| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dongmei Wang, Yiran Zhou, Weiwei Lei, Kehua Zhang, Jian Shi, Ying Hu, Guangwen Shu, Jianguo Son. Signal transducer and activator of transcription 3 (STAT3) regulates adipocyte differentiation via peroxisome-proliferator-activated receptor gamma (PPARgamma). Biology of the cell. vol 102. issue 1. 2010-09-09. PMID:19566485. |
stat3 (signal transducer and activator of transcription 3) is an important transcription factor involved in many biological events, including apoptosis, tumorigenesis, angiogenesis and epithelial-to-mesenchymal transition. |
2010-09-09 |
2023-08-12 |
Not clear |
| Hiroto Ueba, Michael Brines, Michael Yamin, Tomio Umemoto, Junya Ako, Shin-ichi Momomura, Anthony Cerami, Masanobu Kawakam. Cardioprotection by a nonerythropoietic, tissue-protective peptide mimicking the 3D structure of erythropoietin. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 32. 2010-09-07. PMID:20660739. |
in cultured neonatal rat cardiomyocytes, hbsp clearly inhibited apoptosis (approximately 80%) induced by tnf-alpha, which was comparable with the effect of epo, and activated critical signaling pathways of cell survival, including akt, erk1/2, and stat3. |
2010-09-07 |
2023-08-12 |
rat |
| Zu-Yin Yu, Rui Huang, He Xiao, Wen-Feng Sun, Ya-Jun Shan, Bo Wang, Ting-Ting Zhao, Bo Dong, Zhen-Hu Zhao, Xiao-Lan Liu, Sheng-Qi Wang, Ri-Fang Yang, Qing-Liang Luo, Yu-Wen Con. Fluacrypyrim, a novel STAT3 activation inhibitor, induces cell cycle arrest and apoptosis in cancer cells harboring constitutively-active STAT3. International journal of cancer. vol 127. issue 6. 2010-08-24. PMID:20087863. |
fluacrypyrim, a novel stat3 activation inhibitor, induces cell cycle arrest and apoptosis in cancer cells harboring constitutively-active stat3. |
2010-08-24 |
2023-08-12 |
Not clear |
| Hong Chai, Annie Z Luo, Priya Weerasinghe, Robert E Brow. Sorafenib downregulates ERK/Akt and STAT3 survival pathways and induces apoptosis in a human neuroblastoma cell line. International journal of clinical and experimental pathology. vol 3. issue 4. 2010-08-20. PMID:20490331. |
sorafenib downregulates erk/akt and stat3 survival pathways and induces apoptosis in a human neuroblastoma cell line. |
2010-08-20 |
2023-08-12 |
human |
| Hong Chai, Annie Z Luo, Priya Weerasinghe, Robert E Brow. Sorafenib downregulates ERK/Akt and STAT3 survival pathways and induces apoptosis in a human neuroblastoma cell line. International journal of clinical and experimental pathology. vol 3. issue 4. 2010-08-20. PMID:20490331. |
sorafenib is a multikinase inhibitor that also inhibits stat3 signaling and induces apoptosis. |
2010-08-20 |
2023-08-12 |
human |
| Keinosuke Ryu, Michiro Susa, Edwin Choy, Cao Yang, Francis J Hornicek, Henry J Mankin, Zhenfeng Dua. Oleanane triterpenoid CDDO-Me induces apoptosis in multidrug resistant osteosarcoma cells through inhibition of Stat3 pathway. BMC cancer. vol 10. 2010-08-16. PMID:20459702. |
oleanane triterpenoid cddo-me induces apoptosis in multidrug resistant osteosarcoma cells through inhibition of stat3 pathway. |
2010-08-16 |
2023-08-12 |
Not clear |
| Muneyuk Masuda, T Wakasaki, Masumi Suzui, Satoshi Toh, Andrew K Joe, I B Weinstei. Stat3 orchestrates tumor development and progression: the Achilles' heel of head and neck cancers? Current cancer drug targets. vol 10. issue 1. 2010-08-04. PMID:20088788. |
