| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chun-Yu Liu, Tzu-Ting Huang, Pei-Yi Chu, Chun-Teng Huang, Chia-Han Lee, Wan-Lun Wang, Ka-Yi Lau, Wen-Chun Tsai, Tzu-I Chao, Jung-Chen Su, Ming-Huang Chen, Chung-Wai Shiau, Ling-Ming Tseng, Kuen-Feng Che. The tyrosine kinase inhibitor nintedanib activates SHP-1 and induces apoptosis in triple-negative breast cancer cells. Experimental & molecular medicine. vol 49. issue 8. 2018-05-31. PMID:28798401. |
stat3 overexpression suppressed nintedanib-mediated apoptosis and further increased the activity of purified shp-1 protein. |
2018-05-31 |
2023-08-13 |
Not clear |
| Chun-Yu Liu, Tzu-Ting Huang, Pei-Yi Chu, Chun-Teng Huang, Chia-Han Lee, Wan-Lun Wang, Ka-Yi Lau, Wen-Chun Tsai, Tzu-I Chao, Jung-Chen Su, Ming-Huang Chen, Chung-Wai Shiau, Ling-Ming Tseng, Kuen-Feng Che. The tyrosine kinase inhibitor nintedanib activates SHP-1 and induces apoptosis in triple-negative breast cancer cells. Experimental & molecular medicine. vol 49. issue 8. 2018-05-31. PMID:28798401. |
our findings revealed that nintedanib induces tnbc apoptosis by acting as a shp-1 agonist, suggesting that targeting stat3 by enhancing shp-1 expression could be a viable therapeutic strategy against tnbc. |
2018-05-31 |
2023-08-13 |
Not clear |
| Jing Yu, Yimei Wu, Lu Wang, Wen Zhang, Man Xu, Jiayu Song, Yu Fu, Yiyun Cui, Wei Gong, Shuzhen Li, Weiwei Xia, Songming Huang, Aihua Zhang, Zhanjun Ji. mPGES-1-derived prostaglandin E2 stimulates Stat3 to promote podocyte apoptosis. Apoptosis : an international journal on programmed cell death. vol 22. issue 11. 2018-05-31. PMID:28879567. |
mpges-1-derived prostaglandin e2 stimulates stat3 to promote podocyte apoptosis. |
2018-05-31 |
2023-08-13 |
Not clear |
| Jing Yu, Yimei Wu, Lu Wang, Wen Zhang, Man Xu, Jiayu Song, Yu Fu, Yiyun Cui, Wei Gong, Shuzhen Li, Weiwei Xia, Songming Huang, Aihua Zhang, Zhanjun Ji. mPGES-1-derived prostaglandin E2 stimulates Stat3 to promote podocyte apoptosis. Apoptosis : an international journal on programmed cell death. vol 22. issue 11. 2018-05-31. PMID:28879567. |
here we studied the role of mpges-1/pge2 cascade in activating stat3 signaling and the contribution of stat3 in pge2- and adr-induced podocyte apoptosis. |
2018-05-31 |
2023-08-13 |
Not clear |
| Jing Yu, Yimei Wu, Lu Wang, Wen Zhang, Man Xu, Jiayu Song, Yu Fu, Yiyun Cui, Wei Gong, Shuzhen Li, Weiwei Xia, Songming Huang, Aihua Zhang, Zhanjun Ji. mPGES-1-derived prostaglandin E2 stimulates Stat3 to promote podocyte apoptosis. Apoptosis : an international journal on programmed cell death. vol 22. issue 11. 2018-05-31. PMID:28879567. |
in murine podocytes, pge2 dose- and time-dependently increased the phosphorylation of stat3 in line with the enhanced cell apoptosis and reduced podocyte protein podocin. |
2018-05-31 |
2023-08-13 |
Not clear |
| Jing Yu, Yimei Wu, Lu Wang, Wen Zhang, Man Xu, Jiayu Song, Yu Fu, Yiyun Cui, Wei Gong, Shuzhen Li, Weiwei Xia, Songming Huang, Aihua Zhang, Zhanjun Ji. mPGES-1-derived prostaglandin E2 stimulates Stat3 to promote podocyte apoptosis. Apoptosis : an international journal on programmed cell death. vol 22. issue 11. 2018-05-31. PMID:28879567. |
by application of a specific stat3 inhibitor s3i-201, pge2-induced podocyte apoptosis was largely abolished in parallel with a blockade of podocin reduction. |
2018-05-31 |
2023-08-13 |
Not clear |
| Jing Yu, Yimei Wu, Lu Wang, Wen Zhang, Man Xu, Jiayu Song, Yu Fu, Yiyun Cui, Wei Gong, Shuzhen Li, Weiwei Xia, Songming Huang, Aihua Zhang, Zhanjun Ji. mPGES-1-derived prostaglandin E2 stimulates Stat3 to promote podocyte apoptosis. Apoptosis : an international journal on programmed cell death. vol 22. issue 11. 2018-05-31. PMID:28879567. |
