| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Manoj K Pandey, Bokyung Sung, Kwang Seok Ahn, Bharat B Aggarwa. Butein suppresses constitutive and inducible signal transducer and activator of transcription (STAT) 3 activation and STAT3-regulated gene products through the induction of a protein tyrosine phosphatase SHP-1. Molecular pharmacology. vol 75. issue 3. 2009-03-16. PMID:19103760. |
consistent with these results, overexpression of constitutive active stat3 significantly reduced the butein-induced apoptosis. |
2009-03-16 |
2023-08-12 |
Not clear |
| Paul G Tiffen, Nader Omidvar, Nuria Marquez-Almuina, Dawn Croston, Christine J Watson, Richard W E Clarkso. A dual role for oncostatin M signaling in the differentiation and death of mammary epithelial cells in vivo. Molecular endocrinology (Baltimore, Md.). vol 22. issue 12. 2009-03-06. PMID:18927239. |
this resulted in sustained stat3 activity, increased epithelial apoptosis, and enhanced clearance of epithelial structures during the remodeling phase of mammary involution. |
2009-03-06 |
2023-08-12 |
mouse |
| Zohar Yagil, Gillian Kay, Hovav Nechushtan, Ehud Razi. A specific epitope of protein inhibitor of activated STAT3 is responsible for the induction of apoptosis in rat transformed mast cells. Journal of immunology (Baltimore, Md. : 1950). vol 182. issue 4. 2009-03-04. PMID:19201870. |
a specific epitope of protein inhibitor of activated stat3 is responsible for the induction of apoptosis in rat transformed mast cells. |
2009-03-04 |
2023-08-12 |
rat |
| Zohar Yagil, Gillian Kay, Hovav Nechushtan, Ehud Razi. A specific epitope of protein inhibitor of activated STAT3 is responsible for the induction of apoptosis in rat transformed mast cells. Journal of immunology (Baltimore, Md. : 1950). vol 182. issue 4. 2009-03-04. PMID:19201870. |
we have characterized the biological role of a 23-aa domain derived from pias3 that induces apoptosis in these cells by inhibiting the transcriptional activity of both mitf and stat3. |
2009-03-04 |
2023-08-12 |
rat |
| Ajaikumar B Kunnumakkara, Asha S Nair, Bokyung Sung, Manoj K Pandey, Bharat B Aggarwa. Boswellic acid blocks signal transducers and activators of transcription 3 signaling, proliferation, and survival of multiple myeloma via the protein tyrosine phosphatase SHP-1. Molecular cancer research : MCR. vol 7. issue 1. 2009-02-26. PMID:19147543. |
consistent with these results, overexpression of constitutive active stat3 significantly reduced the akba-induced apoptosis. |
2009-02-26 |
2023-08-12 |
human |
| Juxiang Li, Xi-Lin Niu, Nageswara R Madamanch. Leukocyte antigen-related protein tyrosine phosphatase negatively regulates hydrogen peroxide-induced vascular smooth muscle cell apoptosis. The Journal of biological chemistry. vol 283. issue 49. 2009-02-04. PMID:18854310. |
pp2, a fyn-specific inhibitor, blocked jak2, stat3, and p38 mapk activation and significantly attenuated apoptosis induced by h(2)o(2). |
2009-02-04 |
2023-08-12 |
mouse |
| Juxiang Li, Xi-Lin Niu, Nageswara R Madamanch. Leukocyte antigen-related protein tyrosine phosphatase negatively regulates hydrogen peroxide-induced vascular smooth muscle cell apoptosis. The Journal of biological chemistry. vol 283. issue 49. 2009-02-04. PMID:18854310. |
ag490, a jak2-specific inhibitor, significantly attenuated h(2)o(2)-induced apoptosis, and blocked h(2)o(2)-induced activation of stat3, but not p38 mapk in both wild-type and lar(-/-) vsmcs. |
2009-02-04 |
2023-08-12 |
mouse |
| Eun Soo Kim, Sung Yi Hong, Hye Kyung Lee, Seung Won Kim, Min Ji An, Tae Il Kim, Kyoung Ryul Lee, Won Ho Kim, Jae Hee Cheo. Guggulsterone inhibits angiogenesis by blocking STAT3 and VEGF expression in colon cancer cells. Oncology reports. vol 20. issue 6. 2009-02-04. PMID:19020709. |
