| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Helena Cvijic, Kay Bauer, Dennis Löffler, Gabriele Pfeifer, Conny Blumert, Antje K Kretzschmar, Christian Henze, Katja Brocke-Heidrich, Friedemann Hor. Co-activator SRC-1 is dispensable for transcriptional control by STAT3. The Biochemical journal. vol 420. issue 1. 2009-05-20. PMID:19203349. |
altogether, this suggests that functional impairment of stat3 is not involved in the induction of myeloma cell apoptosis by src-1 silencing. |
2009-05-20 |
2023-08-12 |
human |
| Mehdi Shakibaei, Kuzhuvelil B Harikumar, Bharat B Aggarwa. Resveratrol addiction: to die or not to die. Molecular nutrition & food research. vol 53. issue 1. 2009-05-15. PMID:19072742. |
cell killing by this stilbene may be mediated through any of numerous mechanisms that involve activation of mitochondria and of death caspases; upregulation of cyclin-dependent kinase inhibitors, tumor suppressor gene products, or death-inducing cytokines and cytokine receptors; or downregulation of cell survival proteins (survivin, cflip, ciaps, x-linked inhibitor of apoptosis protein (xiap), bcl-2, bcl-xl) or inhibition of cell survival kinases (e.g., mitogen-activiated protein kinases (mapks), akt/phosphoinositide 3-kinase (pi3k), pkc, egfr kinase) and survival transcription factors (nuclear factor-kappab (nf-kappab), activating protein 1 (ap-1), hif-1alpha, signal transducer and activator of transcription (stat3)). |
2009-05-15 |
2023-08-12 |
Not clear |
| Gang Chen, Shiming Zhang, Jixin Shi, Jinglu Ai, Chunhua Han. Effects of recombinant human erythropoietin (rhEPO) on JAK2/STAT3 pathway and endothelial apoptosis in the rabbit basilar artery after subarachnoid hemorrhage. Cytokine. vol 45. issue 3. 2009-05-14. PMID:19144539. |
another aim of the current study was to investigate the modulation of rhepo on the activity of janus kinase 2 (jak2) and signal transducer and activator of transcription 3 (stat3), which played an important role in the signaling of apoptosis. |
2009-05-14 |
2023-08-12 |
human |
| Gang Chen, Shiming Zhang, Jixin Shi, Jinglu Ai, Chunhua Han. Effects of recombinant human erythropoietin (rhEPO) on JAK2/STAT3 pathway and endothelial apoptosis in the rabbit basilar artery after subarachnoid hemorrhage. Cytokine. vol 45. issue 3. 2009-05-14. PMID:19144539. |
as a result, we found that administration of rhepo could activate jak2 and stat3 in the basilar artery and decrease the apoptosis index of endothelial cells following sah. |
2009-05-14 |
2023-08-12 |
human |
| Hong Xin, Chunyan Zhang, Andreas Herrmann, Yan Du, Robert Figlin, Hua Y. Sunitinib inhibition of Stat3 induces renal cell carcinoma tumor cell apoptosis and reduces immunosuppressive cells. Cancer research. vol 69. issue 6. 2009-05-13. PMID:19244102. |
sunitinib inhibition of stat3 induces renal cell carcinoma tumor cell apoptosis and reduces immunosuppressive cells. |
2009-05-13 |
2023-08-12 |
mouse |
| Hong Xin, Chunyan Zhang, Andreas Herrmann, Yan Du, Robert Figlin, Hua Y. Sunitinib inhibition of Stat3 induces renal cell carcinoma tumor cell apoptosis and reduces immunosuppressive cells. Cancer research. vol 69. issue 6. 2009-05-13. PMID:19244102. |
we show that sunitinib induces tumor cell apoptosis and growth arrest in rcc tumor cells, which correlates with signal transducer and activator of transcription 3 (stat3) activity inhibition. |
2009-05-13 |
2023-08-12 |
mouse |
| C J Watso. Immune cell regulators in mouse mammary development and involution. Journal of animal science. vol 87. issue 13 Suppl. 2009-05-08. PMID:18849387. |
both stat3 and nuclear factor-kappab have been shown to regulate acute phase gene expression in addition to apoptosis regulators. |
2009-05-08 |
2023-08-12 |
mouse |
| b' Gordana Konjevi\\xc4\\x8. [STAT proteins in cancerogenesis and therapy of malignancies]. Srpski arhiv za celokupno lekarstvo. vol 137. issue 1-2. 2009-05-08. PMID:19370975.' |
given the critical roles of stat proteins it has been established in many studies that stat3 and stat5 are oncogenes that can contribute to cellular transformation by increasing proliferation and slowing-down apoptosis. |
2009-05-08 |
2023-08-12 |
Not clear |
| Guang-hui Li, Hong Wei, Zheng-tang Chen, Sheng-qing Lv, Chang-lin Yin, Dong-lin Wan. STAT3 silencing with lentivirus inhibits growth and induces apoptosis and differentiation of U251 cells. Journal of neuro-oncology. vol 91. issue 2. 2009-04-20. PMID:18839277. |
stat3 silencing with lentivirus inhibits growth and induces apoptosis and differentiation of u251 cells. |
2009-04-20 |
2023-08-12 |
Not clear |
| Guang-hui Li, Hong Wei, Zheng-tang Chen, Sheng-qing Lv, Chang-lin Yin, Dong-lin Wan. STAT3 silencing with lentivirus inhibits growth and induces apoptosis and differentiation of U251 cells. Journal of neuro-oncology. vol 91. issue 2. 2009-04-20. PMID:18839277. |
knockdown of stat3 expression by rnai suppressed the growth and induced apoptosis of u251 cells by down-regulating expression of bcl-2. |
2009-04-20 |
2023-08-12 |
Not clear |
