| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhiqiang Wu, Bin Xu, Zhiyi Yu, Qin He, Zhuyuan Hu, Shishi Zhou, Meiqin Chen, Liang Zh. Trifolium Flavonoids Overcome Gefitinib Resistance of Non-Small-Cell Lung Cancer Cell by Suppressing ERK and STAT3 Signaling Pathways. BioMed research international. vol 2020. 2021-05-10. PMID:33150167. |
altogether, the results of the present study indicated the potential mechanisms of chemosensitivity of tf in gefitinib-induced apoptosis of nsclc by downregulating erk and stat3 signaling pathways and bcl2 and mcl-1 expression and a promising application of tf in therapy of nsclc with gefitinib resistant. |
2021-05-10 |
2023-08-13 |
Not clear |
| Honggang Chi, Dan Wang, Mengting Chen, Jiantao Lin, Shuhua Zhang, Fengyan Yu, Jun Zhou, Xuebao Zheng, Ying Zo. Shaoyao Decoction Inhibits Inflammation and Improves Intestinal Barrier Function in Mice With Dextran Sulfate Sodium-Induced Colitis. Frontiers in pharmacology. vol 12. 2021-05-08. PMID:33959000. |
additionally, the presence of proinflammatory cytokines, immune cell infiltrates, intestinal cell proliferation, apoptosis, epithelial permeability, signal transducer and activator of transcription 3 (stat3), and nuclear factor-κb (nf-κb) signaling, as well as the intestinal mucosal barrier function, were investigated. |
2021-05-08 |
2023-08-13 |
mouse |
| Byoung Kwon Park, Dongbum Kim, Sangkyu Park, Sony Maharjan, Jinsoo Kim, Jun-Kyu Choi, Madhav Akauliya, Younghee Lee, Hyung-Joo Kwo. Differential Signaling and Virus Production in Calu-3 Cells and Vero Cells upon SARS-CoV-2 Infection. Biomolecules & therapeutics. vol 29. issue 3. 2021-05-07. PMID:33504682. |
sars-cov-2 infection induced dephosphorylation of stat1 and stat3, high virus production, and apoptosis in vero cells. |
2021-05-07 |
2023-08-13 |
Not clear |
| Byoung Kwon Park, Dongbum Kim, Sangkyu Park, Sony Maharjan, Jinsoo Kim, Jun-Kyu Choi, Madhav Akauliya, Younghee Lee, Hyung-Joo Kwo. Differential Signaling and Virus Production in Calu-3 Cells and Vero Cells upon SARS-CoV-2 Infection. Biomolecules & therapeutics. vol 29. issue 3. 2021-05-07. PMID:33504682. |
however, in calu-3 cells, sars-cov-2 infection induced long-lasting phosphorylation of stat1 and stat3, low virus production, and no prominent apoptosis. |
2021-05-07 |
2023-08-13 |
Not clear |
| Yumin Huang, Yingge Wang, Zuowei Duan, Jingyan Liang, Yijun Xu, Shuai Zhang, Tieyu Tan. Restored microRNA-326-5p Inhibits Neuronal Apoptosis and Attenuates Mitochondrial Damage via Suppressing STAT3 in Cerebral Ischemia/Reperfusion Injury. Nanoscale research letters. vol 16. issue 1. 2021-05-07. PMID:33877455. |
restored microrna-326-5p inhibits neuronal apoptosis and attenuates mitochondrial damage via suppressing stat3 in cerebral ischemia/reperfusion injury. |
2021-05-07 |
2023-08-13 |
rat |
| Yumin Huang, Yingge Wang, Zuowei Duan, Jingyan Liang, Yijun Xu, Shuai Zhang, Tieyu Tan. Restored microRNA-326-5p Inhibits Neuronal Apoptosis and Attenuates Mitochondrial Damage via Suppressing STAT3 in Cerebral Ischemia/Reperfusion Injury. Nanoscale research letters. vol 16. issue 1. 2021-05-07. PMID:33877455. |
restoring mir-326-5p or reducing stat3 reinforced viability, inhibited apoptosis and oxidative stress, increased mitochondrial membrane potential and increased mfn2 expression in ogd-treated neurons. |
2021-05-07 |
2023-08-13 |
rat |
| Yumin Huang, Yingge Wang, Zuowei Duan, Jingyan Liang, Yijun Xu, Shuai Zhang, Tieyu Tan. Restored microRNA-326-5p Inhibits Neuronal Apoptosis and Attenuates Mitochondrial Damage via Suppressing STAT3 in Cerebral Ischemia/Reperfusion Injury. Nanoscale research letters. vol 16. issue 1. 2021-05-07. PMID:33877455. |
