| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' Iva Poto\\xc4\\x8dnjak, Jelena Marini\\xc4\\x87, Lara Bati\\xc4\\x8di\\xc4\\x87, Lidija \\xc5\\xa0imi\\xc4\\x87, Dalibor Brozni\\xc4\\x87, Robert Domitrovi\\xc4\\x8. Aucubin administered by either oral or parenteral route protects against cisplatin-induced acute kidney injury in mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 142. 2021-03-29. PMID:32504734.' |
mechanistically, aucubin suppressed the activation of several signaling pathways involved in inflammation and apoptosis, including nuclear factor-kappa b (nf-κb), signal transducer and activator of transcription 3 (stat3), akt, extracellular signal-regulated kinase 1/2 (erk1/2) and forkhead box o3a (foxo3a). |
2021-03-29 |
2023-08-13 |
mouse |
| Na Li, Jinfeng Ou, Na Bao, Cheng Chen, Zhixian Shi, Li Chen, Jianbo Su. Design, synthesis and biological evaluation of novel plumbagin derivatives as potent antitumor agents with STAT3 inhibition. Bioorganic chemistry. vol 104. 2021-03-29. PMID:32919131. |
furthermore, molecular docking indicated that 7a bound to stat3 more tightly than pl, and it could significantly induce the apoptosis of cancer cells in vitro. |
2021-03-29 |
2023-08-13 |
human |
| Linyu Geng, Xiaojun Tang, Shiying Wang, Yue Sun, Dandan Wang, Betty P Tsao, Xuebing Feng, Lingyun Su. Reduced Let-7f in Bone Marrow-Derived Mesenchymal Stem Cells Triggers Treg/Th17 Imbalance in Patients With Systemic Lupus Erythematosus. Frontiers in immunology. vol 11. 2021-03-25. PMID:32133007. |
transient transfection of bm-mscs with let-7f mimics or inhibitors showed reduced levels of let-7f impaired the proliferation rate of bm-mscs, bm-msc-mediated downregulation of th17 cells and upregulation of treg cells, increased the apoptosis rate of bm-mscs through targeting il-6 and activating signal transducers and activators of transcription-3 (stat3) pathway, but had no significant effect on the differentiation of th1 and th2. |
2021-03-25 |
2023-08-13 |
Not clear |
| Lixue Yang, Hui Xue, Yanfu Sun, Lei Zhang, Feng Xue, Ruiliang G. CircularRNA-9119 protects hepatocellular carcinoma cells from apoptosis by intercepting miR-26a/JAK1/STAT3 signaling. Cell death & disease. vol 11. issue 7. 2021-03-25. PMID:32732872. |
administration of the jak1 inhibitor, baricitinib, caused the activation of signal transducer and activator of transcription 3 (stat3) and revealed an effect similar to that of circ9119 silencing on cell proliferation and apoptosis. |
2021-03-25 |
2023-08-13 |
Not clear |
| Ying Hu, Rong Xu, Yue He, Zhibo Zhao, Xudong Mao, Ling Lin, Jun H. Downregulation of microRNA‑106a‑5p alleviates ox‑LDL‑mediated endothelial cell injury by targeting STAT3. Molecular medicine reports. vol 22. issue 2. 2021-03-23. PMID:32626987. |
in addition, it was shown that stat3 is a direct target of mir‑106a‑5p in huvecs, and silencing of stat3 impaired the protective effects of mir‑106a‑5p inhibition on cell apoptosis and oxidative injury induced by ox‑ldl. |
2021-03-23 |
2023-08-13 |
human |
| Ying Hu, Rong Xu, Yue He, Zhibo Zhao, Xudong Mao, Ling Lin, Jun H. Downregulation of microRNA‑106a‑5p alleviates ox‑LDL‑mediated endothelial cell injury by targeting STAT3. Molecular medicine reports. vol 22. issue 2. 2021-03-23. PMID:32626987. |
collectively, these results indicated that mir‑106a‑5p participated in ox‑ldl‑stimulated apoptosis and oxidative injury in huvecs by regulating stat3. |
2021-03-23 |
2023-08-13 |
human |
| Sung Min Kim, Jung-Il Kang, Hoon-Seok Yoon, Youn Kyung Choi, Ji Soo Go, Sun Kyung Oh, Meejung Ahn, Jeongtae Kim, Young Sang Koh, Jin Won Hyun, Eun-Sook Yoo, Hee-Kyoung Kan. HNG, A Humanin Analogue, Promotes Hair Growth by Inhibiting Anagen-to-Catagen Transition. International journal of molecular sciences. vol 21. issue 12. 2021-03-22. PMID:32604799. |
