| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xing-Hua Liao, Yuan Xiang, Cheng-Xi Yu, Jia-Peng Li, Hui Li, Qi Nie, Peng Hu, Jun Zhou, Tong-Cun Zhan. STAT3 is required for MiR-17-5p-mediated sensitization to chemotherapy-induced apoptosis in breast cancer cells. Oncotarget. vol 8. issue 9. 2017-08-24. PMID:28178652. |
finally, mir-17-5p promoted apoptosis by increasing p53 expression, which was inhibited by stat3. |
2017-08-24 |
2023-08-13 |
Not clear |
| Xing-Hua Liao, Yuan Xiang, Cheng-Xi Yu, Jia-Peng Li, Hui Li, Qi Nie, Peng Hu, Jun Zhou, Tong-Cun Zhan. STAT3 is required for MiR-17-5p-mediated sensitization to chemotherapy-induced apoptosis in breast cancer cells. Oncotarget. vol 8. issue 9. 2017-08-24. PMID:28178652. |
these results demonstrate a novel pathway via which mir-17-5p inhibits stat3 and increases p53 expression to promote apoptosis in breast cancer cells. |
2017-08-24 |
2023-08-13 |
Not clear |
| Ji Ma, Shaofeng Shui, Xinwei Han, Dong Guo, Tengfei Li, Lei Ya. microRNA-200a silencing protects neural stem cells against cerebral ischemia/reperfusion injury. PloS one. vol 12. issue 2. 2017-08-21. PMID:28222148. |
the changes in cell viability, apoptosis, migration, the expression of c-myc, and the phosphorylation of stat1, stat3 and mapk were respectively assessed. |
2017-08-21 |
2023-08-13 |
Not clear |
| Dongqing Zuo, Zifei Zhou, Hongsheng Wang, Tao Zhang, Jie Zang, Fei Yin, Wei Sun, Jiepeng Chen, Lili Duan, Jing Xu, Zhuoying Wang, Chongren Wang, Binhui Lin, Zeze Fu, Yuxin Liao, Suoyuan Li, Mengxiong Sun, Yingqi Hua, Longpo Zheng, Zhengdong Ca. Alternol, a natural compound, exerts an anti-tumour effect on osteosarcoma by modulating of STAT3 and ROS/MAPK signalling pathways. Journal of cellular and molecular medicine. vol 21. issue 2. 2017-07-31. PMID:27624867. |
taken together, our results reveal that alternol suppresses cell proliferation, migration and induces apoptosis, cell cycle arrest by modulating of ros-dependent mapk and stat3 signalling pathways in human os cells. |
2017-07-31 |
2023-08-13 |
mouse |
| Tao Zhang, Suoyuan Li, Jingjie Li, Fei Yin, Yingqi Hua, Zhouying Wang, Binhui Lin, Hongsheng Wang, Dongqing Zou, Zifei Zhou, Jing Xu, Chengqing Yi, Zhengdong Ca. Natural product pectolinarigenin inhibits osteosarcoma growth and metastasis via SHP-1-mediated STAT3 signaling inhibition. Cell death & disease. vol 7. issue 10. 2017-07-31. PMID:27735939. |
we also found pectolinarigenin significantly suppressed osteosarcoma cell proliferation, induced apoptosis and reduced the level of stat3 downstream proteins cyclin d1, survivin, b-cell lymphoma 2 (bcl-2), b-cell lymphoma extra-large (bcl-xl) and myeloid cell leukemia 1 (mcl-1). |
2017-07-31 |
2023-08-13 |
Not clear |
| Jiawei Shou, Liangkun You, Junlin Yao, Jiansheng Xie, Jing Jing, Zhao Jing, Liming Jiang, Xinbing Sui, Hongming Pan, Weidong Ha. Cyclosporine A sensitizes human non-small cell lung cancer cells to gefitinib through inhibition of STAT3. Cancer letters. vol 379. issue 1. 2017-07-26. PMID:27264264. |
mechanistically, csa promoted gefitinib-induced apoptosis through inhibition of the stat3 pathway. |
2017-07-26 |
2023-08-13 |
human |
| Jiawei Shou, Liangkun You, Junlin Yao, Jiansheng Xie, Jing Jing, Zhao Jing, Liming Jiang, Xinbing Sui, Hongming Pan, Weidong Ha. Cyclosporine A sensitizes human non-small cell lung cancer cells to gefitinib through inhibition of STAT3. Cancer letters. vol 379. issue 1. 2017-07-26. PMID:27264264. |
similar with the function of csa, sirnas against stat3 also enhanced gefitinib-induced apoptosis in multiple lung cancer cells. |
2017-07-26 |
2023-08-13 |
human |
| Zhiwei Zhou, Xijian Lu, Jin Wang, Jia Xiao, Jing Liu, Feiyue Xin. microRNA let-7c is essential for the anisomycin-elicited apoptosis in Jurkat T cells by linking JNK1/2 to AP-1/STAT1/STAT3 signaling. Scientific reports. vol 6. 2017-07-18. PMID:27087117. |