the results of this study suggest that guggulsterone not only induces apoptosis, but also inhibits angiogenesis and metastasis in colon cancer cells by blocking stat3 and vegf expression, suggesting its therapeutic potential in the treatment of colorectal cancer. |
2009-02-04 |
2023-08-12 |
human |
| Alexander Sainz-Perez, Hélène Gary-Gouy, Françoise Gaudin, Ghyath Maarof, Anne Marfaing-Koka, Thierry de Revel, Ali Dallou. IL-24 induces apoptosis of chronic lymphocytic leukemia B cells engaged into the cell cycle through dephosphorylation of STAT3 and stabilization of p53 expression. Journal of immunology (Baltimore, Md. : 1950). vol 181. issue 9. 2009-01-21. PMID:18941194. |
il-24 induces apoptosis of chronic lymphocytic leukemia b cells engaged into the cell cycle through dephosphorylation of stat3 and stabilization of p53 expression. |
2009-01-21 |
2023-08-12 |
Not clear |
| Joelle Hillion, Surajit Dhara, Takita Felder Sumter, Mita Mukherjee, Francescopaolo Di Cello, Amy Belton, James Turkson, Souyma Jaganathan, Linzhao Cheng, Zhaohui Ye, Richard Jove, Peter Aplan, Ying-Wei Lin, Kelsey Wertzler, Ray Reeves, Ossama Elbahlouh, Jeanne Kowalski, Raka Bhattacharya, Linda M S Resa. The high-mobility group A1a/signal transducer and activator of transcription-3 axis: an achilles heel for hematopoietic malignancies? Cancer research. vol 68. issue 24. 2009-01-15. PMID:19074878. |
blocking stat3 function induced apoptosis in the transgenic leukemia cells but not in controls. |
2009-01-15 |
2023-08-12 |
mouse |
| Natalia Malara, Domenico Focà, Francesca Casadonte, Maria Francesca Sesto, Lorenza Macrina, Lucia Santoro, Monica Scaramuzzino, Rosa Terracciano, Rocco Savin. Simultaneous inhibition of the constitutively activated nuclear factor kappaB and of the interleukin-6 pathways is necessary and sufficient to completely overcome apoptosis resistance of human U266 myeloma cells. Cell cycle (Georgetown, Tex.). vol 7. issue 20. 2008-12-24. PMID:18931595. |
we also observed that u266 treated with the interleukin-6 antagonist sant7 exhibited reduced stat3 activity and preferential cytoplasmic nfkappab location; moreover they became capable of undergoing apoptosis mainly from the g1 phase. |
2008-12-24 |
2023-08-12 |
human |
| Natalia Malara, Domenico Focà, Francesca Casadonte, Maria Francesca Sesto, Lorenza Macrina, Lucia Santoro, Monica Scaramuzzino, Rosa Terracciano, Rocco Savin. Simultaneous inhibition of the constitutively activated nuclear factor kappaB and of the interleukin-6 pathways is necessary and sufficient to completely overcome apoptosis resistance of human U266 myeloma cells. Cell cycle (Georgetown, Tex.). vol 7. issue 20. 2008-12-24. PMID:18931595. |
finally, combined targeting of nfkappab and stat3 signalling pathways was the most effective treatment in inducing apoptosis. |
2008-12-24 |
2023-08-12 |
human |
| Natalia Malara, Domenico Focà, Francesca Casadonte, Maria Francesca Sesto, Lorenza Macrina, Lucia Santoro, Monica Scaramuzzino, Rosa Terracciano, Rocco Savin. Simultaneous inhibition of the constitutively activated nuclear factor kappaB and of the interleukin-6 pathways is necessary and sufficient to completely overcome apoptosis resistance of human U266 myeloma cells. Cell cycle (Georgetown, Tex.). vol 7. issue 20. 2008-12-24. PMID:18931595. |
these findings suggest that combined nfkappab and stat3 targeting warrants further investigations in other apoptosis resistant mm cell lines as well as in suitable mm animal models. |
2008-12-24 |
2023-08-12 |
human |
| Fan Yang, Timothy E Van Meter, Ralf Buettner, Michael Hedvat, Wei Liang, Claudia M Kowolik, Nilesh Mepani, Janni Mirosevich, Sangkil Nam, Mike Y Chen, Gary Tye, Mark Kirschbaum, Richard Jov. Sorafenib inhibits signal transducer and activator of transcription 3 signaling associated with growth arrest and apoptosis of medulloblastomas. Molecular cancer therapeutics. vol 7. issue 11. 2008-12-22. PMID:19001435. |
