| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Song Xue, Shu Xiao-Hong, Sha Lin, Bian Jie, Wang Li-Li, Gu Jia-Yao, Shi Shun, Li Pei-Nan, Wu Mo-Li, Wang Qian, Chen Xiao-Yan, Kong Qing-You, Zhang Peng, Li Hong, Liu Ji. Lumbar puncture-administered resveratrol inhibits STAT3 activation, enhancing autophagy and apoptosis in orthotopic rat glioblastomas. Oncotarget. vol 7. issue 46. 2018-02-26. PMID:27716625. |
in conclusion, lp-delivered resveratrol efficiently inhibited orthotopic rat glioblastoma growth by inactivating stat3 signaling and enhancing autophagy and apoptosis. |
2018-02-26 |
2023-08-13 |
rat |
| Ying Tan, Ning Huang, Xiang Zhang, Jiangang Hu, Si Cheng, Li Pi, Yuan Chen. KIAA0247 suppresses the proliferation, angiogenesis and promote apoptosis of human glioma through inactivation of the AKT and Stat3 signaling pathway. Oncotarget. vol 7. issue 52. 2018-02-22. PMID:27893430. |
kiaa0247 suppresses the proliferation, angiogenesis and promote apoptosis of human glioma through inactivation of the akt and stat3 signaling pathway. |
2018-02-22 |
2023-08-13 |
human |
| Sajita Shah, Chaemin Lee, Hyukjae Choi, Jaya Gautam, Hyeonjin Jang, Geum Jin Kim, Yu-Jeong Lee, Chhabi Lal Chaudhary, Sang Won Park, Tae-Gyu Nam, Jung-Ae Kim, Byeong-Seon Jeon. 5-Hydroxy-7-azaindolin-2-one, a novel hybrid of pyridinol and sunitinib: design, synthesis and cytotoxicity against cancer cells. Organic & biomolecular chemistry. vol 14. issue 21. 2018-02-12. PMID:27145715. |
signaling pathway-associated transcription factor reporter assay and western blot analyses revealed that apoptosis induction in mda-mb-231 human breast cancer cells by 6f is mainly mediated through the p53 increase and down-regulation of phospho-signal transducer and activator of transcription 3 (stat3) and its target gene products, cyclin d, bcl-2, and survivin. |
2018-02-12 |
2023-08-13 |
human |
| Anup Jose, Suman Labala, Venkata Vamsi Krishna Venugant. Co-delivery of curcumin and STAT3 siRNA using deformable cationic liposomes to treat skin cancer. Journal of drug targeting. vol 25. issue 4. 2018-02-06. PMID:27819148. |
the co-delivery of curcumin and stat3 sirna using liposomes resulted in significantly (p < .05) greater cancer cell growth inhibition and apoptosis events compared with neat curcumin and free stat3 sirna treatment. |
2018-02-06 |
2023-08-13 |
human |
| Su Yao, Fangping Xu, Yu Chen, Yan Ge, Fen Zhang, Huijie Huang, Li Li, Danyi Lin, Xinlan Luo, Jie Xu, Donglan Luo, Xiaolan Zhu, Yanhui Li. Fbw7 regulates apoptosis in activated B-cell like diffuse large B-cell lymphoma by targeting Stat3 for ubiquitylation and degradation. Journal of experimental & clinical cancer research : CR. vol 36. issue 1. 2018-02-05. PMID:28069035. |
fbw7 regulates apoptosis in activated b-cell like diffuse large b-cell lymphoma by targeting stat3 for ubiquitylation and degradation. |
2018-02-05 |
2023-08-13 |
Not clear |
| Xiao-Ping Wang, Qiao-Xia Wang, Huan-Ping Lin, Na Chan. Anti-tumor bioactivities of curcumin on mice loaded with gastric carcinoma. Food & function. vol 8. issue 9. 2018-01-24. PMID:28848967. |
our results indicate that curcumin inhibits the proliferation of gastric carcinoma by inducing the apoptosis of tumor cells, activating immune cells to secrete a large amount of cytokines, and down-regulating the dec1, hif-1α, vegf and stat3 signal transduction pathways. |
2018-01-24 |
2023-08-13 |
mouse |
| b' Iva Poto\\xc4\\x8dnjak, Dalibor Brozni\\xc4\\x87, Marija Kindl, Matija Kropek, Sanda Vladimir-Kne\\xc5\\xbeevi\\xc4\\x87, Robert Domitrovi\\xc4\\x8. Stevia and stevioside protect against cisplatin nephrotoxicity through inhibition of ERK1/2, STAT3, and NF-\\xce\\xbaB activation. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 107. issue Pt A. 2018-01-23. PMID:28666887.' |
