| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yan Liu, Aiguo Liu, Huameng Li, Chenglong Li, Jiayuh Li. Celecoxib inhibits interleukin-6/interleukin-6 receptor-induced JAK2/STAT3 phosphorylation in human hepatocellular carcinoma cells. Cancer prevention research (Philadelphia, Pa.). vol 4. issue 8. 2012-01-05. PMID:21490132. |
our results showed that celecoxib decreased stat3 phosphorylation by reducing janus-activated kinase (jak2) phosphorylation and caused apoptosis in hcc cells. |
2012-01-05 |
2023-08-12 |
human |
| Yu-Ching Lin, Ming-Szu Hung, Chin-Kuo Lin, Jhy-Ming Li, Kuan-Der Lee, Ya-Chin Li, Miao-Fen Chen, Jan-Kan Chen, Cheng-Ta Yan. CK2 inhibitors enhance the radiosensitivity of human non-small cell lung cancer cells through inhibition of stat3 activation. Cancer biotherapy & radiopharmaceuticals. vol 26. issue 3. 2012-01-05. PMID:21711111. |
inhibition of ck2 activity can induce apoptosis and suppression of stat3 activation in cancer cells. |
2012-01-05 |
2023-08-12 |
human |
| Francesca Zammarchi, Elisa de Stanchina, Eirini Bournazou, Teerawit Supakorndej, Kathryn Martires, Elyn Riedel, Adriana D Corben, Jacqueline F Bromberg, Luca Cartegn. Antitumorigenic potential of STAT3 alternative splicing modulation. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 43. 2011-12-19. PMID:22006329. |
induction of endogenous stat3β leads to apoptosis and cell-cycle arrest in cell lines with persistent stat3 tyrosine phosphorylation compared with total stat3 knockdown obtained by forced splicing-dependent nonsense-mediated decay (fsd-nmd). |
2011-12-19 |
2023-08-12 |
Not clear |
| Yi-Chieh Nancy Du, Chen-Kung Chou, David S Klimstra, Harold Varmu. Receptor for hyaluronan-mediated motility isoform B promotes liver metastasis in a mouse model of multistep tumorigenesis and a tail vein assay for metastasis. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 40. 2011-12-13. PMID:21940500. |
in initial efforts to identify signaling pathways activated by rhamm(b), we found that rhamm(b) induced phosphorylation of epidermal growth factor receptor (egfr), erk1/2, and stat3 and conferred susceptibility to apoptosis after treatment with an egfr inhibitor, gefitinib. |
2011-12-13 |
2023-08-12 |
mouse |
| Shu Wen, Hong Li, Mo-Li Wu, Shao-Hua Fan, Qian Wang, Xiao-Hong Shu, Qing-You Kong, Xiao-Yan Chen, Jia Li. Inhibition of NF-κB signaling commits resveratrol-treated medulloblastoma cells to apoptosis without neuronal differentiation. Journal of neuro-oncology. vol 104. issue 1. 2011-12-07. PMID:21161674. |
resveratrol promotes differentiation and apoptosis of medulloblastoma cells by suppressing stat3 signaling and a range of cancer-associated gene expression. |
2011-12-07 |
2023-08-12 |
Not clear |
| Andrzej Wincewicz, Marek Baltaziak, Luiza Kanczuga-Koda, Mariusz Koda, Urszula Sulkowska, Waldemar Famulski, Stanislaw Sulkowski, Stanislaw Sulkows. STAT3 and apoptosis regulators: Bak and Bcl-xL in endometrioid adenocarcinomas of different estrogen receptor-α immunoprofile. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. vol 27. issue 8. 2011-12-05. PMID:21726118. |
stat3 and apoptosis regulators: bak and bcl-xl in endometrioid adenocarcinomas of different estrogen receptor-α immunoprofile. |
2011-12-05 |
2023-08-12 |
Not clear |
| Andrzej Wincewicz, Marek Baltaziak, Luiza Kanczuga-Koda, Mariusz Koda, Urszula Sulkowska, Waldemar Famulski, Stanislaw Sulkowski, Stanislaw Sulkows. STAT3 and apoptosis regulators: Bak and Bcl-xL in endometrioid adenocarcinomas of different estrogen receptor-α immunoprofile. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. vol 27. issue 8. 2011-12-05. PMID:21726118. |
the aim of our study was to detect immunohistochemically and compare expressions of stat3 with apoptosis regulators (bak and bcl-xl) in regard to different pathological features and variably pronounced er-α immunoprofile in 78 endometrioid adenocarcinomas. |
