| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gerardo G Mackenzie, Nina Queisser, Manuel L Wolfson, Cesar G Fraga, Ana M Adamo, Patricia I Oteiz. Curcumin induces cell-arrest and apoptosis in association with the inhibition of constitutively active NF-kappaB and STAT3 pathways in Hodgkin's lymphoma cells. International journal of cancer. vol 123. issue 1. 2008-06-02. PMID:18386790. |
curcumin is incorporated into h-rs cells and acts inhibiting both nf-kappab and stat3 activation, leading to a decreased expression of proteins involved in cell proliferation and apoptosis, e.g. |
2008-06-02 |
2023-08-12 |
Not clear |
| Yalai Bai, Usman Ahmad, Yinong Wang, Jie H Li, Jonathan C Choy, Richard W Kim, Nancy Kirkiles-Smith, Stephen E Maher, James G Karras, C Frank Bennett, Alfred L M Bothwell, Jordan S Pober, George Tellide. Interferon-gamma induces X-linked inhibitor of apoptosis-associated factor-1 and Noxa expression and potentiates human vascular smooth muscle cell apoptosis by STAT3 activation. The Journal of biological chemistry. vol 283. issue 11. 2008-05-20. PMID:18192275. |
interferon-gamma induces x-linked inhibitor of apoptosis-associated factor-1 and noxa expression and potentiates human vascular smooth muscle cell apoptosis by stat3 activation. |
2008-05-20 |
2023-08-12 |
mouse |
| Yalai Bai, Usman Ahmad, Yinong Wang, Jie H Li, Jonathan C Choy, Richard W Kim, Nancy Kirkiles-Smith, Stephen E Maher, James G Karras, C Frank Bennett, Alfred L M Bothwell, Jordan S Pober, George Tellide. Interferon-gamma induces X-linked inhibitor of apoptosis-associated factor-1 and Noxa expression and potentiates human vascular smooth muscle cell apoptosis by STAT3 activation. The Journal of biological chemistry. vol 283. issue 11. 2008-05-20. PMID:18192275. |
stat3 activation by ifn-gamma sensitized vsmcs to apoptosis triggered by both death receptor- and mitochondrial-mediated pathways. |
2008-05-20 |
2023-08-12 |
mouse |
| Hui-Fang Xie, Ru-Xiang Xu, Ji-Peng Wei, Xiao-Dan Jiang, Zhen-Hua Li. [P-JAK2 and P-STAT3 protein expression and cell apoptosis following focal cerebral ischemia-reperfusion injury in rats]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 27. issue 2. 2008-05-15. PMID:17355939. |
to investigate the changes in phosphorylated jak2 and stat3 protein expression of and cell apoptosis following focal cerebral ischemia-reperfusion injury in rats. |
2008-05-15 |
2023-08-12 |
rat |
| Shigetoshi Sano, Keith Syson Chan, John DiGiovann. Impact of Stat3 activation upon skin biology: a dichotomy of its role between homeostasis and diseases. Journal of dermatological science. vol 50. issue 1. 2008-04-22. PMID:17601706. |
it was shown that stat3 activation contributed to skin wound healing, keratinocyte migration, hair follicle growth, and resistance to uv irradiation-induced apoptosis. |
2008-04-22 |
2023-08-12 |
mouse |
| Jianzhong Wang, Chun Ouyang, Xiangmei Chen, Bo Fu, Yang Lu, Quan Hon. STAT3 inhibits apoptosis of human renal tubular epithelial cells induced by ATP depletion/recovery. Nephron. Experimental nephrology. vol 108. issue 1. 2008-04-14. PMID:18097150. |
stat3 inhibits apoptosis of human renal tubular epithelial cells induced by atp depletion/recovery. |
2008-04-14 |
2023-08-12 |
human |
| Jianzhong Wang, Chun Ouyang, Xiangmei Chen, Bo Fu, Yang Lu, Quan Hon. STAT3 inhibits apoptosis of human renal tubular epithelial cells induced by ATP depletion/recovery. Nephron. Experimental nephrology. vol 108. issue 1. 2008-04-14. PMID:18097150. |