in this context, an increasing number of preclinical studies have demonstrated that the signal transducers and activators of transcription 3 (stat3) transcription factor plays critical roles in the development and progression of a variety of tumors including hnscc, by regulating cell proliferation, cell cycle progression, apoptosis, angiogenesis, immune evasion, epithelial-mesenchymal transition (emt) and through effects in cancer stem cells. |
2010-08-04 |
2023-08-12 |
Not clear |
| Ana Moran, Anna I Tsimelzon, Mary-Ann A Mastrangelo, Yong Wu, Bi Yu, Susan G Hilsenbeck, Valeria Poli, David J Tweard. Prevention of trauma/hemorrhagic shock-induced lung apoptosis by IL-6-mediated activation of Stat3. Clinical and translational science. vol 2. issue 1. 2010-07-30. PMID:20443866. |
prevention of trauma/hemorrhagic shock-induced lung apoptosis by il-6-mediated activation of stat3. |
2010-07-30 |
2023-08-12 |
mouse |
| Ana Moran, Anna I Tsimelzon, Mary-Ann A Mastrangelo, Yong Wu, Bi Yu, Susan G Hilsenbeck, Valeria Poli, David J Tweard. Prevention of trauma/hemorrhagic shock-induced lung apoptosis by IL-6-mediated activation of Stat3. Clinical and translational science. vol 2. issue 1. 2010-07-30. PMID:20443866. |
to determine if aec apoptosis is a key contributor to ali following t/hs and whether or not signal transducer and activator of translation (stat)3 activation can prevent it, rats were pretreated with a stat3 inhibitor or placebo and subjected to t/hs or sham protocol and resuscitated without or with interleukin (il)-6. |
2010-07-30 |
2023-08-12 |
mouse |
| Ana Moran, Anna I Tsimelzon, Mary-Ann A Mastrangelo, Yong Wu, Bi Yu, Susan G Hilsenbeck, Valeria Poli, David J Tweard. Prevention of trauma/hemorrhagic shock-induced lung apoptosis by IL-6-mediated activation of Stat3. Clinical and translational science. vol 2. issue 1. 2010-07-30. PMID:20443866. |
il-6 treatment stimulated lung stat3 activation and prevented aec apoptosis. |
2010-07-30 |
2023-08-12 |
mouse |
| Ana Moran, Anna I Tsimelzon, Mary-Ann A Mastrangelo, Yong Wu, Bi Yu, Susan G Hilsenbeck, Valeria Poli, David J Tweard. Prevention of trauma/hemorrhagic shock-induced lung apoptosis by IL-6-mediated activation of Stat3. Clinical and translational science. vol 2. issue 1. 2010-07-30. PMID:20443866. |
mice deficient in stat3 beta, a naturally occurring dominant negative isoform of stat3, were resistant to t/hs-induced lung apoptosis. |
2010-07-30 |
2023-08-12 |
mouse |
| Ana Moran, Anna I Tsimelzon, Mary-Ann A Mastrangelo, Yong Wu, Bi Yu, Susan G Hilsenbeck, Valeria Poli, David J Tweard. Prevention of trauma/hemorrhagic shock-induced lung apoptosis by IL-6-mediated activation of Stat3. Clinical and translational science. vol 2. issue 1. 2010-07-30. PMID:20443866. |
thus, t/hs-induced aec apoptosis, which depended on the duration of hypotension, required resuscitation and was prevented by il-6-mediated activation of stat3, which acted to normalize the apoptosis transcriptome. |
2010-07-30 |
2023-08-12 |
mouse |
| Ling Gao, Fengsheng Li, Bo Dong, Junquan Zhang, Yalan Rao, Yue Cong, Bingzhi Mao, Xiaohua Che. Inhibition of STAT3 and ErbB2 suppresses tumor growth, enhances radiosensitivity, and induces mitochondria-dependent apoptosis in glioma cells. International journal of radiation oncology, biology, physics. vol 77. issue 4. 2010-07-27. PMID:20610043. |
inhibition of stat3 and erbb2 suppresses tumor growth, enhances radiosensitivity, and induces mitochondria-dependent apoptosis in glioma cells. |
2010-07-27 |
2023-08-12 |
human |
| Kuei-Li Lin, Jung-Chen Su, Ching-Ming Chien, Pei-Wen Chuang, Long-Sen Chang, Shinne-Ren Li. Down-regulation of the JAK2/PI3K-mediated signaling activation is involved in Taiwan cobra cardiotoxin III-induced apoptosis of human breast MDA-MB-231 cancer cells. Toxicon : official journal of the International Society on Toxinology. vol 55. issue 7. 2010-07-19. PMID:20144642. |
