| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ana Moran, Anna I Tsimelzon, Mary-Ann A Mastrangelo, Yong Wu, Bi Yu, Susan G Hilsenbeck, Valeria Poli, David J Tweard. Prevention of trauma/hemorrhagic shock-induced lung apoptosis by IL-6-mediated activation of Stat3. Clinical and translational science. vol 2. issue 1. 2010-07-30. PMID:20443866. |
mice deficient in stat3 beta, a naturally occurring dominant negative isoform of stat3, were resistant to t/hs-induced lung apoptosis. |
2010-07-30 |
2023-08-12 |
mouse |
| Ana Moran, Anna I Tsimelzon, Mary-Ann A Mastrangelo, Yong Wu, Bi Yu, Susan G Hilsenbeck, Valeria Poli, David J Tweard. Prevention of trauma/hemorrhagic shock-induced lung apoptosis by IL-6-mediated activation of Stat3. Clinical and translational science. vol 2. issue 1. 2010-07-30. PMID:20443866. |
thus, t/hs-induced aec apoptosis, which depended on the duration of hypotension, required resuscitation and was prevented by il-6-mediated activation of stat3, which acted to normalize the apoptosis transcriptome. |
2010-07-30 |
2023-08-12 |
mouse |
| Ling Gao, Fengsheng Li, Bo Dong, Junquan Zhang, Yalan Rao, Yue Cong, Bingzhi Mao, Xiaohua Che. Inhibition of STAT3 and ErbB2 suppresses tumor growth, enhances radiosensitivity, and induces mitochondria-dependent apoptosis in glioma cells. International journal of radiation oncology, biology, physics. vol 77. issue 4. 2010-07-27. PMID:20610043. |
inhibition of stat3 and erbb2 suppresses tumor growth, enhances radiosensitivity, and induces mitochondria-dependent apoptosis in glioma cells. |
2010-07-27 |
2023-08-12 |
human |
| Kuei-Li Lin, Jung-Chen Su, Ching-Ming Chien, Pei-Wen Chuang, Long-Sen Chang, Shinne-Ren Li. Down-regulation of the JAK2/PI3K-mediated signaling activation is involved in Taiwan cobra cardiotoxin III-induced apoptosis of human breast MDA-MB-231 cancer cells. Toxicon : official journal of the International Society on Toxinology. vol 55. issue 7. 2010-07-19. PMID:20144642. |
taken together, these results indicate that ctx iii induces apoptosis in mda-mb-231 cells via concomitant inactivation of the jak2, stat3, pi3k, and akt signaling pathways. |
2010-07-19 |
2023-08-12 |
human |
| Emmanuel Chautard, Gaëlle Loubeau, Andreï Tchirkov, Jacques Chassagne, Claudine Vermot-Desroches, Laurent Morel, Pierre Verrell. Akt signaling pathway: a target for radiosensitizing human malignant glioma. Neuro-oncology. vol 12. issue 5. 2010-07-15. PMID:20406894. |
phosphatidyl-inositol 3-kinase/protein kinase b (akt) and janus kinase (jak)/signal transducer and activator of transcription 3 (stat3) pathways serve to block the apoptosis process, keeping cells alive in very toxic environments such as chemotherapy or ionizing radiation. |
2010-07-15 |
2023-08-12 |
human |
| Corina Borghouts, Hanna Tittmann, Natalia Delis, Marisa Kirchenbauer, Boris Brill, Bernd Grone. The intracellular delivery of a recombinant peptide derived from the acidic domain of PIAS3 inhibits STAT3 transactivation and induces tumor cell death. Molecular cancer research : MCR. vol 8. issue 4. 2010-07-12. PMID:20371673. |
this resulted in the suppression of stat3 target gene expression, in the inhibition of migration and proliferation, and in the induction of apoptosis at low concentrations [half maximal effective concentration (ec(50)), <3 micromol/l]. |
2010-07-12 |
2023-08-12 |
