| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Apar Kishor Gant. Epidermal growth factor receptor signaling in nonsmall cell lung cancer. Cancer investigation. vol 28. issue 5. 2010-05-14. PMID:20073576. |
egfr function is dysregulated in various malignancies including nonsmall cell lung cancer (nsclc) leading to activation of several signal transduction pathways including k-ras, pik3, and stat3 and stat5, that promote cell cycle progression, proliferation, invasion, angiogenesis, and inhibit apoptosis. |
2010-05-14 |
2023-08-12 |
Not clear |
| Young-Kwang Yoon, Hwang-Phill Kim, Sae-Won Han, Do Youn Oh, Seock-Ah Im, Yung-Jue Bang, Tae-You Ki. KRAS mutant lung cancer cells are differentially responsive to MEK inhibitor due to AKT or STAT3 activation: implication for combinatorial approach. Molecular carcinogenesis. vol 49. issue 4. 2010-05-12. PMID:20358631. |
combined stat3 inhibition by a jak2 inhibitor or gene knockdown with mek inhibition blocked stat3 activation, synergistically suppressed cell growth, and induced apoptosis in comutant cells. |
2010-05-12 |
2023-08-12 |
Not clear |
| L-M Liu, J-X Zhang, X-P Wang, H-X Guo, H Deng, J Lu. Pim-3 protects against hepatic failure in D-galactosamine (D-GalN)-sensitized rats. European journal of clinical investigation. vol 40. issue 2. 2010-05-11. PMID:20039932. |
pim-3, a hepatic growth stimulator, belongs to the serine/threonine kinase pim-family that has been implicated in gp130-mediated induction of cell proliferation, protection from apoptosis downstream of signal transducer and activator of transcription 3 (stat3) and vascular endothelial growth factor-a-dependent vasculogenesis and angiogenesis, thus is suggested to possibly play a role in the tissue repair of fhf. |
2010-05-11 |
2023-08-12 |
rat |
| Li Lin, Brian Hutzen, Pui-Kai Li, Sarah Ball, Mingxin Zuo, Stephanie DeAngelis, Elizabeth Foust, Matthew Sobo, Lauren Friedman, Deepak Bhasin, Ling Cen, Chenglong Li, Jiayuh Li. A novel small molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells. Neoplasia (New York, N.Y.). vol 12. issue 1. 2010-05-10. PMID:20072652. |
lll12 was found to inhibit stat3 phosphorylation (tyrosine 705) and induce apoptosis as indicated by the increases of cleaved caspase-3 and poly (adp-ribose) polymerase in various breast, pancreatic, and glioblastoma cancer cell lines expressing elevated levels of stat3 phosphorylation. |
2010-05-10 |
2023-08-12 |
mouse |
| Soumya Jaganathan, Peibin Yue, James Turkso. Enhanced sensitivity of pancreatic cancer cells to concurrent inhibition of aberrant signal transducer and activator of transcription 3 and epidermal growth factor receptor or Src. The Journal of pharmacology and experimental therapeutics. vol 333. issue 2. 2010-05-10. PMID:20100905. |
by contrast, the concurrent inhibition of stat3 and egfr or src induced greater viability loss and apoptosis and decreased the migration/invasion of pancreatic cancer cells in vitro. |
2010-05-10 |
2023-08-12 |
human |
| Fatih M Uckun, Sanjive Qazi, Hong Ma, Lisa Tuel-Ahlgren, Zahide Oze. STAT3 is a substrate of SYK tyrosine kinase in B-lineage leukemia/lymphoma cells exposed to oxidative stress. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 7. 2010-05-10. PMID:20133729. |
these results provide evidence for the existence of a novel mode of cytokine-independent cross-talk that operates between syk and stat3 pathways and regulates apoptosis during os. |
2010-05-10 |
2023-08-12 |
human |