in the in vitro model of renal ischemic injury, we explored the role of the stat3, a major component of the stat family, in apoptosis of human proximal tubular epithelial cell (hkc) induced by atp depletion/recovery. |
2008-04-14 |
2023-08-12 |
human |
| Corina Borghouts, Christian Kunz, Natalia Delis, Bernd Grone. Monomeric recombinant peptide aptamers are required for efficient intracellular uptake and target inhibition. Molecular cancer research : MCR. vol 6. issue 2. 2008-04-09. PMID:18314488. |
we show that treatment of glioblastoma cells, expressing constitutively activated stat3, with the purified peptide aptamers strongly inhibits stat3 signaling, causing cell growth arrest and inducing apoptosis. |
2008-04-09 |
2023-08-12 |
human |
| Rebecka Hellsten, Martin Johansson, Anna Dahlman, Nishtman Dizeyi, Olov Sterner, Anders Bjartel. Galiellalactone is a novel therapeutic candidate against hormone-refractory prostate cancer expressing activated Stat3. The Prostate. vol 68. issue 3. 2008-04-01. PMID:18163422. |
stat3 signaling may be an interesting target for cancer therapy since inhibition of this pathway mediates growth inhibition and apoptosis of these cells. |
2008-04-01 |
2023-08-12 |
Not clear |
| B Belinda Ding, J Jessica Yu, Raymond Y-L Yu, Lourdes M Mendez, Rita Shaknovich, Yonghui Zhang, Giorgio Cattoretti, B Hilda Y. Constitutively activated STAT3 promotes cell proliferation and survival in the activated B-cell subtype of diffuse large B-cell lymphomas. Blood. vol 111. issue 3. 2008-03-26. PMID:17951530. |
most importantly, inactivating stat3 by either ag490 or small interference rna in abc-dlbcl cells inhibits cell proliferation and triggers apoptosis. |
2008-03-26 |
2023-08-12 |
Not clear |
| Khandaker Al Zaid Siddiquee, James Turkso. STAT3 as a target for inducing apoptosis in solid and hematological tumors. Cell research. vol 18. issue 2. 2008-03-25. PMID:18227858. |
stat3 as a target for inducing apoptosis in solid and hematological tumors. |
2008-03-25 |
2023-08-12 |
human |
| Tin Lap Lee, Jason Yeh, Jay Friedman, Bin Yan, Xinping Yang, Ning T Yeh, Carter Van Waes, Zhong Che. A signal network involving coactivated NF-kappaB and STAT3 and altered p53 modulates BAX/BCL-XL expression and promotes cell survival of head and neck squamous cell carcinomas. International journal of cancer. vol 122. issue 9. 2008-03-18. PMID:18172861. |
over-expression of p53 together with inhibition of nf-kappab or stat3 induced greater increase in the bax/bcl-xl ratio and apoptosis than modulation of these transcription factors individually. |
2008-03-18 |
2023-08-12 |
Not clear |
| Ana Quaglino, Carolina Schere-Levy, Leonardo Romorini, Roberto P Meiss, Edith C Kordo. Mouse mammary tumors display Stat3 activation dependent on leukemia inhibitory factor signaling. Breast cancer research : BCR. vol 9. issue 5. 2008-03-11. PMID:17925034. |
it has been demonstrated that leukemia inhibitory factor (lif) induces epithelium apoptosis through stat3 activation during mouse mammary gland involution. |
2008-03-11 |
2023-08-12 |
mouse |
| Akiko Onishi, Qianming Chen, Joseph O Humtsoe, Randall H Krame. STAT3 signaling is induced by intercellular adhesion in squamous cell carcinoma cells. Experimental cell research. vol 314. issue 2. 2008-03-05. PMID:17961551. |
in squamous cell carcinoma of the head and neck (hnscc), stat3 signaling has been shown to inhibit apoptosis and induce a more aggressive phenotype through the activation of specific signaling pathways. |
