| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mazen Kurdi, George W Boo. Jak inhibition, but not Stat1 knockdown, blocks the synergistic effect of IFN-gamma on Fas-induced apoptosis of A549 human non-small cell lung cancer cells. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. vol 27. issue 1. 2007-04-05. PMID:17266440. |
because stat1 and stat3 often elicit opposite effects, we assessed whether stat1 would couple to a549 cell apoptosis. |
2007-04-05 |
2023-08-12 |
human |
| Mazen Kurdi, George W Boo. Jak inhibition, but not Stat1 knockdown, blocks the synergistic effect of IFN-gamma on Fas-induced apoptosis of A549 human non-small cell lung cancer cells. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. vol 27. issue 1. 2007-04-05. PMID:17266440. |
knockdown of stat1 or stat3 with small interfering rna (sirna), separately or together, did not inhibit apoptosis, although a paninhibitor of jak1 did. |
2007-04-05 |
2023-08-12 |
human |
| Anjana Bhardwaj, Gautam Sethi, Saroj Vadhan-Raj, Carlos Bueso-Ramos, Yasunari Takada, Upasna Gaur, Asha S Nair, Shishir Shishodia, Bharat B Aggarwa. Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of STAT3 and nuclear factor-kappaB-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells. Blood. vol 109. issue 6. 2007-04-02. PMID:17164350. |
resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of stat3 and nuclear factor-kappab-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells. |
2007-04-02 |
2023-08-12 |
human |
| Anjana Bhardwaj, Gautam Sethi, Saroj Vadhan-Raj, Carlos Bueso-Ramos, Yasunari Takada, Upasna Gaur, Asha S Nair, Shishir Shishodia, Bharat B Aggarwa. Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of STAT3 and nuclear factor-kappaB-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells. Blood. vol 109. issue 6. 2007-04-02. PMID:17164350. |
when we examined cd138(+) plasma cells from patients with mm, resveratrol inhibited constitutive activation of both nf-kappab and stat3, leading to down-regulation of cell proliferation and potentiation of apoptosis induced by bortezomib and thalidomide. |
2007-04-02 |
2023-08-12 |
human |
| B Mohana Kumar, Hai-Feng Jin, Jung-Gon Kim, Sun-A Ock, Yonggeun Hong, S Balasubramanian, Sang-Yong Choe, Gyu-Jin Rh. Differential gene expression patterns in porcine nuclear transfer embryos reconstructed with fetal fibroblasts and mesenchymal stem cells. Developmental dynamics : an official publication of the American Association of Anatomists. vol 236. issue 2. 2007-04-02. PMID:17191234. |
alterations in the expression pattern of genes implicated in transcription and pluripotency (oct4, stat3, nanog), dna methylation (dnmt1, dnmt3a), histone deacetylation (hdac2), growth factor signaling, and imprinting (igf2, igf2r) and apoptosis (bax, bcl2) regulation were observed in nt embryos. |
2007-04-02 |
2023-08-12 |
Not clear |
| Bharat B Aggarwal, Gautam Sethi, Kwang Seok Ahn, Santosh K Sandur, Manoj K Pandey, Ajaikumar B Kunnumakkara, Bokyung Sung, Haruyo Ichikaw. Targeting signal-transducer-and-activator-of-transcription-3 for prevention and therapy of cancer: modern target but ancient solution. Annals of the New York Academy of Sciences. vol 1091. 2007-03-28. PMID:17341611. |
its role in cancer is indicated by numerous avenues of evidence, including the following: stat3 is constitutively active in tumor cells; stat3 is activated by growth factors (e.g., egf, tgf-alpha, il-6, hepatocyte growth factor) and oncogenic kinases (e.g., src); stat3 regulates the expression of genes that mediate proliferation (e.g., c-myc and cyclin d1), suppress apoptosis (e.g., bcl-x(l) and survivin), or promote angiogenesis (e.g, vegf); stat3 activation has been linked with chemoresistance and radioresistance; and chemopreventive agents have been shown to suppress stat3 activation. |
