| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Valsala Haridas, Goshi Nishimura, Zhi-Xiang Xu, Fiona Connolly, Margaret Hanausek, Zbigniew Walaszek, Robert Zoltaszek, Jordan U Gutterma. Avicin D: a protein reactive plant isoprenoid dephosphorylates Stat 3 by regulating both kinase and phosphatase activities. PloS one. vol 4. issue 5. 2009-08-06. PMID:19440292. |
based on (a) the cross-talk that occurs between redox and phosphorylation processes, and (b) the role of stat3 in the process of apoptosis and carcinogenesis, we chose to study the effects of avicins on the processes of phosphorylation/dephosphorylation in stat3. |
2009-08-06 |
2023-08-12 |
mouse |
| Valsala Haridas, Goshi Nishimura, Zhi-Xiang Xu, Fiona Connolly, Margaret Hanausek, Zbigniew Walaszek, Robert Zoltaszek, Jordan U Gutterma. Avicin D: a protein reactive plant isoprenoid dephosphorylates Stat 3 by regulating both kinase and phosphatase activities. PloS one. vol 4. issue 5. 2009-08-06. PMID:19440292. |
downregulation of both stat3 activity and expression of stat 3-controlled pro-survival proteins, contributes to the induction of apoptosis in avicin treated tumor cells. |
2009-08-06 |
2023-08-12 |
mouse |
| Sateesh Kunigal, Sajani S Lakka, Prasanna Kumar Sodadasu, Norman Estes, Jasti S Ra. Stat3-siRNA induces Fas-mediated apoptosis in vitro and in vivo in breast cancer. International journal of oncology. vol 34. issue 5. 2009-08-03. PMID:19360334. |
previous studies demonstrated that constitutively activated stat3 plays an important role in breast cancer development and progression by promoting cell proliferation and inhibiting apoptosis. |
2009-08-03 |
2023-08-12 |
mouse |
| Sateesh Kunigal, Sajani S Lakka, Prasanna Kumar Sodadasu, Norman Estes, Jasti S Ra. Stat3-siRNA induces Fas-mediated apoptosis in vitro and in vivo in breast cancer. International journal of oncology. vol 34. issue 5. 2009-08-03. PMID:19360334. |
it also suppressed stat3 expression, and downregulated bcl-xl and upregulated fas, fas-l and cleaved caspase-3 expression within the tumor, which significantly induced apoptosis and led to tumor suppression. |
2009-08-03 |
2023-08-12 |
mouse |
| Seon-Hui Shim, Myung-Whun Sung, Seok-Woo Park, Dae Seog He. Absence of STAT1 disturbs the anticancer effect induced by STAT3 inhibition in head and neck carcinoma cell lines. International journal of molecular medicine. vol 23. issue 6. 2009-07-30. PMID:19424608. |
among them, stat1 is associated with an apoptosis pathway, while stat3 is associated with tumorigenicity in various cancer cells. |
2009-07-30 |
2023-08-12 |
Not clear |
| Geethanjali Pickert, Clemens Neufert, Moritz Leppkes, Yan Zheng, Nadine Wittkopf, Moritz Warntjen, Hans-Anton Lehr, Sebastian Hirth, Benno Weigmann, Stefan Wirtz, Wenjun Ouyang, Markus F Neurath, Christoph Becke. STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing. The Journal of experimental medicine. vol 206. issue 7. 2009-07-29. PMID:19564350. |
gene chip analysis indicated that stat3 regulates the cellular stress response, apoptosis, and pathways associated with wound healing in iecs. |
2009-07-29 |
2023-08-12 |
mouse |
| Rathindranath Baral, Anamika Bose, Chinmoyee Ray, Sonali Paul, Smarajit Pal, Enamul Haque, Bhagawan Mishra, Debolina Pal, Jatin Kumar Nagpal, Chinmay Kumar Panda, Bibhu Ranjan Da. Association of early phase of colorectal carcinogenesis with STAT3 activation and its relevance in apoptosis regulation. Experimental and molecular pathology. vol 87. issue 1. 2009-07-28. PMID:19341726. |
