| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fuxue Chen, Yaming Xu, Youqun Luo, Da Zheng, Yichao Song, Kangkang Yu, Hong Li, Li Zhang, Weiwei Zhong, Yonghua J. Down-regulation of Stat3 decreases invasion activity and induces apoptosis of human glioma cells. Journal of molecular neuroscience : MN. vol 40. issue 3. 2010-05-07. PMID:20069389. |
this study investigated the influence of low-level expression of stat3 on invasion and apoptosis in u251 cells. |
2010-05-07 |
2023-08-12 |
human |
| Fuxue Chen, Yaming Xu, Youqun Luo, Da Zheng, Yichao Song, Kangkang Yu, Hong Li, Li Zhang, Weiwei Zhong, Yonghua J. Down-regulation of Stat3 decreases invasion activity and induces apoptosis of human glioma cells. Journal of molecular neuroscience : MN. vol 40. issue 3. 2010-05-07. PMID:20069389. |
the invasion activity in u251 cells was weakened and the apoptosis in u251 cells was induced after down-regulation of stat3. |
2010-05-07 |
2023-08-12 |
human |
| Fuxue Chen, Yaming Xu, Youqun Luo, Da Zheng, Yichao Song, Kangkang Yu, Hong Li, Li Zhang, Weiwei Zhong, Yonghua J. Down-regulation of Stat3 decreases invasion activity and induces apoptosis of human glioma cells. Journal of molecular neuroscience : MN. vol 40. issue 3. 2010-05-07. PMID:20069389. |
these results further indicate that stat3 plays a key role in the invasion and apoptosis of human glioma cell line u251. |
2010-05-07 |
2023-08-12 |
human |
| Andre Luiz Mencalha, B Du Rocher, D Salles, R Binato, E Abdelha. LLL-3, a STAT3 inhibitor, represses BCR-ABL-positive cell proliferation, activates apoptosis and improves the effects of Imatinib mesylate. Cancer chemotherapy and pharmacology. vol 65. issue 6. 2010-05-03. PMID:19701750. |
lll-3, a stat3 inhibitor, represses bcr-abl-positive cell proliferation, activates apoptosis and improves the effects of imatinib mesylate. |
2010-05-03 |
2023-08-12 |
Not clear |
| Zhaolu Kong, Daxing Xie, Thomas Boike, Pavithra Raghavan, Sandeep Burma, David J Chen, Amyn A Habib, Arup Chakraborty, Jer-Tsong Hsieh, Debabrata Sah. Downregulation of human DAB2IP gene expression in prostate cancer cells results in resistance to ionizing radiation. Cancer research. vol 70. issue 7. 2010-05-03. PMID:20332235. |
finally, shdab2ip cells showed resistance to ir-induced apoptosis that could result from a striking decrease in the expression levels of proapoptotic proteins caspase-3, caspase-8, and caspase-9, and significantly higher levels of antiapoptotic proteins bcl-2 and stat3 than those in shvector cells. |
2010-05-03 |
2023-08-12 |
human |
| Li Lin, Brian Hutzen, Mingxin Zuo, Sarah Ball, Stephanie Deangelis, Elizabeth Foust, Bulbul Pandit, Michael A Ihnat, Satyendra S Shenoy, Samuel Kulp, Pui-Kai Li, Chenglong Li, James Fuchs, Jiayuh Li. Novel STAT3 phosphorylation inhibitors exhibit potent growth-suppressive activity in pancreatic and breast cancer cells. Cancer research. vol 70. issue 6. 2010-04-26. PMID:20215512. |
here we show that flll31 and flll32 are effective inhibitors of stat3 phosphorylation, dna-binding activity, and transactivation in vitro, leading to the impediment of multiple oncogenic processes and the induction of apoptosis in pancreatic and breast cancer cell lines. |
2010-04-26 |
2023-08-12 |
mouse |