Not clear |
| Fan Yang, Christine Brown, Ralf Buettner, Michael Hedvat, Renate Starr, Anna Scuto, Anne Schroeder, Michael Jensen, Richard Jov. Sorafenib induces growth arrest and apoptosis of human glioblastoma cells through the dephosphorylation of signal transducers and activators of transcription 3. Molecular cancer therapeutics. vol 9. issue 4. 2010-07-07. PMID:20371721. |
our data suggest that inhibition of stat3 signaling by sorafenib contributes to growth arrest and induction of apoptosis in glioblastoma cells. |
2010-07-07 |
2023-08-12 |
human |
| Navin K Verma, Anthony M Davies, Aideen Long, Dermot Kelleher, Yuri Volko. STAT3 knockdown by siRNA induces apoptosis in human cutaneous T-cell lymphoma line Hut78 via downregulation of Bcl-xL. Cellular & molecular biology letters. vol 15. issue 2. 2010-07-05. PMID:20213502. |
stat3 knockdown by sirna induces apoptosis in human cutaneous t-cell lymphoma line hut78 via downregulation of bcl-xl. |
2010-07-05 |
2023-08-12 |
human |
| Eun-Ryeong Hahm, Shivendra V Sing. Sulforaphane inhibits constitutive and interleukin-6-induced activation of signal transducer and activator of transcription 3 in prostate cancer cells. Cancer prevention research (Philadelphia, Pa.). vol 3. issue 4. 2010-06-25. PMID:20233902. |
the il-6-mediated activation of stat3 conferred partial but marked protection against sfn-induced apoptosis as evidenced by cytoplasmic histone-associated dna fragmentation and cleavage of poly(adp-ribose) polymerase and procaspase-3. |
2010-06-25 |
2023-08-12 |
mouse |
| Chuan-Bian Lim, Nung Ky, Hui-Min Ng, Mohamed Sabry Hamza, Yan Zha. Curcuma wenyujin extract induces apoptosis and inhibits proliferation of human cervical cancer cells in vitro and in vivo. Integrative cancer therapies. vol 9. issue 1. 2010-06-24. PMID:20150221. |
cwe-treated cells displayed reduced pten, akt, and stat3 phosphorylation and downregulation of nfkappab signaling, providing a mechanism for the g1 arrest and apoptosis observed. |
2010-06-24 |
2023-08-12 |
mouse |
| Manoj K Pandey, Bokyung Sung, Bharat B Aggarwa. Betulinic acid suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase SHP-1 in human multiple myeloma cells. International journal of cancer. vol 127. issue 2. 2010-06-22. PMID:19937797. |
consistent with these results, overexpression of constitutive active stat3 significantly reduced the betulinic acid-induced apoptosis. |
2010-06-22 |
2023-08-12 |
human |
| Shengbing Huang, Frank A Sinicrop. Sorafenib inhibits STAT3 activation to enhance TRAIL-mediated apoptosis in human pancreatic cancer cells. Molecular cancer therapeutics. vol 9. issue 3. 2010-06-18. PMID:20197401. |
sorafenib inhibits stat3 activation to enhance trail-mediated apoptosis in human pancreatic cancer cells. |
2010-06-18 |
2023-08-12 |
human |
| Shengbing Huang, Frank A Sinicrop. Sorafenib inhibits STAT3 activation to enhance TRAIL-mediated apoptosis in human pancreatic cancer cells. Molecular cancer therapeutics. vol 9. issue 3. 2010-06-18. PMID:20197401. |
signal transducers and activators of transcription 3 (stat3) is constitutively active in human pancreatic cancer cells and can promote cell growth and apoptosis resistance that contribute to tumorigenesis. |
2010-06-18 |
2023-08-12 |
human |
