| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fei Tian, Ligang Jia, Zhaoping Chu, Hua Han, Yuan Zhang, Jianhui Ca. MicroRNA-519a inhibits the proliferation and promotes the apoptosis of ovarian cancer cells through targeting signal transducer and activator of transcription 3. Experimental and therapeutic medicine. vol 15. issue 2. 2020-10-01. PMID:29434770. |
furthermore, transient overexpression of mir-519a inhibited the proliferation and promoted the apoptosis of skov3 cells, as well as decreased the mrna and protein expression levels of stat3, mcl-1 and bcl-xl. |
2020-10-01 |
2023-08-13 |
Not clear |
| Tomoyuki Yoshikawa, Morikazu Miyamoto, Tadashi Aoyama, Hiroaki Soyama, Tomoko Goto, Junko Hirata, Ayako Suzuki, Isao Nagaoka, Hitoshi Tsuda, Kenichi Furuya, Masashi Takan. JAK2/STAT3 pathway as a therapeutic target in ovarian cancers. Oncology letters. vol 15. issue 4. 2020-10-01. PMID:29545902. |
the effect of an inhibitor of stat3, niclosamide, was evaluated in ovarian clear-cell cancer cells, and niclosamide treatment decreased expression of p-stat3, leading to increased apoptosis in a dose-dependent manner |
2020-10-01 |
2023-08-13 |
Not clear |
| Huitao Xu, Ying Zhou, Wei Li, Bin Zhang, Huanhuan Zhang, Shaolin Zhao, Ping Zheng, Huiyi Wu, Jin Yan. Tumor-derived mesenchymal-stem-cell-secreted IL-6 enhances resistance to cisplatin via the STAT3 pathway in breast cancer. Oncology letters. vol 15. issue 6. 2020-10-01. PMID:29844821. |
mtt and flow cytometry analysis measured cell vitality and apoptosis, respectively, and activation of signal transduced and activator of transcription 3 (stat3) was evaluated by western blotting. |
2020-10-01 |
2023-08-13 |
Not clear |
| Mulu Geletu, Zaid Taha, Patrick T Gunning, Leda Rapti. PI3k and Stat3: Oncogenes that are Required for Gap Junctional, Intercellular Communication. Cancers. vol 11. issue 2. 2020-10-01. PMID:30717267. |
pi3k and stat3 constitute potent survival signals, so that their inhibition in non-transformed cells triggers apoptosis which, in turn, has been independently demonstrated to suppress gjic. |
2020-10-01 |
2023-08-13 |
human |
| Dawei Wang, Zhuoxin Cheng, Ming Zhao, Chengbin Jiao, Qinghui Meng, Huayang Pan, Yu Xie, Long Li, Yexing Zhu, Wei Wang, Chunlei Qu, Deshen Lian. PTPN9 induces cell apoptosis by mitigating the activation of Stat3 and acts as a tumor suppressor in colorectal cancer. Cancer management and research. vol 11. 2020-10-01. PMID:30804683. |
ptpn9 induces cell apoptosis by mitigating the activation of stat3 and acts as a tumor suppressor in colorectal cancer. |
2020-10-01 |
2023-08-13 |
Not clear |
| Wenting Zhang, Aiguo Men. MicroRNA-124 expression in the brains of rats during early cerebral ischemia and reperfusion injury is associated with cell apoptosis involving STAT3. Experimental and therapeutic medicine. vol 17. issue 4. 2020-10-01. PMID:30906474. |
microrna-124 expression in the brains of rats during early cerebral ischemia and reperfusion injury is associated with cell apoptosis involving stat3. |
2020-10-01 |
2023-08-13 |
rat |
| Wenting Zhang, Aiguo Men. MicroRNA-124 expression in the brains of rats during early cerebral ischemia and reperfusion injury is associated with cell apoptosis involving STAT3. Experimental and therapeutic medicine. vol 17. issue 4. 2020-10-01. PMID:30906474. |
as signal transducer and activator of transcription 3 (stat3) is involved in cell apoptosis and associated with bcl-2, the protein expression of stat3 and its active form, phosphorylated (p-)stat3, were analyzed by western blot analysis. |
