| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xing-Hui Shen, Young-Joon Han, Ding-Xiao Zhang, Xiang-Shun Cui, Nam-Hyung Ki. A link between the interleukin-6/Stat3 anti-apoptotic pathway and microRNA-21 in preimplantation mouse embryos. Molecular reproduction and development. vol 76. issue 9. 2009-10-19. PMID:19437447. |
these results suggest that the induction of the stat3 anti-apoptotic pathway by il-6 is linked to mirna-21 expression, which possibly results in the regulation of cell apoptosis in early mouse embryo development. |
2009-10-19 |
2023-08-12 |
mouse |
| Jennifer Dourlat, Wang-Qing Liu, Florence Sancier, Thomas Edmonds, Perayot Pamonsinlapatham, Francisco Cruzalegui, Christiane Garba. A novel non-phosphorylated potential antitumoral peptide inhibits STAT3 biological activity. Biochimie. vol 91. issue 8. 2009-10-13. PMID:19470402. |
further biological evaluation using a stat3-dependent cell line demonstrated that its antennapedia-vectorized form p1a interacted with stat3 within the cell, resulting in a significant effect on cell proliferation and expression of cell cycle and apoptosis regulators controlled by stat3. |
2009-10-13 |
2023-08-12 |
Not clear |
| Ying Wang, Xiuquan Ma, Shousheng Yan, Shensi Shen, Huiling Zhu, Yuan Gu, Hongbing Wang, Guowei Qin, Qiang Y. 17-hydroxy-jolkinolide B inhibits signal transducers and activators of transcription 3 signaling by covalently cross-linking Janus kinases and induces apoptosis of human cancer cells. Cancer research. vol 69. issue 18. 2009-10-07. PMID:19706767. |
finally, we show that hjb inhibits growth and induces apoptosis of tumor cells, particularly those tumor cells with constitutively activated stat3. |
2009-10-07 |
2023-08-12 |
human |
| Karuppaiyah Selvendiran, Anna Bratasz, M Lakshmi Kuppusamy, Mia F Tazi, Brian K Rivera, Periannan Kuppusam. Hypoxia induces chemoresistance in ovarian cancer cells by activation of signal transducer and activator of transcription 3. International journal of cancer. vol 125. issue 9. 2009-09-15. PMID:19623660. |
inhibition of stat3 by ag490 followed by treatment with cisplatin or taxol resulted in a significant increase in apoptosis suggesting that hypoxia-induced stat3 activation is responsible for chemoresistance. |
2009-09-15 |
2023-08-12 |
mouse |
| Amy Kluge, Snehal Dabir, Jeffrey Kern, David Nethery, Balazs Halmos, Patrick Ma, Afshin Dowlat. Cooperative interaction between protein inhibitor of activated signal transducer and activator of transcription-3 with epidermal growth factor receptor blockade in lung cancer. International journal of cancer. vol 125. issue 7. 2009-08-28. PMID:19569236. |
inhibition of stat3 results in nsclc growth inhibition and apoptosis. |
2009-08-28 |
2023-08-12 |
Not clear |
| Zhihao Wu, Xiaoai Zhang, Juntao Yang, Guangzhou Wu, Ying Zhang, Yanzhi Yuan, Chaozhi Jin, Zhijie Chang, Jian Wang, Xiaoming Yang, Fuchu H. Nuclear protein IkappaB-zeta inhibits the activity of STAT3. Biochemical and biophysical research communications. vol 387. issue 2. 2009-08-20. PMID:19595668. |
stat3 (signal transducer and activator of transcription 3) is a key transcription factor of the jak-stat (janus kinase/signal transducer and activator of transcription) pathway that regulates cell proliferation and apoptosis. |
2009-08-20 |
2023-08-12 |
Not clear |
| Zhihao Wu, Xiaoai Zhang, Juntao Yang, Guangzhou Wu, Ying Zhang, Yanzhi Yuan, Chaozhi Jin, Zhijie Chang, Jian Wang, Xiaoming Yang, Fuchu H. Nuclear protein IkappaB-zeta inhibits the activity of STAT3. Biochemical and biophysical research communications. vol 387. issue 2. 2009-08-20. PMID:19595668. |
it also suppressed cell growth and induced cell apoptosis in src-simulated cells, which is partially mediated by down-regulation of expression of a known stat3 target gene, mcl1. |
