| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Howlett, T R Menheniott, L M Judd, A S Girau. Cytokine signalling via gp130 in gastric cancer. Biochimica et biophysica acta. vol 1793. issue 11. 2009-12-23. PMID:19665497. |
it has been established that blockade of shp2 activation of mapk signalling results in hyperactivation of stat3 resulting in increased cell proliferation, angiogenesis, inflammation and inhibition of both immunocyte and epithelial cell apoptosis. |
2009-12-23 |
2023-08-12 |
mouse |
| Boris R A Blechacz, Rory L Smoot, Steven F Bronk, Nathan W Werneburg, Alphonse E Sirica, Gregory J Gore. Sorafenib inhibits signal transducer and activator of transcription-3 signaling in cholangiocarcinoma cells by activating the phosphatase shatterproof 2. Hepatology (Baltimore, Md.). vol 50. issue 6. 2009-12-15. PMID:19821497. |
sorafenib treatment also decreased the expression of mcl-1 messenger rna and protein, a stat3 transcriptional target, as well as sensitizing cca cells to tumor necrosis factor-related apoptosis-inducing ligand (trail)-mediated apoptosis. |
2009-12-15 |
2023-08-12 |
human |
| Boris R A Blechacz, Rory L Smoot, Steven F Bronk, Nathan W Werneburg, Alphonse E Sirica, Gregory J Gore. Sorafenib inhibits signal transducer and activator of transcription-3 signaling in cholangiocarcinoma cells by activating the phosphatase shatterproof 2. Hepatology (Baltimore, Md.). vol 50. issue 6. 2009-12-15. PMID:19821497. |
in this in vivo model, sorafenib also decreased tumor tyr(705) stat3 phosphorylation and increased tumor cell apoptosis. |
2009-12-15 |
2023-08-12 |
human |
| Keiko Yamauchi-Takihar. gp130-mediated pathway and heart failure. Future cardiology. vol 4. issue 4. 2009-12-14. PMID:19804322. |
in addition to various factors, such as bcl-xl, inducible nitric oxide synthase and reactive oxygen species-scavenging proteins, vegf has also been identified as a target gene of stat3 and together can promote cardiac myocyte survival by preventing apoptosis and restoration of energy deprivation. |
2009-12-14 |
2023-08-12 |
human |
| Michael Wagner, M Aq Siddiqu. Signaling networks regulating cardiac myocyte survival and death. Current opinion in investigational drugs (London, England : 2000). vol 10. issue 9. 2009-12-11. PMID:19705335. |
the activation of stat3 affords cardioprotection, whereas activation of stat1 is associated with apoptosis. |
2009-12-11 |
2023-08-12 |
Not clear |
| G Regis, L Icardi, L Conti, R Chiarle, R Piva, M Giovarelli, V Poli, F Novell. IL-6, but not IFN-gamma, triggers apoptosis and inhibits in vivo growth of human malignant T cells on STAT3 silencing. Leukemia. vol 23. issue 11. 2009-12-07. PMID:19626047. |
il-6, but not ifn-gamma, triggers apoptosis and inhibits in vivo growth of human malignant t cells on stat3 silencing. |
2009-12-07 |
2023-08-12 |
mouse |
| G Regis, L Icardi, L Conti, R Chiarle, R Piva, M Giovarelli, V Poli, F Novell. IL-6, but not IFN-gamma, triggers apoptosis and inhibits in vivo growth of human malignant T cells on STAT3 silencing. Leukemia. vol 23. issue 11. 2009-12-07. PMID:19626047. |
in contrast, in the absence of stat3, ifn-gamma could slightly enhance apoptosis but its ability to induce mhc class i expression was unchanged. |
2009-12-07 |
2023-08-12 |
mouse |
