| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mei Tan, Ying Rong, Qiong Su, Yan Che. Artesunate induces apoptosis via inhibition of STAT3 in THP-1 cells. Leukemia research. vol 62. 2017-11-16. PMID:29031126. |
artesunate induces apoptosis via inhibition of stat3 in thp-1 cells. |
2017-11-16 |
2023-08-13 |
Not clear |
| Renata Feuerborn, Susen Becker, Francesco Potì, Petra Nagel, Martin Brodde, Harmut Schmidt, Christina Christoffersen, Uta Ceglarek, Ralph Burkhardt, Jerzy-Roch Nofe. High density lipoprotein (HDL)-associated sphingosine 1-phosphate (S1P) inhibits macrophage apoptosis by stimulating STAT3 activity and survivin expression. Atherosclerosis. vol 257. 2017-11-01. PMID:28038379. |
high density lipoprotein (hdl)-associated sphingosine 1-phosphate (s1p) inhibits macrophage apoptosis by stimulating stat3 activity and survivin expression. |
2017-11-01 |
2023-08-13 |
Not clear |
| Xing Bao, Tingting Ren, Yi Huang, Kunkun Sun, Shidong Wang, Kuisheng Liu, Bingxin Zheng, Wei Gu. Knockdown of long non-coding RNA HOTAIR increases miR-454-3p by targeting Stat3 and Atg12 to inhibit chondrosarcoma growth. Cell death & disease. vol 8. issue 2. 2017-10-31. PMID:28182000. |
further analysis revealed that stat3 and atg12 are targets of mir-454-3p, initiate hotair deficiency-induced apoptosis and reduce autophagy. |
2017-10-31 |
2023-08-13 |
human |
| Shiyu Song, Zhonglan Su, Hui Xu, Mengyuan Niu, Xiufang Chen, Haiyan Min, Bin Zhang, Guibo Sun, Sijing Xie, Hongwei Wang, Qian Ga. Luteolin selectively kills STAT3 highly activated gastric cancer cells through enhancing the binding of STAT3 to SHP-1. Cell death & disease. vol 8. issue 2. 2017-10-31. PMID:28182003. |
silencing of shp-1, a protein tyrosine phosphatase, abolished the inhibitory effect of luteolin on stat3 and cell apoptosis, suggesting that shp-1 is crucial in luteolin-mediated cellular function. |
2017-10-31 |
2023-08-13 |
mouse |
| Chun-Yu Liu, Jung-Chen Su, Tzu-Ting Huang, Pei-Yi Chu, Chun-Teng Huang, Wan-Lun Wang, Chia-Han Lee, Ka-Yi Lau, Wen-Chun Tsai, Hsiu-Ping Yang, Chung-Wai Shiau, Ling-Ming Tseng, Kuen-Feng Che. Sorafenib analogue SC-60 induces apoptosis through the SHP-1/STAT3 pathway and enhances docetaxel cytotoxicity in triple-negative breast cancer cells. Molecular oncology. vol 11. issue 3. 2017-10-23. PMID:28084011. |
sc-60 inhibited proliferation and induced apoptosis by dephosphorylating stat3 in both a dose- and time-dependent manner in tnbc cells (mda-mb-231, mda-mb-468, and hcc1937). |
2017-10-23 |
2023-08-13 |
Not clear |
| Chen Feng, Yiqun Xia, Peng Zou, Miaoshan Shen, Jie Hu, Shilong Ying, Jialing Pan, Zhiguo Liu, Xuanxuan Dai, Weishan Zhuge, Guang Liang, Yeping Rua. Curcumin analog L48H37 induces apoptosis through ROS-mediated endoplasmic reticulum stress and STAT3 pathways in human lung cancer cells. Molecular carcinogenesis. vol 56. issue 7. 2017-10-11. PMID:28218464. |
curcumin analog l48h37 induces apoptosis through ros-mediated endoplasmic reticulum stress and stat3 pathways in human lung cancer cells. |
2017-10-11 |
2023-08-13 |
mouse |