2009-08-20 |
2023-08-12 |
Not clear |
| Su-Ryun Kim, Moon-Kyoung Bae, Jee-Young Kim, Hee-Jun Wee, Mie-Ae Yoo, Soo-Kyung Ba. Aspirin induces apoptosis through the blockade of IL-6-STAT3 signaling pathway in human glioblastoma A172 cells. Biochemical and biophysical research communications. vol 387. issue 2. 2009-08-20. PMID:19595669. |
when administered exogenous il-6 to aspirin-treated a172 cells, the phosphorylation of stat3 and cellular apoptosis were restrained compared to aspirin only-treated cells. |
2009-08-20 |
2023-08-12 |
human |
| Su-Ryun Kim, Moon-Kyoung Bae, Jee-Young Kim, Hee-Jun Wee, Mie-Ae Yoo, Soo-Kyung Ba. Aspirin induces apoptosis through the blockade of IL-6-STAT3 signaling pathway in human glioblastoma A172 cells. Biochemical and biophysical research communications. vol 387. issue 2. 2009-08-20. PMID:19595669. |
taken together, our results indicate that aspirin causes apoptosis via down-regulation of il-6-dependent stat3 signaling, suggesting that aspirin could be therapeutically useful for a potential anti-glioblastoma therapeutic approach. |
2009-08-20 |
2023-08-12 |
human |
| Valsala Haridas, Goshi Nishimura, Zhi-Xiang Xu, Fiona Connolly, Margaret Hanausek, Zbigniew Walaszek, Robert Zoltaszek, Jordan U Gutterma. Avicin D: a protein reactive plant isoprenoid dephosphorylates Stat 3 by regulating both kinase and phosphatase activities. PloS one. vol 4. issue 5. 2009-08-06. PMID:19440292. |
based on (a) the cross-talk that occurs between redox and phosphorylation processes, and (b) the role of stat3 in the process of apoptosis and carcinogenesis, we chose to study the effects of avicins on the processes of phosphorylation/dephosphorylation in stat3. |
2009-08-06 |
2023-08-12 |
mouse |
| Valsala Haridas, Goshi Nishimura, Zhi-Xiang Xu, Fiona Connolly, Margaret Hanausek, Zbigniew Walaszek, Robert Zoltaszek, Jordan U Gutterma. Avicin D: a protein reactive plant isoprenoid dephosphorylates Stat 3 by regulating both kinase and phosphatase activities. PloS one. vol 4. issue 5. 2009-08-06. PMID:19440292. |
downregulation of both stat3 activity and expression of stat 3-controlled pro-survival proteins, contributes to the induction of apoptosis in avicin treated tumor cells. |
2009-08-06 |
2023-08-12 |
mouse |
| Sateesh Kunigal, Sajani S Lakka, Prasanna Kumar Sodadasu, Norman Estes, Jasti S Ra. Stat3-siRNA induces Fas-mediated apoptosis in vitro and in vivo in breast cancer. International journal of oncology. vol 34. issue 5. 2009-08-03. PMID:19360334. |
previous studies demonstrated that constitutively activated stat3 plays an important role in breast cancer development and progression by promoting cell proliferation and inhibiting apoptosis. |
2009-08-03 |
2023-08-12 |
mouse |
| Sateesh Kunigal, Sajani S Lakka, Prasanna Kumar Sodadasu, Norman Estes, Jasti S Ra. Stat3-siRNA induces Fas-mediated apoptosis in vitro and in vivo in breast cancer. International journal of oncology. vol 34. issue 5. 2009-08-03. PMID:19360334. |
it also suppressed stat3 expression, and downregulated bcl-xl and upregulated fas, fas-l and cleaved caspase-3 expression within the tumor, which significantly induced apoptosis and led to tumor suppression. |
2009-08-03 |
2023-08-12 |
mouse |
| Seon-Hui Shim, Myung-Whun Sung, Seok-Woo Park, Dae Seog He. Absence of STAT1 disturbs the anticancer effect induced by STAT3 inhibition in head and neck carcinoma cell lines. International journal of molecular medicine. vol 23. issue 6. 2009-07-30. PMID:19424608. |
among them, stat1 is associated with an apoptosis pathway, while stat3 is associated with tumorigenicity in various cancer cells. |
2009-07-30 |
2023-08-12 |
Not clear |
