| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaowen Bao, Jianwei Zhu, Chaoxing Ren, Ang Zhao, Mingya Zhang, Zhiming Zhu, Xuanzhao Lu, Yuning Zhang, Xiaotian Li, Xinyu Sima, Jiaqi Li, Qi Zhang, Bo M. β-elemonic acid inhibits growth and triggers apoptosis in human castration-resistant prostate cancer cells through the suppression of JAK2/STAT3/MCL-1 and NF-ĸB signal pathways. Chemico-biological interactions. vol 342. 2021-05-19. PMID:33878321. |
the silencing of nf-κb/p65, jak2 and stat3, respectively, increased the sensitivity of the pca cells to β-ea induced apoptosis. |
2021-05-19 |
2023-08-13 |
human |
| Shibo Wu, Weizhuang Chen, Kaitai Liu, Feng Ren, Dawei Zheng, Feng Xu, Hongcheng W. Saikosaponin D inhibits proliferation and induces apoptosis of non-small cell lung cancer cells by inhibiting the STAT3 pathway. The Journal of international medical research. vol 48. issue 9. 2021-05-14. PMID:32962498. |
saikosaponin d inhibits proliferation and induces apoptosis of non-small cell lung cancer cells by inhibiting the stat3 pathway. |
2021-05-14 |
2023-08-13 |
human |
| Tao Lv, Zhen Jian, Dejian Li, Rongguang Ao, Xu Zhang, Baoqing Y. Oxyresveratrol induces apoptosis and inhibits cell viability via inhibition of the STAT3 signaling pathway in Saos‑2 cells. Molecular medicine reports. vol 22. issue 6. 2021-05-13. PMID:33174060. |
oxyresveratrol induces apoptosis and inhibits cell viability via inhibition of the stat3 signaling pathway in saos‑2 cells. |
2021-05-13 |
2023-08-13 |
Not clear |
| Tao Lv, Zhen Jian, Dejian Li, Rongguang Ao, Xu Zhang, Baoqing Y. Oxyresveratrol induces apoptosis and inhibits cell viability via inhibition of the STAT3 signaling pathway in Saos‑2 cells. Molecular medicine reports. vol 22. issue 6. 2021-05-13. PMID:33174060. |
inhibition of cell viability and apoptosis induction by ores were rescued by enhancement of stat3 activation upon treatment with il‑6. |
2021-05-13 |
2023-08-13 |
Not clear |
| Tao Lv, Zhen Jian, Dejian Li, Rongguang Ao, Xu Zhang, Baoqing Y. Oxyresveratrol induces apoptosis and inhibits cell viability via inhibition of the STAT3 signaling pathway in Saos‑2 cells. Molecular medicine reports. vol 22. issue 6. 2021-05-13. PMID:33174060. |
collectively, the present study indicated that ores induced apoptosis and inhibited cell viability, which may be associated with the inhibition of stat3 activation; thus, ores represents a promising agent for treating osteosarcoma. |
2021-05-13 |
2023-08-13 |
Not clear |
| Xingyuan Shi, Manman Xu, Kai Luo, Wenjin Huang, Hongwei Yu, Tongchong Zho. Anticancer activity of bergenin against cervical cancer cells involves apoptosis, cell cycle arrest, inhibition of cell migration and the STAT3 signalling pathway. Experimental and therapeutic medicine. vol 21. issue 6. 2021-05-11. PMID:33968183. |
anticancer activity of bergenin against cervical cancer cells involves apoptosis, cell cycle arrest, inhibition of cell migration and the stat3 signalling pathway. |
2021-05-11 |
2023-08-13 |
Not clear |
| Xingyuan Shi, Manman Xu, Kai Luo, Wenjin Huang, Hongwei Yu, Tongchong Zho. Anticancer activity of bergenin against cervical cancer cells involves apoptosis, cell cycle arrest, inhibition of cell migration and the STAT3 signalling pathway. Experimental and therapeutic medicine. vol 17. issue 5. 2021-05-10. PMID:30988733. |
anticancer activity of bergenin against cervical cancer cells involves apoptosis, cell cycle arrest, inhibition of cell migration and the stat3 signalling pathway. |