2008-03-05 |
2023-08-12 |
Not clear |
| Qiang Cui, Wei Jiang, Yingxin Wang, Chen Lv, Jingjing Luo, Wei Zhang, Fang Lin, Yuexiang Yin, Rong Cai, Ping Wei, Cheng Qia. Transfer of suppressor of cytokine signaling 3 by an oncolytic adenovirus induces potential antitumor activities in hepatocellular carcinoma. Hepatology (Baltimore, Md.). vol 47. issue 1. 2008-03-04. PMID:17935223. |
the constitutive activation of signal transducer and activator of transcription 3 (stat3) participates in carcinogenesis through up-regulation of genes encoding apoptosis inhibitors and cell cycle regulators, such as bcl-xl, cyclins d1 and d2, and c-myc. |
2008-03-04 |
2023-08-12 |
Not clear |
| Stephanie Kreis, Georg A Munz, Serge Haan, Peter C Heinrich, Iris Behrman. Cell density dependent increase of constitutive signal transducers and activators of transcription 3 activity in melanoma cells is mediated by Janus kinases. Molecular cancer research : MCR. vol 5. issue 12. 2008-03-04. PMID:18171991. |
although stat3 activation was completely blocked with jak inhibitor i and to a lesser extent with the common jak inhibitor ag490, only the latter compound markedly decreased proliferation and induced apoptosis. |
2008-03-04 |
2023-08-12 |
Not clear |
| Hiroyuki Fuke, Katsuya Shiraki, Kazushi Sugimoto, Junichiro Tanaka, Tetsuya Beppu, Kentaro Yoneda, Norihiko Yamamoto, Keiichi Ito, Masahiro Masuya, Yoshiyuki Take. Jak inhibitor induces S phase cell-cycle arrest and augments TRAIL-induced apoptosis in human hepatocellular carcinoma cells. Biochemical and biophysical research communications. vol 363. issue 3. 2008-02-11. PMID:17904524. |
signal transducer and activator of transcription 3 (stat3) is constitutively activated in various cancers and plays a crucial role in oncogensis, including the activation of genes encoding apoptosis inhibitors and cell-cycle regulators. |
2008-02-11 |
2023-08-12 |
human |
| Hiroyuki Fuke, Katsuya Shiraki, Kazushi Sugimoto, Junichiro Tanaka, Tetsuya Beppu, Kentaro Yoneda, Norihiko Yamamoto, Keiichi Ito, Masahiro Masuya, Yoshiyuki Take. Jak inhibitor induces S phase cell-cycle arrest and augments TRAIL-induced apoptosis in human hepatocellular carcinoma cells. Biochemical and biophysical research communications. vol 363. issue 3. 2008-02-11. PMID:17904524. |
jak inhibitor ag490 inhibited activation of stat3 and markedly reduced cell viability without significant apoptosis. |
2008-02-11 |
2023-08-12 |
human |
| Olga A Timofeeva, Vadim Gaponenko, Stephen J Lockett, Sergey G Tarasov, Sheng Jiang, Christopher J Michejda, Alan O Perantoni, Nadya I Tarasov. Rationally designed inhibitors identify STAT3 N-domain as a promising anticancer drug target. ACS chemical biology. vol 2. issue 12. 2008-01-31. PMID:18154267. |
activated stat3 may participate in oncogenesis by stimulating cell proliferation and resisting apoptosis, as well as promoting tumor angiogenesis, invasion, and migration. |
2008-01-31 |
2023-08-12 |
Not clear |
| Hiroki Suemoto, Yasuteru Muragaki, Katsuhiro Nishioka, Misako Sato, Akira Ooshima, Shunji Itoh, Ikuji Hatamura, Michitaka Ozaki, Attila Braun, Erika Gustafsson, Reinhard Fässle. Trps1 regulates proliferation and apoptosis of chondrocytes through Stat3 signaling. Developmental biology. vol 312. issue 2. 2008-01-23. PMID:17997399. |
trps1 regulates proliferation and apoptosis of chondrocytes through stat3 signaling. |
2008-01-23 |
2023-08-12 |
mouse |