| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Natalia Malara, Domenico Focà, Francesca Casadonte, Maria Francesca Sesto, Lorenza Macrina, Lucia Santoro, Monica Scaramuzzino, Rosa Terracciano, Rocco Savin. Simultaneous inhibition of the constitutively activated nuclear factor kappaB and of the interleukin-6 pathways is necessary and sufficient to completely overcome apoptosis resistance of human U266 myeloma cells. Cell cycle (Georgetown, Tex.). vol 7. issue 20. 2008-12-24. PMID:18931595. |
finally, combined targeting of nfkappab and stat3 signalling pathways was the most effective treatment in inducing apoptosis. |
2008-12-24 |
2023-08-12 |
human |
| Natalia Malara, Domenico Focà, Francesca Casadonte, Maria Francesca Sesto, Lorenza Macrina, Lucia Santoro, Monica Scaramuzzino, Rosa Terracciano, Rocco Savin. Simultaneous inhibition of the constitutively activated nuclear factor kappaB and of the interleukin-6 pathways is necessary and sufficient to completely overcome apoptosis resistance of human U266 myeloma cells. Cell cycle (Georgetown, Tex.). vol 7. issue 20. 2008-12-24. PMID:18931595. |
these findings suggest that combined nfkappab and stat3 targeting warrants further investigations in other apoptosis resistant mm cell lines as well as in suitable mm animal models. |
2008-12-24 |
2023-08-12 |
human |
| Fan Yang, Timothy E Van Meter, Ralf Buettner, Michael Hedvat, Wei Liang, Claudia M Kowolik, Nilesh Mepani, Janni Mirosevich, Sangkil Nam, Mike Y Chen, Gary Tye, Mark Kirschbaum, Richard Jov. Sorafenib inhibits signal transducer and activator of transcription 3 signaling associated with growth arrest and apoptosis of medulloblastomas. Molecular cancer therapeutics. vol 7. issue 11. 2008-12-22. PMID:19001435. |
together, our data show that sorafenib blocks stat3 signaling as well as expression of cell cycle and apoptosis regulatory proteins, associated with inhibition of cell proliferation and induction of apoptosis in medulloblastomas. |
2008-12-22 |
2023-08-12 |
mouse |
| Vera Cavalcanti de Araújo, Cristiane Furuse, Patricia Ramos Cury, Albina Altemani, Ney Soares de Araúj. STAT3 expression in salivary gland tumours. Oral oncology. vol 44. issue 5. 2008-12-11. PMID:17826306. |
the presence of stat3 in the nuclei of malignant salivary gland tumours may represent an important event in oncogenesis probably contributing to tumour cell proliferation while blocking apoptosis. |
2008-12-11 |
2023-08-12 |
Not clear |
| Cathy Lee, Jaspreet Dhillon, Michelle Y C Wang, Yuanyuan Gao, Kaiji Hu, Eugene Park, Arezoo Astanehe, Mien-Chie Hung, Peter Eirew, Connie J Eaves, Sandra E Dun. Targeting YB-1 in HER-2 overexpressing breast cancer cells induces apoptosis via the mTOR/STAT3 pathway and suppresses tumor growth in mice. Cancer research. vol 68. issue 21. 2008-12-08. PMID:18974106. |
furthering the role of stat3 in these cells, we show that knocking it down recapitulated the induction of apoptosis. |
2008-12-08 |
2023-08-12 |
mouse |
| Kalyan J Gangavarapu, Joy L Olbertz, Alok Bhushan, James C K Lai, Christopher K Daniel. Apoptotic resistance exhibited by dexamethasone-resistant murine 7TD1 cells is controlled independently of interleukin-6 triggered signaling. Apoptosis : an international journal on programmed cell death. vol 13. issue 11. 2008-12-03. PMID:18819004. |
stat3 was constitutively phosphorylated in resistant cells and inhibition of its dimerization induced apoptosis but did not alter their insensitivity to dexamethasone. |
2008-12-03 |
2023-08-12 |
Not clear |
| Miguel A Frias, Sarin Somers, Christine Gerber-Wicht, Lionel H Opie, Sandrine Lecour, Ursula Lan. The PGE2-Stat3 interaction in doxorubicin-induced myocardial apoptosis. Cardiovascular research. vol 80. issue 1. 2008-12-02. PMID:18567640. |
