| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yanan Yang, Xinchao Pan, Weiwei Lei, Jun Wang, Jian Shi, Fuqiang Li, Jianguo Son. Regulation of transforming growth factor-beta 1-induced apoptosis and epithelial-to-mesenchymal transition by protein kinase A and signal transducers and activators of transcription 3. Cancer research. vol 66. issue 17. 2007-11-26. PMID:16951175. |
furthermore, overexpression of a phosphorylation-deficient form of stat3, but not wild-type stat3, produced an inhibitory effect on tgf-beta1-induced apoptosis and emt. |
2007-11-26 |
2023-08-12 |
Not clear |
| Yanan Yang, Xinchao Pan, Weiwei Lei, Jun Wang, Jian Shi, Fuqiang Li, Jianguo Son. Regulation of transforming growth factor-beta 1-induced apoptosis and epithelial-to-mesenchymal transition by protein kinase A and signal transducers and activators of transcription 3. Cancer research. vol 66. issue 17. 2007-11-26. PMID:16951175. |
the results indicate that pka is an upstream regulator for tgf-beta1-induced stat3 activation and plays an important role in tgf-beta1-mediated apoptosis and emt. |
2007-11-26 |
2023-08-12 |
Not clear |
| Andreas Herrmann, Michael Vogt, Martin Mönnigmann, Thomas Clahsen, Ulrike Sommer, Serge Haan, Valeria Poli, Peter C Heinrich, Gerhard Müller-Newe. Nucleocytoplasmic shuttling of persistently activated STAT3. Journal of cell science. vol 120. issue Pt 18. 2007-11-21. PMID:17726064. |
inhibition of exportin-1-mediated nuclear export slowed down nucleocytoplasmic shuttling of v-src-activated stat3 resulting in reduced tyrosine phosphorylation, decreased induction of stat3 target genes and increased apoptosis. |
2007-11-21 |
2023-08-12 |
Not clear |
| Aurélie Cabrespine, Jacques-Olivier Bay, Pierre Verrelle, Laurent More. [Interleukin-6 implication in prostate cancer]. Bulletin du cancer. vol 94. issue 7 Suppl. 2007-11-08. PMID:17845991. |
il-6 seems to be implicated in androgen receptor activation in lack of steroid ligand, apoptosis decrease and increase of invasive capacity and angiogenesis via three major signaling pathways: mapk, stat3 and pi3k-akt. |
2007-11-08 |
2023-08-12 |
Not clear |
| H M Yu, J L Zhi, Y Cui, E H Tang, S N Sun, J Q Feng, P X Che. Role of the JAK-STAT pathway in protection of hydrogen peroxide preconditioning against apoptosis induced by oxidative stress in PC12 cells. Apoptosis : an international journal on programmed cell death. vol 11. issue 6. 2007-11-01. PMID:16547593. |
it was shown that (1) preconditioning with 100 micromol/l h(2)o(2) can markedly protect pc12 cells against apoptosis and cytotoxicity induced by 300 micromol/l h(2)o(2); (2) the expression and tyrosine phosphorylation of jak2, not jak1 were rapidly increased at 5 min after h(2)o(2) preconditioning; (3) the expression of stat1 and stat3 were significantly increased at 15 min after h(2)o(2) preconditioning, and the ptyr-stat1 and ptyr-stat3 were markedly increased at 60 min after h(2)o(2) preconditioning; (4) pretreatment with the jak inhibitor ag-490 (10 micromol/l) 20 min before h(2)o(2) preconditioning blocked not only the activation of jak2, stat1 and stat3, but also the cytoprotection of h(2)o(2) preconditioning against apoptosis and cytotoxicity induced by oxidative stress. |
2007-11-01 |
2023-08-12 |
Not clear |
| M A Scheper, N G Nikitakis, J J Sau. Survivin is a downstream target and effector of sulindac-sensitive oncogenic Stat3 signalling in head and neck cancer. International journal of oral and maxillofacial surgery. vol 36. issue 7. 2007-10-11. PMID:17566705. |
the importance of constitutive stat3 activation in tumourigenesis was confirmed by sirna inhibition of stat3, resulting in cell growth inhibition and apoptosis, via a downregulation of survivin mrna and protein expression. |
2007-10-11 |
2023-08-12 |
Not clear |