together, our data show that sorafenib blocks stat3 signaling as well as expression of cell cycle and apoptosis regulatory proteins, associated with inhibition of cell proliferation and induction of apoptosis in medulloblastomas. |
2008-12-22 |
2023-08-12 |
mouse |
| Vera Cavalcanti de Araújo, Cristiane Furuse, Patricia Ramos Cury, Albina Altemani, Ney Soares de Araúj. STAT3 expression in salivary gland tumours. Oral oncology. vol 44. issue 5. 2008-12-11. PMID:17826306. |
the presence of stat3 in the nuclei of malignant salivary gland tumours may represent an important event in oncogenesis probably contributing to tumour cell proliferation while blocking apoptosis. |
2008-12-11 |
2023-08-12 |
Not clear |
| Cathy Lee, Jaspreet Dhillon, Michelle Y C Wang, Yuanyuan Gao, Kaiji Hu, Eugene Park, Arezoo Astanehe, Mien-Chie Hung, Peter Eirew, Connie J Eaves, Sandra E Dun. Targeting YB-1 in HER-2 overexpressing breast cancer cells induces apoptosis via the mTOR/STAT3 pathway and suppresses tumor growth in mice. Cancer research. vol 68. issue 21. 2008-12-08. PMID:18974106. |
furthering the role of stat3 in these cells, we show that knocking it down recapitulated the induction of apoptosis. |
2008-12-08 |
2023-08-12 |
mouse |
| Kalyan J Gangavarapu, Joy L Olbertz, Alok Bhushan, James C K Lai, Christopher K Daniel. Apoptotic resistance exhibited by dexamethasone-resistant murine 7TD1 cells is controlled independently of interleukin-6 triggered signaling. Apoptosis : an international journal on programmed cell death. vol 13. issue 11. 2008-12-03. PMID:18819004. |
stat3 was constitutively phosphorylated in resistant cells and inhibition of its dimerization induced apoptosis but did not alter their insensitivity to dexamethasone. |
2008-12-03 |
2023-08-12 |
Not clear |
| Miguel A Frias, Sarin Somers, Christine Gerber-Wicht, Lionel H Opie, Sandrine Lecour, Ursula Lan. The PGE2-Stat3 interaction in doxorubicin-induced myocardial apoptosis. Cardiovascular research. vol 80. issue 1. 2008-12-02. PMID:18567640. |
therefore, the purpose of this study was to determine whether pge(2) counteracts cardiac apoptosis induced by doxorubicin (dox), and if so, whether stat3 plays a critical role in this cardioprotective effect. |
2008-12-02 |
2023-08-12 |
Not clear |
| Weike Mao, Chikao Iwai, Jiahao Liu, Shey-Shing Sheu, Michael Fu, Chang-Seng Lian. Darbepoetin alfa exerts a cardioprotective effect in autoimmune cardiomyopathy via reduction of ER stress and activation of the PI3K/Akt and STAT3 pathways. Journal of molecular and cellular cardiology. vol 45. issue 2. 2008-11-07. PMID:18586265. |
the present study was carried out to determine if restoration of the pi3k/akt and stat3 activity by darbepoetin alfa improved cardiac function or reduced cardiomyocyte apoptosis in rabbit autoimmune cardiomyopathy induced by a peptide corresponding to the second extracellular loop of the ss(1)-adrenergic receptor (ss(1)-ec(ii)). |
2008-11-07 |
2023-08-12 |
human |
| b' Hongbo Hu, Hyo-Jeong Lee, Cheng Jiang, Jinhui Zhang, Lei Wang, Yan Zhao, Qiu Xiang, Eun-Ok Lee, Sung-Hoon Kim, Junxuan L\\xc3\\xb. Penta-1,2,3,4,6-O-galloyl-beta-D-glucose induces p53 and inhibits STAT3 in prostate cancer cells in vitro and suppresses prostate xenograft tumor growth in vivo. Molecular cancer therapeutics. vol 7. issue 9. 2008-10-22. PMID:18790750.' |
in du145 cells, which harbor constitutively active signal transducer and activator of transcription 3 (stat3), caspase-mediated apoptosis induction by pgg was associated with an inhibition of stat3 tyr705 phosphorylation and the down-regulation of stat3 transcriptional targets bcl-xl and mcl-1. |
2008-10-22 |
2023-08-12 |
mouse |