association of early phase of colorectal carcinogenesis with stat3 activation and its relevance in apoptosis regulation. |
2009-07-28 |
2023-08-12 |
Not clear |
| Rathindranath Baral, Anamika Bose, Chinmoyee Ray, Sonali Paul, Smarajit Pal, Enamul Haque, Bhagawan Mishra, Debolina Pal, Jatin Kumar Nagpal, Chinmay Kumar Panda, Bibhu Ranjan Da. Association of early phase of colorectal carcinogenesis with STAT3 activation and its relevance in apoptosis regulation. Experimental and molecular pathology. vol 87. issue 1. 2009-07-28. PMID:19341726. |
overall data suggests that crc population was stat3/pstat3 immunoreactive in a stage specific manner and stat3 protects cancerous colorectal epithelial cells from apoptosis. |
2009-07-28 |
2023-08-12 |
Not clear |
| Rathindranath Baral, Anamika Bose, Chinmoyee Ray, Sonali Paul, Smarajit Pal, Enamul Haque, Bhagawan Mishra, Debolina Pal, Jatin Kumar Nagpal, Chinmay Kumar Panda, Bibhu Ranjan Da. Association of early phase of colorectal carcinogenesis with STAT3 activation and its relevance in apoptosis regulation. Experimental and molecular pathology. vol 87. issue 1. 2009-07-28. PMID:19341726. |
bcl-2, cyclin d1 and caspase-3 control the activity of apoptosis regulator, stat3. |
2009-07-28 |
2023-08-12 |
Not clear |
| Stefan Faderl, Ashutosh Pal, William Bornmann, Maher Albitar, David Maxwell, Quin Van, Zhenghong Peng, David Harris, Zhiming Liu, Inbal Hazan-Halevy, Hagop M Kantarjian, Zeev Estro. Kit inhibitor APcK110 induces apoptosis and inhibits proliferation of acute myeloid leukemia cells. Cancer research. vol 69. issue 9. 2009-07-14. PMID:19383925. |
we show that (a) apck110 inhibits proliferation of the mastocytosis cell line hmc1.2 and the scf-responsive cell line oci/aml3 in a dose-dependent manner; (b) apck110 is a more potent inhibitor of oci/aml3 proliferation than the clinically used kit inhibitors imatinib and dasatinib and at least as potent as cytarabine; (c) apck110 inhibits the phosphorylation of kit, stat3, stat5, and akt in a dose-dependent fashion, showing activity of apck110 on kit and its downstream signaling pathways; (d) apck110 induces apoptosis by cleavage of caspase-3 and poly(adp-ribose) polymerase; and (e) apck110 inhibits proliferation of primary aml blasts in a clonogenic assay but does not affect proliferation of normal colony-forming cells. |
2009-07-14 |
2023-08-12 |
Not clear |
| Tianlong Zhang, Sheng Li, Yichen Zhang, Chen Zhong, Zheng Lai, Jianping Din. Crystal structure of the ARL2-GTP-BART complex reveals a novel recognition and binding mode of small GTPase with effector. Structure (London, England : 1993). vol 17. issue 4. 2009-06-25. PMID:19368893. |
bart is an effector of arl2 that is essential for nuclear retention of stat3 and may also be involved in mitochondria transport and apoptosis. |
2009-06-25 |
2023-08-12 |
human |
| Ian L P Beales, Olorunseun O Ogunwob. Glycine-extended gastrin inhibits apoptosis in Barrett's oesophageal and oesophageal adenocarcinoma cells through JAK2/STAT3 activation. Journal of molecular endocrinology. vol 42. issue 4. 2009-06-22. PMID:19153190. |
we conclude that g-gly inhibits apoptosis in bo and oac via mechanisms distinct from those activated by g-17 and involving jak2 and stat3 activation. |
2009-06-22 |
2023-08-12 |
Not clear |
| Shao-Hua Chen, Danielle A Murphy, Wiem Lassoued, Gavin Thurston, Michael D Feldman, William M F Le. Activated STAT3 is a mediator and biomarker of VEGF endothelial activation. Cancer biology & therapy. vol 7. issue 12. 2009-06-19. PMID:18981713. |