blockade of stat3 by s3i-201 significantly ameliorated adr-induced cell apoptosis and podocin reduction. |
2018-05-31 |
2023-08-13 |
Not clear |
| Jing Yu, Yimei Wu, Lu Wang, Wen Zhang, Man Xu, Jiayu Song, Yu Fu, Yiyun Cui, Wei Gong, Shuzhen Li, Weiwei Xia, Songming Huang, Aihua Zhang, Zhanjun Ji. mPGES-1-derived prostaglandin E2 stimulates Stat3 to promote podocyte apoptosis. Apoptosis : an international journal on programmed cell death. vol 22. issue 11. 2018-05-31. PMID:28879567. |
taken together, this study suggested that mpges-1-derived pge2 could activate stat3 signaling to promote podocyte apoptosis. |
2018-05-31 |
2023-08-13 |
Not clear |
| Kai Li, Han Bao, Panying Zhang, Li Che. Inhibitory Effect of AG490 on STAT3 Signal Transduction Pathway in Nasopharyngeal Carcinoma Cells. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP. vol 27. issue 11. 2018-05-28. PMID:29132481. |
to determine the effect of jak kinase inhibitor ag490 on proliferation and apoptosis of nasopharyngeal carcinoma cell line c666-1 and explore the inhibitory effect of ag490 on stat3 signal transduction pathway. |
2018-05-28 |
2023-08-13 |
Not clear |
| Saisai Wang, Yong Shen, Runfeng Qiu, Zhiliang Chen, Zhehang Chen, Wenbin Che. 18 β-glycyrrhetinic acid exhibits potent antitumor effects against colorectal cancer via inhibition of cell proliferation and migration. International journal of oncology. vol 51. issue 2. 2018-05-25. PMID:28656212. |
these results suggest that regulation of the apoptosis, invasion and migration of colorectal cancer cells by gra might be through suppressing pi3k and stat3 signaling pathways. |
2018-05-25 |
2023-08-13 |
Not clear |
| Kazuhiro Yamamoto, Hiroaki Shichiri, Takahiro Ishida, Kenta Kaku, Tatsuya Nishioka, Manabu Kume, Hiroo Makimoto, Tsutomu Nakagawa, Takeshi Hirano, Toshinori Bito, Chikako Nishigori, Ikuko Yano, Midori Hira. Effects of Ascorbyl-2-phosphate Magnesium on Human Keratinocyte Toxicity and Pathological Changes by Sorafenib. Biological & pharmaceutical bulletin. vol 40. issue 9. 2018-05-24. PMID:28867735. |
moreover, p-vc-mg inhibited the decrease of signal transducer and activator of transcription 3 (stat3) phosphorylation and the expression of apoptosis suppressors treated by sorafenib. |
2018-05-24 |
2023-08-13 |
human |
| Kazuhiro Yamamoto, Hiroaki Shichiri, Takahiro Ishida, Kenta Kaku, Tatsuya Nishioka, Manabu Kume, Hiroo Makimoto, Tsutomu Nakagawa, Takeshi Hirano, Toshinori Bito, Chikako Nishigori, Ikuko Yano, Midori Hira. Effects of Ascorbyl-2-phosphate Magnesium on Human Keratinocyte Toxicity and Pathological Changes by Sorafenib. Biological & pharmaceutical bulletin. vol 40. issue 9. 2018-05-24. PMID:28867735. |
these findings suggest that p-vc-mg attenuates sorafenib-induced apoptosis and pathological changes in human keratinocyte cells and in the 3d skin model mediated by the maintenance of stat3 activity. |
2018-05-24 |
2023-08-13 |
human |
| Jian Wang, Jie Xu, Guoqiang Xin. Lycorine inhibits the growth and metastasis of breast cancer through the blockage of STAT3 signaling pathway. Acta biochimica et biophysica Sinica. vol 49. issue 9. 2018-05-23. PMID:28910973. |
lycorine also downregulated the expressions of stat3 target genes, including mcl-1, bcl-xl, mmp-2, mmp-9, which are involved in apoptosis and invasion of breast cancer. |
2018-05-23 |
2023-08-13 |
mouse |
