| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ke-Yan Cheng, Min Ha. Mammalian Target of Rapamycin (mTOR) Regulates Transforming Growth Factor-β1 (TGF-β1)-Induced Epithelial-Mesenchymal Transition via Decreased Pyruvate Kinase M2 (PKM2) Expression in Cervical Cancer Cells. Medical science monitor : international medical journal of experimental and clinical research. vol 23. 2018-03-22. PMID:28446743. |
cell migration was detected by wound-healing assay; apoptosis was analyzed by flow cytometry; mtor inhibitors inhibited mtor pathway to assess the expression of e-cadherin, vimentin stat3, snail2, p-p70s6k, and pkm2 expression. |
2018-03-22 |
2023-08-13 |
Not clear |
| Jing Li, Jia Li, Guowei Cai, Lin Shen, Furong L. Proapoptotic and Growth-inhibitory Effects of Plumbagin on Human Gastric Cancer Cells Via Suppression of Signal Transducer and Activator of Transcription 3 and Protein Kinase B. Alternative therapies in health and medicine. vol 23. issue 5. 2018-03-21. PMID:28236621. |
conclusions • plumbagin inhibits cell apoptosis in human gc cells, and that effect may be related with its ability to suppress phosphorylation of stat3 and akt. |
2018-03-21 |
2023-08-13 |
human |
| Hui-Long Wen, Guang Yang, Qi-Rong Don. Ellipticine inhibits the proliferation and induces apoptosis in rheumatoid arthritis fibroblast-like synoviocytes via the STAT3 pathway. Immunopharmacology and immunotoxicology. vol 39. issue 4. 2018-03-21. PMID:28555524. |
ellipticine inhibits the proliferation and induces apoptosis in rheumatoid arthritis fibroblast-like synoviocytes via the stat3 pathway. |
2018-03-21 |
2023-08-13 |
Not clear |
| Mengjie Wang, Bi Meng, Yangchen Liu, Jingwen Yu, Qiaoyun Chen, Yangchen Li. MiR-124 Inhibits Growth and Enhances Radiation-Induced Apoptosis in Non-Small Cell Lung Cancer by Inhibiting STAT3. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 44. issue 5. 2018-03-14. PMID:29237164. |
mir-124 inhibits growth and enhances radiation-induced apoptosis in non-small cell lung cancer by inhibiting stat3. |
2018-03-14 |
2023-08-13 |
Not clear |
| Chulwon Kim, Il Ho Lee, Ho Bong Hyun, Jong-Chan Kim, Rajendra Gyawali, Seok-Geun Lee, Junhee Lee, Sung-Hoon Kim, Bum Sang Shim, Somi K Cho, Kwang Seok Ah. Supercritical Fluid Extraction of Citrus iyo Hort. ex Tanaka Pericarp Inhibits Growth and Induces Apoptosis Through Abrogation of STAT3 Regulated Gene Products in Human Prostate Cancer Xenograft Mouse Model. Integrative cancer therapies. vol 16. issue 2. 2018-03-06. PMID:27185319. |
ex tanaka pericarp inhibits growth and induces apoptosis through abrogation of stat3 regulated gene products in human prostate cancer xenograft mouse model. |
2018-03-06 |
2023-08-13 |
mouse |
| Chulwon Kim, Il Ho Lee, Ho Bong Hyun, Jong-Chan Kim, Rajendra Gyawali, Seok-Geun Lee, Junhee Lee, Sung-Hoon Kim, Bum Sang Shim, Somi K Cho, Kwang Seok Ah. Supercritical Fluid Extraction of Citrus iyo Hort. ex Tanaka Pericarp Inhibits Growth and Induces Apoptosis Through Abrogation of STAT3 Regulated Gene Products in Human Prostate Cancer Xenograft Mouse Model. Integrative cancer therapies. vol 16. issue 2. 2018-03-06. PMID:27185319. |
the effect of supercritical extracts of yeagam peel (seyg) on stat3 activation, associated protein kinases, stat3-regulated gene products, cellular proliferation, and apoptosis was examined. |
2018-03-06 |
2023-08-13 |
mouse |
| Yao Yao, Yueyue Sun, Min Shi, Dandan Xia, Kai Zhao, Lingyu Zeng, Ruosi Yao, Ying Zhang, Zhenyu Li, Mingshan Niu, Kailin X. Piperlongumine induces apoptosis and reduces bortezomib resistance by inhibiting STAT3 in multiple myeloma cells. Oncotarget. vol 7. issue 45. 2018-03-05. PMID:27634873. |