| Rebecca J Leeman-Neill, Sarah E Wheeler, Shivendra V Singh, Sufi M Thomas, Raja R Seethala, Daniel B Neill, Mary C Panahandeh, Eun-Ryeong Hahm, Sonali C Joyce, Malabika Sen, Quan Cai, Maria L Freilino, Changyou Li, Daniel E Johnson, Jennifer R Grandi. Guggulsterone enhances head and neck cancer therapies via inhibition of signal transducer and activator of transcription-3. Carcinogenesis. vol 30. issue 11. 2009-12-07. PMID:19762335. |
in a xenograft model of hnscc, guggulsterone treatment resulted in increased apoptosis and decreased expression of stat3. |
2009-12-07 |
2023-08-12 |
human |
| Cong Liu, Sheng Zhou, Chang-Shu Ke, Na-Ping Li, Ren-Liang W. [Activation and prognostic significance of AKT, NF-kappaB and STAT3 in breast cancer with lymph node metastasis and estrogen receptor expression]. Ai zheng = Aizheng = Chinese journal of cancer. vol 26. issue 9. 2009-12-03. PMID:17927847. |
being downstream targets of the phosphatase and tensin homolog deleted on chromosome ten (pten) and epidermal growth factor receptor (egfr) pathways, serine/threonine kinase akt, nuclear factor-kappab (nf-kappab) and signal transducer and activator of transcription-3 (stat3), play important roles in cell proliferation, apoptosis and oncogenesis. |
2009-12-03 |
2023-08-12 |
Not clear |
| Xinchao Pan, Xunde Wang, Weiwei Lei, Lihua Min, Yanan Yang, Xin Wang, Jianguo Son. Nitric oxide suppresses transforming growth factor-beta1-induced epithelial-to-mesenchymal transition and apoptosis in mouse hepatocytes. Hepatology (Baltimore, Md.). vol 50. issue 5. 2009-12-03. PMID:19821529. |
no and fccp also inhibited tgf-beta1-induced stat3 activation, suggesting that signal transducer and activator of transcription 3 inactivation is involved in the no-induced effects on tgf-beta1-induced emt and apoptosis. |
2009-12-03 |
2023-08-12 |
mouse |
| Murugavel Ponnusamy, Maoyin Pang, Pavan Kumar Annamaraju, Zhu Zhang, Rujun Gong, Y Eugene Chin, Shougang Zhuan. Transglutaminase-1 protects renal epithelial cells from hydrogen peroxide-induced apoptosis through activation of STAT3 and AKT signaling pathways. American journal of physiology. Renal physiology. vol 297. issue 5. 2009-11-17. PMID:19710241. |
transglutaminase-1 protects renal epithelial cells from hydrogen peroxide-induced apoptosis through activation of stat3 and akt signaling pathways. |
2009-11-17 |
2023-08-12 |
mouse |
| Murugavel Ponnusamy, Maoyin Pang, Pavan Kumar Annamaraju, Zhu Zhang, Rujun Gong, Y Eugene Chin, Shougang Zhuan. Transglutaminase-1 protects renal epithelial cells from hydrogen peroxide-induced apoptosis through activation of STAT3 and AKT signaling pathways. American journal of physiology. Renal physiology. vol 297. issue 5. 2009-11-17. PMID:19710241. |
concurrent with rptc apoptosis, phosphorylation of akt, signal transducer and activator of transcription-3 (stat3), and glucogen synthase kinase-3beta (gsk-3beta) were observed. |
2009-11-17 |
2023-08-12 |
mouse |
| Murugavel Ponnusamy, Maoyin Pang, Pavan Kumar Annamaraju, Zhu Zhang, Rujun Gong, Y Eugene Chin, Shougang Zhuan. Transglutaminase-1 protects renal epithelial cells from hydrogen peroxide-induced apoptosis through activation of STAT3 and AKT signaling pathways. American journal of physiology. Renal physiology. vol 297. issue 5. 2009-11-17. PMID:19710241. |
furthermore, treatment with gsk-3beta inhibitors reduced h2o2-induced apoptosis and abolished the death-promoting effect of akt and stat3 inhibition. |
2009-11-17 |
2023-08-12 |
mouse |
| Charles E Egwuag. STAT3 in CD4+ T helper cell differentiation and inflammatory diseases. Cytokine. vol 47. issue 3. 2009-11-12. PMID:19648026. |
