| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xing Fan, Leila Khaki, Thant S Zhu, Mary E Soules, Caroline E Talsma, Naheed Gul, Cheryl Koh, Jiangyang Zhang, Yue-Ming Li, Jarek Maciaczyk, Guido Nikkhah, Francesco Dimeco, Sara Piccirillo, Angelo L Vescovi, Charles G Eberhar. NOTCH pathway blockade depletes CD133-positive glioblastoma cells and inhibits growth of tumor neurospheres and xenografts. Stem cells (Dayton, Ohio). vol 28. issue 1. 2010-03-01. PMID:19904829. |
we found that notch pathway inhibition appears to deplete stem-like cancer cells through reduced proliferation and increased apoptosis associated with decreased akt and stat3 phosphorylation. |
2010-03-01 |
2023-08-12 |
mouse |
| Maureen M Sherry, Andrew Reeves, Julian K Wu, Brent H Cochra. STAT3 is required for proliferation and maintenance of multipotency in glioblastoma stem cells. Stem cells (Dayton, Ohio). vol 27. issue 10. 2010-02-17. PMID:19658181. |
signal transducer and activator of transcription 3 (stat3) regulates diverse cellular processes, including cell growth, differentiation, and apoptosis, and is frequently activated during tumorigenesis. |
2010-02-17 |
2023-08-12 |
Not clear |
| Maureen M Sherry, Andrew Reeves, Julian K Wu, Brent H Cochra. STAT3 is required for proliferation and maintenance of multipotency in glioblastoma stem cells. Stem cells (Dayton, Ohio). vol 27. issue 10. 2010-02-17. PMID:19658181. |
although stat3 inhibition can induce apoptosis in serum-derived gbm cell lines, this effect was not observed in gbm-scs grown in stem cell medium. |
2010-02-17 |
2023-08-12 |
Not clear |
| Hui Wang, Justin D Lathia, Qiulian Wu, Jialiang Wang, Zhizhong Li, John M Heddleston, Christine E Eyler, Jennifer Elderbroom, Joseph Gallagher, Jesse Schuschu, Jennifer MacSwords, Yiting Cao, Roger E McLendon, Xiao-Fan Wang, Anita B Hjelmeland, Jeremy N Ric. Targeting interleukin 6 signaling suppresses glioma stem cell survival and tumor growth. Stem cells (Dayton, Ohio). vol 27. issue 10. 2010-02-17. PMID:19658188. |
perturbation of il6 signaling in gscs attenuates signal transducers and activators of transcription three (stat3) activation, and small molecule inhibitors of stat3 potently induce gsc apoptosis. |
2010-02-17 |
2023-08-12 |
mouse |
| Jingchun Gao, Zhong Zheng, Bhupendra Rawal, Michael J Schell, Gerold Bepler, Eric B Haur. Mirk/Dyrk1B, a novel therapeutic target, mediates cell survival in non-small cell lung cancer cells. Cancer biology & therapy. vol 8. issue 17. 2010-02-12. PMID:19633423. |
mirk knockdown by small interfering rna induced cell apoptosis concomitant with upregulation of bak, a bcl-2 family member, and downregulation of signal transducers and activators of transcription 3 (stat3) tyrosine phosphorylation. |
2010-02-12 |
2023-08-12 |
mouse |
| Li Zhou, Ping Fu, Xiao R Huang, Fei Liu, Kar Neng Lai, Hui Y La. Activation of p53 promotes renal injury in acute aristolochic acid nephropathy. Journal of the American Society of Nephrology : JASN. vol 21. issue 1. 2010-02-03. PMID:19892935. |
aa induced dephosphorylation of stat3 and the subsequent activation of p53 and tec apoptosis. |
2010-02-03 |
2023-08-12 |
mouse |
| Li Zhou, Ping Fu, Xiao R Huang, Fei Liu, Kar Neng Lai, Hui Y La. Activation of p53 promotes renal injury in acute aristolochic acid nephropathy. Journal of the American Society of Nephrology : JASN. vol 21. issue 1. 2010-02-03. PMID:19892935. |
in contrast, overexpression of stat3, p53 inhibition, or p53 knockdown with small interfering rna all attenuated aa-induced tec apoptosis. |
