| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ian L P Beales, Olorunseun O Ogunwob. Glycine-extended gastrin inhibits apoptosis in Barrett's oesophageal and oesophageal adenocarcinoma cells through JAK2/STAT3 activation. Journal of molecular endocrinology. vol 42. issue 4. 2009-06-22. PMID:19153190. |
we conclude that g-gly inhibits apoptosis in bo and oac via mechanisms distinct from those activated by g-17 and involving jak2 and stat3 activation. |
2009-06-22 |
2023-08-12 |
Not clear |
| Shao-Hua Chen, Danielle A Murphy, Wiem Lassoued, Gavin Thurston, Michael D Feldman, William M F Le. Activated STAT3 is a mediator and biomarker of VEGF endothelial activation. Cancer biology & therapy. vol 7. issue 12. 2009-06-19. PMID:18981713. |
activated stat3 mediated vegf induction of ec bcl-2 and contributed to vegf protection of ec from apoptosis. |
2009-06-19 |
2023-08-12 |
mouse |
| Xuejun Xu, Moses M Kasembeli, Xueqing Jiang, Benjamin J Tweardy, David J Tweard. Chemical probes that competitively and selectively inhibit Stat3 activation. PloS one. vol 4. issue 3. 2009-06-15. PMID:19274102. |
all 5 selective compounds inhibited nuclear-to-cytoplasmic translocation of stat3, while 3 of 5 compounds induced apoptosis preferentially of breast cancer cell lines with constitutive stat3 activation. |
2009-06-15 |
2023-08-12 |
Not clear |
| Xuejun Xu, Moses M Kasembeli, Xueqing Jiang, Benjamin J Tweardy, David J Tweard. Chemical probes that competitively and selectively inhibit Stat3 activation. PloS one. vol 4. issue 3. 2009-06-15. PMID:19274102. |
thus, virtual ligand screening of compound libraries that targeted the stat3 py-peptide binding pocket identified for the first time 3 lead compounds that competitively inhibited stat3 binding to its py-peptide ligand; these compounds were selective for stat3 vs. stat1 and induced apoptosis preferentially of breast cancer cells lines with constitutively activated stat3. |
2009-06-15 |
2023-08-12 |
Not clear |
| Teruhiko Fujii, Naoko Seki, Roka Namoto-Matsubayashi, Hiroki Takahashi, Yuka Inoue, Uhi Toh, Masayoshi Kage, Kazuo Shirouz. YB-1 prevents apoptosis via the mTOR/STAT3 pathway in HER-2-overexpressing breast cancer cells. Future oncology (London, England). vol 5. issue 2. 2009-06-05. PMID:19284373. |
when stat3 was knocked down by sistat3, apoptosis was induced and constitutively active phosphorylated stat3 was found to rescue yb-1-induced apoptosis. |
2009-06-05 |
2023-08-12 |
mouse |
| Hyung Gyun Kim, Yong Pil Hwang, Hye Gwang Jeon. Kahweol blocks STAT3 phosphorylation and induces apoptosis in human lung adenocarcinoma A549 cells. Toxicology letters. vol 187. issue 1. 2009-05-26. PMID:19429240. |
kahweol blocks stat3 phosphorylation and induces apoptosis in human lung adenocarcinoma a549 cells. |
2009-05-26 |
2023-08-12 |
human |
| Hyung Gyun Kim, Yong Pil Hwang, Hye Gwang Jeon. Kahweol blocks STAT3 phosphorylation and induces apoptosis in human lung adenocarcinoma A549 cells. Toxicology letters. vol 187. issue 1. 2009-05-26. PMID:19429240. |
an overexpression in stat3 led to resistance to kahweol-induced apoptosis, suggesting that stat3 was a critical target of kahweol. |
2009-05-26 |
2023-08-12 |
human |
| Hyung Gyun Kim, Yong Pil Hwang, Hye Gwang Jeon. Kahweol blocks STAT3 phosphorylation and induces apoptosis in human lung adenocarcinoma A549 cells. Toxicology letters. vol 187. issue 1. 2009-05-26. PMID:19429240. |
these findings suggest that kahweol inhibited a549 cell growth and induced apoptosis via down-regulation of stat3 signaling pathway. |
2009-05-26 |
2023-08-12 |
human |
| Helena Cvijic, Kay Bauer, Dennis Löffler, Gabriele Pfeifer, Conny Blumert, Antje K Kretzschmar, Christian Henze, Katja Brocke-Heidrich, Friedemann Hor. Co-activator SRC-1 is dispensable for transcriptional control by STAT3. The Biochemical journal. vol 420. issue 1. 2009-05-20. PMID:19203349. |
in fact, silencing of src-1 by rna interference rapidly induced apoptosis in il-6-dependent ina-6 human myeloma cells, comparable with what was observed upon silencing of stat3. |
2009-05-20 |
2023-08-12 |
human |
| Helena Cvijic, Kay Bauer, Dennis Löffler, Gabriele Pfeifer, Conny Blumert, Antje K Kretzschmar, Christian Henze, Katja Brocke-Heidrich, Friedemann Hor. Co-activator SRC-1 is dispensable for transcriptional control by STAT3. The Biochemical journal. vol 420. issue 1. 2009-05-20. PMID:19203349. |
altogether, this suggests that functional impairment of stat3 is not involved in the induction of myeloma cell apoptosis by src-1 silencing. |
2009-05-20 |
2023-08-12 |
human |
| Mehdi Shakibaei, Kuzhuvelil B Harikumar, Bharat B Aggarwa. Resveratrol addiction: to die or not to die. Molecular nutrition & food research. vol 53. issue 1. 2009-05-15. PMID:19072742. |
