| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yi-Wei Chen, Kuan-Hsuan Chen, Pin-I Huang, Yu-Chih Chen, Guang-Yu Chiou, Wen-Liang Lo, Ling-Ming Tseng, Han-Sui Hsu, Kuo-Wei Chang, Shih-Hwa Chio. Cucurbitacin I suppressed stem-like property and enhanced radiation-induced apoptosis in head and neck squamous carcinoma--derived CD44(+)ALDH1(+) cells. Molecular cancer therapeutics. vol 9. issue 11. 2011-02-28. PMID:21062915. |
notably, 150 nmol/l cucurbitacin i effectively blocked stat3 signaling and downstream survivin and bcl-2 expression, and it induced apoptosis in hnscc-cd44(+)aldh1(+). |
2011-02-28 |
2023-08-12 |
mouse |
| Vikas Kumar Srivastava, Rishi Kumar Gara, M L B Bhatt, D P Sahu, Durga Prasad Mishr. Centchroman inhibits proliferation of head and neck cancer cells through the modulation of PI3K/mTOR pathway. Biochemical and biophysical research communications. vol 404. issue 1. 2011-02-14. PMID:21094138. |
further studies showed that cc treatment induced apoptosis, inhibited akt/mtor and signal transducers and activators of transcription protein 3 (stat3) signaling, altered proteins associated with cell cycle regulation and dna damage and inhibited colony forming efficiency of hnscc cells. |
2011-02-14 |
2023-08-12 |
Not clear |
| Wei Zhao, Soumya Jaganathan, James Turkso. A cell-permeable Stat3 SH2 domain mimetic inhibits Stat3 activation and induces antitumor cell effects in vitro. The Journal of biological chemistry. vol 285. issue 46. 2011-02-09. PMID:20807764. |
significantly, treatment with spi of human breast, pancreatic, prostate, and non-small cell lung cancer cells harboring constitutively active stat3 induced extensive morphology changes, associated with viability loss and apoptosis. |
2011-02-09 |
2023-08-12 |
human |
| Xiaoguang Chen, Cunshuan Xu, Fuchun Zhang, Ji M. Microarray approach reveals the relevance of interferon signaling pathways with rat liver restoration post 2/3 hepatectomy at cellular level. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. vol 30. issue 7. 2011-02-04. PMID:20626293. |
it is inferred that stat3, in contrast to stat1, seemingly takes a more active role in ifn-alpha1-mediated jak/stat pathway in hepatocyte; ifn-beta1-mediated p38 mapk pathway possibly to some extent affects inflammation and apoptosis of biliary epithelial cell during liver regeneration; ifn-gamma-induced jak/stat pathway may be associated with the attenuated apoptosis induction in hsc, kc, and dc. |
2011-02-04 |
2023-08-12 |
rat |
| Jun-Ge Wang, Xiao-Ming Li, Ying-Hui Chen, Xiu-Ying L. [Molecular mechanisms involved in regulation of proliferation and apoptosis by STAT3 antisense oligonucleotide and chemotherapy in laryngeal cancer cells]. Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery. vol 42. issue 3. 2011-02-03. PMID:17633284. |
[molecular mechanisms involved in regulation of proliferation and apoptosis by stat3 antisense oligonucleotide and chemotherapy in laryngeal cancer cells]. |
2011-02-03 |
2023-08-12 |
Not clear |
| Yan Liu, James Fuchs, Chenglong Li, Jiayuh Li. IL-6, a risk factor for hepatocellular carcinoma: FLLL32 inhibits IL-6-induced STAT3 phosphorylation in human hepatocellular cancer cells. Cell cycle (Georgetown, Tex.). vol 9. issue 17. 2011-01-24. PMID:20818158. |
stat3 is major pathway to mediate signal from il-6 to the nucleus, where different genes associated with proliferation and apoptosis are regulated. |
2011-01-24 |
2023-08-12 |
human |