stat3 also has potent anti-inflammatory effects and regulates critical cellular processes such as, cell growth, apoptosis and transcription of inflammatory genes. |
2009-11-12 |
2023-08-12 |
Not clear |
| Elena A Goncharova, Dmitry A Goncharov, Gautam Damera, Omar Tliba, Yassine Amrani, Reynold A Panettieri, Vera P Krymskay. Signal transducer and activator of transcription 3 is required for abnormal proliferation and survival of TSC2-deficient cells: relevance to pulmonary lymphangioleiomyomatosis. Molecular pharmacology. vol 76. issue 4. 2009-11-03. PMID:19596836. |
reduction of stat3 protein levels or activity using specific small interfering rna or inhibitory peptide, respectively, decreased proliferation and induced apoptosis in tsc2-null and lamd cells and sensitized cells to growth-inhibitory and proapoptotic effects of ifn-gamma. |
2009-11-03 |
2023-08-12 |
human |
| Bao-Rang Zhu, Jian-Ming Cai, Gu-Sheng Tang, Bai-Long Li, Fu Gao, Jian-Guo Cui, Han-Chen Li. [Effects of STAT3 antisense oligonucleotide on proliferation and apoptosis of non-small cell lung cancer cell line A549]. Ai zheng = Aizheng = Chinese journal of cancer. vol 26. issue 8. 2009-10-29. PMID:17697540. |
[effects of stat3 antisense oligonucleotide on proliferation and apoptosis of non-small cell lung cancer cell line a549]. |
2009-10-29 |
2023-08-12 |
human |
| Bao-Rang Zhu, Jian-Ming Cai, Gu-Sheng Tang, Bai-Long Li, Fu Gao, Jian-Guo Cui, Han-Chen Li. [Effects of STAT3 antisense oligonucleotide on proliferation and apoptosis of non-small cell lung cancer cell line A549]. Ai zheng = Aizheng = Chinese journal of cancer. vol 26. issue 8. 2009-10-29. PMID:17697540. |
this study was to design effective antisense oligonucleotide targeting stat3 mrna, and explore its effect on the proliferation and apoptosis of human non-small cell lung cancer cell line a549. |
2009-10-29 |
2023-08-12 |
human |
| Long-Bo Gong, Xue-Lai Luo, Shuang-You Liu, De-Ding Tao, Jian-Ping Gong, Jun-Bo H. [Correlations of GRIM-19 and its target gene product STAT3 to malignancy of human colorectal carcinoma]. Ai zheng = Aizheng = Chinese journal of cancer. vol 26. issue 7. 2009-10-27. PMID:17626740. |
stat3 and its pathway are involved in modulating cell proliferation, apoptosis, differentiation, and mediating malignant transformation of cells. |
2009-10-27 |
2023-08-12 |
human |
| Xing-Hui Shen, Young-Joon Han, Ding-Xiao Zhang, Xiang-Shun Cui, Nam-Hyung Ki. A link between the interleukin-6/Stat3 anti-apoptotic pathway and microRNA-21 in preimplantation mouse embryos. Molecular reproduction and development. vol 76. issue 9. 2009-10-19. PMID:19437447. |
signal transducers and activators of transcription-3 (stat3) plays a central role in interleukin-6 (il-6)-mediated cell proliferation by inhibiting apoptosis in a variety of cell types. |
2009-10-19 |
2023-08-12 |
mouse |
| Xing-Hui Shen, Young-Joon Han, Ding-Xiao Zhang, Xiang-Shun Cui, Nam-Hyung Ki. A link between the interleukin-6/Stat3 anti-apoptotic pathway and microRNA-21 in preimplantation mouse embryos. Molecular reproduction and development. vol 76. issue 9. 2009-10-19. PMID:19437447. |
in order to determine whether the il-6 induced stat3 anti-apoptosis pathway is linked with mirna-21, we first determined the effects of recombinant mouse il-6 on stat3 expression, mouse embryo viability, and the mrna levels of apoptosis related genes and mirna-21 during mouse embryo development in vitro. |
2009-10-19 |
2023-08-12 |
mouse |