2011-12-05 |
2023-08-12 |
Not clear |
| Jin-Jin Zhang, You-Lei Wang, Xue-Bin Feng, Xiao-Dong Song, Wen-Bo Li. Rosmarinic acid inhibits proliferation and induces apoptosis of hepatic stellate cells. Biological & pharmaceutical bulletin. vol 34. issue 3. 2011-11-22. PMID:21372382. |
in conclusion, these results suggested that rosa was able to inhibit proliferation and induce apoptosis in hsc-t6, partly due to the inhibition of phosphorylation in stat3, which contributed to the reversal of hepatic fibrosis. |
2011-11-22 |
2023-08-12 |
Not clear |
| Sahdeo Prasad, Manoj K Pandey, Vivek R Yadav, Bharat B Aggarwa. Gambogic acid inhibits STAT3 phosphorylation through activation of protein tyrosine phosphatase SHP-1: potential role in proliferation and apoptosis. Cancer prevention research (Philadelphia, Pa.). vol 4. issue 7. 2011-11-15. PMID:21490133. |
gambogic acid inhibits stat3 phosphorylation through activation of protein tyrosine phosphatase shp-1: potential role in proliferation and apoptosis. |
2011-11-15 |
2023-08-12 |
human |
| Sahdeo Prasad, Manoj K Pandey, Vivek R Yadav, Bharat B Aggarwa. Gambogic acid inhibits STAT3 phosphorylation through activation of protein tyrosine phosphatase SHP-1: potential role in proliferation and apoptosis. Cancer prevention research (Philadelphia, Pa.). vol 4. issue 7. 2011-11-15. PMID:21490133. |
we found that ga induced apoptosis in human multiple myeloma cells that correlated with the inhibition of both constitutive and inducible stat3 activation. |
2011-11-15 |
2023-08-12 |
human |
| Sahdeo Prasad, Manoj K Pandey, Vivek R Yadav, Bharat B Aggarwa. Gambogic acid inhibits STAT3 phosphorylation through activation of protein tyrosine phosphatase SHP-1: potential role in proliferation and apoptosis. Cancer prevention research (Philadelphia, Pa.). vol 4. issue 7. 2011-11-15. PMID:21490133. |
deletion of the shp-1 gene by sirna suppressed the ability of ga to inhibit stat3 activation and to induce apoptosis, suggesting the critical role of shp-1 in its action. |
2011-11-15 |
2023-08-12 |
human |
| Sahdeo Prasad, Manoj K Pandey, Vivek R Yadav, Bharat B Aggarwa. Gambogic acid inhibits STAT3 phosphorylation through activation of protein tyrosine phosphatase SHP-1: potential role in proliferation and apoptosis. Cancer prevention research (Philadelphia, Pa.). vol 4. issue 7. 2011-11-15. PMID:21490133. |
overall, these results suggest that ga blocks stat3 activation, leading to suppression of tumor cell proliferation and induction of apoptosis. |
2011-11-15 |
2023-08-12 |
human |
| Hyun-Mee Oh, Cheng-Rong Yu, Nady Golestaneh, Ahjoku Amadi-Obi, Yun Sang Lee, Amarachi Eseonu, Rashid M Mahdi, Charles E Egwuag. STAT3 protein promotes T-cell survival and inhibits interleukin-2 production through up-regulation of Class O Forkhead transcription factors. The Journal of biological chemistry. vol 286. issue 35. 2011-10-25. PMID:21730069. |
it is notable that their exaggerated increase in il-2 production rendered stat3-deficient lymphocytes more susceptible to activation-induced cell death, suggesting that stat3 might protect t-cells from apoptosis by limiting their production of il-2 through up-regulation of foxo1/foxo3a expression. |
2011-10-25 |
2023-08-12 |
Not clear |
| Jingya Zhang, Yueting Zhang, Dipankar J Dutta, Azeb T Argaw, Virginie Bonnamain, Jeremy Seto, David A Braun, Andleeb Zameer, Fernand Hayot, Carolina B Lòpez, Cedric S Raine, Gareth R Joh. Proapoptotic and antiapoptotic actions of Stat1 versus Stat3 underlie neuroprotective and immunoregulatory functions of IL-11. Journal of immunology (Baltimore, Md. : 1950). vol 187. issue 3. 2011-10-24. PMID:21709156. |
in this study, we demonstrate that these effects of il-11 are mediated via differential regulation of apoptosis in oligodendrocytes versus ag-presenting dendritic cells (dcs), and are dependent on lineage-specific activity of the transcription factors stat1 versus stat3. |
