| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hao Wu, Ning Li, Ronghua Jin, Qinghua Meng, Peng Chen, Guoxian Zhao, Rui Wang, Li Li, Wei L. Cytokine levels contribute to the pathogenesis of minimal hepatic encephalopathy in patients with hepatocellular carcinoma via STAT3 activation. Scientific reports. vol 6. 2016-12-13. PMID:26757951. |
treatment with a stat3 inhibitor protected neurons from cytokine-induced apoptosis in vitro. |
2016-12-13 |
2023-08-13 |
human |
| Hao Wu, Ning Li, Ronghua Jin, Qinghua Meng, Peng Chen, Guoxian Zhao, Rui Wang, Li Li, Wei L. Cytokine levels contribute to the pathogenesis of minimal hepatic encephalopathy in patients with hepatocellular carcinoma via STAT3 activation. Scientific reports. vol 6. 2016-12-13. PMID:26757951. |
the cytokines investigated may induce neural apoptosis via stat3 in the pathogenesis of mhe in hcc. |
2016-12-13 |
2023-08-13 |
human |
| Jing Liu, Hui Fu, Fen Chang, Jinlan Wang, Shangli Zhang, Yi Caudle, Jing Zhao, Deling Yi. Sodium orthovanadate suppresses palmitate-induced cardiomyocyte apoptosis by regulation of the JAK2/STAT3 signaling pathway. Apoptosis : an international journal on programmed cell death. vol 21. issue 5. 2016-12-13. PMID:26921179. |
the data suggested that jnk may be another upstream factor regulating stat3, and verified the important function of p-stat3 (y705) in pa-induced cardiomyocyte apoptosis. |
2016-12-13 |
2023-08-13 |
Not clear |
| Elizabeth Reyes-Zárate, Yesennia Sánchez-Pérez, María Concepción Gutiérrez-Ruiz, Yolanda I Chirino, Álvaro Román Osornio-Vargas, Rocío Morales-Bárcenas, Verónica Souza-Arroyo, Claudia María García-Cuella. Atmospheric particulate matter (PM10) exposure-induced cell cycle arrest and apoptosis evasion through STAT3 activation via PKCζ and Src kinases in lung cells. Environmental pollution (Barking, Essex : 1987). vol 214. 2016-12-13. PMID:27131825. |
atmospheric particulate matter (pm10) exposure-induced cell cycle arrest and apoptosis evasion through stat3 activation via pkcζ and src kinases in lung cells. |
2016-12-13 |
2023-08-13 |
Not clear |
| Elizabeth Reyes-Zárate, Yesennia Sánchez-Pérez, María Concepción Gutiérrez-Ruiz, Yolanda I Chirino, Álvaro Román Osornio-Vargas, Rocío Morales-Bárcenas, Verónica Souza-Arroyo, Claudia María García-Cuella. Atmospheric particulate matter (PM10) exposure-induced cell cycle arrest and apoptosis evasion through STAT3 activation via PKCζ and Src kinases in lung cells. Environmental pollution (Barking, Essex : 1987). vol 214. 2016-12-13. PMID:27131825. |
the inhibition of stat3 phosphorylation prevented cell cycle arrest and triggered apoptosis. |
2016-12-13 |
2023-08-13 |
Not clear |
| Elizabeth Reyes-Zárate, Yesennia Sánchez-Pérez, María Concepción Gutiérrez-Ruiz, Yolanda I Chirino, Álvaro Román Osornio-Vargas, Rocío Morales-Bárcenas, Verónica Souza-Arroyo, Claudia María García-Cuella. Atmospheric particulate matter (PM10) exposure-induced cell cycle arrest and apoptosis evasion through STAT3 activation via PKCζ and Src kinases in lung cells. Environmental pollution (Barking, Essex : 1987). vol 214. 2016-12-13. PMID:27131825. |
these results suggest that pm10 exposure might activate a survival pathway related to stat3 activation, similar to what has been described as part of the immune system and apoptosis evasion during tumor promotion and development. |
2016-12-13 |
2023-08-13 |
Not clear |
| Meng-Chi Yen, Ying-Chu Shih, Ya-Ling Hsu, En-Shyh Lin, Yi-Shiuan Lin, Eing-Mei Tsai, Ya-Wen Ho, Ming-Feng Hou, Po-Lin Ku. Isolinderalactone enhances the inhibition of SOCS3 on STAT3 activity by decreasing miR-30c in breast cancer. Oncology reports. vol 35. issue 3. 2016-10-28. PMID:26707189. |