2010-02-03 |
2023-08-12 |
mouse |
| Li Zhou, Ping Fu, Xiao R Huang, Fei Liu, Kar Neng Lai, Hui Y La. Activation of p53 promotes renal injury in acute aristolochic acid nephropathy. Journal of the American Society of Nephrology : JASN. vol 21. issue 1. 2010-02-03. PMID:19892935. |
taken together, these results suggest that aa induces tec death via apoptosis by dephosphorylation of stat3 and posttranslational activation of p53, supporting the hypothesis that p53 promotes renal injury in acute aan. |
2010-02-03 |
2023-08-12 |
mouse |
| Takuji Tanaka, Mariangela B M de Azevedo, Nelson Durán, Joel B Alderete, Francesco Epifano, Salvatore Genovese, Mayu Tanaka, Takahiro Tanaka, Massimo Curin. Colorectal cancer chemoprevention by 2 beta-cyclodextrin inclusion compounds of auraptene and 4'-geranyloxyferulic acid. International journal of cancer. vol 126. issue 4. 2010-02-01. PMID:19688830. |
the dietary administration with gofa/beta-cd and aur/beta-cd inhibited colonic inflammation and also modulated proliferation, apoptosis and the expression of several proinflammatory cytokines, such as nuclear factor-kappab, tumor necrosis factor-alpha, stat3, nf-e2-related factor 2, interleukin (il)-6 and il-1beta, which were induced in the adenocarcinomas. |
2010-02-01 |
2023-08-12 |
mouse |
| Changyou Li, Yan Zang, Malabika Sen, Rebecca J Leeman-Neill, David S K Man, Jennifer R Grandis, Daniel E Johnso. Bortezomib up-regulates activated signal transducer and activator of transcription-3 and synergizes with inhibitors of signal transducer and activator of transcription-3 to promote head and neck squamous cell carcinoma cell death. Molecular cancer therapeutics. vol 8. issue 8. 2010-01-19. PMID:19638453. |
in addition, specific inhibition of stat3 with the use of a stat3 decoy oligonucleotide resulted in enhancement of bortezomib-induced apoptosis signaling and loss of clonogenic survival. |
2010-01-19 |
2023-08-12 |
Not clear |
| Matthew A Bill, Courtney Bakan, Don M Benson, James Fuchs, Gregory Young, Gregory B Lesinsk. Curcumin induces proapoptotic effects against human melanoma cells and modulates the cellular response to immunotherapeutic cytokines. Molecular cancer therapeutics. vol 8. issue 9. 2010-01-05. PMID:19723881. |
immunoblot analysis confirmed that curcumin induced apoptosis and revealed caspase-3 processing, poly adp ribose polymerase cleavage, reduced bcl-2, and decreased basal phosphorylated signal transducers and activators of transcription 3 (stat3). |
2010-01-05 |
2023-08-12 |
human |
| M Howlett, T R Menheniott, L M Judd, A S Girau. Cytokine signalling via gp130 in gastric cancer. Biochimica et biophysica acta. vol 1793. issue 11. 2009-12-23. PMID:19665497. |
it has been established that blockade of shp2 activation of mapk signalling results in hyperactivation of stat3 resulting in increased cell proliferation, angiogenesis, inflammation and inhibition of both immunocyte and epithelial cell apoptosis. |
2009-12-23 |
2023-08-12 |
mouse |
| Boris R A Blechacz, Rory L Smoot, Steven F Bronk, Nathan W Werneburg, Alphonse E Sirica, Gregory J Gore. Sorafenib inhibits signal transducer and activator of transcription-3 signaling in cholangiocarcinoma cells by activating the phosphatase shatterproof 2. Hepatology (Baltimore, Md.). vol 50. issue 6. 2009-12-15. PMID:19821497. |
sorafenib treatment also decreased the expression of mcl-1 messenger rna and protein, a stat3 transcriptional target, as well as sensitizing cca cells to tumor necrosis factor-related apoptosis-inducing ligand (trail)-mediated apoptosis. |