hng stimulated the anagen phase longer with vegf up-regulation, and it prevented apoptosis by activating erk1/2, akt, and stat3 signaling. |
2021-03-22 |
2023-08-13 |
mouse |
| Bashir Ahmad, Yaser Gamallat, Muhammad Fiaz Khan, Syed Riaz Din, Muhammad Israr, Manzoor Ahmad, Naeem Tahir, Nasir Azam, Khalil Ur Rahman, Wang Xin, Wang Zexu, Peng Linjie, Pengyu Su, Wang Lian. Natural Polyphyllins (I, II, D, VI, VII) Reverses Cancer Through Apoptosis, Autophagy, Mitophagy, Inflammation, and Necroptosis. OncoTargets and therapy. vol 14. 2021-03-20. PMID:33732000. |
nps cure cancer by regulating different pathways, such as pi3k/akt/mtor, er stress, jnk, wnt, stat3, mapks, nf-kb, mek-erk, inflammation, oxidative stress, apoptosis, autophagy, mitophagy, and necroptosis. |
2021-03-20 |
2023-08-13 |
Not clear |
| Hao Wang, Zhennan Tao, Ming Feng, Xuetao Li, Zhitong Deng, Guozheng Zhao, Haoran Yin, Tingzheng Pan, Guangliang Chen, Zibin Feng, Yanyan Li, Youxin Zho. Dual PLK1 and STAT3 inhibition promotes glioblastoma cells apoptosis through MYC. Biochemical and biophysical research communications. vol 533. issue 3. 2021-03-18. PMID:32962858. |
dual plk1 and stat3 inhibition promotes glioblastoma cells apoptosis through myc. |
2021-03-18 |
2023-08-13 |
Not clear |
| Hao Wang, Zhennan Tao, Ming Feng, Xuetao Li, Zhitong Deng, Guozheng Zhao, Haoran Yin, Tingzheng Pan, Guangliang Chen, Zibin Feng, Yanyan Li, Youxin Zho. Dual PLK1 and STAT3 inhibition promotes glioblastoma cells apoptosis through MYC. Biochemical and biophysical research communications. vol 533. issue 3. 2021-03-18. PMID:32962858. |
compared to monotherapy, combined treatment of glioma cells with plk1 and stat3 inhibitors, bi2536 and stattic, respectively, showed lower expression of myc, synergistic induction of cell invasion and apoptosis in vitro, and tumor inhibition in xenografts. |
2021-03-18 |
2023-08-13 |
Not clear |
| Hao Wang, Zhennan Tao, Ming Feng, Xuetao Li, Zhitong Deng, Guozheng Zhao, Haoran Yin, Tingzheng Pan, Guangliang Chen, Zibin Feng, Yanyan Li, Youxin Zho. Dual PLK1 and STAT3 inhibition promotes glioblastoma cells apoptosis through MYC. Biochemical and biophysical research communications. vol 533. issue 3. 2021-03-18. PMID:32962858. |
plk1 and stat3 were able to directly regulate the expression of myc and induce apoptosis of glioma cells through the regulation of myc. |
2021-03-18 |
2023-08-13 |
Not clear |
| Antonella Di Sotto, Silvia Di Giacomo, Elisabetta Rubini, Alberto Macone, Marco Gulli, Caterina Loredana Mammola, Margherita Eufemi, Romina Mancinelli, Gabriela Mazzant. Modulation of STAT3 Signaling, Cell Redox Defenses and Cell Cycle Checkpoints by β-Caryophyllene in Cholangiocarcinoma Cells: Possible Mechanisms Accounting for Doxorubicin Chemosensitization and Chemoprevention. Cells. vol 9. issue 4. 2021-03-15. PMID:32252311. |
the modulation of stat3 signaling, oxidative stress, dna damage response, cell cycle progression and apoptosis was investigated as possible mechanisms of action. |
2021-03-15 |
2023-08-13 |
Not clear |
| Fengchang Zhu, Xi Zhao, Junping Li, Lianhong Guo, Liping Bai, Xiaoqiang Q. A new compound Trichomicin exerts antitumor activity through STAT3 signaling inhibition. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 121. 2021-03-11. PMID:31707338. |
trichomicin can significantly induce cancer cell apoptosis and reduced il-6 expression and phosphorylation of stat3 were found in response to trichomicin treatment. |
2021-03-11 |
2023-08-13 |
human |
| Milad Ashrafizadeh, Mohammad Hossein Gholami, Sepideh Mirzaei, Amirhossein Zabolian, Amirabbas Haddadi, Mahdi Vasheghani Farahani, Sharareh Hosseinzadeh Kashani, Kiavash Hushmandi, Masoud Najafi, Ali Zarrabi, Kwang Seok Ahn, Haroon Kha. Dual relationship between long non-coding RNAs and STAT3 signaling in different cancers: New insight to proliferation and metastasis. Life sciences. vol 270. 2021-03-11. PMID:33421521. |
