| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nicole M Jackson, Brian P Ceres. EGFR-mediated apoptosis via STAT3. Experimental cell research. vol 356. issue 1. 2017-09-26. PMID:28433699. |
the effector assessment revealed stat3 as a potential mediator of egf-induced apoptosis. |
2017-09-26 |
2023-08-13 |
Not clear |
| Nicole M Jackson, Brian P Ceres. EGFR-mediated apoptosis via STAT3. Experimental cell research. vol 356. issue 1. 2017-09-26. PMID:28433699. |
our findings support stat3 as a positive mediator of egf-induced apoptosis in mda-mb-468 cells. |
2017-09-26 |
2023-08-13 |
Not clear |
| Dan Shao, Jie Ma, Chao Zhou, Jia-Nan Zhao, Lu-Lu Li, Tong-Jian Zhao, Xi-Lei Ai, Ping Jia. STAT3 down-regulation induces mitochondria-dependent G2/M cell cycle arrest and apoptosis in oesophageal carcinoma cells. Clinical and experimental pharmacology & physiology. vol 44. issue 3. 2017-09-21. PMID:27896845. |
stat3 down-regulation induces mitochondria-dependent g2/m cell cycle arrest and apoptosis in oesophageal carcinoma cells. |
2017-09-21 |
2023-08-13 |
human |
| Dan Shao, Jie Ma, Chao Zhou, Jia-Nan Zhao, Lu-Lu Li, Tong-Jian Zhao, Xi-Lei Ai, Ping Jia. STAT3 down-regulation induces mitochondria-dependent G2/M cell cycle arrest and apoptosis in oesophageal carcinoma cells. Clinical and experimental pharmacology & physiology. vol 44. issue 3. 2017-09-21. PMID:27896845. |
to explore stat3 down-regulation in human oesophageal cancer cells, cell proliferation, apoptosis and mitochondrial mechanisms were explored in oesophageal carcinoma te1 cell cultures. |
2017-09-21 |
2023-08-13 |
human |
| Dan Shao, Jie Ma, Chao Zhou, Jia-Nan Zhao, Lu-Lu Li, Tong-Jian Zhao, Xi-Lei Ai, Ping Jia. STAT3 down-regulation induces mitochondria-dependent G2/M cell cycle arrest and apoptosis in oesophageal carcinoma cells. Clinical and experimental pharmacology & physiology. vol 44. issue 3. 2017-09-21. PMID:27896845. |
we demonstrate for the first time that stat3 down-regulation by rnai is sufficient to inhibit oesophageal cancer cell proliferation inducing cell apoptosis. |
2017-09-21 |
2023-08-13 |
human |
| Dan Shao, Jie Ma, Chao Zhou, Jia-Nan Zhao, Lu-Lu Li, Tong-Jian Zhao, Xi-Lei Ai, Ping Jia. STAT3 down-regulation induces mitochondria-dependent G2/M cell cycle arrest and apoptosis in oesophageal carcinoma cells. Clinical and experimental pharmacology & physiology. vol 44. issue 3. 2017-09-21. PMID:27896845. |
thus, our results suggest that stat3 inhibition is a valid approach to induce oesophageal carcinoma cell mitochondrial-dependent apoptosis in therapeutic strategies against oesophageal cancers. |
2017-09-21 |
2023-08-13 |
human |
| Zhu Zhang, Bin Zhou, Kui Zhang, Yaping Song, Lin Zhang, Mingrong X. IL-27 suppresses SKOV3 cells proliferation by enhancing STAT3 and inhibiting the Akt signal pathway. Molecular immunology. vol 78. 2017-09-15. PMID:27639718. |
our data show that il-27 has direct antitumor capacity in ovarian cancer cells via enhancing apoptosis by inducing the stat3 pathway and restraining the akt pathway. |
2017-09-15 |
2023-08-13 |
Not clear |