| M Tsutsui, H Yasuda, H Suto, H Imai, Y Isobe, M Sasaki, Y Kojima, K Oshimi, K Sugimot. Frequent STAT3 activation is associated with Mcl-1 expression in nasal NK-cell lymphoma. International journal of laboratory hematology. vol 32. issue 4. 2011-01-14. PMID:19968719. |
effects of stat3 inhibitor ag490 on nk-ys cell line were analyzed by western blotting and flow cytometric apoptosis assay. |
2011-01-14 |
2023-08-12 |
Not clear |
| M Tsutsui, H Yasuda, H Suto, H Imai, Y Isobe, M Sasaki, Y Kojima, K Oshimi, K Sugimot. Frequent STAT3 activation is associated with Mcl-1 expression in nasal NK-cell lymphoma. International journal of laboratory hematology. vol 32. issue 4. 2011-01-14. PMID:19968719. |
inhibition of stat3 activation by jak inhibitor ag490 decreased mcl-1 expression and induced apoptosis in stat3-active nk-ys cells. |
2011-01-14 |
2023-08-12 |
Not clear |
| Lifang Yang, Zhongxin Lu, Xiaoqian Ma, Ya Cao, Lun-Quan Su. A therapeutic approach to nasopharyngeal carcinomas by DNAzymes targeting EBV LMP-1 gene. Molecules (Basel, Switzerland). vol 15. issue 9. 2011-01-04. PMID:20877211. |
dz1 could significantly down-regulate the expression of lmp1 in npc cells, inhibit cell proliferation, metastasis, promote apoptosis and enhance radiosensitivity of npc through interfering signal pathways which are abnormally activated by lmp1, including nf-κb, ap-1 and stat3 signal pathways. |
2011-01-04 |
2023-08-12 |
Not clear |
| Paola Y Bertucci, Ana Quaglino, Andrea G Pozzi, Edith C Kordon, Adali Pecc. Glucocorticoid-induced impairment of mammary gland involution is associated with STAT5 and STAT3 signaling modulation. Endocrinology. vol 151. issue 12. 2011-01-04. PMID:20881248. |
during involution, stat3 activation mediates epithelial cell apoptosis and mammary gland remodeling. |
2011-01-04 |
2023-08-12 |
mouse |
| Paola Y Bertucci, Ana Quaglino, Andrea G Pozzi, Edith C Kordon, Adali Pecc. Glucocorticoid-induced impairment of mammary gland involution is associated with STAT5 and STAT3 signaling modulation. Endocrinology. vol 151. issue 12. 2011-01-04. PMID:20881248. |
our results show that the synthetic glucocorticoid dexamethasone (dex) modulates stat5a and stat3 signaling and inhibits apoptosis induction in postlactating mouse mammary glands, only when administered within the first 48 h upon cessation of suckling. |
2011-01-04 |
2023-08-12 |
mouse |
| Yulong Chen, Jiong Deng, Junya Fujimoto, Humam Kadara, Taoyan Men, Dafna Lotan, Reuben Lota. Gprc5a deletion enhances the transformed phenotype in normal and malignant lung epithelial cells by eliciting persistent Stat3 signaling induced by autocrine leukemia inhibitory factor. Cancer research. vol 70. issue 21. 2010-12-21. PMID:20959490. |
inhibition of stat3 signaling in gprc5a(-/-) normal and cancer cells by the janus-activated kinase 2 inhibitor ag490 or by a dominant negative stat3(y705f) increased starvation-induced apoptosis and inhibited colony formation. |
2010-12-21 |
2023-08-12 |
mouse |
| Ching-Ming Chien, Shang-Yu Chang, Kuei-Li Lin, Chien-Chih Chiu, Long-Sen Chang, Shinne-Ren Li. Taiwan cobra cardiotoxin III inhibits Src kinase leading to apoptosis and cell cycle arrest of oral squamous cell carcinoma Ca9-22 cells. Toxicon : official journal of the International Society on Toxinology. vol 56. issue 4. 2010-12-13. PMID:20493203. |
taken together, these results indicate that ctx iii induces apoptosis and s-phase arrest in ca9-22 cells via concomitant inactivation of the src, egfr, stat3, stat5, pi3 k(p110), and akt signaling pathways. |
2010-12-13 |
2023-08-12 |
Not clear |