stat3 is a tumor-promoting factors in cancers due to its role in cancer proliferation (cell cycle progression and apoptosis inhibition) and metastasis (emt induction). |
2021-03-11 |
2023-08-13 |
Not clear |
| Mohammad Rahmati, Behrooz Johari, Mehdi Kadivar, Elham Rismani, Yousef Mortazav. Suppressing the metastatic properties of the breast cancer cells using STAT3 decoy oligodeoxynucleotides: A promising approach for eradication of cancer cells by differentiation therapy. Journal of cellular physiology. vol 235. issue 6. 2021-03-09. PMID:31912904. |
stat3 decoy odns treatment showed cell growth inhibition by decreasing cell viability (17%), increasing the percentage of arrested cells in g0/g1 phases (18%), and triggering apoptosis (29%). |
2021-03-09 |
2023-08-13 |
Not clear |
| Carmen Tse, Ashleigh Warner, Rufaik Farook, James G Croni. Phytochemical Targeting of STAT3 Orchestrated Lipid Metabolism in Therapy-Resistant Cancers. Biomolecules. vol 10. issue 8. 2021-03-09. PMID:32731620. |
signal transducer and activator of transcription 3 (stat3) plays a key role in cellular processes such as cell growth, apoptosis and lipid metabolism. |
2021-03-09 |
2023-08-13 |
human |
| Xueming Cao, Na Zhu, Yuwei Zhang, Yan Chen, Jing Zhang, Jiang Li, Peiyuan Hao, Chuanyu Gao, Li L. Y-box protein 1 promotes hypoxia/reoxygenation- or ischemia/reperfusion-induced cardiomyocyte apoptosis via SHP-1-dependent STAT3 inactivation. Journal of cellular physiology. vol 235. issue 11. 2021-03-08. PMID:31967332. |
y-box protein 1 promotes hypoxia/reoxygenation- or ischemia/reperfusion-induced cardiomyocyte apoptosis via shp-1-dependent stat3 inactivation. |
2021-03-08 |
2023-08-13 |
Not clear |
| Xueming Cao, Na Zhu, Yuwei Zhang, Yan Chen, Jing Zhang, Jiang Li, Peiyuan Hao, Chuanyu Gao, Li L. Y-box protein 1 promotes hypoxia/reoxygenation- or ischemia/reperfusion-induced cardiomyocyte apoptosis via SHP-1-dependent STAT3 inactivation. Journal of cellular physiology. vol 235. issue 11. 2021-03-08. PMID:31967332. |
in vitro, h/r treatment upregulated the yb1 expression in h9c2 cells, whereas yb1 knockdown inhibited h/r-induced cardiomyocyte apoptosis and induced h9c2 cell proliferation via src homology region 2 domain-containing phosphatase 1 (shp-1)-mediated activation of signal transducer and activator of transcription 3 (stat3). |
2021-03-08 |
2023-08-13 |
Not clear |
| Xueming Cao, Na Zhu, Yuwei Zhang, Yan Chen, Jing Zhang, Jiang Li, Peiyuan Hao, Chuanyu Gao, Li L. Y-box protein 1 promotes hypoxia/reoxygenation- or ischemia/reperfusion-induced cardiomyocyte apoptosis via SHP-1-dependent STAT3 inactivation. Journal of cellular physiology. vol 235. issue 11. 2021-03-08. PMID:31967332. |
in vivo, yb1 knockdown ameliorated ami, reducing infarct size, cardiomyocyte apoptosis, and oxidative stress, via shp-1-mediated inactivation of stat3. |
2021-03-08 |
2023-08-13 |
Not clear |
| Jinya Takahashi, Mai Yamamoto, Hideo Yasukawa, Shoichiro Nohara, Takanobu Nagata, Koutatsu Shimozono, Toshiyuki Yanai, Tomoko Sasaki, Kota Okabe, Tatsuhiro Shibata, Kazutoshi Mawatari, Tatsuyuki Kakuma, Hiroki Aoki, Yoshihiro Fukumot. Interleukin-22 Directly Activates Myocardial STAT3 (Signal Transducer and Activator of Transcription-3) Signaling Pathway and Prevents Myocardial Ischemia Reperfusion Injury. Journal of the American Heart Association. vol 9. issue 8. 2021-03-08. PMID:32301368. |
following ischemia reperfusion, compared with pbs-treated mice, il-22-treated mice exhibited a significantly reduced infarct size, significantly reduced myocardial apoptosis, and significantly enhanced phosphorylated stat3 expression. |
2021-03-08 |
2023-08-13 |
mouse |