up-regulating mir-326-5p or down-regulating stat3 relieved pathological changes, inhibited apoptosis and elevated mitochondrial membrane potential and mfn2 expression in brain tissues of rats with mcao. |
2021-05-07 |
2023-08-13 |
rat |
| Yang Luo, Min-Hao Yu, Ya-Ru Yan, Yong Zhou, Shao-Lan Qin, Yi-Zhou Huang, Jun Qin, Ming Zhon. Rab27A promotes cellular apoptosis and ROS production by regulating the miRNA-124-3p/STAT3/RelA signalling pathway in ulcerative colitis. Journal of cellular and molecular medicine. vol 24. issue 19. 2021-05-06. PMID:32815642. |
in addition, enhanced expression of mir-124-3p attenuated apoptosis and ros production by targeting regulation of stat3 in lps-induced colonic cells. |
2021-05-06 |
2023-08-13 |
mouse |
| Huiqi Huang, Ji Hao, Kejian Pang, Yibing Lv, Dingrong Wan, Chaoqun Wu, Yuanren Ma, Xinzhou Yang, Wei K Zhan. A biflavonoid-rich extract from Selaginella moellendorffii Hieron. induces apoptosis via STAT3 and Akt/NF-κB signalling pathways in laryngeal carcinoma. Journal of cellular and molecular medicine. vol 24. issue 20. 2021-05-06. PMID:32869923. |
induces apoptosis via stat3 and akt/nf-κb signalling pathways in laryngeal carcinoma. |
2021-05-06 |
2023-08-13 |
mouse |
| Wan-Ting Xu, Gui-Nan Shen, Tian-Zhu Li, Yu Zhang, Tong Zhang, Hui Xue, Wen-Bo Zuo, Yan-Nan Li, Dong-Jie Zhang, Cheng-Hao Ji. Isoorientin induces the apoptosis and cell cycle arrest of A549 human lung cancer cells via the ROS‑regulated MAPK, STAT3 and NF‑κB signaling pathways. International journal of oncology. vol 57. issue 2. 2021-05-05. PMID:32626938. |
isoorientin induces the apoptosis and cell cycle arrest of a549 human lung cancer cells via the ros‑regulated mapk, stat3 and nf‑κb signaling pathways. |
2021-05-05 |
2023-08-13 |
human |
| Manyi Sun, Yue Sun, Jinfeng Ma, Kezhong L. YY1 promotes SOCS3 expression to inhibit STAT3‑mediated neuroinflammation and neuropathic pain. Molecular medicine reports. vol 23. issue 2. 2021-05-04. PMID:33300076. |
the results revealed that yy1 overexpression promoted socs3 expression, increased cell proliferation and suppressed cell apoptosis, and reduced the activation of stat3 and stat3‑mediated production of inflammatory factors. |
2021-05-04 |
2023-08-13 |
rat |
| Navneet Joshi, Farnaz Hajizadeh, Ehsan Ansari Dezfouli, Angelina Olegovna Zekiy, Mohsen Nabi Afjadi, Seyedeh Mahboubeh Mousavi, Mohammad Hojjat-Farsangi, Vahid Karpisheh, Ata Mahmoodpoor, Hadi Hassannia, Sanam Dolati, Hamed Mohammadi, Mehdi Yousefi, Farhad Jadidi-Niarag. Silencing STAT3 enhances sensitivity of cancer cells to doxorubicin and inhibits tumor progression. Life sciences. vol 275. 2021-05-03. PMID:33745894. |
because stat3 plays a very important role in the survival and susceptibility of cancer cells to apoptosis, we hypothesized that suppression of stat3 expression could induce greater susceptibility to dox-induced cancer cell death. |
2021-05-03 |
2023-08-13 |
Not clear |
| Chuan Zhang, Kun Ma, Yanmei Yang, Fuqiang Wang, Wuyin L. Glaucocalyxin A suppresses inflammatory responses and induces apoptosis in TNF-a-induced human rheumatoid arthritis via modulation of the STAT3 pathway. Chemico-biological interactions. vol 341. 2021-05-03. PMID:33798506. |
glaucocalyxin a suppresses inflammatory responses and induces apoptosis in tnf-a-induced human rheumatoid arthritis via modulation of the stat3 pathway. |
2021-05-03 |
2023-08-13 |
human |
| Vladimir A D'yakonov, Alexey A Makarov, Lilya U Dzhemileva, Ilfir R Ramazanov, Elina Kh Makarova, Usein M Dzhemile. Natural Trienoic Acids as Anticancer Agents: First Stereoselective Synthesis, Cell Cycle Analysis, Induction of Apoptosis, Cell Signaling and Mitochondrial Targeting Studies. Cancers. vol 13. issue 8. 2021-05-02. PMID:33920067. |
