| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Junhe Zhang, Wenwen Yang, Yunxi Xiao, Linlin Sha. MiR-125b Inhibits Cell Proliferation and Induces Apoptosis in Human Colon Cancer SW480 Cells via Targeting STAT3. Recent patents on anti-cancer drug discovery. 2021-07-09. PMID:34238196. |
mir-125b inhibits cell proliferation and induces apoptosis in human colon cancer sw480 cells via targeting stat3. |
2021-07-09 |
2023-08-13 |
human |
| Chaoqun Wu, Guangwen Shu, Huiqi Huang, Kejian Pang, Xinzhou Yang, Guangzhong Yan. Methylgerambullin derived from plant Glyccsmis pentaphylla (Retz) correa. Mediates anti-hepatocellular carcinoma cancer effect by activating mitochondrial and endoplasmic reticulum stress signaling and inhibiting AKT and STAT3 pathways. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 149. 2021-07-06. PMID:33529679. |
overall, these results suggest that methylgerambullin can inhibit hcc cells proliferation by inducing mitochondrial apoptosis, activating ers signaling pathways and inhibiting the akt and stat3 pathways. |
2021-07-06 |
2023-08-13 |
mouse |
| Shiqi Dong, Xiying Wu, Yuting Xu, Guohua Yang, Ming Ya. Molecular vision. vol 26. 2021-07-02. PMID:32753832. |
signal transducer and activator of transcription 3 (stat3) is a dna-binding protein that regulates various biologic processes, including cell growth, apoptosis, and malignant transformation. |
2021-07-02 |
2023-08-13 |
Not clear |
| Aliaa M Mohassab, Heba A Hassan, Dalia Abdelhamid, Mohamed Abdel-Azi. STAT3 transcription factor as target for anti-cancer therapy. Pharmacological reports : PR. vol 72. issue 5. 2021-07-02. PMID:32880101. |
the activation of stat3 was observed to regulate multiple gene functions during cancer-like cell proliferation, differentiation, apoptosis, metastasis, inflammation, immunity, cell survival, and angiogenesis. |
2021-07-02 |
2023-08-13 |
Not clear |
| Zhenjiang Pan, Jing Bao, Liujun Zhang, Shepeng We. UBE2D3 Activates SHP-2 Ubiquitination to Promote Glycolysis and Proliferation of Glioma Frontiers in oncology. vol 11. 2021-07-02. PMID:34195079. |
by analysis with the cancer genome atlas-glioblastoma multiforme (tcga-gbm) dataset, we found that ube2d3 was highly expressed in glioma and it is positive correlation with glycolysis, apoptosis, and stat3 pathway. |
2021-07-02 |
2023-08-13 |
Not clear |
| Jijun Xiong, Jie Quan, Chaosheng Qin, Xiaogang Wang, Qinghua Dong, Bingdong Zhan. Dexmedetomidine Exerts Brain-Protective Effects Under Cardiopulmonary Bypass Through Inhibiting the Janus Kinase 2/Signal Transducers and Activators of Transcription 3 Pathway. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. vol 40. issue 2. 2021-07-01. PMID:31834821. |
dex suppressed janus kinase 2 (jak2)/signal transducers and activators of transcription 3 (stat3) pathway activated by cpb, ameliorated cpb-induced brain injury in rats by reducing inflammatory response, and inhibited neuronal apoptosis. |
2021-07-01 |
2023-08-13 |
rat |
| Tadashi Matsuda, Kenji Oritan. STAP-2 Adaptor Protein Regulates Multiple Steps of Immune and Inflammatory Responses. Biological & pharmaceutical bulletin. vol 44. issue 7. 2021-07-01. PMID:34193686. |
stap-2 influences the stat3 and stat5 activity, integrin-mediated t cell adhesion, chemokine-induced t cell migration, fas-mediated t cell apoptosis, toll-like receptor-mediated macrophage functions, macrophage colony-stimulating factor-induced macrophage activation, and the high-affinity immunoglobulin e receptor-mediated mast cell activation. |
2021-07-01 |
2023-08-13 |
Not clear |
