| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mark Luedde, Saskia Spaich, Hans-Joerg Hippe, Sebastian Busch, Rainer Will, Issam Abu-Taha, Tilman Klein, Christian Kuhn, Derk Frank, Hugo A Katus, Norbert Fre. Affixin (β-parvin) promotes cardioprotective signaling via STAT3 activation. Journal of molecular and cellular cardiology. vol 50. issue 5. 2011-08-03. PMID:21295579. |
consistent with stat3 activation, overexpression of affixin also protected cardiomyocytes from doxorubicin-induced apoptosis. |
2011-08-03 |
2023-08-12 |
rat |
| Mark Luedde, Saskia Spaich, Hans-Joerg Hippe, Sebastian Busch, Rainer Will, Issam Abu-Taha, Tilman Klein, Christian Kuhn, Derk Frank, Hugo A Katus, Norbert Fre. Affixin (β-parvin) promotes cardioprotective signaling via STAT3 activation. Journal of molecular and cellular cardiology. vol 50. issue 5. 2011-08-03. PMID:21295579. |
in conclusion, we demonstrate that affixin activates stat3 in cardiomyocytes and promotes characteristic stat3-related effects such as hypertrophy, protection against apoptosis, and angiogenesis. |
2011-08-03 |
2023-08-12 |
rat |
| Tadashi Ashizawa, Haruo Miyata, Hidee Ishii, Chie Oshita, Kenji Matsuno, Yoshiaki Masuda, Toshio Furuya, Tadashi Okawara, Masami Otsuka, Naohisa Ogo, Akira Asai, Yasuto Akiyam. Antitumor activity of a novel small molecule STAT3 inhibitor against a human lymphoma cell line with high STAT3 activation. International journal of oncology. vol 38. issue 5. 2011-08-03. PMID:21369699. |
stx-0119 suppressed the growth of scc3 cells, a human lymphoma cell line with highly activated stat3, through apoptosis and down-regulation of stat3 targets such as c-myc, cyclin d1, survivin and bcl-xl. |
2011-08-03 |
2023-08-12 |
mouse |
| Tadashi Ashizawa, Haruo Miyata, Hidee Ishii, Chie Oshita, Kenji Matsuno, Yoshiaki Masuda, Toshio Furuya, Tadashi Okawara, Masami Otsuka, Naohisa Ogo, Akira Asai, Yasuto Akiyam. Antitumor activity of a novel small molecule STAT3 inhibitor against a human lymphoma cell line with high STAT3 activation. International journal of oncology. vol 38. issue 5. 2011-08-03. PMID:21369699. |
stx-0119 demonstrated potent antitumor effects in vivo in scc3-bearing nude mice by way of the down-regulation of stat3 target genes and induction of apoptosis in the tumors. |
2011-08-03 |
2023-08-12 |
mouse |
| Paul A Johnston, Jennifer R Grandi. STAT3 signaling: anticancer strategies and challenges. Molecular interventions. vol 11. issue 1. 2011-07-29. PMID:21441118. |
stat3 modulates the transcription of a variety of genes involved in the regulation of critical functions, including cell differentiation, proliferation, apoptosis, angiogenesis, metastasis, and immune responses. |
2011-07-29 |
2023-08-12 |
human |
| Shenxian Qian, George Somlo, Bingsen Zhou, Yun Ye. Therapeutic effects of thalidomide in myeloma are associated with the expression of fibroblast growth factor receptor 3. Therapeutics and clinical risk management. vol 1. issue 3. 2011-07-14. PMID:18360564. |
further results suggested that thal inhibition of dna synthesis, induction of apoptosis, and down-regulation of vegf and il-6 might be dependent on fgfr3-associated signal transduction of the erk and stat3 phosphorylation pathway. |
2011-07-14 |
2023-08-12 |
human |
| Ana Moran, Ayse Akcan Arikan, Mary-Ann A Mastrangelo, Yong Wu, Bi Yu, Valeria Poli, David J Tweard. Prevention of trauma and hemorrhagic shock-mediated liver apoptosis by activation of stat3alpha. International journal of clinical and experimental medicine. vol 1. issue 3. 2011-07-14. PMID:18997875. |