cell killing by this stilbene may be mediated through any of numerous mechanisms that involve activation of mitochondria and of death caspases; upregulation of cyclin-dependent kinase inhibitors, tumor suppressor gene products, or death-inducing cytokines and cytokine receptors; or downregulation of cell survival proteins (survivin, cflip, ciaps, x-linked inhibitor of apoptosis protein (xiap), bcl-2, bcl-xl) or inhibition of cell survival kinases (e.g., mitogen-activiated protein kinases (mapks), akt/phosphoinositide 3-kinase (pi3k), pkc, egfr kinase) and survival transcription factors (nuclear factor-kappab (nf-kappab), activating protein 1 (ap-1), hif-1alpha, signal transducer and activator of transcription (stat3)). |
2009-05-15 |
2023-08-12 |
Not clear |
| Gang Chen, Shiming Zhang, Jixin Shi, Jinglu Ai, Chunhua Han. Effects of recombinant human erythropoietin (rhEPO) on JAK2/STAT3 pathway and endothelial apoptosis in the rabbit basilar artery after subarachnoid hemorrhage. Cytokine. vol 45. issue 3. 2009-05-14. PMID:19144539. |
another aim of the current study was to investigate the modulation of rhepo on the activity of janus kinase 2 (jak2) and signal transducer and activator of transcription 3 (stat3), which played an important role in the signaling of apoptosis. |
2009-05-14 |
2023-08-12 |
human |
| Gang Chen, Shiming Zhang, Jixin Shi, Jinglu Ai, Chunhua Han. Effects of recombinant human erythropoietin (rhEPO) on JAK2/STAT3 pathway and endothelial apoptosis in the rabbit basilar artery after subarachnoid hemorrhage. Cytokine. vol 45. issue 3. 2009-05-14. PMID:19144539. |
as a result, we found that administration of rhepo could activate jak2 and stat3 in the basilar artery and decrease the apoptosis index of endothelial cells following sah. |
2009-05-14 |
2023-08-12 |
human |
| Hong Xin, Chunyan Zhang, Andreas Herrmann, Yan Du, Robert Figlin, Hua Y. Sunitinib inhibition of Stat3 induces renal cell carcinoma tumor cell apoptosis and reduces immunosuppressive cells. Cancer research. vol 69. issue 6. 2009-05-13. PMID:19244102. |
sunitinib inhibition of stat3 induces renal cell carcinoma tumor cell apoptosis and reduces immunosuppressive cells. |
2009-05-13 |
2023-08-12 |
mouse |
| Hong Xin, Chunyan Zhang, Andreas Herrmann, Yan Du, Robert Figlin, Hua Y. Sunitinib inhibition of Stat3 induces renal cell carcinoma tumor cell apoptosis and reduces immunosuppressive cells. Cancer research. vol 69. issue 6. 2009-05-13. PMID:19244102. |
we show that sunitinib induces tumor cell apoptosis and growth arrest in rcc tumor cells, which correlates with signal transducer and activator of transcription 3 (stat3) activity inhibition. |
2009-05-13 |
2023-08-12 |
mouse |
| C J Watso. Immune cell regulators in mouse mammary development and involution. Journal of animal science. vol 87. issue 13 Suppl. 2009-05-08. PMID:18849387. |
both stat3 and nuclear factor-kappab have been shown to regulate acute phase gene expression in addition to apoptosis regulators. |
2009-05-08 |
2023-08-12 |
mouse |
| b' Gordana Konjevi\\xc4\\x8. [STAT proteins in cancerogenesis and therapy of malignancies]. Srpski arhiv za celokupno lekarstvo. vol 137. issue 1-2. 2009-05-08. PMID:19370975.' |
given the critical roles of stat proteins it has been established in many studies that stat3 and stat5 are oncogenes that can contribute to cellular transformation by increasing proliferation and slowing-down apoptosis. |
2009-05-08 |
2023-08-12 |
Not clear |
| Guang-hui Li, Hong Wei, Zheng-tang Chen, Sheng-qing Lv, Chang-lin Yin, Dong-lin Wan. STAT3 silencing with lentivirus inhibits growth and induces apoptosis and differentiation of U251 cells. Journal of neuro-oncology. vol 91. issue 2. 2009-04-20. PMID:18839277. |
stat3 silencing with lentivirus inhibits growth and induces apoptosis and differentiation of u251 cells. |
2009-04-20 |
2023-08-12 |
Not clear |
| Guang-hui Li, Hong Wei, Zheng-tang Chen, Sheng-qing Lv, Chang-lin Yin, Dong-lin Wan. STAT3 silencing with lentivirus inhibits growth and induces apoptosis and differentiation of U251 cells. Journal of neuro-oncology. vol 91. issue 2. 2009-04-20. PMID:18839277. |
knockdown of stat3 expression by rnai suppressed the growth and induced apoptosis of u251 cells by down-regulating expression of bcl-2. |
2009-04-20 |
2023-08-12 |
Not clear |
| Hajime Isomot. Epigenetic alterations in cholangiocarcinoma-sustained IL-6/STAT3 signaling in cholangio- carcinoma due to SOCS3 epigenetic silencing. Digestion. vol 79 Suppl 1. 2009-04-06. PMID:19153483. |
interleukin-6 (il-6)-mediated signal transducers and activators of transcription 3 (stat3) activation are aberrantly sustained in cca cells, resulting in resistance to apoptosis. |
2009-04-06 |
2023-08-12 |
Not clear |