2020-10-01 |
2023-08-13 |
rat |
| Wenting Zhang, Aiguo Men. MicroRNA-124 expression in the brains of rats during early cerebral ischemia and reperfusion injury is associated with cell apoptosis involving STAT3. Experimental and therapeutic medicine. vol 17. issue 4. 2020-10-01. PMID:30906474. |
in summary, during the early stage of cerebral ischemia and reperfusion, the dynamic expression of microrna-124 exhibited protective effects through the inhibition of apoptosis via anti-apoptotic proteins bcl-2 and stat3. |
2020-10-01 |
2023-08-13 |
rat |
| Tsung-Teng Huang, Ying-Wei Lan, Chuan-Mu Chen, Yun-Fei Ko, David M Ojcius, Jan Martel, John D Young, Kowit-Yu Chon. Antrodia cinnamomea induces anti-tumor activity by inhibiting the STAT3 signaling pathway in lung cancer cells. Scientific reports. vol 9. issue 1. 2020-10-01. PMID:30914735. |
our findings therefore indicate that acee inhibits lung tumor growth and metastasis by inducing apoptosis and by inhibiting the stat3 signaling pathway in cancer cells. |
2020-10-01 |
2023-08-13 |
mouse |
| Savita Bisht, Jens Nolting, Jörg Wenzel, Peter Brossart, Georg Feldman. EF24 Suppresses Cholangiocellular Carcinoma Progression, Inhibits STAT3 Phosphorylation, and Induces Apoptosis via ROS-Mediated Oxidative Stress. Journal of oncology. vol 2019. 2020-10-01. PMID:30949204. |
ef24 suppresses cholangiocellular carcinoma progression, inhibits stat3 phosphorylation, and induces apoptosis via ros-mediated oxidative stress. |
2020-10-01 |
2023-08-13 |
Not clear |
| Wei Jing, Na Song, Yun-Peng Liu, Xiu-Juan Qu, Ya-Fei Qi, Ce Li, Ke-Zuo Hou, Xiao-Fang Che, Xiang-Hong Yan. DNMT3a promotes proliferation by activating the STAT3 signaling pathway and depressing apoptosis in pancreatic cancer. Cancer management and research. vol 11. 2020-10-01. PMID:31372043. |
dnmt3a promotes proliferation by activating the stat3 signaling pathway and depressing apoptosis in pancreatic cancer. |
2020-10-01 |
2023-08-13 |
Not clear |
| Chongyang Wang, Mingyu Zheng, Yunho Choi, Jingzhi Jiang, Li Li, Junfeng Li, Chang Xu, Zhemin Xian, Yan Li, Hongmei Piao, Liangchang Li, Guanghai Ya. Cryptotanshinone Attenuates Airway Remodeling by Inhibiting Crosstalk Between Tumor Necrosis Factor-Like Weak Inducer of Apoptosis and Transforming Growth Factor Beta 1 Signaling Pathways in Asthma. Frontiers in pharmacology. vol 10. 2020-10-01. PMID:31780948. |
cts also inhibited the expressions of alpha-smooth muscle actin, tumor necrosis factor-like weak inducer of apoptosis (tweak), fn14, transforming growth factor (tgf)-β1, smad4, and phosphorylation of smad2/3 and stat3 (tyr705). |
2020-10-01 |
2023-08-13 |
mouse |
| Max Kullberg, Alexandra Francian, Ameneh Arabi, Troy Olsson, Kristine Mann, Holly A Martinso. Liposome Delivery of Natural STAT3 Inhibitors for the Treatment of Cancer. Pharmaceutical frontiers. vol 1. 2020-10-01. PMID:31886474. |
stat3 activation in cancer cells drives tumorigenic changes that allow for increased survival, proliferation, and resistance to apoptosis. |
2020-10-01 |
2023-08-13 |
Not clear |
| Michael E Grossmann, Da-Qing Yang, Zhijun Guo, David A Potter, Margot P Clear. Metformin Treatment for the Prevention and/or Treatment of Breast/Mammary Tumorigenesis. Current pharmacology reports. vol 1. issue 5. 2020-09-30. PMID:26405648. |