therefore, the purpose of this study was to determine whether pge(2) counteracts cardiac apoptosis induced by doxorubicin (dox), and if so, whether stat3 plays a critical role in this cardioprotective effect. |
2008-12-02 |
2023-08-12 |
Not clear |
| Weike Mao, Chikao Iwai, Jiahao Liu, Shey-Shing Sheu, Michael Fu, Chang-Seng Lian. Darbepoetin alfa exerts a cardioprotective effect in autoimmune cardiomyopathy via reduction of ER stress and activation of the PI3K/Akt and STAT3 pathways. Journal of molecular and cellular cardiology. vol 45. issue 2. 2008-11-07. PMID:18586265. |
the present study was carried out to determine if restoration of the pi3k/akt and stat3 activity by darbepoetin alfa improved cardiac function or reduced cardiomyocyte apoptosis in rabbit autoimmune cardiomyopathy induced by a peptide corresponding to the second extracellular loop of the ss(1)-adrenergic receptor (ss(1)-ec(ii)). |
2008-11-07 |
2023-08-12 |
human |
| b' Hongbo Hu, Hyo-Jeong Lee, Cheng Jiang, Jinhui Zhang, Lei Wang, Yan Zhao, Qiu Xiang, Eun-Ok Lee, Sung-Hoon Kim, Junxuan L\\xc3\\xb. Penta-1,2,3,4,6-O-galloyl-beta-D-glucose induces p53 and inhibits STAT3 in prostate cancer cells in vitro and suppresses prostate xenograft tumor growth in vivo. Molecular cancer therapeutics. vol 7. issue 9. 2008-10-22. PMID:18790750.' |
in du145 cells, which harbor constitutively active signal transducer and activator of transcription 3 (stat3), caspase-mediated apoptosis induction by pgg was associated with an inhibition of stat3 tyr705 phosphorylation and the down-regulation of stat3 transcriptional targets bcl-xl and mcl-1. |
2008-10-22 |
2023-08-12 |
mouse |
| Jinhai Gu, Gang Li, Tao Sun, Yuhang Su, Xulong Zhang, Jie Shen, Zhigang Tian, Jian Zhan. Blockage of the STAT3 signaling pathway with a decoy oligonucleotide suppresses growth of human malignant glioma cells. Journal of neuro-oncology. vol 89. issue 1. 2008-10-20. PMID:18415045. |
the stat3 decoy odn treatment specifically blocked stat3 signaling and subsequently inhibited u251 and a172 cell proliferation by inducing apoptosis and cell-cycle arrest. |
2008-10-20 |
2023-08-12 |
human |
| Björn Lamprecht, Stephan Kreher, Ioannis Anagnostopoulos, Korinna Jöhrens, Giovanni Monteleone, Franziska Jundt, Harald Stein, Martin Janz, Bernd Dörken, Stephan Matha. Aberrant expression of the Th2 cytokine IL-21 in Hodgkin lymphoma cells regulates STAT3 signaling and attracts Treg cells via regulation of MIP-3alpha. Blood. vol 112. issue 8. 2008-10-16. PMID:18684866. |
we demonstrate that il-21 activates stat3 in hrs cells, up-regulates stat3 target genes, and protects hrs cells from cd95 death receptor-induced apoptosis. |
2008-10-16 |
2023-08-12 |
Not clear |
| R Novosyadlyy, N Kurshan, D Lann, A Vijayakumar, S Yakar, D LeRoit. Insulin-like growth factor-I protects cells from ER stress-induced apoptosis via enhancement of the adaptive capacity of endoplasmic reticulum. Cell death and differentiation. vol 15. issue 8. 2008-10-14. PMID:18437163. |
application of signal transduction inhibitors of mek (u1026), pi3k (ly294002 and wortmannin), jnk (sp600125), p38 (sb203580), protein kinases a and c (h-89 and staurosporine) and stat3 (stattic) does not prevent igf-i-mediated protection from er stress-induced apoptosis. |
2008-10-14 |
2023-08-12 |
human |
| Daisuke Iizuka, Aki Ogura, Mikinori Kuwabara, Osamu Inanam. Purvalanol A induces apoptosis and downregulation of antiapoptotic proteins through abrogation of phosphorylation of JAK2/STAT3 and RNA polymerase II. Anti-cancer drugs. vol 19. issue 6. 2008-10-14. PMID:18525315. |
to clarify the mechanisms of purvalanol a in the induction of apoptosis, we investigated whether purvalanol a influenced the rna synthesis and expression of rna polymerase ii and signal transducer and activator of transcription 3 (stat3). |
2008-10-14 |
2023-08-12 |
Not clear |