activated stat3 mediated vegf induction of ec bcl-2 and contributed to vegf protection of ec from apoptosis. |
2009-06-19 |
2023-08-12 |
mouse |
| Xuejun Xu, Moses M Kasembeli, Xueqing Jiang, Benjamin J Tweardy, David J Tweard. Chemical probes that competitively and selectively inhibit Stat3 activation. PloS one. vol 4. issue 3. 2009-06-15. PMID:19274102. |
all 5 selective compounds inhibited nuclear-to-cytoplasmic translocation of stat3, while 3 of 5 compounds induced apoptosis preferentially of breast cancer cell lines with constitutive stat3 activation. |
2009-06-15 |
2023-08-12 |
Not clear |
| Xuejun Xu, Moses M Kasembeli, Xueqing Jiang, Benjamin J Tweardy, David J Tweard. Chemical probes that competitively and selectively inhibit Stat3 activation. PloS one. vol 4. issue 3. 2009-06-15. PMID:19274102. |
thus, virtual ligand screening of compound libraries that targeted the stat3 py-peptide binding pocket identified for the first time 3 lead compounds that competitively inhibited stat3 binding to its py-peptide ligand; these compounds were selective for stat3 vs. stat1 and induced apoptosis preferentially of breast cancer cells lines with constitutively activated stat3. |
2009-06-15 |
2023-08-12 |
Not clear |
| Teruhiko Fujii, Naoko Seki, Roka Namoto-Matsubayashi, Hiroki Takahashi, Yuka Inoue, Uhi Toh, Masayoshi Kage, Kazuo Shirouz. YB-1 prevents apoptosis via the mTOR/STAT3 pathway in HER-2-overexpressing breast cancer cells. Future oncology (London, England). vol 5. issue 2. 2009-06-05. PMID:19284373. |
when stat3 was knocked down by sistat3, apoptosis was induced and constitutively active phosphorylated stat3 was found to rescue yb-1-induced apoptosis. |
2009-06-05 |
2023-08-12 |
mouse |
| Hyung Gyun Kim, Yong Pil Hwang, Hye Gwang Jeon. Kahweol blocks STAT3 phosphorylation and induces apoptosis in human lung adenocarcinoma A549 cells. Toxicology letters. vol 187. issue 1. 2009-05-26. PMID:19429240. |
kahweol blocks stat3 phosphorylation and induces apoptosis in human lung adenocarcinoma a549 cells. |
2009-05-26 |
2023-08-12 |
human |
| Hyung Gyun Kim, Yong Pil Hwang, Hye Gwang Jeon. Kahweol blocks STAT3 phosphorylation and induces apoptosis in human lung adenocarcinoma A549 cells. Toxicology letters. vol 187. issue 1. 2009-05-26. PMID:19429240. |
an overexpression in stat3 led to resistance to kahweol-induced apoptosis, suggesting that stat3 was a critical target of kahweol. |
2009-05-26 |
2023-08-12 |
human |
| Hyung Gyun Kim, Yong Pil Hwang, Hye Gwang Jeon. Kahweol blocks STAT3 phosphorylation and induces apoptosis in human lung adenocarcinoma A549 cells. Toxicology letters. vol 187. issue 1. 2009-05-26. PMID:19429240. |
these findings suggest that kahweol inhibited a549 cell growth and induced apoptosis via down-regulation of stat3 signaling pathway. |
2009-05-26 |
2023-08-12 |
human |
| Helena Cvijic, Kay Bauer, Dennis Löffler, Gabriele Pfeifer, Conny Blumert, Antje K Kretzschmar, Christian Henze, Katja Brocke-Heidrich, Friedemann Hor. Co-activator SRC-1 is dispensable for transcriptional control by STAT3. The Biochemical journal. vol 420. issue 1. 2009-05-20. PMID:19203349. |
in fact, silencing of src-1 by rna interference rapidly induced apoptosis in il-6-dependent ina-6 human myeloma cells, comparable with what was observed upon silencing of stat3. |
2009-05-20 |
2023-08-12 |
human |