both se and stevioside attenuated cp nephrotoxicity by suppressing oxidative stress, inflammation, and apoptosis through mechanism involving erk1/2, stat3, and nf-κb suppression. |
2018-01-23 |
2023-08-13 |
mouse |
| Shuhui Guo, Weiwei Luo, Lijuan Liu, Xiaocong Pang, Hong Zhu, Ailin Liu, Jinjian Lu, Dik-Lung Ma, Chung-Hang Leung, Yitao Wang, Xiuping Che. Isocryptotanshinone, a STAT3 inhibitor, induces apoptosis and pro-death autophagy in A549 lung cancer cells. Journal of drug targeting. vol 24. issue 10. 2018-01-12. PMID:26904961. |
isocryptotanshinone, a stat3 inhibitor, induces apoptosis and pro-death autophagy in a549 lung cancer cells. |
2018-01-12 |
2023-08-13 |
Not clear |
| Jianshuang Li, Di Lu, Huadie Liu, Bart O Williams, Paul A Overbeek, Brendan Lee, Ling Zheng, Tao Yan. Sclt1 deficiency causes cystic kidney by activating ERK and STAT3 signaling. Human molecular genetics. vol 26. issue 15. 2018-01-08. PMID:28486600. |
sclt1-loss decreases the number of cilia in kidney; increases proliferation and apoptosis of renal tubule epithelial cells; elevates protein kinase a, extracellular signal-regulated kinases, smad and signal transducer and activator of transcription 3 (stat3) pathways; and enhances pro-inflammation and pro-fibrosis pathways with disease progression. |
2018-01-08 |
2023-08-13 |
mouse |
| Nadezda Dolgikh, Simone Fuld. Rhabdomyosarcoma cells are susceptible to cell death by LDK378 alone or in combination with sorafenib independently of anaplastic lymphoma kinase status. Anti-cancer drugs. vol 28. issue 10. 2018-01-03. PMID:29045271. |
before the onset of apoptosis, ldk378 reduces phosphorylation of akt, s6 ribosomal protein, stat3 and - to a lesser extent - phosphorylation of erk, showing that it suppresses key survival pathways. |
2018-01-03 |
2023-08-13 |
Not clear |
| Marisa Granato, Celeste Rizzello, Maria Saveria Gilardini Montani, Laura Cuomo, Marina Vitillo, Roberta Santarelli, Roberta Gonnella, Gabriella D'Orazi, Alberto Faggioni, Mara Ciron. Quercetin induces apoptosis and autophagy in primary effusion lymphoma cells by inhibiting PI3K/AKT/mTOR and STAT3 signaling pathways. The Journal of nutritional biochemistry. vol 41. 2017-12-22. PMID:28092744. |
quercetin induces apoptosis and autophagy in primary effusion lymphoma cells by inhibiting pi3k/akt/mtor and stat3 signaling pathways. |
2017-12-22 |
2023-08-13 |
Not clear |
| Feng-Ting Liu, Li Jia, Ping Wang, Huaqing Wang, Timothy W Farren, Samir G Agrawa. STAT3 and NF-κB cooperatively control in vitro spontaneous apoptosis and poor chemo-responsiveness in patients with chronic lymphocytic leukemia. Oncotarget. vol 7. issue 22. 2017-12-20. PMID:27074565. |
stat3 and nf-κb cooperatively control in vitro spontaneous apoptosis and poor chemo-responsiveness in patients with chronic lymphocytic leukemia. |
2017-12-20 |
2023-08-13 |
Not clear |
| Feng-Ting Liu, Li Jia, Ping Wang, Huaqing Wang, Timothy W Farren, Samir G Agrawa. STAT3 and NF-κB cooperatively control in vitro spontaneous apoptosis and poor chemo-responsiveness in patients with chronic lymphocytic leukemia. Oncotarget. vol 7. issue 22. 2017-12-20. PMID:27074565. |
we hypothesize that the sensitivity of cll cells to spontaneous apoptosis may be associated with the constitutive activities of transcription factors stat3 and/or nf-κb. |
2017-12-20 |
2023-08-13 |
Not clear |
| Feng-Ting Liu, Li Jia, Ping Wang, Huaqing Wang, Timothy W Farren, Samir G Agrawa. STAT3 and NF-κB cooperatively control in vitro spontaneous apoptosis and poor chemo-responsiveness in patients with chronic lymphocytic leukemia. Oncotarget. vol 7. issue 22. 2017-12-20. PMID:27074565. |