| Maria L Jaramillo, Myriam Banville, Catherine Collins, Beatrice Paul-Roc, Lucie Bourget, Maureen O'Connor-McCour. Differential sensitivity of A549 non-small lung carcinoma cell responses to epidermal growth factor receptor pathway inhibitors. Cancer biology & therapy. vol 7. issue 4. 2008-10-06. PMID:18296914. |
we found that the limited ability of 225 mab to inhibit mapk, pi3k and stat3 phosphorylation correlated with its inability to promote anchorage independent apoptosis, but did not correlate with its ability to inhibit motility. |
2008-10-06 |
2023-08-12 |
Not clear |
| Pawel Gaj, Michal Mikula, Lucjan S Wyrwicz, Jaroslaw Regula, Jerzy Ostrowsk. Barrett's esophagus associates with a variant of IL23R gene. Acta biochimica Polonica. vol 55. issue 2. 2008-09-30. PMID:18560602. |
the il23/il23r pathway may modulate stat3 transcriptional activity which is an essential regulator not only of immune-mediated inflammation, but also of inflammatory-associated apoptosis resistance. |
2008-09-30 |
2023-08-12 |
Not clear |
| Yanjie Lu, Jin Zhou, Chaoqian Xu, Huixian Lin, Jiening Xiao, Zhiguo Wang, Baofeng Yan. JAK/STAT and PI3K/AKT pathways form a mutual transactivation loop and afford resistance to oxidative stress-induced apoptosis in cardiomyocytes. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 21. issue 4. 2008-09-29. PMID:18441519. |
we identified a population of cells bearing higher resistance to apoptosis and found that the cells that survived from apoptotic insults had markedly higher levels of akt and stat3. |
2008-09-29 |
2023-08-12 |
rat |
| Priya Weerasinghe, Yifei Li, Yongli Guan, Ruiwen Zhang, David J Tweardy, Naijie Jin. T40214/PEI complex: a potent therapeutics for prostate cancer that targets STAT3 signaling. The Prostate. vol 68. issue 13. 2008-09-05. PMID:18615483. |
stat3 has become a very important molecular target for pc therapy since it upregulates the oncogenes encoding apoptosis inhibitors, cell cycle regulators, and inducers of angiogenesis. |
2008-09-05 |
2023-08-12 |
Not clear |
| H Dan Lewis, Ashley Winter, Thomas F Murphy, Snehlata Tripathi, Virendra N Pandey, Beverly E Barto. STAT3 inhibition in prostate and pancreatic cancer lines by STAT3 binding sequence oligonucleotides: differential activity between 5' and 3' ends. Molecular cancer therapeutics. vol 7. issue 6. 2008-08-22. PMID:18566225. |
previously, we reported that single-stranded oligonucleotides containing consensus stat3 binding sequences (13410 and 13411) were more effective for inducing apoptosis in prostate cancer cells than antisense stat3 oligonucleotides. |
2008-08-22 |
2023-08-12 |
Not clear |
| H Dan Lewis, Ashley Winter, Thomas F Murphy, Snehlata Tripathi, Virendra N Pandey, Beverly E Barto. STAT3 inhibition in prostate and pancreatic cancer lines by STAT3 binding sequence oligonucleotides: differential activity between 5' and 3' ends. Molecular cancer therapeutics. vol 7. issue 6. 2008-08-22. PMID:18566225. |
here, we report that authentic stat3 binding sequences, identified from published literature, were more effective for inducing apoptosis in prostate cancer cells and pancreatic cancer cells than was oligonucleotide 13410. |
2008-08-22 |
2023-08-12 |
Not clear |
| H Dan Lewis, Ashley Winter, Thomas F Murphy, Snehlata Tripathi, Virendra N Pandey, Beverly E Barto. STAT3 inhibition in prostate and pancreatic cancer lines by STAT3 binding sequence oligonucleotides: differential activity between 5' and 3' ends. Molecular cancer therapeutics. vol 7. issue 6. 2008-08-22. PMID:18566225. |
we conclude that truncating the 5' end left intact enough of the canonical stat3 binding site for effective hybridization to the genome, whereas truncation of the 3' end, which is outside the canonical binding site, may have affected binding of required cofactors essential for stat3 activity, thereby reducing the capacity of this modified oligonucleotide to induce apoptosis. |
2008-08-22 |
2023-08-12 |
Not clear |