| Kristin Bixel, Uksha Saini, Hemant Kumar Bid, John Fowler, Maria Riley, Ross Wanner, Kalpana Deepa Priya Dorayappan, Sneha Rajendran, Ikuo Konishi, Noriomi Matsumura, David E Cohn, Karuppaiyah Selvendira. Targeting STAT3 by HO3867 induces apoptosis in ovarian clear cell carcinoma. International journal of cancer. vol 141. issue 9. 2017-10-09. PMID:28646535. |
targeting stat3 by ho3867 induces apoptosis in ovarian clear cell carcinoma. |
2017-10-09 |
2023-08-13 |
human |
| Yuki Uchihara, Fumihito Ueda, Kenji Tago, Yosuke Nakazawa, Tomoyuki Ohe, Tadahiko Mashino, Shigenobu Yokota, Tadashi Kasahara, Hiroomi Tamura, Megumi Funakoshi-Tag. Alpha-tocopherol attenuates the anti-tumor activity of crizotinib against cells transformed by NPM-ALK. PloS one. vol 12. issue 8. 2017-10-09. PMID:28806414. |
the alk inhibitor, crizotinib specifically induced apoptosis in ba/f3 cells expressing npm-alk by inhibiting the activation of npm-alk and its downstream molecule, signal transducer and activator of transcription factor 3 (stat3). |
2017-10-09 |
2023-08-13 |
Not clear |
| Yinli Yang, Bingqing Zheng, Qiuju Han, Cai Zhang, Zhigang Tian, Jian Zhan. Targeting blockage of STAT3 inhibits hepatitis B virus-related hepatocellular carcinoma. Cancer biology & therapy. vol 17. issue 4. 2017-09-27. PMID:26934469. |
the results showed that blocking stat3 signaling by shrnas could promote hbv positive hcc cell apoptosis and induce cell cycle arrest, resulting in hcc cell growth inhibition in vitro. |
2017-09-27 |
2023-08-13 |
mouse |
| Nicole M Jackson, Brian P Ceres. EGFR-mediated apoptosis via STAT3. Experimental cell research. vol 356. issue 1. 2017-09-26. PMID:28433699. |
egfr-mediated apoptosis via stat3. |
2017-09-26 |
2023-08-13 |
Not clear |
| Nicole M Jackson, Brian P Ceres. EGFR-mediated apoptosis via STAT3. Experimental cell research. vol 356. issue 1. 2017-09-26. PMID:28433699. |
the effector assessment revealed stat3 as a potential mediator of egf-induced apoptosis. |
2017-09-26 |
2023-08-13 |
Not clear |
| Nicole M Jackson, Brian P Ceres. EGFR-mediated apoptosis via STAT3. Experimental cell research. vol 356. issue 1. 2017-09-26. PMID:28433699. |
our findings support stat3 as a positive mediator of egf-induced apoptosis in mda-mb-468 cells. |
2017-09-26 |
2023-08-13 |
Not clear |
| Dan Shao, Jie Ma, Chao Zhou, Jia-Nan Zhao, Lu-Lu Li, Tong-Jian Zhao, Xi-Lei Ai, Ping Jia. STAT3 down-regulation induces mitochondria-dependent G2/M cell cycle arrest and apoptosis in oesophageal carcinoma cells. Clinical and experimental pharmacology & physiology. vol 44. issue 3. 2017-09-21. PMID:27896845. |
stat3 down-regulation induces mitochondria-dependent g2/m cell cycle arrest and apoptosis in oesophageal carcinoma cells. |
2017-09-21 |
2023-08-13 |
human |
| Dan Shao, Jie Ma, Chao Zhou, Jia-Nan Zhao, Lu-Lu Li, Tong-Jian Zhao, Xi-Lei Ai, Ping Jia. STAT3 down-regulation induces mitochondria-dependent G2/M cell cycle arrest and apoptosis in oesophageal carcinoma cells. Clinical and experimental pharmacology & physiology. vol 44. issue 3. 2017-09-21. PMID:27896845. |
to explore stat3 down-regulation in human oesophageal cancer cells, cell proliferation, apoptosis and mitochondrial mechanisms were explored in oesophageal carcinoma te1 cell cultures. |
