| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kanji Yamaguchi, Yoshito Itoh, Chihiro Yokomizo, Takeshi Nishimura, Toshihisa Niimi, Atsushi Umemura, Hideki Fujii, Takeshi Okanoue, Toshikazu Yoshikaw. Blockade of IL-6 signaling exacerbates liver injury and suppresses antiapoptotic gene expression in methionine choline-deficient diet-fed db/db mice. Laboratory investigation; a journal of technical methods and pathology. vol 91. issue 4. 2011-06-01. PMID:21321532. |
mr16-1 treatment of mcd diet-fed db/db mice further repressed stat3 activities and expression of stat3-related antiapoptotic genes, such as bcl-2 and ref-1, but increased plasma-free fatty acid and hepatic markers of lipid peroxidation/oxidant stress, leading to increased liver injury, hepatocyte apoptosis and liver fibrosis. |
2011-06-01 |
2023-08-12 |
mouse |
| Kanji Yamaguchi, Yoshito Itoh, Chihiro Yokomizo, Takeshi Nishimura, Toshihisa Niimi, Atsushi Umemura, Hideki Fujii, Takeshi Okanoue, Toshikazu Yoshikaw. Blockade of IL-6 signaling exacerbates liver injury and suppresses antiapoptotic gene expression in methionine choline-deficient diet-fed db/db mice. Laboratory investigation; a journal of technical methods and pathology. vol 91. issue 4. 2011-06-01. PMID:21321532. |
although 'moderate' blockade of enhanced il-6-stat3 signaling may be beneficial in nash, as we reported previously, these findings demonstrate that a profound defect in stat3 activation is detrimental in terms of liver injury, hepatocyte apoptosis and liver fibrosis, indicating the hepato-protective role of il-6 signaling in this severe nash model. |
2011-06-01 |
2023-08-12 |
mouse |
| Minoru Shigekawa, Tetsuo Takehara, Takahiro Kodama, Hayato Hikita, Satoshi Shimizu, Wei Li, Takuya Miyagi, Atsushi Hosui, Tomohide Tatsumi, Hisashi Ishida, Tatsuya Kanto, Naoki Hiramatsu, Norio Hayash. Involvement of STAT3-regulated hepatic soluble factors in attenuation of stellate cell activity and liver fibrogenesis in mice. Biochemical and biophysical research communications. vol 406. issue 4. 2011-05-24. PMID:21356197. |
glycoprotein 130 (gp130)/signal transducer and activator of transcription 3 (stat3) signaling in hepatocytes controls a variety of physiological and pathological processes including liver regeneration, apoptosis resistance and metabolism. |
2011-05-24 |
2023-08-12 |
mouse |
| Su Hui Yang, Daulat Bikram Khadka, Suk Hee Cho, Hye-Kyung Ju, Kwang Youl Lee, Ho Jae Han, Kyung-Tae Lee, Won-Jea Ch. Virtual screening and synthesis of quinazolines as novel JAK2 inhibitors. Bioorganic & medicinal chemistry. vol 19. issue 2. 2011-05-03. PMID:21185195. |
moreover, 5p showed a positive correlation between jak2 inhibition and cytotoxicity; 5p treatment in ht-29 cells strongly inhibited jak2 activation and subsequent stat3 phosphorylation, reduced anti-apoptotic protein levels, and finally induced apoptosis. |
2011-05-03 |
2023-08-12 |
mouse |
| Sun-Hee Kim, Kwang Seok Ahn, Soo-Jin Jeong, Tae-Rin Kwon, Ji Hoon Jung, Sun-Mi Yun, Ihn Han, Seok-Geun Lee, Dae Keun Kim, Minkyung Kang, Chang-Yan Chen, Jung Weon Lee, Sung-Hoon Ki. Janus activated kinase 2/signal transducer and activator of transcription 3 pathway mediates icariside II-induced apoptosis in U266 multiple myeloma cells. European journal of pharmacology. vol 654. issue 1. 2011-04-25. PMID:21172343. |
to analyze the effects on signal transducer and activator of transcription 3 (stat3) signaling and apoptosis, u266 multiple myeloma cells were treated with icariside ii and performed western blotting, electrophoretic mobility gel shift assay (emsa), rt-pcr, proliferation assay, cell cycle analysis and terminal deoxynucleotidyl transferase dutp nick end labeling (tunel) assay. |
2011-04-25 |
2023-08-12 |
human |