| Matthew A Bill, James R Fuchs, Chenglong Li, Jennifer Yui, Courtney Bakan, Don M Benson, Eric B Schwartz, Dalia Abdelhamid, Jiayuh Lin, Dale G Hoyt, Stacey L Fossey, Gregory S Young, William E Carson, Pui-Kai Li, Gregory B Lesinsk. The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity. Molecular cancer. vol 9. 2010-12-06. PMID:20576164. |
the small molecule curcumin analog flll32 induces apoptosis in melanoma cells via stat3 inhibition and retains the cellular response to cytokines with anti-tumor activity. |
2010-12-06 |
2023-08-12 |
Not clear |
| Matthew A Bill, James R Fuchs, Chenglong Li, Jennifer Yui, Courtney Bakan, Don M Benson, Eric B Schwartz, Dalia Abdelhamid, Jiayuh Lin, Dale G Hoyt, Stacey L Fossey, Gregory S Young, William E Carson, Pui-Kai Li, Gregory B Lesinsk. The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity. Molecular cancer. vol 9. 2010-12-06. PMID:20576164. |
we hypothesized this lead compound would specifically inhibit the stat3 signaling pathway to induce apoptosis in melanoma cells. |
2010-12-06 |
2023-08-12 |
Not clear |
| Andrew M Miller, Hua Wang, Ogyi Park, Norio Horiguchi, Fouad Lafdil, Partha Mukhopadhyay, Akira Moh, Xin Yuan Fu, George Kunos, Pal Pacher, Bin Ga. Anti-inflammatory and anti-apoptotic roles of endothelial cell STAT3 in alcoholic liver injury. Alcoholism, clinical and experimental research. vol 34. issue 4. 2010-11-26. PMID:20102572. |
il-6-deficient mice are more susceptible to alcohol-induced hepatocyte apoptosis and steatosis and elevation of serum alanine transaminase (alt); however, whereas hepatocyte-specific stat3 knockout mice are more susceptible to alcohol-induced hepatic steatosis, they have similar hepatocyte apoptosis and serum alt after alcohol feeding compared with wild-type mice. |
2010-11-26 |
2023-08-12 |
mouse |
| Joomin Lee, Eun-Ryeong Hahm, Shivendra V Sing. Withaferin A inhibits activation of signal transducer and activator of transcription 3 in human breast cancer cells. Carcinogenesis. vol 31. issue 11. 2010-11-16. PMID:20724373. |
general implication of these findings is that wa can trigger apoptosis and largely inhibit cell migration/invasion of breast cancer cells even after il-6-induced activation of stat3, which should be viewed as a therapeutic advantage for this agent. |
2010-11-16 |
2023-08-12 |
human |
| Xuegang Sun, Shengnan Wu, Da Xin. The reactive oxygen species-Src-Stat3 pathway provokes negative feedback inhibition of apoptosis induced by high-fluence low-power laser irradiation. The FEBS journal. vol 277. issue 22. 2010-11-16. PMID:20977672. |
signal transducer and activator of transcription 3 (stat3) is an important transcription factor in the modulation of cell proliferation and apoptosis. |
2010-11-16 |
2023-08-12 |
Not clear |
| Xuegang Sun, Shengnan Wu, Da Xin. The reactive oxygen species-Src-Stat3 pathway provokes negative feedback inhibition of apoptosis induced by high-fluence low-power laser irradiation. The FEBS journal. vol 277. issue 22. 2010-11-16. PMID:20977672. |
stat3 activation attenuated hf-lpli-induced apoptosis, as shown by the fact that both dominant negative stat3 (y705f) and stat3 small interfering rna expression enhanced cellular apoptosis induced by hf-lpli. |
2010-11-16 |
2023-08-12 |
Not clear |
| Xuegang Sun, Shengnan Wu, Da Xin. The reactive oxygen species-Src-Stat3 pathway provokes negative feedback inhibition of apoptosis induced by high-fluence low-power laser irradiation. The FEBS journal. vol 277. issue 22. 2010-11-16. PMID:20977672. |
our research will provide new insights into the mechanism of apoptosis caused by hf-lpli, and also extend the functional study of stat3. |
2010-11-16 |
2023-08-12 |
Not clear |