treatment of isolinderalactone increased the protein level of the suppressor of cytokine signaling 3 (scos3), decreased phosphorylation of the signal transducer and activator of transcription 3 (stat3), and suppressed expression of the down-stream genes of the x-linked inhibitor of apoptosis protein in mda-mb-231 cells. |
2016-10-28 |
2023-08-13 |
mouse |
| Meng-Chi Yen, Ying-Chu Shih, Ya-Ling Hsu, En-Shyh Lin, Yi-Shiuan Lin, Eing-Mei Tsai, Ya-Wen Ho, Ming-Feng Hou, Po-Lin Ku. Isolinderalactone enhances the inhibition of SOCS3 on STAT3 activity by decreasing miR-30c in breast cancer. Oncology reports. vol 35. issue 3. 2016-10-28. PMID:26707189. |
in conclusion, isolinderalactone induces apoptosis in mda-mb‑231 cells and suppresses stat3 signaling pathway through regulation of socs3 and mir-30c. |
2016-10-28 |
2023-08-13 |
mouse |
| Shan Xu, Ning Zhao, Lian Hui, Min Song, Zi-Wei Miao, Xue-Jun Jian. MicroRNA-124-3p inhibits the growth and metastasis of nasopharyngeal carcinoma cells by targeting STAT3. Oncology reports. vol 35. issue 3. 2016-10-28. PMID:26707908. |
to sum up, this study shows that mir-124-3p may negatively regulate the transcription of the stat3 by interfering with its 3'utr, and the degradation of stat3 affects its downstream expression of such as p-stat3, ccnd2 and mmp-2, thereby promoting npc cells apoptosis and inhibiting proliferation, migration and invasion of npc cells. |
2016-10-28 |
2023-08-13 |
mouse |
| Seung Ho Baek, Jeong-Hyeon Ko, Hanwool Lee, Jinhong Jung, Moonkyoo Kong, Jung-woo Lee, Junhee Lee, Arunachalam Chinnathambi, M E Zayed, Sulaiman Ali Alharbi, Seok-Geun Lee, Bum Sang Shim, Gautam Sethi, Sung-Hoon Kim, Woong Mo Yang, Jae-Young Um, Kwang Seok Ah. Resveratrol inhibits STAT3 signaling pathway through the induction of SOCS-1: Role in apoptosis induction and radiosensitization in head and neck tumor cells. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 23. issue 5. 2016-10-21. PMID:27064016. |
resveratrol inhibits stat3 signaling pathway through the induction of socs-1: role in apoptosis induction and radiosensitization in head and neck tumor cells. |
2016-10-21 |
2023-08-13 |
Not clear |
| Joohyun Lee, Min Kyung Jung, Hyun Jeong Park, Kyung Eun Kim, Daeho Ch. Erdr1 Suppresses Murine Melanoma Growth via Regulation of Apoptosis. International journal of molecular sciences. vol 17. issue 1. 2016-10-20. PMID:26784177. |
additionally, erdr1 downregulated stat3 activity, inhibiting apoptosis via regulation of the bcl-2 family. |
2016-10-20 |
2023-08-13 |
mouse |
| Seung Ho Baek, Jae Hwi Lee, Jeong-Hyeon Ko, Hanwool Lee, Dongwoo Nam, Seok Geun Lee, Woong Mo Yang, Jae-Young Um, Junhee Lee, Sung-Hoon Kim, Bum Sang Shim, Kwang Seok Ah. Ginkgetin Blocks Constitutive STAT3 Activation and Induces Apoptosis through Induction of SHP-1 and PTEN Tyrosine Phosphatases. Phytotherapy research : PTR. vol 30. issue 4. 2016-10-20. PMID:27059688. |
ginkgetin blocks constitutive stat3 activation and induces apoptosis through induction of shp-1 and pten tyrosine phosphatases. |
2016-10-20 |
2023-08-13 |
Not clear |
| Teng-Fei Fan, Lin-Lin Bu, Wei-Ming Wang, Si-Rui Ma, Jian-Feng Liu, Wei-Wei Deng, Liang Mao, Guang-Tao Yu, Cong-Fa Huang, Bing Liu, Wen-Feng Zhang, Zhi-Jun Su. Tumor growth suppression by inhibiting both autophagy and STAT3 signaling in HNSCC. Oncotarget. vol 6. issue 41. 2016-10-11. PMID:26561201. |
the pharmacological or genetic inhibition of autophagy and stat3 further sensitized hnscc cells to apoptosis. |
2016-10-11 |
2023-08-13 |
human |
| Yan Yang, Shiyu Song, Haiyan Min, Xiufang Chen, Qian Ga. STAT3 degradation mediated by calcineurin involved in the neurotoxicity of isoflurane. Neuroreport. vol 27. issue 2. 2016-10-06. PMID:26694943. |