the let-7c over-expression and the addition of its mimics facilitated the activation of ap-1, stat1 and bim by linking jnk1/2 to ap-1/stat1, but rather inhibited the activation of stat3 and bcl-xl by connecting jnk1/2 to stat3, followed by the augmented apoptosis in the cells. |
2017-07-18 |
2023-08-13 |
human |
| Zhiwei Zhou, Xijian Lu, Jin Wang, Jia Xiao, Jing Liu, Feiyue Xin. microRNA let-7c is essential for the anisomycin-elicited apoptosis in Jurkat T cells by linking JNK1/2 to AP-1/STAT1/STAT3 signaling. Scientific reports. vol 6. 2017-07-18. PMID:27087117. |
the let-7c deficiency reduced the ap-1, stat1 and bim activities, and enhanced the stat3 and bcl-xl, alleviating the anisomycin-induced apoptosis. |
2017-07-18 |
2023-08-13 |
human |
| Lou Zhong, Siyuan Sun, Jiahai Shi, Fei Cao, Xiao Han, Zhong Che. MicroRNA-125a-5p plays a role as a tumor suppressor in lung carcinoma cells by directly targeting STAT3. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 39. issue 6. 2017-07-18. PMID:28631574. |
taken together, mir-125a-5p inhibited the proliferation and invasion of lung cancer cells and facilitated lung cancer cell apoptosis through suppressing stat3. |
2017-07-18 |
2023-08-13 |
human |
| Hiroe Nakamura, Ayumi Taguchi, Kei Kawana, Akira Kawata, Mitsuyo Yoshida, Asaha Fujimoto, Juri Ogishima, Masakazu Sato, Tomoko Inoue, Haruka Nishida, Hitomi Furuya, Kensuke Tomio, Satoko Eguchi, Mayuyo Mori-Uchino, Aki Yamashita, Katsuyuki Adachi, Takahide Arimoto, Osamu Wada-Hiraike, Katsutoshi Oda, Takeshi Nagamatsu, Yutaka Osuga, Tomoyuki Fuji. STAT3 activity regulates sensitivity to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in cervical cancer cells. International journal of oncology. vol 49. issue 5. 2017-07-13. PMID:27599897. |
stat3 activity regulates sensitivity to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in cervical cancer cells. |
2017-07-13 |
2023-08-13 |
human |
| Hiroe Nakamura, Ayumi Taguchi, Kei Kawana, Akira Kawata, Mitsuyo Yoshida, Asaha Fujimoto, Juri Ogishima, Masakazu Sato, Tomoko Inoue, Haruka Nishida, Hitomi Furuya, Kensuke Tomio, Satoko Eguchi, Mayuyo Mori-Uchino, Aki Yamashita, Katsuyuki Adachi, Takahide Arimoto, Osamu Wada-Hiraike, Katsutoshi Oda, Takeshi Nagamatsu, Yutaka Osuga, Tomoyuki Fuji. STAT3 activity regulates sensitivity to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in cervical cancer cells. International journal of oncology. vol 49. issue 5. 2017-07-13. PMID:27599897. |
signal transducer and activator of transcription 3 (stat3) is a hub molecule that shifts the cellular fate to apoptosis or survival in response to cellular stresses. |
2017-07-13 |
2023-08-13 |
human |
| Hiroe Nakamura, Ayumi Taguchi, Kei Kawana, Akira Kawata, Mitsuyo Yoshida, Asaha Fujimoto, Juri Ogishima, Masakazu Sato, Tomoko Inoue, Haruka Nishida, Hitomi Furuya, Kensuke Tomio, Satoko Eguchi, Mayuyo Mori-Uchino, Aki Yamashita, Katsuyuki Adachi, Takahide Arimoto, Osamu Wada-Hiraike, Katsutoshi Oda, Takeshi Nagamatsu, Yutaka Osuga, Tomoyuki Fuji. STAT3 activity regulates sensitivity to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in cervical cancer cells. International journal of oncology. vol 49. issue 5. 2017-07-13. PMID:27599897. |
however, the contribution of stat3 activity to trail-induced apoptosis in cervical cancer remains unknown. |
2017-07-13 |
2023-08-13 |
human |
| Hiroe Nakamura, Ayumi Taguchi, Kei Kawana, Akira Kawata, Mitsuyo Yoshida, Asaha Fujimoto, Juri Ogishima, Masakazu Sato, Tomoko Inoue, Haruka Nishida, Hitomi Furuya, Kensuke Tomio, Satoko Eguchi, Mayuyo Mori-Uchino, Aki Yamashita, Katsuyuki Adachi, Takahide Arimoto, Osamu Wada-Hiraike, Katsutoshi Oda, Takeshi Nagamatsu, Yutaka Osuga, Tomoyuki Fuji. STAT3 activity regulates sensitivity to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in cervical cancer cells. International journal of oncology. vol 49. issue 5. 2017-07-13. PMID:27599897. |