| Hajime Isomot. Epigenetic alterations in cholangiocarcinoma-sustained IL-6/STAT3 signaling in cholangio- carcinoma due to SOCS3 epigenetic silencing. Digestion. vol 79 Suppl 1. 2009-04-06. PMID:19153483. |
interleukin-6 (il-6)-mediated signal transducers and activators of transcription 3 (stat3) activation are aberrantly sustained in cca cells, resulting in resistance to apoptosis. |
2009-04-06 |
2023-08-12 |
Not clear |
| David J Tweardy, Naijie Jin. Enhancing or eliminating signals for cell survival to treat disease. Transactions of the American Clinical and Climatological Association. vol 117. 2009-04-02. PMID:18528463. |
we developed a rat model of severe hemorrhagic shock (hs) to assess the benefits of promoting stat3 activity in diseases marked by excessive apoptosis. |
2009-04-02 |
2023-08-12 |
mouse |
| David J Tweardy, Naijie Jin. Enhancing or eliminating signals for cell survival to treat disease. Transactions of the American Clinical and Climatological Association. vol 117. 2009-04-02. PMID:18528463. |
administration of the stat3-activating cytokine il-6 at the initiation of resuscitation from hs activated intra-cardiac stat3, reversed cardiac apoptosis, left ventricular dysfunction and hypovolemic circulatory collapse (hcc) and resulted in a 5-fold reduction in mortality; pre-treatment of rats with gq-odn prevented the reversal of cardiac apoptosis and hcc by il-6. |
2009-04-02 |
2023-08-12 |
mouse |
| David J Tweardy, Naijie Jin. Enhancing or eliminating signals for cell survival to treat disease. Transactions of the American Clinical and Climatological Association. vol 117. 2009-04-02. PMID:18528463. |
thus, targeting of stat3 may be a useful for treatment of multiple cancers; agents that activate stat3 may be beneficial in acute insults that cause apoptosis in organs critical for survival. |
2009-04-02 |
2023-08-12 |
mouse |
| Zhenfeng Duan, Rachel Y Ames, Meagan Ryan, Francis J Hornicek, Henry Mankin, Michael V Seide. CDDO-Me, a synthetic triterpenoid, inhibits expression of IL-6 and Stat3 phosphorylation in multi-drug resistant ovarian cancer cells. Cancer chemotherapy and pharmacology. vol 63. issue 4. 2009-03-31. PMID:18587580. |
this inhibition of the il-6-stat3 pathway correlated with suppression of the anti-apoptotic stat3 target genes bcl-x(l), survivin, and mcl-1, and with apoptosis induction as measured by monitoring parp and its cleavage product, as well as by quantitative measurement of the apoptosis-associated ck18asp396. |
2009-03-31 |
2023-08-12 |
Not clear |
| Jianzhong Wang, Chun Ouyang, Xiangmei Chen, Bo Fu, Yang Lu, Quan Hon. Effect of Jak2 kinase inhibition on Stat1 and Stat3 activation and apoptosis of tubular epithelial cells induced by ATP depletion/recovery. Journal of nephrology. vol 21. issue 6. 2009-03-24. PMID:19034877. |
effect of jak2 kinase inhibition on stat1 and stat3 activation and apoptosis of tubular epithelial cells induced by atp depletion/recovery. |
2009-03-24 |
2023-08-12 |
human |
| Jianzhong Wang, Chun Ouyang, Xiangmei Chen, Bo Fu, Yang Lu, Quan Hon. Effect of Jak2 kinase inhibition on Stat1 and Stat3 activation and apoptosis of tubular epithelial cells induced by ATP depletion/recovery. Journal of nephrology. vol 21. issue 6. 2009-03-24. PMID:19034877. |
in an in vitro model of renal ischemia/reperfusion injury (iri), we investigated the role of jak2 kinase inhibition on signal transducer and activator of transcription 1 (stat1) and stat3 activations as well as apoptosis of human proximal tubular epithelial cells (hkcs) induced by adenosine triphosphate (atp) depletion/recovery. |
2009-03-24 |
2023-08-12 |
human |
| Qin Li, Rui Zhang, Yun-Liang Guo, Yuan-Wu Me. Effect of neuregulin on apoptosis and expressions of STAT3 and GFAP in rats following cerebral ischemic reperfusion. Journal of molecular neuroscience : MN. vol 37. issue 1. 2009-03-23. PMID:18633737. |
effect of neuregulin on apoptosis and expressions of stat3 and gfap in rats following cerebral ischemic reperfusion. |
2009-03-23 |
2023-08-12 |
rat |
| Qin Li, Rui Zhang, Yun-Liang Guo, Yuan-Wu Me. Effect of neuregulin on apoptosis and expressions of STAT3 and GFAP in rats following cerebral ischemic reperfusion. Journal of molecular neuroscience : MN. vol 37. issue 1. 2009-03-23. PMID:18633737. |
the aim is to investigate the effect of neuregulin-1beta (nrg-1beta) on the neuronal apoptosis and the expressions of signal transducer and activator of transcription (stat3) and glial fibrillary acidic protein (gfap) in rats following cerebral ischemia/reperfusion. |
2009-03-23 |
2023-08-12 |
rat |
| Banibrata Sen, Babita Saigal, Nila Parikh, Gary Gallick, Faye M Johnso. Sustained Src inhibition results in signal transducer and activator of transcription 3 (STAT3) activation and cancer cell survival via altered Janus-activated kinase-STAT3 binding. Cancer research. vol 69. issue 5. 2009-03-20. PMID:19223541. |
to determine the biological significance of stat3 activation, we combined specific stat3 depletion with a pharmacologic sfk inhibitor and observed increased cell cycle arrest and apoptosis. |
2009-03-20 |
2023-08-12 |
Not clear |