piperlongumine induces apoptosis and reduces bortezomib resistance by inhibiting stat3 in multiple myeloma cells. |
2018-03-05 |
2023-08-13 |
mouse |
| Teresa L Ramos, Luis Ignacio Sánchez-Abarca, Alba Redondo, Ángel Hernández-Hernández, Antonio M Almeida, Noemí Puig, Concepción Rodríguez, Rebeca Ortega, Silvia Preciado, Ana Rico, Sandra Muntión, José Ramón González Porras, Consuelo Del Cañizo, Fermín Sánchez-Guij. HDAC8 overexpression in mesenchymal stromal cells from JAK2+ myeloproliferative neoplasms: a new therapeutic target? Oncotarget. vol 8. issue 17. 2018-03-05. PMID:28390197. |
mechanistic studies using different mpn cell lines revealed that pci34051 induced their apoptosis, which is enhanced when were co-cultured with jak2v617f-msc, decreased their colony formation and the phosphorylation of stat3 and stat5. |
2018-03-05 |
2023-08-13 |
Not clear |
| Song Xue, Shu Xiao-Hong, Sha Lin, Bian Jie, Wang Li-Li, Gu Jia-Yao, Shi Shun, Li Pei-Nan, Wu Mo-Li, Wang Qian, Chen Xiao-Yan, Kong Qing-You, Zhang Peng, Li Hong, Liu Ji. Lumbar puncture-administered resveratrol inhibits STAT3 activation, enhancing autophagy and apoptosis in orthotopic rat glioblastomas. Oncotarget. vol 7. issue 46. 2018-02-26. PMID:27716625. |
lumbar puncture-administered resveratrol inhibits stat3 activation, enhancing autophagy and apoptosis in orthotopic rat glioblastomas. |
2018-02-26 |
2023-08-13 |
rat |
| Song Xue, Shu Xiao-Hong, Sha Lin, Bian Jie, Wang Li-Li, Gu Jia-Yao, Shi Shun, Li Pei-Nan, Wu Mo-Li, Wang Qian, Chen Xiao-Yan, Kong Qing-You, Zhang Peng, Li Hong, Liu Ji. Lumbar puncture-administered resveratrol inhibits STAT3 activation, enhancing autophagy and apoptosis in orthotopic rat glioblastomas. Oncotarget. vol 7. issue 46. 2018-02-26. PMID:27716625. |
intracranial drug availabilities, tumor sizes, average life spans and the impacts on stat3 signaling, apoptosis and autophagy rates were evaluated. |
2018-02-26 |
2023-08-13 |
rat |
| Song Xue, Shu Xiao-Hong, Sha Lin, Bian Jie, Wang Li-Li, Gu Jia-Yao, Shi Shun, Li Pei-Nan, Wu Mo-Li, Wang Qian, Chen Xiao-Yan, Kong Qing-You, Zhang Peng, Li Hong, Liu Ji. Lumbar puncture-administered resveratrol inhibits STAT3 activation, enhancing autophagy and apoptosis in orthotopic rat glioblastomas. Oncotarget. vol 7. issue 46. 2018-02-26. PMID:27716625. |
in conclusion, lp-delivered resveratrol efficiently inhibited orthotopic rat glioblastoma growth by inactivating stat3 signaling and enhancing autophagy and apoptosis. |
2018-02-26 |
2023-08-13 |
rat |
| Ying Tan, Ning Huang, Xiang Zhang, Jiangang Hu, Si Cheng, Li Pi, Yuan Chen. KIAA0247 suppresses the proliferation, angiogenesis and promote apoptosis of human glioma through inactivation of the AKT and Stat3 signaling pathway. Oncotarget. vol 7. issue 52. 2018-02-22. PMID:27893430. |
kiaa0247 suppresses the proliferation, angiogenesis and promote apoptosis of human glioma through inactivation of the akt and stat3 signaling pathway. |
2018-02-22 |
2023-08-13 |
human |
| Sajita Shah, Chaemin Lee, Hyukjae Choi, Jaya Gautam, Hyeonjin Jang, Geum Jin Kim, Yu-Jeong Lee, Chhabi Lal Chaudhary, Sang Won Park, Tae-Gyu Nam, Jung-Ae Kim, Byeong-Seon Jeon. 5-Hydroxy-7-azaindolin-2-one, a novel hybrid of pyridinol and sunitinib: design, synthesis and cytotoxicity against cancer cells. Organic & biomolecular chemistry. vol 14. issue 21. 2018-02-12. PMID:27145715. |
signaling pathway-associated transcription factor reporter assay and western blot analyses revealed that apoptosis induction in mda-mb-231 human breast cancer cells by 6f is mainly mediated through the p53 increase and down-regulation of phospho-signal transducer and activator of transcription 3 (stat3) and its target gene products, cyclin d, bcl-2, and survivin. |
2018-02-12 |
2023-08-13 |
human |