2017-09-21 |
2023-08-13 |
human |
| Dan Shao, Jie Ma, Chao Zhou, Jia-Nan Zhao, Lu-Lu Li, Tong-Jian Zhao, Xi-Lei Ai, Ping Jia. STAT3 down-regulation induces mitochondria-dependent G2/M cell cycle arrest and apoptosis in oesophageal carcinoma cells. Clinical and experimental pharmacology & physiology. vol 44. issue 3. 2017-09-21. PMID:27896845. |
we demonstrate for the first time that stat3 down-regulation by rnai is sufficient to inhibit oesophageal cancer cell proliferation inducing cell apoptosis. |
2017-09-21 |
2023-08-13 |
human |
| Dan Shao, Jie Ma, Chao Zhou, Jia-Nan Zhao, Lu-Lu Li, Tong-Jian Zhao, Xi-Lei Ai, Ping Jia. STAT3 down-regulation induces mitochondria-dependent G2/M cell cycle arrest and apoptosis in oesophageal carcinoma cells. Clinical and experimental pharmacology & physiology. vol 44. issue 3. 2017-09-21. PMID:27896845. |
thus, our results suggest that stat3 inhibition is a valid approach to induce oesophageal carcinoma cell mitochondrial-dependent apoptosis in therapeutic strategies against oesophageal cancers. |
2017-09-21 |
2023-08-13 |
human |
| Zhu Zhang, Bin Zhou, Kui Zhang, Yaping Song, Lin Zhang, Mingrong X. IL-27 suppresses SKOV3 cells proliferation by enhancing STAT3 and inhibiting the Akt signal pathway. Molecular immunology. vol 78. 2017-09-15. PMID:27639718. |
our data show that il-27 has direct antitumor capacity in ovarian cancer cells via enhancing apoptosis by inducing the stat3 pathway and restraining the akt pathway. |
2017-09-15 |
2023-08-13 |
Not clear |
| Sachin K Deshmukh, Sanjeev K Srivastava, Haseeb Zubair, Arun Bhardwaj, Nikhil Tyagi, Ahmed Al-Ghadhban, Ajay P Singh, Donna L Dyess, James E Carter, Seema Sing. Resistin potentiates chemoresistance and stemness of breast cancer cells: Implications for racially disparate therapeutic outcomes. Cancer letters. vol 396. 2017-09-14. PMID:28302531. |
mechanistic studies revealed that resistin-induced chemoresistance, apoptosis and stemness of bc cells were mediated through stat3 activation. |
2017-09-14 |
2023-08-13 |
Not clear |
| Y Pan, S Wang, B Su, F Zhou, R Zhang, T Xu, R Zhang, V Leventaki, E Drakos, W Liu, F X Clare. Stat3 contributes to cancer progression by regulating Jab1/Csn5 expression. Oncogene. vol 36. issue 8. 2017-09-13. PMID:27524414. |
consistently, silencing of stat3 in tumors reduced jab1/csn5 expression, thereby sensitizing npc cells to cisplatin-induced apoptosis both in vitro and in vivo. |
2017-09-13 |
2023-08-13 |
Not clear |
| Andrey V Markov, Marina A Zenkova, Evgeniya B Logashenk. Modulation of Tumour-Related Signaling Pathways by Natural Pentacyclic Triterpenoids and their Semisynthetic Derivatives. Current medicinal chemistry. vol 24. issue 13. 2017-09-08. PMID:28078994. |
among the most relevant mechanisms involved are cell cycle arrest, apoptosis and autophagy triggered by the effect of triterpenoids on tgf-β and her cell surface receptors and the downstream pi3kakt- mtor and ikk/nf-kb signaling axis, stat3 pathway and mapk cascades. |
2017-09-08 |
2023-08-13 |
Not clear |