| Sachin K Deshmukh, Sanjeev K Srivastava, Haseeb Zubair, Arun Bhardwaj, Nikhil Tyagi, Ahmed Al-Ghadhban, Ajay P Singh, Donna L Dyess, James E Carter, Seema Sing. Resistin potentiates chemoresistance and stemness of breast cancer cells: Implications for racially disparate therapeutic outcomes. Cancer letters. vol 396. 2017-09-14. PMID:28302531. |
mechanistic studies revealed that resistin-induced chemoresistance, apoptosis and stemness of bc cells were mediated through stat3 activation. |
2017-09-14 |
2023-08-13 |
Not clear |
| Y Pan, S Wang, B Su, F Zhou, R Zhang, T Xu, R Zhang, V Leventaki, E Drakos, W Liu, F X Clare. Stat3 contributes to cancer progression by regulating Jab1/Csn5 expression. Oncogene. vol 36. issue 8. 2017-09-13. PMID:27524414. |
consistently, silencing of stat3 in tumors reduced jab1/csn5 expression, thereby sensitizing npc cells to cisplatin-induced apoptosis both in vitro and in vivo. |
2017-09-13 |
2023-08-13 |
Not clear |
| Andrey V Markov, Marina A Zenkova, Evgeniya B Logashenk. Modulation of Tumour-Related Signaling Pathways by Natural Pentacyclic Triterpenoids and their Semisynthetic Derivatives. Current medicinal chemistry. vol 24. issue 13. 2017-09-08. PMID:28078994. |
among the most relevant mechanisms involved are cell cycle arrest, apoptosis and autophagy triggered by the effect of triterpenoids on tgf-β and her cell surface receptors and the downstream pi3kakt- mtor and ikk/nf-kb signaling axis, stat3 pathway and mapk cascades. |
2017-09-08 |
2023-08-13 |
Not clear |
| Jaya Srivastava, John DiGiovann. Non-canonical Stat3 signaling in cancer. Molecular carcinogenesis. vol 55. issue 12. 2017-09-05. PMID:26649644. |
stat3 is a member of the signal transducers and activators of transcription family and is a known regulator of essential biologic processes including angiogenesis, apoptosis, cell cycle progression, and cell migration. |
2017-09-05 |
2023-08-13 |
Not clear |
| R Bharti, G Dey, P K Ojha, S Rajput, S K Jaganathan, R Sen, M Manda. Diacerein-mediated inhibition of IL-6/IL-6R signaling induces apoptotic effects on breast cancer. Oncogene. vol 35. issue 30. 2017-09-01. PMID:26616855. |
the in vivo antitumor effect was correlated with decreased proliferation (ki-67), increased apoptosis (tunel) and inhibition of il-6/il-6r-mediated stat3, mapk and akt pathway in tumor remnants. |
2017-09-01 |
2023-08-13 |
Not clear |
| G Wang, Y Yu, C Sun, T Liu, T Liang, L Zhan, X Lin, X-H Fen. STAT3 selectively interacts with Smad3 to antagonize TGF-β signalling. Oncogene. vol 35. issue 33. 2017-08-30. PMID:26616859. |
depletion of stat3 promotes tgf-β-mediated transcriptional and physiological responses, including cell cycle arrest, apoptosis and epithelial-to-mesenchymal transition. |
2017-08-30 |
2023-08-13 |
Not clear |
| Nathan De Beule, Kim De Veirman, Ken Maes, Elke De Bruyne, Eline Menu, Karine Breckpot, Hendrik De Raeve, Rian Van Rampelbergh, Jo A Van Ginderachter, Rik Schots, Els Van Valckenborgh, Karin Vanderkerke. Tumour-associated macrophage-mediated survival of myeloma cells through STAT3 activation. The Journal of pathology. vol 241. issue 4. 2017-08-29. PMID:27976373. |
the pro-survival effect was associated with activation of the stat3 pathway in 5t33mm cells, less cleavage of caspase-3, and thus less apoptosis. |
2017-08-29 |
2023-08-13 |
Not clear |
