozhi Jin, Zhijie Chang, Jian Wang, Xiaoming Yang, Fuchu H. Nuclear protein IkappaB-zeta inhibits the activity of STAT3. Biochemical and biophysical research communications. vol 387. issue 2. 2009-08-20. PMID:19595668. |
it also suppressed cell growth and induced cell apoptosis in src-simulated cells, which is partially mediated by down-regulation of expression of a known stat3 target gene, mcl1. |
2009-08-20 |
2023-08-12 |
Not clear |
| Su-Ryun Kim, Moon-Kyoung Bae, Jee-Young Kim, Hee-Jun Wee, Mie-Ae Yoo, Soo-Kyung Ba. Aspirin induces apoptosis through the blockade of IL-6-STAT3 signaling pathway in human glioblastoma A172 cells. Biochemical and biophysical research communications. vol 387. issue 2. 2009-08-20. PMID:19595669. |
when administered exogenous il-6 to aspirin-treated a172 cells, the phosphorylation of stat3 and cellular apoptosis were restrained compared to aspirin only-treated cells. |
2009-08-20 |
2023-08-12 |
human |
| Su-Ryun Kim, Moon-Kyoung Bae, Jee-Young Kim, Hee-Jun Wee, Mie-Ae Yoo, Soo-Kyung Ba. Aspirin induces apoptosis through the blockade of IL-6-STAT3 signaling pathway in human glioblastoma A172 cells. Biochemical and biophysical research communications. vol 387. issue 2. 2009-08-20. PMID:19595669. |
taken together, our results indicate that aspirin causes apoptosis via down-regulation of il-6-dependent stat3 signaling, suggesting that aspirin could be therapeutically useful for a potential anti-glioblastoma therapeutic approach. |
2009-08-20 |
2023-08-12 |
human |