| Shengbing Huang, Frank A Sinicrop. Sorafenib inhibits STAT3 activation to enhance TRAIL-mediated apoptosis in human pancreatic cancer cells. Molecular cancer therapeutics. vol 9. issue 3. 2010-06-18. PMID:20197401. |
we determined if sorafenib, a multikinase inhibitor, can induce apoptosis by targeting stat3 signaling to enhance apoptosis induction by tumor necrosis factor-related apoptosis-inducing ligand (trail). |
2010-06-18 |
2023-08-12 |
human |
| Shengbing Huang, Frank A Sinicrop. Sorafenib inhibits STAT3 activation to enhance TRAIL-mediated apoptosis in human pancreatic cancer cells. Molecular cancer therapeutics. vol 9. issue 3. 2010-06-18. PMID:20197401. |
stat3 knockdown or a dn stat3 was shown to downregulate mcl-1 and bcl-x(l) and to sensitize cells to trail-mediated apoptosis. |
2010-06-18 |
2023-08-12 |
human |
| Shengbing Huang, Frank A Sinicrop. Sorafenib inhibits STAT3 activation to enhance TRAIL-mediated apoptosis in human pancreatic cancer cells. Molecular cancer therapeutics. vol 9. issue 3. 2010-06-18. PMID:20197401. |
the suppression of stat3 by genetic means or using sorafenib was shown to downregulate mcl-1 and bcl-x(l) and to sensitize cells to trail-mediated apoptosis. |
2010-06-18 |
2023-08-12 |
human |
| Karuppaiyah Selvendiran, Shabnam Ahmed, Alex Dayton, M Lakshmi Kuppusamy, Mia Tazi, Anna Bratasz, Liyue Tong, Brian K Rivera, Tamás Kálai, Kálmán Hideg, Periannan Kuppusam. Safe and targeted anticancer efficacy of a novel class of antioxidant-conjugated difluorodiarylidenyl piperidones: differential cytotoxicity in healthy and cancer cells. Free radical biology & medicine. vol 48. issue 9. 2010-06-16. PMID:20156552. |
western blot analysis showed that the dap-induced growth arrest and apoptosis in cancer cells were mediated by inhibition of stat3 phosphorylation at the tyr705 and ser727 residues and induction of apoptotic markers of cleaved caspase-3 and parp. |
2010-06-16 |
2023-08-12 |
human |
| Hsuan-Heng Yeh, Raghavaraju Giri, Tsuey-Yu Chang, Cheng-Yang Chou, Wu-Chou Su, Hsiao-Sheng Li. Ha-ras oncogene-induced Stat3 phosphorylation enhances oncogenicity of the cell. DNA and cell biology. vol 28. issue 3. 2010-06-14. PMID:19182994. |
ha-ras-induced stat3 phosphorylation at serine-727 plays a pivotal role in transcriptional activation of cyclin d1 and suppression of cell apoptosis. |
2010-06-14 |
2023-08-12 |
mouse |
| Tan Li, Wei Wang, Hong Chen, Tong Li, Lu Y. Evaluation of anti-leukemia effect of resveratrol by modulating STAT3 signaling. International immunopharmacology. vol 10. issue 1. 2010-06-14. PMID:19796711. |
our data indicate that resveratrol contributes to inhibiting growth, inducing apoptosis and cell cycle arrest in the three leukemia cell lines (jurkat, sup-b15, and kasumi-1), and reducing the phosphorylation of stat3, meanwhile modulating the expression of bcl-2 and bax. |
2010-06-14 |
2023-08-12 |
mouse |
| Jun Wan, Amy K Y Fu, Fanny C F Ip, Ho-Keung Ng, Jacques Hugon, Guylène Page, Jerry H Wang, Kwok-On Lai, Zhenguo Wu, Nancy Y I. Tyk2/STAT3 signaling mediates beta-amyloid-induced neuronal cell death: implications in Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 20. 2010-06-04. PMID:20484629. |
importantly, reduction of either the expression or activation of stat3 markedly attenuates abeta-induced neuronal apoptosis, suggesting that stat3 activation contributes to neuronal death after abeta exposure. |
2010-06-04 |
2023-08-12 |
mouse |