| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Paola Y Bertucci, Ana Quaglino, Andrea G Pozzi, Edith C Kordon, Adali Pecc. Glucocorticoid-induced impairment of mammary gland involution is associated with STAT5 and STAT3 signaling modulation. Endocrinology. vol 151. issue 12. 2011-01-04. PMID:20881248. |
our results show that the synthetic glucocorticoid dexamethasone (dex) modulates stat5a and stat3 signaling and inhibits apoptosis induction in postlactating mouse mammary glands, only when administered within the first 48 h upon cessation of suckling. |
2011-01-04 |
2023-08-12 |
mouse |
| Yulong Chen, Jiong Deng, Junya Fujimoto, Humam Kadara, Taoyan Men, Dafna Lotan, Reuben Lota. Gprc5a deletion enhances the transformed phenotype in normal and malignant lung epithelial cells by eliciting persistent Stat3 signaling induced by autocrine leukemia inhibitory factor. Cancer research. vol 70. issue 21. 2010-12-21. PMID:20959490. |
inhibition of stat3 signaling in gprc5a(-/-) normal and cancer cells by the janus-activated kinase 2 inhibitor ag490 or by a dominant negative stat3(y705f) increased starvation-induced apoptosis and inhibited colony formation. |
2010-12-21 |
2023-08-12 |
mouse |
| Ching-Ming Chien, Shang-Yu Chang, Kuei-Li Lin, Chien-Chih Chiu, Long-Sen Chang, Shinne-Ren Li. Taiwan cobra cardiotoxin III inhibits Src kinase leading to apoptosis and cell cycle arrest of oral squamous cell carcinoma Ca9-22 cells. Toxicon : official journal of the International Society on Toxinology. vol 56. issue 4. 2010-12-13. PMID:20493203. |
taken together, these results indicate that ctx iii induces apoptosis and s-phase arrest in ca9-22 cells via concomitant inactivation of the src, egfr, stat3, stat5, pi3 k(p110), and akt signaling pathways. |
2010-12-13 |
2023-08-12 |
Not clear |
| Matthew A Bill, James R Fuchs, Chenglong Li, Jennifer Yui, Courtney Bakan, Don M Benson, Eric B Schwartz, Dalia Abdelhamid, Jiayuh Lin, Dale G Hoyt, Stacey L Fossey, Gregory S Young, William E Carson, Pui-Kai Li, Gregory B Lesinsk. The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity. Molecular cancer. vol 9. 2010-12-06. PMID:20576164. |
the small molecule curcumin analog flll32 induces apoptosis in melanoma cells via stat3 inhibition and retains the cellular response to cytokines with anti-tumor activity. |
2010-12-06 |
2023-08-12 |
Not clear |
| Matthew A Bill, James R Fuchs, Chenglong Li, Jennifer Yui, Courtney Bakan, Don M Benson, Eric B Schwartz, Dalia Abdelhamid, Jiayuh Lin, Dale G Hoyt, Stacey L Fossey, Gregory S Young, William E Carson, Pui-Kai Li, Gregory B Lesinsk. The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity. Molecular cancer. vol 9. 2010-12-06. PMID:20576164. |
we hypothesized this lead compound would specifically inhibit the stat3 signaling pathway to induce apoptosis in melanoma cells. |
2010-12-06 |
2023-08-12 |
Not clear |
| Andrew M Miller, Hua Wang, Ogyi Park, Norio Horiguchi, Fouad Lafdil, Partha Mukhopadhyay, Akira Moh, Xin Yuan Fu, George Kunos, Pal Pacher, Bin Ga. Anti-inflammatory and anti-apoptotic roles of endothelial cell STAT3 in alcoholic liver injury. Alcoholism, clinical and experimental research. vol 34. issue 4. 2010-11-26. PMID:20102572. |
il-6-deficient mice are more susceptible to alcohol-induced hepatocyte apoptosis and steatosis and elevation of serum alanine transaminase (alt); however, whereas hepatocyte-specific stat3 knockout mice are more susceptible to alcohol-induced hepatic steatosis, they have similar hepatocyte apoptosis and serum alt after alcohol feeding compared with wild-type mice. |