2021-05-10 |
2023-08-13 |
Not clear |
| Hongchao He, Ran Zhuo, Jun Dai, Xiaojing Wang, Xin Huang, Haofei Wang, Danfeng X. Chelerythrine induces apoptosis via ROS-mediated endoplasmic reticulum stress and STAT3 pathways in human renal cell carcinoma. Journal of cellular and molecular medicine. vol 24. issue 1. 2021-05-10. PMID:31568643. |
chelerythrine induces apoptosis via ros-mediated endoplasmic reticulum stress and stat3 pathways in human renal cell carcinoma. |
2021-05-10 |
2023-08-13 |
human |
| Hongchao He, Ran Zhuo, Jun Dai, Xiaojing Wang, Xin Huang, Haofei Wang, Danfeng X. Chelerythrine induces apoptosis via ROS-mediated endoplasmic reticulum stress and STAT3 pathways in human renal cell carcinoma. Journal of cellular and molecular medicine. vol 24. issue 1. 2021-05-10. PMID:31568643. |
in addition, che increased cellular ros level, leading to endoplasmic reticulum (er) stress, inactivating stat3 activities and inducing apoptosis in rcc cells which were suppressed by nac, a special ros inhibitor. |
2021-05-10 |
2023-08-13 |
human |
| Hongchao He, Ran Zhuo, Jun Dai, Xiaojing Wang, Xin Huang, Haofei Wang, Danfeng X. Chelerythrine induces apoptosis via ROS-mediated endoplasmic reticulum stress and STAT3 pathways in human renal cell carcinoma. Journal of cellular and molecular medicine. vol 24. issue 1. 2021-05-10. PMID:31568643. |
we further found that both knockdown of atf4 protein and overexpression of stat3 protein could reduce che-induced apoptosis in caki cells. |
2021-05-10 |
2023-08-13 |
human |
| Hongchao He, Ran Zhuo, Jun Dai, Xiaojing Wang, Xin Huang, Haofei Wang, Danfeng X. Chelerythrine induces apoptosis via ROS-mediated endoplasmic reticulum stress and STAT3 pathways in human renal cell carcinoma. Journal of cellular and molecular medicine. vol 24. issue 1. 2021-05-10. PMID:31568643. |
these results demonstrated that the apoptosis induced by che was mediated by ros-caused er stress and stat3 inactivation. |
2021-05-10 |
2023-08-13 |
human |
| Zhiqiang Wu, Bin Xu, Zhiyi Yu, Qin He, Zhuyuan Hu, Shishi Zhou, Meiqin Chen, Liang Zh. Trifolium Flavonoids Overcome Gefitinib Resistance of Non-Small-Cell Lung Cancer Cell by Suppressing ERK and STAT3 Signaling Pathways. BioMed research international. vol 2020. 2021-05-10. PMID:33150167. |
altogether, the results of the present study indicated the potential mechanisms of chemosensitivity of tf in gefitinib-induced apoptosis of nsclc by downregulating erk and stat3 signaling pathways and bcl2 and mcl-1 expression and a promising application of tf in therapy of nsclc with gefitinib resistant. |
2021-05-10 |
2023-08-13 |
Not clear |
| Honggang Chi, Dan Wang, Mengting Chen, Jiantao Lin, Shuhua Zhang, Fengyan Yu, Jun Zhou, Xuebao Zheng, Ying Zo. Shaoyao Decoction Inhibits Inflammation and Improves Intestinal Barrier Function in Mice With Dextran Sulfate Sodium-Induced Colitis. Frontiers in pharmacology. vol 12. 2021-05-08. PMID:33959000. |
additionally, the presence of proinflammatory cytokines, immune cell infiltrates, intestinal cell proliferation, apoptosis, epithelial permeability, signal transducer and activator of transcription 3 (stat3), and nuclear factor-κb (nf-κb) signaling, as well as the intestinal mucosal barrier function, were investigated. |
2021-05-08 |
2023-08-13 |
mouse |