| Fan Yang, Veronica Jove, Hong Xin, Michael Hedvat, Timothy E Van Meter, Hua Y. Sunitinib induces apoptosis and growth arrest of medulloblastoma tumor cells by inhibiting STAT3 and AKT signaling pathways. Molecular cancer research : MCR. vol 8. issue 1. 2010-04-22. PMID:20053726. |
sunitinib induces apoptosis and growth arrest of medulloblastoma tumor cells by inhibiting stat3 and akt signaling pathways. |
2010-04-22 |
2023-08-12 |
human |
| Santosh K Sandur, Manoj K Pandey, Bokyung Sung, Bharat B Aggarwa. 5-hydroxy-2-methyl-1,4-naphthoquinone, a vitamin K3 analogue, suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase, SHP-1: potential role in chemosensitization. Molecular cancer research : MCR. vol 8. issue 1. 2010-04-22. PMID:20068065. |
consistent with these results, overexpression of constitutive active stat3 significantly reduced the plumbagin-induced apoptosis. |
2010-04-22 |
2023-08-12 |
Not clear |
| Hua Wang, Ogyi Park, Fouad Lafdil, Kezhen Shen, Norio Horiguchi, Shi Yin, Xin-Yuan Fu, George Kunos, Bin Ga. Interplay of hepatic and myeloid signal transducer and activator of transcription 3 in facilitating liver regeneration via tempering innate immunity. Hepatology (Baltimore, Md.). vol 51. issue 4. 2010-04-21. PMID:20041412. |
indeed, conditional deletion of stat3 in both hepatocytes and myeloid cells results in elevated activation of stat1 and apoptosis of hepatocytes, and a dramatic reduction in survival after partial hepatectomy, whereas additional global deletion of stat1 protects against these effects. |
2010-04-21 |
2023-08-12 |
Not clear |
| Wei-Guang Wu, Yue-Cheng Yu, Ya-Qiong Chen, Xiu-Qin Ca. [Construction of RNA recombinant vector expressing STAT3 short hairpin and its effects on proliferation and apoptosis of SiHa cells]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 24. issue 10. 2010-04-08. PMID:18845085. |
[construction of rna recombinant vector expressing stat3 short hairpin and its effects on proliferation and apoptosis of siha cells]. |
2010-04-08 |
2023-08-12 |
Not clear |
| Wei-Guang Wu, Yue-Cheng Yu, Ya-Qiong Chen, Xiu-Qin Ca. [Construction of RNA recombinant vector expressing STAT3 short hairpin and its effects on proliferation and apoptosis of SiHa cells]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 24. issue 10. 2010-04-08. PMID:18845085. |
to investigate the effects of eukaryotic vector expressing short hairpin rna (shrna) of signal transducers and activators of transcription 3 (stat3) on the proliferation and apoptosis of siha cells. |
2010-04-08 |
2023-08-12 |
Not clear |
| Wen-Ling Shih, Ming-Huei Liao, Ping-Yuan Lin, Chi-I Chang, Hsueh-Ling Cheng, Feng-Ling Yu, Jeng-Woei Le. PI 3-kinase/Akt and STAT3 are required for the prevention of TGF-beta-induced Hep3B cell apoptosis by autocrine motility factor/phosphoglucose isomerase. Cancer letters. vol 290. issue 2. 2010-04-07. PMID:19819066. |
pi 3-kinase/akt and stat3 are required for the prevention of tgf-beta-induced hep3b cell apoptosis by autocrine motility factor/phosphoglucose isomerase. |
2010-04-07 |
2023-08-12 |
Not clear |
| Chao Tang, Hong-li Xue, Hai-bo Huang, Xiao-gang Wan. Tanshinone IIA inhibits constitutive STAT3 activation, suppresses proliferation, and induces apoptosis in rat C6 glioma cells. Neuroscience letters. vol 470. issue 2. 2010-04-06. PMID:20045721. |
tanshinone iia inhibits constitutive stat3 activation, suppresses proliferation, and induces apoptosis in rat c6 glioma cells. |