| Zhuan-Yi Yang, Ying Wang, Qing Liu, Ming W. microRNA cluster MC-let-7a-1~let-7d promotes autophagy and apoptosis of glioma cells by down-regulating STAT3. CNS neuroscience & therapeutics. vol 26. issue 3. 2021-06-30. PMID:31868319. |
microrna cluster mc-let-7a-1~let-7d promotes autophagy and apoptosis of glioma cells by down-regulating stat3. |
2021-06-30 |
2023-08-13 |
Not clear |
| G-J Wang, Z Yang, J Huai, Q-Q Xian. Pravastatin alleviates oxidative stress and decreases placental trophoblastic cell apoptosis through IL-6/STAT3 signaling pathway in preeclampsia rats. European review for medical and pharmacological sciences. vol 24. issue 24. 2021-06-30. PMID:33378046. |
the aim of this study was to explore the effects of pravastatin on oxidative stress and placental trophoblastic cell apoptosis in preeclampsia rats via the interleukin (il)-6/signal transducer and activator of transcription 3 (stat3) signaling pathway. |
2021-06-30 |
2023-08-13 |
rat |
| Patrik Oleksak, Miroslav Psotka, Marketa Vancurova, Olena Sapega, Jana Bieblova, Milan Reinis, David Rysanek, Romana Mikyskova, Katarina Chalupova, David Malinak, Jana Svobodova, Rudolf Andrys, Helena Rehulkova, Vojtech Skopek, Pham Ngoc Lam, Jiri Bartek, Zdenek Hodny, Kamil Musile. Design, synthesis, and Journal of enzyme inhibition and medicinal chemistry. vol 36. issue 1. 2021-06-24. PMID:33440995. |
the ability of selected bp-1-102 analogs to induce apoptosis and inhibition of stat3 receptor-mediated phosphorylation was confirmed. |
2021-06-24 |
2023-08-13 |
mouse |
| Xin Chou, Kunpeng Ma, Yue Shen, Zhen Min, Qing Wu, Daoyuan Su. Dual role of inositol-requiring enzyme 1α (IRE-1α) in Cd-induced apoptosis in human renal tubular epithelial cells: Endoplasmic reticulum stress and STAT3 signaling activation. Toxicology. vol 456. 2021-06-22. PMID:33813002. |
dual role of inositol-requiring enzyme 1α (ire-1α) in cd-induced apoptosis in human renal tubular epithelial cells: endoplasmic reticulum stress and stat3 signaling activation. |
2021-06-22 |
2023-08-13 |
human |
| Hong Wang, Yangchun Xu, Meishan Jin, Hongxia Li, Shanshan L. miR-383 reduces keratinocyte proliferation and induces the apoptosis in psoriasis via disruption of LCN2-dependent JAK/STAT pathway activation. International immunopharmacology. vol 96. 2021-06-22. PMID:33819732. |
notably, mir-383 overexpression or lcn2 knockdown attenuated psoriasis-like symptoms, suppressed inflammatory response, reduced the expression of jak3 and stat3, ceased keratinocyte proliferation, and promoted the apoptosis. |
2021-06-22 |
2023-08-13 |
rat |
| Yutang Wu, Zhizhao Chen, Yaoguo Wang, Fangzhan Pen. MiR-3691-5p is upregulated in docosahexaenoic acid-treated vascular endothelial cell and targets serpin family E member 1. Journal of cellular biochemistry. vol 121. issue 3. 2021-06-17. PMID:31674071. |
mir-mimics and inhibitors modulation results indicated that mir-3691-5p regulates endothelial apoptosis through activating antiapoptotic response which controlled by the stat3 signaling pathway. |
2021-06-17 |
2023-08-13 |
Not clear |
| Zhuo Chen, Shen-Jun Yuan, Ke Li, Quan Zhang, Tong-Fei Li, Hui-Chao An, Hua-Zhen Xu, Yuan Yue, Min Han, Yong-Hong Xu, Naoki Komatsu, Li Zhao, Xiao Che. Doxorubicin-polyglycerol-nanodiamond conjugates disrupt STAT3/IL-6-mediated reciprocal activation loop between glioblastoma cells and astrocytes. Journal of controlled release : official journal of the Controlled Release Society. vol 320. 2021-06-17. PMID:31987922. |
astrocyte-derived il-6 acted back on the gbc causing further activation of stat3 and leading to enhanced downstream events that promote proliferation, migration, invasion and apoptosis resistance of the gbc. |