we then inhibited stat3 expression in the siha cell line using sirna against stat3 and suppressed stat3 activity using a stat3 inhibitor; both these treatments sensitized trail-induced apoptosis in the siha cell line. |
2017-07-13 |
2023-08-13 |
human |
| Hiroe Nakamura, Ayumi Taguchi, Kei Kawana, Akira Kawata, Mitsuyo Yoshida, Asaha Fujimoto, Juri Ogishima, Masakazu Sato, Tomoko Inoue, Haruka Nishida, Hitomi Furuya, Kensuke Tomio, Satoko Eguchi, Mayuyo Mori-Uchino, Aki Yamashita, Katsuyuki Adachi, Takahide Arimoto, Osamu Wada-Hiraike, Katsutoshi Oda, Takeshi Nagamatsu, Yutaka Osuga, Tomoyuki Fuji. STAT3 activity regulates sensitivity to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in cervical cancer cells. International journal of oncology. vol 49. issue 5. 2017-07-13. PMID:27599897. |
accompanied by stat3 inactivation, tm pretreatment significantly enhanced trail-induced apoptosis. |
2017-07-13 |
2023-08-13 |
human |
| Hiroe Nakamura, Ayumi Taguchi, Kei Kawana, Akira Kawata, Mitsuyo Yoshida, Asaha Fujimoto, Juri Ogishima, Masakazu Sato, Tomoko Inoue, Haruka Nishida, Hitomi Furuya, Kensuke Tomio, Satoko Eguchi, Mayuyo Mori-Uchino, Aki Yamashita, Katsuyuki Adachi, Takahide Arimoto, Osamu Wada-Hiraike, Katsutoshi Oda, Takeshi Nagamatsu, Yutaka Osuga, Tomoyuki Fuji. STAT3 activity regulates sensitivity to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in cervical cancer cells. International journal of oncology. vol 49. issue 5. 2017-07-13. PMID:27599897. |
we therefore concluded that trail-induced apoptosis was regulated by stat3 in response to trail stimulation. |
2017-07-13 |
2023-08-13 |
human |
| Uri Rozovski, David M Harris, Ping Li, Zhiming Liu, Ji Yuan Wu, Srdana Grgurevic, Stefan Faderl, Alessandra Ferrajoli, William G Wierda, Matthew Martinez, Srdan Verstovsek, Michael J Keating, Zeev Estro. At High Levels, Constitutively Activated STAT3 Induces Apoptosis of Chronic Lymphocytic Leukemia Cells. Journal of immunology (Baltimore, Md. : 1950). vol 196. issue 10. 2017-06-30. PMID:27076684. |
at high levels, constitutively activated stat3 induces apoptosis of chronic lymphocytic leukemia cells. |
2017-06-30 |
2023-08-13 |
Not clear |
| Uri Rozovski, David M Harris, Ping Li, Zhiming Liu, Ji Yuan Wu, Srdana Grgurevic, Stefan Faderl, Alessandra Ferrajoli, William G Wierda, Matthew Martinez, Srdan Verstovsek, Michael J Keating, Zeev Estro. At High Levels, Constitutively Activated STAT3 Induces Apoptosis of Chronic Lymphocytic Leukemia Cells. Journal of immunology (Baltimore, Md. : 1950). vol 196. issue 10. 2017-06-30. PMID:27076684. |
although we previously found that stat3 protects cll cells from apoptosis, stat3 levels were significantly higher in cells from patients with high counts than in cells from patients with low counts. |
2017-06-30 |
2023-08-13 |
Not clear |
| Uri Rozovski, David M Harris, Ping Li, Zhiming Liu, Ji Yuan Wu, Srdana Grgurevic, Stefan Faderl, Alessandra Ferrajoli, William G Wierda, Matthew Martinez, Srdan Verstovsek, Michael J Keating, Zeev Estro. At High Levels, Constitutively Activated STAT3 Induces Apoptosis of Chronic Lymphocytic Leukemia Cells. Journal of immunology (Baltimore, Md. : 1950). vol 196. issue 10. 2017-06-30. PMID:27076684. |
using chromatin immunoprecipitation and emsa, we found that stat3 binds with low affinity to the caspase-3 promoter, suggesting that at high levels, stat3 activates proapoptotic mechanisms and induces apoptosis in cll cells. |
2017-06-30 |
2023-08-13 |
Not clear |
| Xiaolong Zhang, Xiaoyi Wu, Fangling Zhang, Shouyong Mo, Yuanyuan Lu, Wei Wei, Xiaoling Chen, Linhua Lan, Bin Lu, Yongzhang Li. Paclitaxel induces apoptosis of esophageal squamous cell carcinoma cells by downregulating STAT3 phosphorylation at Ser727. Oncology reports. vol 37. issue 4. 2017-06-29. PMID:28350087. |
paclitaxel induces apoptosis of esophageal squamous cell carcinoma cells by downregulating stat3 phosphorylation at ser727. |
2017-06-29 |
2023-08-13 |
human |