| Sun-Hee Kim, Kwang Seok Ahn, Soo-Jin Jeong, Tae-Rin Kwon, Ji Hoon Jung, Sun-Mi Yun, Ihn Han, Seok-Geun Lee, Dae Keun Kim, Minkyung Kang, Chang-Yan Chen, Jung Weon Lee, Sung-Hoon Ki. Janus activated kinase 2/signal transducer and activator of transcription 3 pathway mediates icariside II-induced apoptosis in U266 multiple myeloma cells. European journal of pharmacology. vol 654. issue 1. 2011-04-25. PMID:21172343. |
pervanadate reversed the icariside ii-mediated stat3 inactivation and also blocked the cleavages of caspase-3 and parp, suggesting involvement of stat3 pathway in icariside ii-induced apoptosis. |
2011-04-25 |
2023-08-12 |
human |
| Hui Ying Zhang, Qiuyang Zhang, Xi Zhang, Chunhua Yu, Xiaofang Huo, Edaire Cheng, David H Wang, Stuart J Spechler, Rhonda F Souz. Cancer-related inflammation and Barrett's carcinogenesis: interleukin-6 and STAT3 mediate apoptotic resistance in transformed Barrett's cells. American journal of physiology. Gastrointestinal and liver physiology. vol 300. issue 3. 2011-04-21. PMID:21148399. |
we also used small interfering rnas (sirnas) to stat3 and mcl-1 to assess effects of stat3 pathway inhibition on apoptosis. |
2011-04-21 |
2023-08-12 |
human |
| Hui Ying Zhang, Qiuyang Zhang, Xi Zhang, Chunhua Yu, Xiaofang Huo, Edaire Cheng, David H Wang, Stuart J Spechler, Rhonda F Souz. Cancer-related inflammation and Barrett's carcinogenesis: interleukin-6 and STAT3 mediate apoptotic resistance in transformed Barrett's cells. American journal of physiology. Gastrointestinal and liver physiology. vol 300. issue 3. 2011-04-21. PMID:21148399. |
in transformed barrett's cells, rates of apoptosis following exposure to deoxycholic acid were significantly increased by transfection with sirnas for stat3 and mcl-1. |
2011-04-21 |
2023-08-12 |
human |
| Zhenlian Wang, Feijun Luo, Lili Li, Lifang Yang, Duosha Hu, Xiaoqian Ma, Zhongxin Lu, Lunquan Sun, Ya Ca. STAT3 activation induced by Epstein-Barr virus latent membrane protein1 causes vascular endothelial growth factor expression and cellular invasiveness via JAK3 And ERK signaling. European journal of cancer (Oxford, England : 1990). vol 46. issue 16. 2011-03-28. PMID:20709526. |
signal transducer and activator of transcription 3 (stat3) is a master transcriptional regulator in proliferation and apoptosis and is newly implicated in angiogenesis and invasiveness, which, in turn, are likely to contribute to the highly invasive character of npc. |
2011-03-28 |
2023-08-12 |
human |
| Ganchimeg Ishdorj, James B Johnston, Spencer B Gibso. Inhibition of constitutive activation of STAT3 by curcurbitacin-I (JSI-124) sensitized human B-leukemia cells to apoptosis. Molecular cancer therapeutics. vol 9. issue 12. 2011-03-28. PMID:21159613. |
inhibition of constitutive activation of stat3 by curcurbitacin-i (jsi-124) sensitized human b-leukemia cells to apoptosis. |
2011-03-28 |
2023-08-12 |
human |
| Ganchimeg Ishdorj, James B Johnston, Spencer B Gibso. Inhibition of constitutive activation of STAT3 by curcurbitacin-I (JSI-124) sensitized human B-leukemia cells to apoptosis. Molecular cancer therapeutics. vol 9. issue 12. 2011-03-28. PMID:21159613. |
jsi-124 potently induces apoptosis in 3 b-leukemia cell lines (bjab, i-83, and nalm-6) and in primary cll cells and was associated with a reduction in serine 727 phosphorylation of stat3. |
2011-03-28 |
2023-08-12 |
human |
| Ganchimeg Ishdorj, James B Johnston, Spencer B Gibso. Inhibition of constitutive activation of STAT3 by curcurbitacin-I (JSI-124) sensitized human B-leukemia cells to apoptosis. Molecular cancer therapeutics. vol 9. issue 12. 2011-03-28. PMID:21159613. |
similarly, knockdown of stat3 expression induced apoptosis in these leukemia cells. |
2011-03-28 |
2023-08-12 |
human |