2011-10-24 |
2023-08-12 |
mouse |
| Jingya Zhang, Yueting Zhang, Dipankar J Dutta, Azeb T Argaw, Virginie Bonnamain, Jeremy Seto, David A Braun, Andleeb Zameer, Fernand Hayot, Carolina B Lòpez, Cedric S Raine, Gareth R Joh. Proapoptotic and antiapoptotic actions of Stat1 versus Stat3 underlie neuroprotective and immunoregulatory functions of IL-11. Journal of immunology (Baltimore, Md. : 1950). vol 187. issue 3. 2011-10-24. PMID:21709156. |
importantly, sirna inhibition of stat1 enhanced the antiapoptotic effects of il-11 on opcs, but il-11 induced apoptosis in the presence of stat3 silencing. |
2011-10-24 |
2023-08-12 |
mouse |
| Muthu K Shanmugam, Peramaiyan Rajendran, Feng Li, Tarang Nema, Shireen Vali, Taher Abbasi, Shweta Kapoor, Ashish Sharma, Alan Prem Kumar, Paul C Ho, Kam M Hui, Gautam Seth. Ursolic acid inhibits multiple cell survival pathways leading to suppression of growth of prostate cancer xenograft in nude mice. Journal of molecular medicine (Berlin, Germany). vol 89. issue 7. 2011-10-17. PMID:21465181. |
ua also downregulated the expression of various nf-κb and stat3 regulated gene products involved in proliferation, survival, and angiogenesis and induced apoptosis in both cells lines as evidenced by dna fragmentation and annexin v staining. |
2011-10-17 |
2023-08-12 |
mouse |
| Jolyane Meloche, Roxane Paulin, Audrey Courboulin, Caroline Lambert, Marjorie Barrier, Pierre Bonnet, Malik Bisserier, Mélanie Roy, Mark A Sussman, Mohsen Agharazii, Sébastien Bonne. RAGE-dependent activation of the oncoprotein Pim1 plays a critical role in systemic vascular remodeling processes. Arteriosclerosis, thrombosis, and vascular biology. vol 31. issue 9. 2011-10-13. PMID:21680901. |
methods/results- in vitro, freshly isolated human carotid vsmcs exposed to rage activator nε-(carboxymethyl)lysine (cml) for 48 hours had (1) activated stat3 (increased p-stat3/stat3 ratio and p-stat3 nuclear translocation); (2) increased stat3-dependent pim1 expression resulting in nfatc1 activation; and (3) increased pim1/nfat-dependent vsmc proliferation (pcna, ki67) and resistance to mitochondrial-dependent apoptosis (tmrm, annexin v, tunel). |
2011-10-13 |
2023-08-12 |
mouse |
| Edmund A Rossi, Diane L Rossi, Thomas M Cardillo, Rhona Stein, David M Goldenberg, Chien-Hsing Chan. Preclinical studies on targeted delivery of multiple IFNα2b to HLA-DR in diverse hematologic cancers. Blood. vol 118. issue 7. 2011-10-12. PMID:21680794. |
phosphorylation of stat1 was more robust and persistent than that of stat3, which may promote apoptosis. |
2011-10-12 |
2023-08-12 |
human |
| Byung Hak Kim, Yun Sook Min, Jung Sook Choi, Gyeong Hun Baeg, Young Soo Kim, Jong Wook Shin, Tae Yoon Kim, Sang Kyu Y. Benzoxathiol derivative BOT-4-one suppresses L540 lymphoma cell survival and proliferation via inhibition of JAK3/STAT3 signaling. Experimental & molecular medicine. vol 43. issue 5. 2011-10-03. PMID:21499010. |
here, we report that 2-cyclohexylimino-6-methyl-6,7-dihydro-5h-benzo [1,3]oxathiol-4-one (bot-4-one), a small molecule inhibitor of jak/stat3 signaling, induces apoptosis through inhibition of stat3 activation. |
2011-10-03 |
2023-08-12 |
human |
| Byung Hak Kim, Yun Sook Min, Jung Sook Choi, Gyeong Hun Baeg, Young Soo Kim, Jong Wook Shin, Tae Yoon Kim, Sang Kyu Y. Benzoxathiol derivative BOT-4-one suppresses L540 lymphoma cell survival and proliferation via inhibition of JAK3/STAT3 signaling. Experimental & molecular medicine. vol 43. issue 5. 2011-10-03. PMID:21499010. |
in addition, bot-4-one-treated hodgkin's lymphoma cells showed decreased cell survival and proliferation by inducing apoptosis through down-regulation of stat3 downstream target anti-apoptotic gene expression. |
2011-10-03 |
2023-08-12 |
human |