| Bong Hee Park, Joung Eun Lim, Hwang Gyun Jeon, Seong Il Seo, Hyun Moo Lee, Han Yong Choi, Seong Soo Jeon, Byong Chang Jeon. Curcumin potentiates antitumor activity of cisplatin in bladder cancer cell lines via ROS-mediated activation of ERK1/2. Oncotarget. vol 7. issue 39. 2018-05-22. PMID:27564099. |
unlike 253j-bv cells, t24 cells were co-treated with curcumin and cisplatin revealed an induction of apoptosis through decreased p-signal transducer and activator of transcription 3(stat3) expression. |
2018-05-22 |
2023-08-13 |
Not clear |
| Xiaoni Liu, Jianji Xu, Shuang Wang, Xiaoxiao Yu, Boxin Kou, Mengyin Chai, Yunjin Zang, Dexi Che. Synergistic inhibitory effects on hepatocellular carcinoma with recombinant human adenovirus Aspp2 and oxaliplatin via p53-independent pathway in vitro and in vivo. International journal of oncology. vol 51. issue 4. 2018-05-14. PMID:28902369. |
in conclusion, aspp2-ad, in p53-independent manner, regulated erk and stat3 signal moleculars to inhibit hepatocarcinoma in coordination with oxaliplatin by influencing the protein expression of proliferation, apoptosis, autophagy and vascular growth. |
2018-05-14 |
2023-08-13 |
human |
| JingJing Duan, Wen Yue, JianYu E, Jyoti Malhotra, Shou-En Lu, Jun Gu, Feng Xu, Xiang-Lin Ta. In vitro comparative studies of resveratrol and triacetylresveratrol on cell proliferation, apoptosis, and STAT3 and NFκB signaling in pancreatic cancer cells. Scientific reports. vol 6. 2018-05-09. PMID:27539371. |
in vitro comparative studies of resveratrol and triacetylresveratrol on cell proliferation, apoptosis, and stat3 and nfκb signaling in pancreatic cancer cells. |
2018-05-09 |
2023-08-13 |
mouse |
| JingJing Duan, Wen Yue, JianYu E, Jyoti Malhotra, Shou-En Lu, Jun Gu, Feng Xu, Xiang-Lin Ta. In vitro comparative studies of resveratrol and triacetylresveratrol on cell proliferation, apoptosis, and STAT3 and NFκB signaling in pancreatic cancer cells. Scientific reports. vol 6. 2018-05-09. PMID:27539371. |
we comparatively evaluated their effects on cell proliferation, apoptosis and the molecular changes in stat3, nfκb and apoptotic signaling pathways in pancreatic cancer cells. |
2018-05-09 |
2023-08-13 |
mouse |
| Kenrie P Y Hui, Hung Sing Li, Man Chun Cheung, Renee W Y Chan, Kit M Yuen, Chris K P Mok, John M Nicholls, J S Malik Peiris, Michael C W Cha. Highly pathogenic avian influenza H5N1 virus delays apoptotic responses via activation of STAT3. Scientific reports. vol 6. 2018-05-08. PMID:27344974. |
more importantly, stat3 knock-down increased apoptosis by h5n1 infection suggesting that h5n1 virus delays apoptosis through activation of stat3. |
2018-05-08 |
2023-08-13 |
human |
| Kenrie P Y Hui, Hung Sing Li, Man Chun Cheung, Renee W Y Chan, Kit M Yuen, Chris K P Mok, John M Nicholls, J S Malik Peiris, Michael C W Cha. Highly pathogenic avian influenza H5N1 virus delays apoptotic responses via activation of STAT3. Scientific reports. vol 6. 2018-05-08. PMID:27344974. |
taken together, we demonstrate that stat3 is involved in h5n1-delayed apoptosis compared to h1n1. |
2018-05-08 |
2023-08-13 |
human |
| Kenrie P Y Hui, Hung Sing Li, Man Chun Cheung, Renee W Y Chan, Kit M Yuen, Chris K P Mok, John M Nicholls, J S Malik Peiris, Michael C W Cha. Highly pathogenic avian influenza H5N1 virus delays apoptotic responses via activation of STAT3. Scientific reports. vol 6. 2018-05-08. PMID:27344974. |
since delay in apoptosis prolongs the duration of virus replication and production of pro-inflammatory cytokines and trail from h5n1-infected cells, which contribute to orchestrate cytokine storm and tissue damage, our results suggest that stat3 may play a previously unsuspected role in h5n1 pathogenesis. |
2018-05-08 |
2023-08-13 |
human |