2010-04-06 |
2023-08-12 |
rat |
| Ping-Yuan Lin, Hung-Jen Liu, Ming-Huei Liao, Ching-Dong Chang, Chi-I Chang, Hsueh-Ling Cheng, Jeng-Woei Lee, Wen-Ling Shi. Activation of PI 3-kinase/Akt/NF-kappaB and Stat3 signaling by avian reovirus S1133 in the early stages of infection results in an inflammatory response and delayed apoptosis. Virology. vol 400. issue 1. 2010-04-02. PMID:20170934. |
activation of pi 3-kinase/akt/nf-kappab and stat3 signaling by avian reovirus s1133 in the early stages of infection results in an inflammatory response and delayed apoptosis. |
2010-04-02 |
2023-08-12 |
chicken |
| Jing Zhou, Choon-Nam Ong, Gang-Min Hur, Han-Ming She. Inhibition of the JAK-STAT3 pathway by andrographolide enhances chemosensitivity of cancer cells to doxorubicin. Biochemical pharmacology. vol 79. issue 9. 2010-04-01. PMID:20026083. |
for understanding the biological significance of the inhibitory effect of andro on stat3, we next investigated the effect of andro on doxorubicin-induced apoptosis in human cancer cells. |
2010-04-01 |
2023-08-12 |
human |
| Jing Zhou, Choon-Nam Ong, Gang-Min Hur, Han-Ming She. Inhibition of the JAK-STAT3 pathway by andrographolide enhances chemosensitivity of cancer cells to doxorubicin. Biochemical pharmacology. vol 79. issue 9. 2010-04-01. PMID:20026083. |
in our study the constitutive activation level of stat3 was found to be correlated to the resistance of cancer cells to doxorubicin-induced apoptosis. |
2010-04-01 |
2023-08-12 |
human |
| Julia Bollrath, Florian R Grete. IKK/NF-kappaB and STAT3 pathways: central signalling hubs in inflammation-mediated tumour promotion and metastasis. EMBO reports. vol 10. issue 12. 2010-03-30. PMID:19893576. |
by contrast, in tumorigenic cells, both nf-kappab and stat3 control apoptosis, and stat3 can also enhance proliferation. |
2010-03-30 |
2023-08-12 |
Not clear |
| Reeti Behera, Vinit Kumar, Kirti Lohite, Swapnil Karnik, Gopal C Kund. Activation of JAK2/STAT3 signaling by osteopontin promotes tumor growth in human breast cancer cells. Carcinogenesis. vol 31. issue 2. 2010-03-04. PMID:19926637. |
however, the molecular mechanism by which osteopontin (opn), a chemokine-like extracellular matrix-associated protein, regulates stat3 activation that leads to tumor progression and inhibits apoptosis in breast cancer cells is not well understood. |
2010-03-04 |
2023-08-12 |
mouse |
| Steven Fletcher, Joel A Drewry, Vijay M Shahani, Brent D G Page, Patrick T Gunnin. Molecular disruption of oncogenic signal transducer and activator of transcription 3 (STAT3) protein. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 87. issue 6. 2010-03-04. PMID:19935868. |
constitutively activated stat3 protein activity is routinely observed in human cancers, promoting uncontrolled cell proliferation and suppressing apoptosis. |
2010-03-04 |
2023-08-12 |
human |
| b' Aws Alshamsan, Samar Hamdy, John Samuel, Ayman O S El-Kadi, Afsaneh Lavasanifar, Hasan Uluda\\xc4\\x9. The induction of tumor apoptosis in B16 melanoma following STAT3 siRNA delivery with a lipid-substituted polyethylenimine. Biomaterials. vol 31. issue 6. 2010-03-03. PMID:19913908.' |
the induction of tumor apoptosis in b16 melanoma following stat3 sirna delivery with a lipid-substituted polyethylenimine. |
2010-03-03 |
2023-08-12 |
Not clear |