| Ganchimeg Ishdorj, James B Johnston, Spencer B Gibso. Inhibition of constitutive activation of STAT3 by curcurbitacin-I (JSI-124) sensitized human B-leukemia cells to apoptosis. Molecular cancer therapeutics. vol 9. issue 12. 2011-03-28. PMID:21159613. |
in addition, we found that jsi-124 and knockdown of stat3 decreased antiapoptotic protein xiap expression and overexpression of xiap blocked jsi-124-induced apoptosis. |
2011-03-28 |
2023-08-12 |
human |
| Ganchimeg Ishdorj, James B Johnston, Spencer B Gibso. Inhibition of constitutive activation of STAT3 by curcurbitacin-I (JSI-124) sensitized human B-leukemia cells to apoptosis. Molecular cancer therapeutics. vol 9. issue 12. 2011-03-28. PMID:21159613. |
thus, we present here for the first time that jsi-124 induced suppression of serine 727 phosphorylation of stat3, leading to apoptosis and cell-cycle arrest through alterations in gene transcription in b-leukemia cells. |
2011-03-28 |
2023-08-12 |
human |
| H Zhang, D Zhang, X Luan, G Xie, X Pa. Inhibition of the signal transducers and activators of transcription (STAT) 3 signalling pathway by AG490 in laryngeal carcinoma cells. The Journal of international medical research. vol 38. issue 5. 2011-03-10. PMID:21309481. |
this study showed that ag490 significantly inhibited proliferation and induced apoptosis of laryngeal carcinoma cells through down-regulation of stat3 and survivin, suggesting a potential target for laryngeal carcinoma treatment. |
2011-03-10 |
2023-08-12 |
human |
| Aya Nakaya, Morihiko Sagawa, Akihiro Muto, Hideo Uchida, Yasuo Ikeda, Masahiro Kizak. The gold compound auranofin induces apoptosis of human multiple myeloma cells through both down-regulation of STAT3 and inhibition of NF-κB activity. Leukemia research. vol 35. issue 2. 2011-03-09. PMID:20542334. |
the gold compound auranofin induces apoptosis of human multiple myeloma cells through both down-regulation of stat3 and inhibition of nf-κb activity. |
2011-03-09 |
2023-08-12 |
human |
| Wei Zhao, Tao Zhang, Bingqian Qu, Xingxin Wu, Xu Zhu, Fanyu Meng, Yanhong Gu, Yongqian Shu, Yan Shen, Yang Sun, Qiang X. Sorafenib induces apoptosis in HL60 cells by inhibiting Src kinase-mediated STAT3 phosphorylation. Anti-cancer drugs. vol 22. issue 1. 2011-03-04. PMID:20881478. |
sorafenib induces apoptosis in hl60 cells by inhibiting src kinase-mediated stat3 phosphorylation. |
2011-03-04 |
2023-08-12 |
human |
| Wei Zhao, Tao Zhang, Bingqian Qu, Xingxin Wu, Xu Zhu, Fanyu Meng, Yanhong Gu, Yongqian Shu, Yan Shen, Yang Sun, Qiang X. Sorafenib induces apoptosis in HL60 cells by inhibiting Src kinase-mediated STAT3 phosphorylation. Anti-cancer drugs. vol 22. issue 1. 2011-03-04. PMID:20881478. |
signal transducer and activator of transcription 3 (stat3) is constitutively active in approximately 50% of acute myeloid leukemia (aml) cases and mediates multiple cellular processes including cell resistance to apoptosis. |
2011-03-04 |
2023-08-12 |
human |
| Wei Zhao, Tao Zhang, Bingqian Qu, Xingxin Wu, Xu Zhu, Fanyu Meng, Yanhong Gu, Yongqian Shu, Yan Shen, Yang Sun, Qiang X. Sorafenib induces apoptosis in HL60 cells by inhibiting Src kinase-mediated STAT3 phosphorylation. Anti-cancer drugs. vol 22. issue 1. 2011-03-04. PMID:20881478. |
inhibition of constitutively active stat3 has been shown to induce aml cell apoptosis. |
2011-03-04 |
2023-08-12 |
human |
| Wei Zhao, Tao Zhang, Bingqian Qu, Xingxin Wu, Xu Zhu, Fanyu Meng, Yanhong Gu, Yongqian Shu, Yan Shen, Yang Sun, Qiang X. Sorafenib induces apoptosis in HL60 cells by inhibiting Src kinase-mediated STAT3 phosphorylation. Anti-cancer drugs. vol 22. issue 1. 2011-03-04. PMID:20881478. |
taken together, our study indicates that sorafenib blocks src kinase-mediated stat3 phosphorylation and decreases the expression of apoptosis regulatory proteins mcl-1 and bcl-2, which are associated with increased apoptosis in hl60 cells. |
2011-03-04 |
2023-08-12 |
human |