taken together, these results indicate that ctx iii induces apoptosis in mda-mb-231 cells via concomitant inactivation of the jak2, stat3, pi3k, and akt signaling pathways. |
2010-07-19 |
2023-08-12 |
human |
| Emmanuel Chautard, Gaëlle Loubeau, Andreï Tchirkov, Jacques Chassagne, Claudine Vermot-Desroches, Laurent Morel, Pierre Verrell. Akt signaling pathway: a target for radiosensitizing human malignant glioma. Neuro-oncology. vol 12. issue 5. 2010-07-15. PMID:20406894. |
phosphatidyl-inositol 3-kinase/protein kinase b (akt) and janus kinase (jak)/signal transducer and activator of transcription 3 (stat3) pathways serve to block the apoptosis process, keeping cells alive in very toxic environments such as chemotherapy or ionizing radiation. |
2010-07-15 |
2023-08-12 |
human |
| Corina Borghouts, Hanna Tittmann, Natalia Delis, Marisa Kirchenbauer, Boris Brill, Bernd Grone. The intracellular delivery of a recombinant peptide derived from the acidic domain of PIAS3 inhibits STAT3 transactivation and induces tumor cell death. Molecular cancer research : MCR. vol 8. issue 4. 2010-07-12. PMID:20371673. |
this resulted in the suppression of stat3 target gene expression, in the inhibition of migration and proliferation, and in the induction of apoptosis at low concentrations [half maximal effective concentration (ec(50)), <3 micromol/l]. |
2010-07-12 |
2023-08-12 |
Not clear |
| Fan Yang, Christine Brown, Ralf Buettner, Michael Hedvat, Renate Starr, Anna Scuto, Anne Schroeder, Michael Jensen, Richard Jov. Sorafenib induces growth arrest and apoptosis of human glioblastoma cells through the dephosphorylation of signal transducers and activators of transcription 3. Molecular cancer therapeutics. vol 9. issue 4. 2010-07-07. PMID:20371721. |
our data suggest that inhibition of stat3 signaling by sorafenib contributes to growth arrest and induction of apoptosis in glioblastoma cells. |
2010-07-07 |
2023-08-12 |
human |
| Navin K Verma, Anthony M Davies, Aideen Long, Dermot Kelleher, Yuri Volko. STAT3 knockdown by siRNA induces apoptosis in human cutaneous T-cell lymphoma line Hut78 via downregulation of Bcl-xL. Cellular & molecular biology letters. vol 15. issue 2. 2010-07-05. PMID:20213502. |
stat3 knockdown by sirna induces apoptosis in human cutaneous t-cell lymphoma line hut78 via downregulation of bcl-xl. |
2010-07-05 |
2023-08-12 |
human |
| Eun-Ryeong Hahm, Shivendra V Sing. Sulforaphane inhibits constitutive and interleukin-6-induced activation of signal transducer and activator of transcription 3 in prostate cancer cells. Cancer prevention research (Philadelphia, Pa.). vol 3. issue 4. 2010-06-25. PMID:20233902. |
the il-6-mediated activation of stat3 conferred partial but marked protection against sfn-induced apoptosis as evidenced by cytoplasmic histone-associated dna fragmentation and cleavage of poly(adp-ribose) polymerase and procaspase-3. |
2010-06-25 |
2023-08-12 |
mouse |
| Chuan-Bian Lim, Nung Ky, Hui-Min Ng, Mohamed Sabry Hamza, Yan Zha. Curcuma wenyujin extract induces apoptosis and inhibits proliferation of human cervical cancer cells in vitro and in vivo. Integrative cancer therapies. vol 9. issue 1. 2010-06-24. PMID:20150221. |
cwe-treated cells displayed reduced pten, akt, and stat3 phosphorylation and downregulation of nfkappab signaling, providing a mechanism for the g1 arrest and apoptosis observed. |
2010-06-24 |
2023-08-12 |
mouse |