| Byoung Kwon Park, Dongbum Kim, Sangkyu Park, Sony Maharjan, Jinsoo Kim, Jun-Kyu Choi, Madhav Akauliya, Younghee Lee, Hyung-Joo Kwo. Differential Signaling and Virus Production in Calu-3 Cells and Vero Cells upon SARS-CoV-2 Infection. Biomolecules & therapeutics. vol 29. issue 3. 2021-05-07. PMID:33504682. |
sars-cov-2 infection induced dephosphorylation of stat1 and stat3, high virus production, and apoptosis in vero cells. |
2021-05-07 |
2023-08-13 |
Not clear |
| Byoung Kwon Park, Dongbum Kim, Sangkyu Park, Sony Maharjan, Jinsoo Kim, Jun-Kyu Choi, Madhav Akauliya, Younghee Lee, Hyung-Joo Kwo. Differential Signaling and Virus Production in Calu-3 Cells and Vero Cells upon SARS-CoV-2 Infection. Biomolecules & therapeutics. vol 29. issue 3. 2021-05-07. PMID:33504682. |
however, in calu-3 cells, sars-cov-2 infection induced long-lasting phosphorylation of stat1 and stat3, low virus production, and no prominent apoptosis. |
2021-05-07 |
2023-08-13 |
Not clear |
| Yumin Huang, Yingge Wang, Zuowei Duan, Jingyan Liang, Yijun Xu, Shuai Zhang, Tieyu Tan. Restored microRNA-326-5p Inhibits Neuronal Apoptosis and Attenuates Mitochondrial Damage via Suppressing STAT3 in Cerebral Ischemia/Reperfusion Injury. Nanoscale research letters. vol 16. issue 1. 2021-05-07. PMID:33877455. |
restored microrna-326-5p inhibits neuronal apoptosis and attenuates mitochondrial damage via suppressing stat3 in cerebral ischemia/reperfusion injury. |
2021-05-07 |
2023-08-13 |
rat |
| Yumin Huang, Yingge Wang, Zuowei Duan, Jingyan Liang, Yijun Xu, Shuai Zhang, Tieyu Tan. Restored microRNA-326-5p Inhibits Neuronal Apoptosis and Attenuates Mitochondrial Damage via Suppressing STAT3 in Cerebral Ischemia/Reperfusion Injury. Nanoscale research letters. vol 16. issue 1. 2021-05-07. PMID:33877455. |
restoring mir-326-5p or reducing stat3 reinforced viability, inhibited apoptosis and oxidative stress, increased mitochondrial membrane potential and increased mfn2 expression in ogd-treated neurons. |
2021-05-07 |
2023-08-13 |
rat |
| Yumin Huang, Yingge Wang, Zuowei Duan, Jingyan Liang, Yijun Xu, Shuai Zhang, Tieyu Tan. Restored microRNA-326-5p Inhibits Neuronal Apoptosis and Attenuates Mitochondrial Damage via Suppressing STAT3 in Cerebral Ischemia/Reperfusion Injury. Nanoscale research letters. vol 16. issue 1. 2021-05-07. PMID:33877455. |
up-regulating mir-326-5p or down-regulating stat3 relieved pathological changes, inhibited apoptosis and elevated mitochondrial membrane potential and mfn2 expression in brain tissues of rats with mcao. |
2021-05-07 |
2023-08-13 |
rat |
| Yang Luo, Min-Hao Yu, Ya-Ru Yan, Yong Zhou, Shao-Lan Qin, Yi-Zhou Huang, Jun Qin, Ming Zhon. Rab27A promotes cellular apoptosis and ROS production by regulating the miRNA-124-3p/STAT3/RelA signalling pathway in ulcerative colitis. Journal of cellular and molecular medicine. vol 24. issue 19. 2021-05-06. PMID:32815642. |
in addition, enhanced expression of mir-124-3p attenuated apoptosis and ros production by targeting regulation of stat3 in lps-induced colonic cells. |
2021-05-06 |
2023-08-13 |
mouse |
| Huiqi Huang, Ji Hao, Kejian Pang, Yibing Lv, Dingrong Wan, Chaoqun Wu, Yuanren Ma, Xinzhou Yang, Wei K Zhan. A biflavonoid-rich extract from Selaginella moellendorffii Hieron. induces apoptosis via STAT3 and Akt/NF-κB signalling pathways in laryngeal carcinoma. Journal of cellular and molecular medicine. vol 24. issue 20. 2021-05-06. PMID:32869923. |
induces apoptosis via stat3 and akt/nf-κb signalling pathways in laryngeal carcinoma. |
2021-05-06 |
2023-08-13 |
mouse |