in addition to the anticancer effect of metformin mediated through the ampk pathway, additional mechanisms of action that directly target tissues have been identified including effects on stem cells, apoptosis, stat3 and her2. |
2020-09-30 |
2023-08-13 |
Not clear |
| Shulong Jiang, Yebo Gao, Wei Hou, Rui Liu, Xin Qi, Xia Xu, Jie Li, Yanju Bao, Honggang Zheng, Baojin Hu. Sinomenine inhibits A549 human lung cancer cell invasion by mediating the STAT3 signaling pathway. Oncology letters. vol 12. issue 2. 2020-09-30. PMID:27446441. |
signal transducer and activator of transcription 3 (stat3), an epithelial-mesenchymal transition-inducing transcription factor, is a key signaling molecule involved in the proliferation, apoptosis, invasion and metastasis of tumor cells. |
2020-09-30 |
2023-08-13 |
human |
| Cheng-Cao Sun, Shu-Jun Li, Feng Zhang, Ya-Dong Zhang, Zhen-Yu Zuo, Yong-Yong Xi, Liang Wang, De-Jia L. The Novel miR-9600 Suppresses Tumor Progression and Promotes Paclitaxel Sensitivity in Non-small-cell Lung Cancer Through Altering STAT3 Expression. Molecular therapy. Nucleic acids. vol 5. issue 11. 2020-09-30. PMID:27845771. |
furthermore, we identified that mir-9600 augmented paclitaxel and cisplatin sensitivity by downregulating stat3 and promoting chemotherapy-induced apoptosis. |
2020-09-30 |
2023-08-13 |
mouse |
| Lingyi Shi, Hailun Zheng, Wanle Hu, Bin Zhou, Xuanxuan Dai, Yi Zhang, Zhiguo Liu, Xiaoping Wu, Chengguang Zhao, Guang Lian. Niclosamide inhibition of STAT3 synergizes with erlotinib in human colon cancer. OncoTargets and therapy. vol 10. 2020-09-30. PMID:28367059. |
combined inhibition of epidermal growth factor receptor and stat3 by erlotinib and niclosamide synergistically induces apoptosis and antiproliferation in colon cancer cell lines. |
2020-09-30 |
2023-08-13 |
human |
| María Florencia Gottardo, Mariela Moreno Ayala, Jimena Ferraris, Sandra Zárate, Daniel Pisera, Marianela Candolfi, Gabriela Jaita, Adriana Seilicovic. Humanin inhibits apoptosis in pituitary tumor cells through several signaling pathways including NF-κB activation. Journal of cell communication and signaling. vol 11. issue 4. 2020-09-30. PMID:28378125. |
stat3 inhibition reversed the inhibitory effect of hn on tnf-α-induced apoptosis in normal and pituitary tumor cells, indicating that stat3 signaling pathway mediates the antiapoptotic effect of hn on pituitary cells. |
2020-09-30 |
2023-08-13 |
rat |
| Changjiang Zhang, Yinzhi Deng, Yuhua Lei, Jingbo Zhao, Wen Wei, Yuanhong L. Effects of selenium on myocardial apoptosis by modifying the activity of mitochondrial STAT3 and regulating potassium channel expression. Experimental and therapeutic medicine. vol 14. issue 3. 2020-09-30. PMID:28962142. |
effects of selenium on myocardial apoptosis by modifying the activity of mitochondrial stat3 and regulating potassium channel expression. |
2020-09-30 |
2023-08-13 |
mouse |
| Changjiang Zhang, Yinzhi Deng, Yuhua Lei, Jingbo Zhao, Wen Wei, Yuanhong L. Effects of selenium on myocardial apoptosis by modifying the activity of mitochondrial STAT3 and regulating potassium channel expression. Experimental and therapeutic medicine. vol 14. issue 3. 2020-09-30. PMID:28962142. |
the present study investigated the effects of myocardial mitochondrial signal transduction and activator of transcription 3 (stat3), succinate dehydrogenase activity and changes of potassium channel expression on cardiomyocyte apoptosis under low selenium conditions. |
2020-09-30 |
2023-08-13 |
mouse |