| Fatih M Uckun, Sanjive Qazi, Hong Ma, Lisa Tuel-Ahlgren, Zahide Oze. STAT3 is a substrate of SYK tyrosine kinase in B-lineage leukemia/lymphoma cells exposed to oxidative stress. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 7. 2010-05-10. PMID:20133729. |
notably, inhibition of syk with a small molecule drug candidate prevents os-induced activation of stat3 and overcomes the resistance of human b-lineage leukemia/lymphoma cells to os-induced apoptosis. |
2010-05-10 |
2023-08-12 |
human |
| E V Mitiushova, N D Aksenov, I I Marakhov. [Specific function of STAT5 in regulation of proliferation of chronic leukemia K562 cells: inhibitory effect of WHI-P131]. Tsitologiia. vol 52. issue 2. 2010-05-10. PMID:20352702. |
thus, our findings indicate a preferential role for stat5 (not constitutively active stat3) in proliferation of leukemia to other jak drugs which stimulate apoptosis and decrease proliferation, whi-p131 prevents k562 cells growth by arresting in g2/m phases of cell cycle. |
2010-05-10 |
2023-08-12 |
Not clear |
| Fuxue Chen, Yaming Xu, Youqun Luo, Da Zheng, Yichao Song, Kangkang Yu, Hong Li, Li Zhang, Weiwei Zhong, Yonghua J. Down-regulation of Stat3 decreases invasion activity and induces apoptosis of human glioma cells. Journal of molecular neuroscience : MN. vol 40. issue 3. 2010-05-07. PMID:20069389. |
down-regulation of stat3 decreases invasion activity and induces apoptosis of human glioma cells. |
2010-05-07 |
2023-08-12 |
human |
| Fuxue Chen, Yaming Xu, Youqun Luo, Da Zheng, Yichao Song, Kangkang Yu, Hong Li, Li Zhang, Weiwei Zhong, Yonghua J. Down-regulation of Stat3 decreases invasion activity and induces apoptosis of human glioma cells. Journal of molecular neuroscience : MN. vol 40. issue 3. 2010-05-07. PMID:20069389. |
this study investigated the influence of low-level expression of stat3 on invasion and apoptosis in u251 cells. |
2010-05-07 |
2023-08-12 |
human |
| Fuxue Chen, Yaming Xu, Youqun Luo, Da Zheng, Yichao Song, Kangkang Yu, Hong Li, Li Zhang, Weiwei Zhong, Yonghua J. Down-regulation of Stat3 decreases invasion activity and induces apoptosis of human glioma cells. Journal of molecular neuroscience : MN. vol 40. issue 3. 2010-05-07. PMID:20069389. |
the invasion activity in u251 cells was weakened and the apoptosis in u251 cells was induced after down-regulation of stat3. |
2010-05-07 |
2023-08-12 |
human |
| Fuxue Chen, Yaming Xu, Youqun Luo, Da Zheng, Yichao Song, Kangkang Yu, Hong Li, Li Zhang, Weiwei Zhong, Yonghua J. Down-regulation of Stat3 decreases invasion activity and induces apoptosis of human glioma cells. Journal of molecular neuroscience : MN. vol 40. issue 3. 2010-05-07. PMID:20069389. |
these results further indicate that stat3 plays a key role in the invasion and apoptosis of human glioma cell line u251. |
2010-05-07 |
2023-08-12 |
human |
| Andre Luiz Mencalha, B Du Rocher, D Salles, R Binato, E Abdelha. LLL-3, a STAT3 inhibitor, represses BCR-ABL-positive cell proliferation, activates apoptosis and improves the effects of Imatinib mesylate. Cancer chemotherapy and pharmacology. vol 65. issue 6. 2010-05-03. PMID:19701750. |
lll-3, a stat3 inhibitor, represses bcr-abl-positive cell proliferation, activates apoptosis and improves the effects of imatinib mesylate. |
2010-05-03 |
2023-08-12 |
Not clear |
| Zhaolu Kong, Daxing Xie, Thomas Boike, Pavithra Raghavan, Sandeep Burma, David J Chen, Amyn A Habib, Arup Chakraborty, Jer-Tsong Hsieh, Debabrata Sah. Downregulation of human DAB2IP gene expression in prostate cancer cells results in resistance to ionizing radiation. Cancer research. vol 70. issue 7. 2010-05-03. PMID:20332235. |