| Anup Jose, Suman Labala, Venkata Vamsi Krishna Venugant. Co-delivery of curcumin and STAT3 siRNA using deformable cationic liposomes to treat skin cancer. Journal of drug targeting. vol 25. issue 4. 2018-02-06. PMID:27819148. |
the co-delivery of curcumin and stat3 sirna using liposomes resulted in significantly (p < .05) greater cancer cell growth inhibition and apoptosis events compared with neat curcumin and free stat3 sirna treatment. |
2018-02-06 |
2023-08-13 |
human |
| Su Yao, Fangping Xu, Yu Chen, Yan Ge, Fen Zhang, Huijie Huang, Li Li, Danyi Lin, Xinlan Luo, Jie Xu, Donglan Luo, Xiaolan Zhu, Yanhui Li. Fbw7 regulates apoptosis in activated B-cell like diffuse large B-cell lymphoma by targeting Stat3 for ubiquitylation and degradation. Journal of experimental & clinical cancer research : CR. vol 36. issue 1. 2018-02-05. PMID:28069035. |
fbw7 regulates apoptosis in activated b-cell like diffuse large b-cell lymphoma by targeting stat3 for ubiquitylation and degradation. |
2018-02-05 |
2023-08-13 |
Not clear |
| Xiao-Ping Wang, Qiao-Xia Wang, Huan-Ping Lin, Na Chan. Anti-tumor bioactivities of curcumin on mice loaded with gastric carcinoma. Food & function. vol 8. issue 9. 2018-01-24. PMID:28848967. |
our results indicate that curcumin inhibits the proliferation of gastric carcinoma by inducing the apoptosis of tumor cells, activating immune cells to secrete a large amount of cytokines, and down-regulating the dec1, hif-1α, vegf and stat3 signal transduction pathways. |
2018-01-24 |
2023-08-13 |
mouse |
| b' Iva Poto\\xc4\\x8dnjak, Dalibor Brozni\\xc4\\x87, Marija Kindl, Matija Kropek, Sanda Vladimir-Kne\\xc5\\xbeevi\\xc4\\x87, Robert Domitrovi\\xc4\\x8. Stevia and stevioside protect against cisplatin nephrotoxicity through inhibition of ERK1/2, STAT3, and NF-\\xce\\xbaB activation. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 107. issue Pt A. 2018-01-23. PMID:28666887.' |
both se and stevioside attenuated cp nephrotoxicity by suppressing oxidative stress, inflammation, and apoptosis through mechanism involving erk1/2, stat3, and nf-κb suppression. |
2018-01-23 |
2023-08-13 |
mouse |
| Shuhui Guo, Weiwei Luo, Lijuan Liu, Xiaocong Pang, Hong Zhu, Ailin Liu, Jinjian Lu, Dik-Lung Ma, Chung-Hang Leung, Yitao Wang, Xiuping Che. Isocryptotanshinone, a STAT3 inhibitor, induces apoptosis and pro-death autophagy in A549 lung cancer cells. Journal of drug targeting. vol 24. issue 10. 2018-01-12. PMID:26904961. |
isocryptotanshinone, a stat3 inhibitor, induces apoptosis and pro-death autophagy in a549 lung cancer cells. |
2018-01-12 |
2023-08-13 |
Not clear |
| Jianshuang Li, Di Lu, Huadie Liu, Bart O Williams, Paul A Overbeek, Brendan Lee, Ling Zheng, Tao Yan. Sclt1 deficiency causes cystic kidney by activating ERK and STAT3 signaling. Human molecular genetics. vol 26. issue 15. 2018-01-08. PMID:28486600. |
sclt1-loss decreases the number of cilia in kidney; increases proliferation and apoptosis of renal tubule epithelial cells; elevates protein kinase a, extracellular signal-regulated kinases, smad and signal transducer and activator of transcription 3 (stat3) pathways; and enhances pro-inflammation and pro-fibrosis pathways with disease progression. |
2018-01-08 |
2023-08-13 |
mouse |
| Nadezda Dolgikh, Simone Fuld. Rhabdomyosarcoma cells are susceptible to cell death by LDK378 alone or in combination with sorafenib independently of anaplastic lymphoma kinase status. Anti-cancer drugs. vol 28. issue 10. 2018-01-03. PMID:29045271. |
before the onset of apoptosis, ldk378 reduces phosphorylation of akt, s6 ribosomal protein, stat3 and - to a lesser extent - phosphorylation of erk, showing that it suppresses key survival pathways. |
2018-01-03 |
2023-08-13 |
Not clear |