| Chapla Agarwal, Alpna Tyagi, Manjinder Kaur, Rajesh Agarwa. Silibinin inhibits constitutive activation of Stat3, and causes caspase activation and apoptotic death of human prostate carcinoma DU145 cells. Carcinogenesis. vol 28. issue 7. 2007-10-04. PMID:17341659. |
given a critical role of stat3 activation in pca, our results showed that silibinin inhibits constitutively active stat3 and induces apoptosis in du145 cells, and thus might have potential significance in therapeutic intervention of this deadly malignancy. |
2007-10-04 |
2023-08-12 |
human |
| A Pardanani, J Hood, T Lasho, R L Levine, M B Martin, G Noronha, C Finke, C C Mak, R Mesa, H Zhu, R Soll, D G Gilliland, A Teffer. TG101209, a small molecule JAK2-selective kinase inhibitor potently inhibits myeloproliferative disorder-associated JAK2V617F and MPLW515L/K mutations. Leukemia. vol 21. issue 8. 2007-09-25. PMID:17541402. |
in a human jak2v617f-expressing acute myeloid leukemia cell line, tg101209-induced cell cycle arrest and apoptosis, and inhibited phosphorylation of jak2v617f, stat5 and stat3. |
2007-09-25 |
2023-08-12 |
mouse |
| Xiao Tang Yu, Shi Neng Zhu, Zu De Xu, Xi Qi Hu, Teng Fang Zhu, Jie Qing Chen, Shi Lun L. Roles of EGFR-Stat3 signal pathway in carcinogenesis of experimental hepatoma in rats. Journal of cancer research and clinical oncology. vol 133. issue 3. 2007-09-20. PMID:17031671. |
tgfalpha-egfr autocrine ring formation may lead to the activation of stat3 and in turn, promote proliferation and regulate the transcription of genes regulating cell apoptosis and cell cycle. |
2007-09-20 |
2023-08-12 |
rat |
| Rosane de Oliveira Duarte Achcar, Philip T Cagle, Jaishree Jagirda. Expression of activated and latent signal transducer and activator of transcription 3 in 303 non-small cell lung carcinomas and 44 malignant mesotheliomas: possible role for chemotherapeutic intervention. Archives of pathology & laboratory medicine. vol 131. issue 9. 2007-09-20. PMID:17824789. |
signal transducer and activator of transcription 3 (stat3) is constitutively activated in diverse human cancers and plays a critical role in tumor cell survival, proliferation, migration, invasion, angiogenesis, and inhibition of apoptosis. |
2007-09-20 |
2023-08-12 |
human |
| Priya Weerasinghe, Gabriela E Garcia, Qiqing Zhu, Ping Yuan, Lili Feng, Li Mao, Naijie Jin. Inhibition of Stat3 activation and tumor growth suppression of non-small cell lung cancer by G-quartet oligonucleotides. International journal of oncology. vol 31. issue 1. 2007-09-14. PMID:17549413. |
results show that gq-odn t40214 and t40231 significantly suppress the growth of nsclc tumors in nude mice by selectively inhibiting the activation of stat3 and its downstream proteins bcl-2, bcl-xl, mcl-1, survivin, vegf, cyclin d1 and c-myc; thereby, promoting apoptosis and reducing angiogenesis and cell proliferation. |
2007-09-14 |
2023-08-12 |
mouse |
| C-L Chen, F-C Hsieh, J C Lieblein, J Brown, C Chan, J A Wallace, G Cheng, B M Hall, J Li. Stat3 activation in human endometrial and cervical cancers. British journal of cancer. vol 96. issue 4. 2007-09-13. PMID:17311011. |
expression of a dominant-negative stat3 mutant using adenovirus-mediated gene transfer inhibited cell growth and induced apoptosis in hela and siha cervical cancer cell lines expressing elevated levels of stat3 phosphorylation. |
2007-09-13 |
2023-08-12 |
mouse |
| C-L Chen, F-C Hsieh, J C Lieblein, J Brown, C Chan, J A Wallace, G Cheng, B M Hall, J Li. Stat3 activation in human endometrial and cervical cancers. British journal of cancer. vol 96. issue 4. 2007-09-13. PMID:17311011. |
further, a jak/stat3 small molecular inhibitor, jsi-124, induced apoptosis more selectively in hela and siha cancer cell lines than ishikawa cell line without elevated levels of stat3 phosphorylation. |
2007-09-13 |
2023-08-12 |
mouse |