finally, shdab2ip cells showed resistance to ir-induced apoptosis that could result from a striking decrease in the expression levels of proapoptotic proteins caspase-3, caspase-8, and caspase-9, and significantly higher levels of antiapoptotic proteins bcl-2 and stat3 than those in shvector cells. |
2010-05-03 |
2023-08-12 |
human |
| Li Lin, Brian Hutzen, Mingxin Zuo, Sarah Ball, Stephanie Deangelis, Elizabeth Foust, Bulbul Pandit, Michael A Ihnat, Satyendra S Shenoy, Samuel Kulp, Pui-Kai Li, Chenglong Li, James Fuchs, Jiayuh Li. Novel STAT3 phosphorylation inhibitors exhibit potent growth-suppressive activity in pancreatic and breast cancer cells. Cancer research. vol 70. issue 6. 2010-04-26. PMID:20215512. |
here we show that flll31 and flll32 are effective inhibitors of stat3 phosphorylation, dna-binding activity, and transactivation in vitro, leading to the impediment of multiple oncogenic processes and the induction of apoptosis in pancreatic and breast cancer cell lines. |
2010-04-26 |
2023-08-12 |
mouse |
| Fan Yang, Veronica Jove, Hong Xin, Michael Hedvat, Timothy E Van Meter, Hua Y. Sunitinib induces apoptosis and growth arrest of medulloblastoma tumor cells by inhibiting STAT3 and AKT signaling pathways. Molecular cancer research : MCR. vol 8. issue 1. 2010-04-22. PMID:20053726. |
sunitinib induces apoptosis and growth arrest of medulloblastoma tumor cells by inhibiting stat3 and akt signaling pathways. |
2010-04-22 |
2023-08-12 |
human |
| Santosh K Sandur, Manoj K Pandey, Bokyung Sung, Bharat B Aggarwa. 5-hydroxy-2-methyl-1,4-naphthoquinone, a vitamin K3 analogue, suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase, SHP-1: potential role in chemosensitization. Molecular cancer research : MCR. vol 8. issue 1. 2010-04-22. PMID:20068065. |
consistent with these results, overexpression of constitutive active stat3 significantly reduced the plumbagin-induced apoptosis. |
2010-04-22 |
2023-08-12 |
Not clear |
| Hua Wang, Ogyi Park, Fouad Lafdil, Kezhen Shen, Norio Horiguchi, Shi Yin, Xin-Yuan Fu, George Kunos, Bin Ga. Interplay of hepatic and myeloid signal transducer and activator of transcription 3 in facilitating liver regeneration via tempering innate immunity. Hepatology (Baltimore, Md.). vol 51. issue 4. 2010-04-21. PMID:20041412. |
indeed, conditional deletion of stat3 in both hepatocytes and myeloid cells results in elevated activation of stat1 and apoptosis of hepatocytes, and a dramatic reduction in survival after partial hepatectomy, whereas additional global deletion of stat1 protects against these effects. |
2010-04-21 |
2023-08-12 |
Not clear |
| Wei-Guang Wu, Yue-Cheng Yu, Ya-Qiong Chen, Xiu-Qin Ca. [Construction of RNA recombinant vector expressing STAT3 short hairpin and its effects on proliferation and apoptosis of SiHa cells]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 24. issue 10. 2010-04-08. PMID:18845085. |
[construction of rna recombinant vector expressing stat3 short hairpin and its effects on proliferation and apoptosis of siha cells]. |
2010-04-08 |
2023-08-12 |
Not clear |
| Wei-Guang Wu, Yue-Cheng Yu, Ya-Qiong Chen, Xiu-Qin Ca. [Construction of RNA recombinant vector expressing STAT3 short hairpin and its effects on proliferation and apoptosis of SiHa cells]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 24. issue 10. 2010-04-08. PMID:18845085. |
to investigate the effects of eukaryotic vector expressing short hairpin rna (shrna) of signal transducers and activators of transcription 3 (stat3) on the proliferation and apoptosis of siha cells. |
2010-04-08 |
2023-08-12 |
Not clear |