2009-12-15 |
2023-08-12 |
human |
| Boris R A Blechacz, Rory L Smoot, Steven F Bronk, Nathan W Werneburg, Alphonse E Sirica, Gregory J Gore. Sorafenib inhibits signal transducer and activator of transcription-3 signaling in cholangiocarcinoma cells by activating the phosphatase shatterproof 2. Hepatology (Baltimore, Md.). vol 50. issue 6. 2009-12-15. PMID:19821497. |
in this in vivo model, sorafenib also decreased tumor tyr(705) stat3 phosphorylation and increased tumor cell apoptosis. |
2009-12-15 |
2023-08-12 |
human |
| Keiko Yamauchi-Takihar. gp130-mediated pathway and heart failure. Future cardiology. vol 4. issue 4. 2009-12-14. PMID:19804322. |
in addition to various factors, such as bcl-xl, inducible nitric oxide synthase and reactive oxygen species-scavenging proteins, vegf has also been identified as a target gene of stat3 and together can promote cardiac myocyte survival by preventing apoptosis and restoration of energy deprivation. |
2009-12-14 |
2023-08-12 |
human |
| Michael Wagner, M Aq Siddiqu. Signaling networks regulating cardiac myocyte survival and death. Current opinion in investigational drugs (London, England : 2000). vol 10. issue 9. 2009-12-11. PMID:19705335. |
the activation of stat3 affords cardioprotection, whereas activation of stat1 is associated with apoptosis. |
2009-12-11 |
2023-08-12 |
Not clear |
| G Regis, L Icardi, L Conti, R Chiarle, R Piva, M Giovarelli, V Poli, F Novell. IL-6, but not IFN-gamma, triggers apoptosis and inhibits in vivo growth of human malignant T cells on STAT3 silencing. Leukemia. vol 23. issue 11. 2009-12-07. PMID:19626047. |
il-6, but not ifn-gamma, triggers apoptosis and inhibits in vivo growth of human malignant t cells on stat3 silencing. |
2009-12-07 |
2023-08-12 |
mouse |
| G Regis, L Icardi, L Conti, R Chiarle, R Piva, M Giovarelli, V Poli, F Novell. IL-6, but not IFN-gamma, triggers apoptosis and inhibits in vivo growth of human malignant T cells on STAT3 silencing. Leukemia. vol 23. issue 11. 2009-12-07. PMID:19626047. |
in contrast, in the absence of stat3, ifn-gamma could slightly enhance apoptosis but its ability to induce mhc class i expression was unchanged. |
2009-12-07 |
2023-08-12 |
mouse |
| Rebecca J Leeman-Neill, Sarah E Wheeler, Shivendra V Singh, Sufi M Thomas, Raja R Seethala, Daniel B Neill, Mary C Panahandeh, Eun-Ryeong Hahm, Sonali C Joyce, Malabika Sen, Quan Cai, Maria L Freilino, Changyou Li, Daniel E Johnson, Jennifer R Grandi. Guggulsterone enhances head and neck cancer therapies via inhibition of signal transducer and activator of transcription-3. Carcinogenesis. vol 30. issue 11. 2009-12-07. PMID:19762335. |
in a xenograft model of hnscc, guggulsterone treatment resulted in increased apoptosis and decreased expression of stat3. |
2009-12-07 |
2023-08-12 |
human |
| Cong Liu, Sheng Zhou, Chang-Shu Ke, Na-Ping Li, Ren-Liang W. [Activation and prognostic significance of AKT, NF-kappaB and STAT3 in breast cancer with lymph node metastasis and estrogen receptor expression]. Ai zheng = Aizheng = Chinese journal of cancer. vol 26. issue 9. 2009-12-03. PMID:17927847. |
being downstream targets of the phosphatase and tensin homolog deleted on chromosome ten (pten) and epidermal growth factor receptor (egfr) pathways, serine/threonine kinase akt, nuclear factor-kappab (nf-kappab) and signal transducer and activator of transcription-3 (stat3), play important roles in cell proliferation, apoptosis and oncogenesis. |
2009-12-03 |
2023-08-12 |
Not clear |