2021-06-17 |
2023-08-13 |
Not clear |
| Xuan-Qi Zheng, Jin-Feng Huang, Jia-Liang Lin, Ya-Xin Zhu, Min-Qi Wang, Mei-Liang Guo, Xing-Jie Zan, Ai-Min W. Controlled release of baricitinib from a thermos-responsive hydrogel system inhibits inflammation by suppressing JAK2/STAT3 pathway in acute spinal cord injury. Colloids and surfaces. B, Biointerfaces. vol 199. 2021-06-17. PMID:33385822. |
baricitinib can effectively inhibit the jak2/stat3 pathway of microglia in vitro; while in vivo experiments show that bari-p hydrogel treatment can inhibit the phosphorylation of jak2, stat3 and suppress the production of inflammatory cytokines, and reduces neuronal apoptosis. |
2021-06-17 |
2023-08-13 |
rat |
| Ze-Bo Jiang, Wen-Jun Wang, Cong Xu, Ya-Jia Xie, Xuan-Run Wang, Yi-Zhong Zhang, Ju-Min Huang, Min Huang, Chun Xie, Pei Liu, Xing-Xing Fan, Yu-Po Ma, Pei-Yu Yan, Liang Liu, Xiao-Jun Yao, Qi-Biao Wu, Elaine Lai-Han Leun. Luteolin and its derivative apigenin suppress the inducible PD-L1 expression to improve anti-tumor immunity in KRAS-mutant lung cancer. Cancer letters. vol 515. 2021-06-15. PMID:34052328. |
luteolin and apigenin significantly inhibited lung cancer cell growth, induced cell apoptosis, and down-regulated the ifn-γ-induced pd-l1 expression by suppressing the phosphorylation of stat3. |
2021-06-15 |
2023-08-13 |
mouse |
| Xin-Mei Lin, Shao-Bin Liu, Ying-Hua Luo, Wan-Ting Xu, Yu Zhang, Tong Zhang, Hui Xue, Wen-Bo Zuo, Yan-Nan Li, Bao-Xin Lu, Cheng-Hao Ji. 10-HDA Induces ROS-Mediated Apoptosis in A549 Human Lung Cancer Cells by Regulating the MAPK, STAT3, NF- BioMed research international. vol 2020. 2021-06-08. PMID:33376719. |
10-hda induces ros-mediated apoptosis in a549 human lung cancer cells by regulating the mapk, stat3, nf- 10-hydroxy-2-decenoic acid (10-hda), also known as royal jelly acid, has a variety of physiological functions, and recent studies have shown that it also has anticancer effects. |
2021-06-08 |
2023-08-13 |
human |
| Hongwei Tang, Hongbo Fang, Wenzhi Guo, Shengli Cao, Danfeng Guo, Huapeng Zhang, Jie Gao, Shuijun Zhan. Single nucleotide polymorphisms in interleukin-6 attenuates hepatocytes injury in hypoxia/re-oxygenation via STAT3 signal pathway mediated autophagy. Molecular biology reports. vol 48. issue 2. 2021-06-07. PMID:33484391. |
and the further study revealed the pre-treatment with il-6 activated the stat3 signaling pathway in the l02 cells and then caused the activation of autophagy and apoptosis inhibition. |
2021-06-07 |
2023-08-13 |
human |
| Attalla F El-Kott, Eman R ElBealy, Ali S Alshehri, Ayman E El-Kenawy, Heba S Khalifa, Amira M AlRamlaw. Salidroside induces cell apoptosis and inhibits the invasiveness of HT29 colorectal cells by regulating protein kinase R, NF-κB and STAT3. Cancer biomarkers : section A of Disease markers. vol 31. issue 1. 2021-06-07. PMID:33749640. |
salidroside induces cell apoptosis and inhibits the invasiveness of ht29 colorectal cells by regulating protein kinase r, nf-κb and stat3. |
2021-06-07 |
2023-08-13 |
Not clear |
| Zhaofeng Tan, Haibin Xue, Yuli Sun, Chuanlong Zhang, Yonglei Song, Yuanfu Q. The Role of Tumor Inflammatory Microenvironment in Lung Cancer. Frontiers in pharmacology. vol 12. 2021-06-05. PMID:34079469. |
inflammatory cells and inflammatory factors in the tumor inflammatory microenvironment promote the activation of the nf-κb and stat3 inflammatory pathways and the occurrence, development, and metastasis of lung cancer by promoting immune escape, tumor angiogenesis, epithelial-mesenchymal transition, apoptosis, and other mechanisms. |
2021-06-05 |
2023-08-13 |
Not clear |