2007-03-28 |
2023-08-12 |
Not clear |
| Jinxia Deng, Fedora Grande, Nouri Neamat. Small molecule inhibitors of Stat3 signaling pathway. Current cancer drug targets. vol 7. issue 1. 2007-03-20. PMID:17305481. |
compelling evidence from mechanistic studies with antisense, rna interference (rnai), peptides, and small molecular inhibitors indicate that blocking stat3 signaling can lead to successful suppression of tumor cell growth and apoptosis. |
2007-03-20 |
2023-08-12 |
Not clear |
| Sweeta R Choudhari, Muhammad A Khan, Genesis Harris, Donald Picker, Gary S Jacob, Timothy Block, Kunwar Shailubha. Deactivation of Akt and STAT3 signaling promotes apoptosis, inhibits proliferation, and enhances the sensitivity of hepatocellular carcinoma cells to an anticancer agent, Atiprimod. Molecular cancer therapeutics. vol 6. issue 1. 2007-03-16. PMID:17237271. |
deactivation of akt and stat3 signaling promotes apoptosis, inhibits proliferation, and enhances the sensitivity of hepatocellular carcinoma cells to an anticancer agent, atiprimod. |
2007-03-16 |
2023-08-12 |
Not clear |
| Sweeta R Choudhari, Muhammad A Khan, Genesis Harris, Donald Picker, Gary S Jacob, Timothy Block, Kunwar Shailubha. Deactivation of Akt and STAT3 signaling promotes apoptosis, inhibits proliferation, and enhances the sensitivity of hepatocellular carcinoma cells to an anticancer agent, Atiprimod. Molecular cancer therapeutics. vol 6. issue 1. 2007-03-16. PMID:17237271. |
in this study, we report that atiprimod selectively inhibited proliferation and induced apoptosis in hcc cells that expressed either hepatitis b virus (hbv) or hepatitis c virus, through deactivation of protein kinase b (akt) and signal transducers and activators of transcription 3 (stat3) signaling. |
2007-03-16 |
2023-08-12 |
Not clear |
| Benjamin Barré, Arnaud Vigneron, Neil Perkins, Igor B Roninson, Erick Gamelin, Olivier Coquere. The STAT3 oncogene as a predictive marker of drug resistance. Trends in molecular medicine. vol 13. issue 1. 2007-03-09. PMID:17118707. |
constitutive activation of stat3 (signal transducer and activator of transcription) has been reported in several primary cancers and tumor cell lines where it induces cell transformation through a combined inhibition of apoptosis and cell-cycle activation. |
2007-03-09 |
2023-08-12 |
Not clear |
| Vladimir N Ivanov, Tom K He. Sodium arsenite accelerates TRAIL-mediated apoptosis in melanoma cells through upregulation of TRAIL-R1/R2 surface levels and downregulation of cFLIP expression. Experimental cell research. vol 312. issue 20. 2007-02-13. PMID:17070520. |
ap-1/cjun, nf-kappab and stat3 transcription factors control expression of numerous genes, which regulate critical cell functions including proliferation, survival and apoptosis. |
2007-02-13 |
2023-08-12 |
mouse |
| Zsuzsanna S Nagy, Hallgeir Rui, Stanislaw M Stepkowski, James Karras, Robert A Kirke. A preferential role for STAT5, not constitutively active STAT3, in promoting survival of a human lymphoid tumor. Journal of immunology (Baltimore, Md. : 1950). vol 177. issue 8. 2007-02-06. PMID:17015686. |
depletion of stat3 protein expression reduced tumor cell viability with protracted kinetics (72-96 h), while tunel assays demonstrated cell death occurred via apoptosis. |
2007-02-06 |
2023-08-12 |
human |
| Xiangde Li. STAT3 activation inhibits human bronchial epithelial cell apoptosis in response to cigarette smoke exposure. Biochemical and biophysical research communications. vol 353. issue 1. 2007-02-06. PMID:17173857. |
stat3 activation inhibits human bronchial epithelial cell apoptosis in response to cigarette smoke exposure. |