we established that il-6 administration at the start of resuscitation is capable of completely reversing liver apoptosis and is associated with increased stat3 activation. |
2011-07-14 |
2023-08-12 |
Not clear |
| Ana Moran, Ayse Akcan Arikan, Mary-Ann A Mastrangelo, Yong Wu, Bi Yu, Valeria Poli, David J Tweard. Prevention of trauma and hemorrhagic shock-mediated liver apoptosis by activation of stat3alpha. International journal of clinical and experimental medicine. vol 1. issue 3. 2011-07-14. PMID:18997875. |
pharmacological inhibition of stat3 activity within the liver blocked the ability of il-6 to prevent liver apoptosis and to normalize the trauma/hs- induced liver apoptosis transcriptome. |
2011-07-14 |
2023-08-12 |
Not clear |
| Ana Moran, Ayse Akcan Arikan, Mary-Ann A Mastrangelo, Yong Wu, Bi Yu, Valeria Poli, David J Tweard. Prevention of trauma and hemorrhagic shock-mediated liver apoptosis by activation of stat3alpha. International journal of clinical and experimental medicine. vol 1. issue 3. 2011-07-14. PMID:18997875. |
genetic deletion of a stat3beta, a naturally occurring, dominant-negative isoform of the stat3, attenuated trauma/hs-induced liver apoptosis, confirming a role for stat3, especially stat3alpha, in preventing trauma/hs-mediated liver apoptosis. |
2011-07-14 |
2023-08-12 |
Not clear |
| Valentina Caldera, Marta Mellai, Laura Annovazzi, Guido Valente, Luciana Tessitore, Davide Schiffe. Stat3 expression and its correlation with proliferation and apoptosis/autophagy in gliomas. Journal of oncology. vol 2008. 2011-07-14. PMID:19421400. |
the goal of the study was to investigate whether activated stat3 (phospho-stat3) levels correlated with cell proliferation, apoptosis, and autophagy. |
2011-07-14 |
2023-08-12 |
Not clear |
| Valentina Caldera, Marta Mellai, Laura Annovazzi, Guido Valente, Luciana Tessitore, Davide Schiffe. Stat3 expression and its correlation with proliferation and apoptosis/autophagy in gliomas. Journal of oncology. vol 2008. 2011-07-14. PMID:19421400. |
stat3 and akt did not show any correlation with apoptosis, whereas they showed an inverse correlation with beclin 1, a stimulator of autophagy, which was rarely positive in glioblastomas. |
2011-07-14 |
2023-08-12 |
Not clear |
| Charles Guo, Guanyu Yang, Kyle Khun, Xiantian Kong, David Levy, Peng Lee, Jonathan Melame. Activation of Stat3 in renal tumors. American journal of translational research. vol 1. issue 3. 2011-07-14. PMID:19956438. |
signal transducer and activator of transcription 3 (stat3) plays a vital role in signal transduction pathways that mediate transformation and inhibit apoptosis. |
2011-07-14 |
2023-08-12 |
human |
| Wolfgang Glienke, Eva Hausmann, Lothar Bergman. Downregulation of STAT3 signaling induces apoptosis but also promotes anti-apoptotic gene expression in human pancreatic cancer cell lines. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 32. issue 3. 2011-07-14. PMID:21174186. |
downregulation of stat3 signaling induces apoptosis but also promotes anti-apoptotic gene expression in human pancreatic cancer cell lines. |
2011-07-14 |
2023-08-12 |
human |