we now show that the sensitivity of fresh cll cells to spontaneous apoptosis is highly variable among different patients during 48 hours' cell culture and inversely correlated with in vivo constitutively activated stat3 and nf-κb (p < 0.001). |
2017-12-20 |
2023-08-13 |
Not clear |
| Feng-Ting Liu, Li Jia, Ping Wang, Huaqing Wang, Timothy W Farren, Samir G Agrawa. STAT3 and NF-κB cooperatively control in vitro spontaneous apoptosis and poor chemo-responsiveness in patients with chronic lymphocytic leukemia. Oncotarget. vol 7. issue 22. 2017-12-20. PMID:27074565. |
our data suggest that the sensitivity of cll cells to in vitro spontaneous apoptosis is co-regulated by constitutively activated stat3 and nf-κb and reflects the in vivo chemo-responsiveness and clinical outcomes. |
2017-12-20 |
2023-08-13 |
Not clear |
| Chongqiang Zhao, Wenlong Wang, Wenying Yu, David Jou, Yina Wang, Haiyan Ma, Hui Xiao, Hua Qin, Cuntai Zhang, Jiagao Lü, Sheng Li, Chenglong Li, Jiayuh Lin, Li Li. A novel small molecule STAT3 inhibitor, LY5, inhibits cell viability, colony formation, and migration of colon and liver cancer cells. Oncotarget. vol 7. issue 11. 2017-11-21. PMID:26883202. |
we demonstrated that ly5 inhibited constitutive interleukin-6 (il-6)-induced stat3 phosphorylation, stat3 nuclear translocation, decreased stat3 downstream targeted gene expression and induced apoptosis in liver and colon cancer cells. |
2017-11-21 |
2023-08-13 |
mouse |
| Qingsheng Ye, Cuida Meng, Yannan Shen, Jianjun Ji, Xiaochun Wang, Sheng Zhou, Lili Jia, Yanqun Wan. Caveolin-1 Mediates Low-Intensity Ultrasound-Induced Apoptosis via Downregulation of Signal Transducer and Activator of Transcription 3 Phosphorylation in Laryngeal Carcinoma Cells. Ultrasound in medicine & biology. vol 42. issue 9. 2017-11-20. PMID:27289429. |
in addition, inhibition of cav-1 expression promoted phosphorylation of signal transducer and activator of transcription 3 (stat3), suggesting that the stat3 signaling pathway was involved in low-intensity ultrasound-induced apoptosis via cav-1 regulation. |
2017-11-20 |
2023-08-13 |
Not clear |
| Yan Hu, Chengguang Zhao, Hailun Zheng, Kongqin Lu, Dengjian Shi, Zhiguo Liu, Xuanxuan Dai, Yi Zhang, Xiuhua Zhang, Wanle Hu, Guang Lian. A novel STAT3 inhibitor HO-3867 induces cell apoptosis by reactive oxygen species-dependent endoplasmic reticulum stress in human pancreatic cancer cells. Anti-cancer drugs. vol 28. issue 4. 2017-11-16. PMID:28067673. |
a novel stat3 inhibitor ho-3867 induces cell apoptosis by reactive oxygen species-dependent endoplasmic reticulum stress in human pancreatic cancer cells. |
2017-11-16 |
2023-08-13 |
human |
| Yan Hu, Chengguang Zhao, Hailun Zheng, Kongqin Lu, Dengjian Shi, Zhiguo Liu, Xuanxuan Dai, Yi Zhang, Xiuhua Zhang, Wanle Hu, Guang Lian. A novel STAT3 inhibitor HO-3867 induces cell apoptosis by reactive oxygen species-dependent endoplasmic reticulum stress in human pancreatic cancer cells. Anti-cancer drugs. vol 28. issue 4. 2017-11-16. PMID:28067673. |
in addition, independent of the ros pathway, direct stat3 inhibition was observed in ho-3867-induced cell apoptosis. |
2017-11-16 |
2023-08-13 |
human |
| Yan Hu, Chengguang Zhao, Hailun Zheng, Kongqin Lu, Dengjian Shi, Zhiguo Liu, Xuanxuan Dai, Yi Zhang, Xiuhua Zhang, Wanle Hu, Guang Lian. A novel STAT3 inhibitor HO-3867 induces cell apoptosis by reactive oxygen species-dependent endoplasmic reticulum stress in human pancreatic cancer cells. Anti-cancer drugs. vol 28. issue 4. 2017-11-16. PMID:28067673. |
taken together, the results of this work suggest that both the ros-dependent er stress and stat3 pathways were implicated in the cell apoptosis induced by the novel compound ho-3867. |
2017-11-16 |
2023-08-13 |
human |