2010-11-26 |
2023-08-12 |
mouse |
| Joomin Lee, Eun-Ryeong Hahm, Shivendra V Sing. Withaferin A inhibits activation of signal transducer and activator of transcription 3 in human breast cancer cells. Carcinogenesis. vol 31. issue 11. 2010-11-16. PMID:20724373. |
general implication of these findings is that wa can trigger apoptosis and largely inhibit cell migration/invasion of breast cancer cells even after il-6-induced activation of stat3, which should be viewed as a therapeutic advantage for this agent. |
2010-11-16 |
2023-08-12 |
human |
| Xuegang Sun, Shengnan Wu, Da Xin. The reactive oxygen species-Src-Stat3 pathway provokes negative feedback inhibition of apoptosis induced by high-fluence low-power laser irradiation. The FEBS journal. vol 277. issue 22. 2010-11-16. PMID:20977672. |
signal transducer and activator of transcription 3 (stat3) is an important transcription factor in the modulation of cell proliferation and apoptosis. |
2010-11-16 |
2023-08-12 |
Not clear |
| Xuegang Sun, Shengnan Wu, Da Xin. The reactive oxygen species-Src-Stat3 pathway provokes negative feedback inhibition of apoptosis induced by high-fluence low-power laser irradiation. The FEBS journal. vol 277. issue 22. 2010-11-16. PMID:20977672. |
stat3 activation attenuated hf-lpli-induced apoptosis, as shown by the fact that both dominant negative stat3 (y705f) and stat3 small interfering rna expression enhanced cellular apoptosis induced by hf-lpli. |
2010-11-16 |
2023-08-12 |
Not clear |
| Xuegang Sun, Shengnan Wu, Da Xin. The reactive oxygen species-Src-Stat3 pathway provokes negative feedback inhibition of apoptosis induced by high-fluence low-power laser irradiation. The FEBS journal. vol 277. issue 22. 2010-11-16. PMID:20977672. |
our research will provide new insights into the mechanism of apoptosis caused by hf-lpli, and also extend the functional study of stat3. |
2010-11-16 |
2023-08-12 |
Not clear |
| Lan V Pham, Archito T Tamayo, Changping Li, William Bornmann, Waldemar Priebe, Richard J For. Degrasyn potentiates the antitumor effects of bortezomib in mantle cell lymphoma cells in vitro and in vivo: therapeutic implications. Molecular cancer therapeutics. vol 9. issue 7. 2010-11-04. PMID:20606045. |
the apoptosis in these cells was correlated with the downregulation of constitutive nf-kappab and phosphorylated stat3 activation, leading to the inhibition of c-myc, cyclin d1, and bcl-2 protein expression and the upregulation of bax protein expression. |
2010-11-04 |
2023-08-12 |
mouse |
| Anurima Majumder, Lakshmanan Govindasamy, Andrew Magis, Róbert Kiss, Tímea Polgár, Rebekah Baskin, Robert W Allan, Mavis Agbandje-McKenna, Gary W Reuther, György M Keseru, Kirpal S Bisht, Peter P Sayesk. Structure-function correlation of G6, a novel small molecule inhibitor of Jak2: indispensability of the stilbenoid core. The Journal of biological chemistry. vol 285. issue 41. 2010-11-04. PMID:20667821. |
they also inhibited phosphorylation of jak2, stat3, and stat5 proteins within cells, resulting in higher levels of apoptosis via the intrinsic apoptotic pathway. |
2010-11-04 |
2023-08-12 |
human |
| Joo Eun Jung, Gab Seok Kim, Hai Chen, Carolina M Maier, Purnima Narasimhan, Yun Seon Song, Kuniyasu Niizuma, Masataka Katsu, Nobuya Okami, Hideyuki Yoshioka, Hiroyuki Sakata, Christina E Goeders, Pak H Cha. Reperfusion and neurovascular dysfunction in stroke: from basic mechanisms to potential strategies for neuroprotection. Molecular neurobiology. vol 41. issue 2-3. 2010-10-08. PMID:20157789. |