2007-02-06 |
2023-08-12 |
human |
| Sylvane Desrivières, Christian Kunz, Itamar Barash, Vida Vafaizadeh, Corina Borghouts, Bernd Grone. The biological functions of the versatile transcription factors STAT3 and STAT5 and new strategies for their targeted inhibition. Journal of mammary gland biology and neoplasia. vol 11. issue 1. 2007-01-30. PMID:16947086. |
in the mammary gland, stat5-induced genes contribute mainly to the prolactin dependent lobulo-alveolar development, whereas stat3 induced genes control apoptosis during involution. |
2007-01-30 |
2023-08-12 |
mouse |
| Yang Lu, Satoru Fukuyama, Ryoko Yoshida, Takashi Kobayashi, Kazuko Saeki, Hiroshi Shiraishi, Akihiko Yoshimura, Giichi Takaes. Loss of SOCS3 gene expression converts STAT3 function from anti-apoptotic to pro-apoptotic. The Journal of biological chemistry. vol 281. issue 48. 2007-01-30. PMID:17028185. |
exogenous expression of the dominant negative form of stat3 but not stat1 suppressed lif-induced apoptosis of socs3(-/-) mefs, indicating that stat3 plays a critical role in apoptosis induction. |
2007-01-30 |
2023-08-12 |
Not clear |
| Yang Lu, Satoru Fukuyama, Ryoko Yoshida, Takashi Kobayashi, Kazuko Saeki, Hiroshi Shiraishi, Akihiko Yoshimura, Giichi Takaes. Loss of SOCS3 gene expression converts STAT3 function from anti-apoptotic to pro-apoptotic. The Journal of biological chemistry. vol 281. issue 48. 2007-01-30. PMID:17028185. |
furthermore, we found that some of the stat3 target genes related to apoptosis and proliferation, such as bcl-2 and cyclin d1, were repressed upon lif treatment in socs3(-/-) cells. |
2007-01-30 |
2023-08-12 |
Not clear |
| H Yamashita, M Nishio, Y Ando, Z Zhang, M Hamaguchi, K Mita, S Kobayashi, Y Fujii, H Iwas. Stat5 expression predicts response to endocrine therapy and improves survival in estrogen receptor-positive breast cancer. Endocrine-related cancer. vol 13. issue 3. 2007-01-08. PMID:16954437. |
constitutively activated signal transducers and activators of transcription (stats), in particular stat3 and stat5, have been demonstrated to directly contribute to oncogenesis by stimulating cell proliferation and preventing apoptosis in various cancers. |
2007-01-08 |
2023-08-12 |
human |
| H Yamashita, M Nishio, Y Ando, Z Zhang, M Hamaguchi, K Mita, S Kobayashi, Y Fujii, H Iwas. Stat5 expression predicts response to endocrine therapy and improves survival in estrogen receptor-positive breast cancer. Endocrine-related cancer. vol 13. issue 3. 2007-01-08. PMID:16954437. |
stat3 is essential in mammary gland epithelial cell apoptosis and involution, whereas stat5 is well established as a key factor in mammary epithelial cell growth and differentiation. |
2007-01-08 |
2023-08-12 |
human |
| Dennis C Otero, Valeria Poli, Michael David, Robert C Ricker. Cutting edge: inherent and acquired resistance to radiation-induced apoptosis in B cells: a pivotal role for STAT3. Journal of immunology (Baltimore, Md. : 1950). vol 177. issue 10. 2007-01-05. PMID:17082570. |
cutting edge: inherent and acquired resistance to radiation-induced apoptosis in b cells: a pivotal role for stat3. |
2007-01-05 |
2023-08-12 |
mouse |
| Daniel G Rosen, Imelda Mercado-Uribe, Gong Yang, Robert C Bast, Hesham M Amin, Raymond Lai, Jinsong Li. The role of constitutively active signal transducer and activator of transcription 3 in ovarian tumorigenesis and prognosis. Cancer. vol 107. issue 11. 2006-12-19. PMID:17063503. |
signal transducer and activator of transcription 3 (stat3), which is a latent transcription factor that participates in the transcriptional activation of apoptosis and cell cycle progression, has been implicated as an oncogene in several neoplastic diseases. |
2006-12-19 |
2023-08-12 |
Not clear |