the activation and inhibition of the most versatile intracellular signaling pathways (creb, jnk, nfkb, p38, erk1/2, akt, p70s6k, stat3 and stat5 tyrosine kinases) responsible for cell proliferation and for initiation of apoptosis were studied by multiplex assay technology (luminex xmap). |
2021-05-02 |
2023-08-13 |
human |
| Antonio Markotic, Darja Flegar, Danka Grcevic, Alan Sucur, Hrvoje Lalic, Petra Turcic, Natasa Kovacic, Nina Lukac, Danijel Pravdic, Katarina Vukojevic, Ivan Cavar, Tomislav Kelav. LPS-induced inflammation desensitizes hepatocytes to Fas-induced apoptosis through Stat3 activation-The effect can be reversed by ruxolitinib. Journal of cellular and molecular medicine. vol 24. issue 5. 2021-04-28. PMID:32022429. |
lps-induced inflammation desensitizes hepatocytes to fas-induced apoptosis through stat3 activation-the effect can be reversed by ruxolitinib. |
2021-04-28 |
2023-08-13 |
Not clear |
| Antonio Markotic, Darja Flegar, Danka Grcevic, Alan Sucur, Hrvoje Lalic, Petra Turcic, Natasa Kovacic, Nina Lukac, Danijel Pravdic, Katarina Vukojevic, Ivan Cavar, Tomislav Kelav. LPS-induced inflammation desensitizes hepatocytes to Fas-induced apoptosis through Stat3 activation-The effect can be reversed by ruxolitinib. Journal of cellular and molecular medicine. vol 24. issue 5. 2021-04-28. PMID:32022429. |
pre-treatment with ruxolitinib, a selective janus kinase (jak) 1/2 inhibitor, prevented the lps-induced stat3 phosphorylation and restored the sensitivity of hepatocytes to fas-mediated apoptosis. |
2021-04-28 |
2023-08-13 |
Not clear |
| Guo-Wan Zheng, Ming-Min Tang, Chen-Yan Shu, Wen-Xiu Xin, Yan-Hua Zhang, Bin-Bin Chi, Mu-Ran Shi, Xing Guo, Zhi-Zhen Zhang, Xiao-Yuan Lia. A small natural molecule CADPE kills residual colorectal cancer cells by inhibiting key transcription factors and translation initiation factors. Cell death & disease. vol 11. issue 11. 2021-04-28. PMID:33191401. |
consistently, cadpe suppressed crc tumor growth associated with robust apoptosis and depleted levels of c-myc, stat3, nf-κb, eif4f, anti-apoptotic proteins, and pro-stemness proteins. |
2021-04-28 |
2023-08-13 |
Not clear |
| Min Hee Yang, In Jin Ha, Jae-Young Um, Kwang Seok Ah. Albendazole Exhibits Anti-Neoplastic Actions against Gastric Cancer Cells by Affecting STAT3 and STAT5 Activation by Pleiotropic Mechanism(s). Biomedicines. vol 9. issue 4. 2021-04-28. PMID:33807326. |
silencing of shp-1 gene by small interfering rna (sirna) reversed the abz-promoted attenuation of stat3 as well as stat5 activation and cellular apoptosis. |
2021-04-28 |
2023-08-13 |
Not clear |
| Hamza A Alaswad, Amani A Mahbub, Christine L Le Maitre, Nicola Jordan-Mah. Molecular Action of Polyphenols in Leukaemia and Their Therapeutic Potential. International journal of molecular sciences. vol 22. issue 6. 2021-04-22. PMID:33802972. |
polyphenols have multiple mechanisms of action and have been reported to decrease cell proliferation, arrest cell cycle and induce apoptosis via the activation of caspase (3, 8 and 9); the loss of mitochondrial membrane potential and the release of cytochrome c. polyphenols have been shown to suppress activation of transcription factors, including nf-kb and stat3. |
2021-04-22 |
2023-08-13 |
Not clear |
| Erum Zafar, Muhammad Faisal Maqbool, Asia Iqbal, Amara Maryam, Hafiz Abdullah Shakir, Muhammad Irfan, Muhammad Khan, Yongming Li, Tonghui M. A comprehensive review on anticancer mechanism of bazedoxifene. Biotechnology and applied biochemistry. 2021-04-17. PMID:33759222. |
bza could effectively inhibit stat3, pi3k/akt, and mapk signaling pathways and induce apoptosis. |
2021-04-17 |
2023-08-13 |
Not clear |