| Wolfgang Glienke, Eva Hausmann, Lothar Bergman. Downregulation of STAT3 signaling induces apoptosis but also promotes anti-apoptotic gene expression in human pancreatic cancer cell lines. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 32. issue 3. 2011-07-14. PMID:21174186. |
in pancreatic cancer, constitutive activation of stat3 contributes to oncogenesis by preventing apoptosis through upregulation of anti-apoptotic proteins. |
2011-07-14 |
2023-08-12 |
human |
| Wolfgang Glienke, Eva Hausmann, Lothar Bergman. Downregulation of STAT3 signaling induces apoptosis but also promotes anti-apoptotic gene expression in human pancreatic cancer cell lines. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 32. issue 3. 2011-07-14. PMID:21174186. |
sirna targeting stat3 was used to evaluate the role of stat3 in modulating the expression of survivin/birc5 and bcl-xl in the pancreatic cancer cell lines panc-1 and bxpc-3 and induction of apoptosis. |
2011-07-14 |
2023-08-12 |
human |
| Wolfgang Glienke, Eva Hausmann, Lothar Bergman. Downregulation of STAT3 signaling induces apoptosis but also promotes anti-apoptotic gene expression in human pancreatic cancer cell lines. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 32. issue 3. 2011-07-14. PMID:21174186. |
stat3 downregulation resulted in a decrease of cell viability in both cell lines and induced apoptosis in bxpc-3 cells. |
2011-07-14 |
2023-08-12 |
human |
| Wolfgang Glienke, Eva Hausmann, Lothar Bergman. Downregulation of STAT3 signaling induces apoptosis but also promotes anti-apoptotic gene expression in human pancreatic cancer cell lines. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 32. issue 3. 2011-07-14. PMID:21174186. |
inactivation of stat3 in pancreatic cancer cell lines induces apoptosis but also may promote the expression of anti-apoptotic genes. |
2011-07-14 |
2023-08-12 |
human |
| Toshinori Bito, Nahoko Sumita, Masashi Ashida, Arief Budiyanto, Masato Ueda, Masamitsu Ichihashi, Yoshiki Tokura, Chikako Nishigor. Inhibition of Epidermal Growth Factor Receptor and PI3K/Akt Signaling Suppresses Cell Proliferation and Survival through Regulation of Stat3 Activation in Human Cutaneous Squamous Cell Carcinoma. Journal of skin cancer. vol 2011. 2011-07-14. PMID:21197106. |
ag1478 inhibited cell proliferation and induced apoptosis of hsc-1 cells but did not inhibit the growth of normal human epidermal keratinocytes that did not show stat3 activation. |
2011-07-14 |
2023-08-12 |
human |
| Toshinori Bito, Nahoko Sumita, Masashi Ashida, Arief Budiyanto, Masato Ueda, Masamitsu Ichihashi, Yoshiki Tokura, Chikako Nishigor. Inhibition of Epidermal Growth Factor Receptor and PI3K/Akt Signaling Suppresses Cell Proliferation and Survival through Regulation of Stat3 Activation in Human Cutaneous Squamous Cell Carcinoma. Journal of skin cancer. vol 2011. 2011-07-14. PMID:21197106. |
combined treatment with the pi3k inhibitor and ag1478 strongly suppressed stat3 activity and dramatically induced apoptosis of hsc-1 cells. |
2011-07-14 |
2023-08-12 |
human |
| Jun Peng, Youqin Chen, Jiumao Lin, Qunchuan Zhuang, Wei Xu, Zhenfeng Hong, Thomas J Sferr. Patrinia scabiosaefolia extract suppresses proliferation and promotes apoptosis by inhibiting the STAT3 pathway in human multiple myeloma cells. Molecular medicine reports. vol 4. issue 2. 2011-07-12. PMID:21468570. |
patrinia scabiosaefolia extract suppresses proliferation and promotes apoptosis by inhibiting the stat3 pathway in human multiple myeloma cells. |
2011-07-12 |
2023-08-12 |
human |