| Geethanjali Pickert, Clemens Neufert, Moritz Leppkes, Yan Zheng, Nadine Wittkopf, Moritz Warntjen, Hans-Anton Lehr, Sebastian Hirth, Benno Weigmann, Stefan Wirtz, Wenjun Ouyang, Markus F Neurath, Christoph Becke. STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing. The Journal of experimental medicine. vol 206. issue 7. 2009-07-29. PMID:19564350. |
gene chip analysis indicated that stat3 regulates the cellular stress response, apoptosis, and pathways associated with wound healing in iecs. |
2009-07-29 |
2023-08-12 |
mouse |
| Rathindranath Baral, Anamika Bose, Chinmoyee Ray, Sonali Paul, Smarajit Pal, Enamul Haque, Bhagawan Mishra, Debolina Pal, Jatin Kumar Nagpal, Chinmay Kumar Panda, Bibhu Ranjan Da. Association of early phase of colorectal carcinogenesis with STAT3 activation and its relevance in apoptosis regulation. Experimental and molecular pathology. vol 87. issue 1. 2009-07-28. PMID:19341726. |
association of early phase of colorectal carcinogenesis with stat3 activation and its relevance in apoptosis regulation. |
2009-07-28 |
2023-08-12 |
Not clear |
| Rathindranath Baral, Anamika Bose, Chinmoyee Ray, Sonali Paul, Smarajit Pal, Enamul Haque, Bhagawan Mishra, Debolina Pal, Jatin Kumar Nagpal, Chinmay Kumar Panda, Bibhu Ranjan Da. Association of early phase of colorectal carcinogenesis with STAT3 activation and its relevance in apoptosis regulation. Experimental and molecular pathology. vol 87. issue 1. 2009-07-28. PMID:19341726. |
overall data suggests that crc population was stat3/pstat3 immunoreactive in a stage specific manner and stat3 protects cancerous colorectal epithelial cells from apoptosis. |
2009-07-28 |
2023-08-12 |
Not clear |
| Rathindranath Baral, Anamika Bose, Chinmoyee Ray, Sonali Paul, Smarajit Pal, Enamul Haque, Bhagawan Mishra, Debolina Pal, Jatin Kumar Nagpal, Chinmay Kumar Panda, Bibhu Ranjan Da. Association of early phase of colorectal carcinogenesis with STAT3 activation and its relevance in apoptosis regulation. Experimental and molecular pathology. vol 87. issue 1. 2009-07-28. PMID:19341726. |
bcl-2, cyclin d1 and caspase-3 control the activity of apoptosis regulator, stat3. |
2009-07-28 |
2023-08-12 |
Not clear |
| Stefan Faderl, Ashutosh Pal, William Bornmann, Maher Albitar, David Maxwell, Quin Van, Zhenghong Peng, David Harris, Zhiming Liu, Inbal Hazan-Halevy, Hagop M Kantarjian, Zeev Estro. Kit inhibitor APcK110 induces apoptosis and inhibits proliferation of acute myeloid leukemia cells. Cancer research. vol 69. issue 9. 2009-07-14. PMID:19383925. |
we show that (a) apck110 inhibits proliferation of the mastocytosis cell line hmc1.2 and the scf-responsive cell line oci/aml3 in a dose-dependent manner; (b) apck110 is a more potent inhibitor of oci/aml3 proliferation than the clinically used kit inhibitors imatinib and dasatinib and at least as potent as cytarabine; (c) apck110 inhibits the phosphorylation of kit, stat3, stat5, and akt in a dose-dependent fashion, showing activity of apck110 on kit and its downstream signaling pathways; (d) apck110 induces apoptosis by cleavage of caspase-3 and poly(adp-ribose) polymerase; and (e) apck110 inhibits proliferation of primary aml blasts in a clonogenic assay but does not affect proliferation of normal colony-forming cells. |
2009-07-14 |
2023-08-12 |
Not clear |
| Tianlong Zhang, Sheng Li, Yichen Zhang, Chen Zhong, Zheng Lai, Jianping Din. Crystal structure of the ARL2-GTP-BART complex reveals a novel recognition and binding mode of small GTPase with effector. Structure (London, England : 1993). vol 17. issue 4. 2009-06-25. PMID:19368893. |
bart is an effector of arl2 that is essential for nuclear retention of stat3 and may also be involved in mitochondria transport and apoptosis. |
2009-06-25 |
2023-08-12 |
human |