| Wei Li, Hongxiu Zhang, Mingxiu Nie, Yanlei Tian, Xu Chen, Ceshi Chen, Haijun Chen, Rong Li. Ursolic acid derivative FZU-03,010 inhibits STAT3 and induces cell cycle arrest and apoptosis in renal and breast cancer cells. Acta biochimica et biophysica Sinica. vol 49. issue 4. 2017-08-29. PMID:28338932. |
ursolic acid derivative fzu-03,010 inhibits stat3 and induces cell cycle arrest and apoptosis in renal and breast cancer cells. |
2017-08-29 |
2023-08-13 |
Not clear |
| Schafiq Nabhani, Cyrill Schipp, Hagit Miskin, Carina Levin, Sergey Postovsky, Tal Dujovny, Ariel Koren, Dan Harlev, Anne-Marie Bis, Franziska Auer, Baerbel Keller, Klaus Warnatz, Michael Gombert, Sebastian Ginzel, Arndt Borkhardt, Polina Stepensky, Ute Fische. STAT3 gain-of-function mutations associated with autoimmune lymphoproliferative syndrome like disease deregulate lymphocyte apoptosis and can be targeted by BH3 mimetic compounds. Clinical immunology (Orlando, Fla.). vol 181. 2017-08-28. PMID:28579554. |
stat3 gain-of-function mutations associated with autoimmune lymphoproliferative syndrome like disease deregulate lymphocyte apoptosis and can be targeted by bh3 mimetic compounds. |
2017-08-28 |
2023-08-13 |
Not clear |
| Schafiq Nabhani, Cyrill Schipp, Hagit Miskin, Carina Levin, Sergey Postovsky, Tal Dujovny, Ariel Koren, Dan Harlev, Anne-Marie Bis, Franziska Auer, Baerbel Keller, Klaus Warnatz, Michael Gombert, Sebastian Ginzel, Arndt Borkhardt, Polina Stepensky, Ute Fische. STAT3 gain-of-function mutations associated with autoimmune lymphoproliferative syndrome like disease deregulate lymphocyte apoptosis and can be targeted by BH3 mimetic compounds. Clinical immunology (Orlando, Fla.). vol 181. 2017-08-28. PMID:28579554. |
hyperactivity of stat3, a known repressor of fas, was associated with decreased fas-mediated apoptosis, mimicking alps caused by fas mutations. |
2017-08-28 |
2023-08-13 |
Not clear |
| Xing-Hua Liao, Yuan Xiang, Cheng-Xi Yu, Jia-Peng Li, Hui Li, Qi Nie, Peng Hu, Jun Zhou, Tong-Cun Zhan. STAT3 is required for MiR-17-5p-mediated sensitization to chemotherapy-induced apoptosis in breast cancer cells. Oncotarget. vol 8. issue 9. 2017-08-24. PMID:28178652. |
stat3 is required for mir-17-5p-mediated sensitization to chemotherapy-induced apoptosis in breast cancer cells. |
2017-08-24 |
2023-08-13 |
Not clear |
| Xing-Hua Liao, Yuan Xiang, Cheng-Xi Yu, Jia-Peng Li, Hui Li, Qi Nie, Peng Hu, Jun Zhou, Tong-Cun Zhan. STAT3 is required for MiR-17-5p-mediated sensitization to chemotherapy-induced apoptosis in breast cancer cells. Oncotarget. vol 8. issue 9. 2017-08-24. PMID:28178652. |
on the other hand, mir-17-5p induced apoptosis in breast cancer cells, and overexpression of mir-17-5p sensitized mcf-7 cells to paclitaxel-induced apoptosis via stat3. |
2017-08-24 |
2023-08-13 |
Not clear |
| Xing-Hua Liao, Yuan Xiang, Cheng-Xi Yu, Jia-Peng Li, Hui Li, Qi Nie, Peng Hu, Jun Zhou, Tong-Cun Zhan. STAT3 is required for MiR-17-5p-mediated sensitization to chemotherapy-induced apoptosis in breast cancer cells. Oncotarget. vol 8. issue 9. 2017-08-24. PMID:28178652. |
overexpression of stat3 in mcf-7 cells decreased paclitaxel-induced apoptosis, but stat3 knockout abolished the mir-17-5p-induced increases in apoptosis. |
2017-08-24 |
2023-08-13 |
Not clear |