during reperfusion, activation of stat3 and its recruitment into the sod2 gene were blocked, resulting in increased oxidative stress and neuronal apoptosis. |
2010-10-08 |
2023-08-12 |
mouse |
| Mi-Ae Lyu, Bokyung Sung, Lawrence H Cheung, John W Marks, Bharat B Aggarwal, Ricardo C T Aguiar, Michael G Rosenblu. The rGel/BLyS fusion toxin inhibits STAT3 signaling via down-regulation of interleukin-6 receptor in diffuse large B-cell lymphoma. Biochemical pharmacology. vol 80. issue 9. 2010-10-06. PMID:20654581. |
inhibition of il-6r-mediated stat3 signaling by rgel/blys led to growth inhibition, triggered accumulation of cells in the sub-g(1) phase of the cell cycle, and induced apoptosis. |
2010-10-06 |
2023-08-12 |
human |
| Ling-di Ma, Min Zhou, Shi-hong Wen, Cheng Ni, Li-jia Jiang, Jing Fan, Lei Xi. Effects of STAT3 silencing on fate of chronic myelogenous leukemia K562 cells. Leukemia & lymphoma. vol 51. issue 7. 2010-09-30. PMID:20497005. |
knockdown of stat3 by stat3 sirna caused a decrease in stat3 protein level, inhibition of growth and proliferation, cell cycle blockade, visible morphologic changes, and induction of apoptosis in k562 cells. |
2010-09-30 |
2023-08-12 |
human |
| Guang-Hui Li, Hong Wei, Sheng-Qing Lv, Hua Ji, Dong-Lin Wan. Knockdown of STAT3 expression by RNAi suppresses growth and induces apoptosis and differentiation in glioblastoma stem cells. International journal of oncology. vol 37. issue 1. 2010-09-27. PMID:20514402. |
knockdown of stat3 expression by rnai suppresses growth and induces apoptosis and differentiation in glioblastoma stem cells. |
2010-09-27 |
2023-08-12 |
human |
| Guang-Hui Li, Hong Wei, Sheng-Qing Lv, Hua Ji, Dong-Lin Wan. Knockdown of STAT3 expression by RNAi suppresses growth and induces apoptosis and differentiation in glioblastoma stem cells. International journal of oncology. vol 37. issue 1. 2010-09-27. PMID:20514402. |
stat3 plays a key role in proliferation, apoptosis and differentiation in embryonic stem cells and several cancer types. |
2010-09-27 |
2023-08-12 |
human |
| Guang-Hui Li, Hong Wei, Sheng-Qing Lv, Hua Ji, Dong-Lin Wan. Knockdown of STAT3 expression by RNAi suppresses growth and induces apoptosis and differentiation in glioblastoma stem cells. International journal of oncology. vol 37. issue 1. 2010-09-27. PMID:20514402. |
knockdown of stat3 induces apoptosis and reduces significantly expression of bcl-2 and cyclin-d in human primary gscs, whereas no significance was achieved in bax and caspase-3 expression. |
2010-09-27 |
2023-08-12 |
human |
| Guang-Hui Li, Hong Wei, Sheng-Qing Lv, Hua Ji, Dong-Lin Wan. Knockdown of STAT3 expression by RNAi suppresses growth and induces apoptosis and differentiation in glioblastoma stem cells. International journal of oncology. vol 37. issue 1. 2010-09-27. PMID:20514402. |
together, these studies suggest that stat3 is an important target for human gscs in regulation of gscs growth, apoptosis, differentiation and tumorigenic potential. |
2010-09-27 |
2023-08-12 |
human |
| Yan Liu, Pui-Kai Li, Chenglong Li, Jiayuh Li. Inhibition of STAT3 signaling blocks the anti-apoptotic activity of IL-6 in human liver cancer cells. The Journal of biological chemistry. vol 285. issue 35. 2010-09-17. PMID:20562100. |
targeting stat3 with stat3 sirna reduced the protection of il-6 against doxorubicin-induced apoptosis, indicating that stat3 signaling contributed to the anti-apoptotic effect of il-6. |
2010-09-17 |
2023-08-12 |
human |