| Hiroyuki Mori, Takashi Shichita, Qingsheng Yu, Ryoko Yoshida, Masayuki Hashimoto, Fuyuki Okamoto, Takahiro Torisu, Mako Nakaya, Takashi Kobayashi, Giichi Takaesu, Akihiko Yoshimur. Suppression of SOCS3 expression in the pancreatic beta-cell leads to resistance to type 1 diabetes. Biochemical and biophysical research communications. vol 359. issue 4. 2007-08-23. PMID:17562326. |
the islets from cko mice demonstrated hyperactivation of stat3 and higher induction of bcl-xl than did islets from wt mice, and socs3-deficient beta-cells were more resistant to apoptosis induced by stz in vitro than were wt beta-cells. |
2007-08-23 |
2023-08-12 |
mouse |
| Xulong Zhang, Jian Zhang, Haiming Wei, Zhigang Tia. STAT3-decoy oligodeoxynucleotide inhibits the growth of human lung cancer via down-regulating its target genes. Oncology reports. vol 17. issue 6. 2007-08-17. PMID:17487394. |
in this study, it was noted that stat3 was overactivated in human lung cancer cells, and stat3-decoy odn, which was high-efficiently transfected into nucleus of cancer cells, significantly inhibited the proliferation of pg cells by inducing apoptosis or cell cycle arrest. |
2007-08-17 |
2023-08-12 |
human |
| Gertraud W Robinson, Margit Pacher-Zavisin, Bing Mei Zhu, Akihiko Yoshimura, Lothar Hennighause. Socs 3 modulates the activity of the transcription factor Stat3 in mammary tissue and controls alveolar homeostasis. Developmental dynamics : an official publication of the American Association of Anatomists. vol 236. issue 3. 2007-08-01. PMID:17205581. |
thus, socs3 serves as a modulator of stat3 activity to ensure controlled proliferation and apoptosis in pregnancy and involution, respectively. |
2007-08-01 |
2023-08-12 |
Not clear |
| O Kosmider, N Denis, P Dubreuil, F Moreau-Gacheli. Semaxinib (SU5416) as a therapeutic agent targeting oncogenic Kit mutants resistant to imatinib mesylate. Oncogene. vol 26. issue 26. 2007-07-09. PMID:17173066. |
using these cells in vitro, we demonstrate that the tyrosine kinase inhibitor su5416 (semaxinib) induces growth arrest and apoptosis independent of the mutation type by inhibiting the functions of kit, including kit autophosphorylation and activation of akt, erk1/erk2 and stat3 downstream signaling pathways. |
2007-07-09 |
2023-08-12 |
mouse |
| Khandaker Siddiquee, Shumin Zhang, Wayne C Guida, Michelle A Blaskovich, Benjamin Greedy, Harshani R Lawrence, M L Richard Yip, Richard Jove, Mark M McLaughlin, Nicholas J Lawrence, Said M Sebti, James Turkso. Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 18. 2007-06-20. PMID:17463090. |
furthermore, s3i-201 inhibits growth and induces apoptosis preferentially in tumor cells that contain persistently activated stat3. |
2007-06-20 |
2023-08-12 |
human |
| Khandaker Siddiquee, Shumin Zhang, Wayne C Guida, Michelle A Blaskovich, Benjamin Greedy, Harshani R Lawrence, M L Richard Yip, Richard Jove, Mark M McLaughlin, Nicholas J Lawrence, Said M Sebti, James Turkso. Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 18. 2007-06-20. PMID:17463090. |
constitutively dimerized and active stat3c and stat3 sh2 domain rescue tumor cells from s3i-201-induced apoptosis. |
2007-06-20 |
2023-08-12 |
human |
| Xiaoyang Ling, Marina Konopleva, Zhihong Zeng, Vivian Ruvolo, L Clifton Stephens, Wendy Schober, Teresa McQueen, Martin Dietrich, Timothy L Madden, Michael Andreef. The novel triterpenoid C-28 methyl ester of 2-cyano-3, 12-dioxoolen-1, 9-dien-28-oic acid inhibits metastatic murine breast tumor growth through inactivation of STAT3 signaling. Cancer research. vol 67. issue 9. 2007-06-18. PMID:17483332. |
in vitro, after treatment of 4t1 cells with 500 nmol/l cddo-me for 2 h, we found (a) inactivation of stat3, (b) inactivation of src and akt, (c) 4-fold reduction of c-myc mrna levels, (d) accumulation of cells in g(2)-m cell cycle phase, (e) abrogation of invasive growth of 4t1 cells, and (f) lack of apoptosis induction. |
2007-06-18 |
2023-08-12 |
mouse |