we found that inhibiting the activity of calcineurin, which specifically promotes stat3 degradation, alleviated isoflurane-induced neural apoptosis. |
2016-10-06 |
2023-08-13 |
mouse |
| David S Rowlands, Andre R Nelson, Frederic Raymond, Sylviane Metairon, Robert Mansourian, Jim Clarke, Trent Stellingwerff, Stuart M Phillip. Protein-leucine ingestion activates a regenerative inflammo-myogenic transcriptome in skeletal muscle following intense endurance exercise. Physiological genomics. vol 48. issue 1. 2016-10-05. PMID:26508702. |
by 240 min, the protein-leucine transcriptome was anti-inflammatory and promyogenic (il-6, nf- β, smad, stat3 network inhibition), with overrepresented functions including decreased leukocyte migration and connective tissue development (-1.8-2.4, p < 0.01), increased apoptosis of myeloid and muscle cells (2.2-3.0, p < 0.002), and cell metabolism (2.0-2.4, p < 0.01). |
2016-10-05 |
2023-08-13 |
Not clear |
| Chulwon Kim, Sang Hyun Baek, Jae-Young Um, Bum Sang Shim, Kwang Seok Ah. Resveratrol attenuates constitutive STAT3 and STAT5 activation through induction of PTPε and SHP-2 tyrosine phosphatases and potentiates sorafenib-induced apoptosis in renal cell carcinoma. BMC nephrology. vol 17. 2016-10-05. PMID:26911335. |
resveratrol attenuates constitutive stat3 and stat5 activation through induction of ptpε and shp-2 tyrosine phosphatases and potentiates sorafenib-induced apoptosis in renal cell carcinoma. |
2016-10-05 |
2023-08-13 |
Not clear |
| Sun Mi Kwon, Yu Yeon Jung, Chul Ju Hwang, Mi Hee Park, Na Young Yoon, Tae Myung Kim, Ji Myung Yu, Dae Hwan Kim, Doo Won Seo, Hyu Seok Youn, Hyun Ok Seo, In Sung Chung, Sang Bae Han, Bang Yeon Hwang, Hwan-Soo Yoo, Jae-Kyung Jung, Heesoon Lee, Jin Tae Hon. Anti-cancer effect of N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2,3-dihydronaphtho[1,2-b]furan-2-carboxamide, a novel synthetic compound. Molecular carcinogenesis. vol 55. issue 5. 2016-09-21. PMID:25865242. |
nhdc also induced expression of the apoptosis regulating genes as well as inhibiting the action of stat3. |
2016-09-21 |
2023-08-13 |
Not clear |
| Sadeesh Em, Fozia Shah, P S Yada. Differential developmental competence and gene expression patterns in buffalo (Bubalus bubalis) nuclear transfer embryos reconstructed with fetal fibroblasts and amnion mesenchymal stem cells. Cytotechnology. vol 68. issue 5. 2016-09-16. PMID:26660476. |
alterations in the expression pattern of genes implicated in transcription and pluripotency (oct4, stat3, nanog), dna methylation (dnmt1, dnmt3a), histone deacetylation (hdac2), growth factor signaling and imprinting (igf2, igf2r), apoptosis (bax, bcl2), metabolism (glut1) and oxidative stress (mnsod) regulation were observed in cloned embryos. |
2016-09-16 |
2023-08-13 |
Not clear |
| W Ruoming, Y Zhen, Z Tengteng, H Jishen. Tumor suppressor microRNA-31 inhibits gastric carcinogenesis by targeting Smad4 and SGPP2. Cancer gene therapy. vol 22. issue 12. 2016-09-13. PMID:26494556. |
functional studies showed that increasing mir-31 inhibited gc cell proliferation, promoted apoptosis and attenuated cell migration, which were also linked to downregulation of stat3. |
2016-09-13 |
2023-08-13 |
mouse |
| W Ruoming, Y Zhen, Z Tengteng, H Jishen. Tumor suppressor microRNA-31 inhibits gastric carcinogenesis by targeting Smad4 and SGPP2. Cancer gene therapy. vol 22. issue 12. 2016-09-13. PMID:26494556. |
this study has revealed mir-31 as a tumor suppressor and has identified sgpp2 and smad4 as novel targets of mir-31, linking to stat3 for regulating cancer cell proliferation, apoptosis and migration in gc. |
2016-09-13 |
2023-08-13 |
mouse |