| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nana Xu, Jingnuan Hu, Ke Han, Yang Ou, Tingting Ji, Jialiang Xin. Shionone suppresses the growth, migration and invasion of human breast cancer cells via induction of apoptosis and inhibition of MEK/ERK and STAT3 signalling pathways. Journal of B.U.ON. : official journal of the Balkan Union of Oncology. vol 25. issue 4. 2021-07-22. PMID:33099919. |
shionone suppresses the growth, migration and invasion of human breast cancer cells via induction of apoptosis and inhibition of mek/erk and stat3 signalling pathways. |
2021-07-22 |
2023-08-13 |
human |
| Jie Zhao, Xin Liu, Yao Chen, Lin-Shuang Zhang, Ya-Rong Zhang, Deng-Ren Ji, Shi-Meng Liu, Mo-Zhi Jia, Yong-Hong Zhu, Yong-Fen Qi, Feng-Min Lu, Yan-Rong Y. STAT3 Promotes Schistosome-Induced Liver Injury by Inflammation, Oxidative Stress, Proliferation, and Apoptosis Signal Pathway. Infection and immunity. vol 89. issue 3. 2021-07-22. PMID:33257536. |
stat3 promotes schistosome-induced liver injury by inflammation, oxidative stress, proliferation, and apoptosis signal pathway. |
2021-07-22 |
2023-08-13 |
mouse |
| Lijuan Chen, Zhi Guo, Yongming Zhou, Jian Ni, Jianhua Zhu, Xu Fan, Xuexing Chen, Yiling Liu, Ziping Li, Hao Zho. microRNA-1246-containing extracellular vesicles from acute myeloid leukemia cells promote the survival of leukemia stem cells via the LRIG1-meditated STAT3 pathway. Aging. vol 13. issue 10. 2021-07-22. PMID:33893245. |
mir-1246 inhibitor or ev-encapsulated mir-1246 inhibitor was found to suppress the viability and colony formation abilities but promoted the apoptosis and differentiation of lscs through inactivation of stat3 pathway by up-regulating lrig1. |
2021-07-22 |
2023-08-13 |
Not clear |
| Matthew B Minus, Haopei Wang, Jaime O Munoz, Alexandra M Stevens, Alicia E Mangubat-Medina, Michael J Krueger, Wei Liu, Moses M Kasembeli, Julian C Cooper, Mikhail I Kolosov, David J Tweardy, Michele S Redell, Zachary T Bal. Targeting STAT3 anti-apoptosis pathways with organic and hybrid organic-inorganic inhibitors. Organic & biomolecular chemistry. vol 18. issue 17. 2021-07-21. PMID:32286579. |
this paper describes synthetic studies and biological assays for a naphthalene sulfonamide inhibitor class of molecules that inhibit g-csf-induced stat3 phosphorylation in cellulo and induce apoptosis in aml cells. |
2021-07-21 |
2023-08-13 |
Not clear |
| Miao Mo, Yangle Li, Xiheng H. Serum CXCL5 level is associated with tumor progression in penile cancer. Bioscience reports. vol 41. issue 1. 2021-07-21. PMID:33458757. |
furthermore, knockdown of cxcl5 or cxcr2 expression markedly suppressed malignant phenotypes (cell proliferation, clonogenesis, apoptosis escape, migration, and invasion), attenuated stat3 and akt signaling, and reduced mmp2/9 secretion in pc cell lines. |
2021-07-21 |
2023-08-13 |
Not clear |
| Jiankuo Guo, Dongmei Dou, Tianlun Zhang, Bo Wan. HOTAIR Promotes Cisplatin Resistance of Osteosarcoma Cells by Regulating Cell Proliferation, Invasion, and Apoptosis via miR-106a-5p/STAT3 Axis. Cell transplantation. vol 29. 2021-07-19. PMID:32757663. |
what's more, the transfection of stat3 sirna reversed the decrease of ddp resistance, cell proliferation, and invasion and rescued the increase of apoptosis induced by mir-106a-5p inhibition. |
2021-07-19 |
2023-08-13 |
Not clear |
| Xiaodong Sun, Qianqian Xu, Lian Zeng, Lixia Xie, Qiang Zhao, Hongxia Xu, Xuanbin Wang, Nan Jiang, Pan Fu, Ming San. Resveratrol suppresses the growth and metastatic potential of cervical cancer by inhibiting STAT3 Cancer medicine. vol 9. issue 22. 2021-07-19. PMID:33040485. |
resveratrol suppresses the growth and metastatic potential of cervical cancer by inhibiting stat3 aberrant signal transducer and activator of transcription 3 (stat3) signaling promotes the initiation and progression of cancer in humans by either inhibiting apoptosis or inducing cell proliferation, angiogenesis, invasion, and metastasis. |
2021-07-19 |
2023-08-13 |
mouse |
| Dongjun Jiang, Jiaqi Xu, Sitong Liu, Moussa Ide Nasser, Wei Wei, Tianjiao Mao, Xintong Liu, Xiaopan Zou, Jiang Li, Xiaomeng L. Rosmanol induces breast cancer cells apoptosis by regulating PI3K/AKT and STAT3/JAK2 signaling pathways. Oncology letters. vol 22. issue 2. 2021-07-17. PMID:34267823. |
moreover, rosmanol inhibited proliferation and promoted apoptosis of cancer cells via the inhibition of erk and stat3 signals, attributable to the increase in p-p38, the overexpression of protein inhibitor of activated stat3, and the decrease in pi3k/akt, erk and jak2/stat3. |
2021-07-17 |
2023-08-13 |
human |
| Fengyun Zhou, Ting Feng, Xiangqi Lu, Huicheng Wang, Yangping Chen, Qiuxia Zhang, Xinlu Zhang, Jiancheng Xi. Interleukin 35 protects cardiomyocytes following ischemia/reperfusion-induced apoptosis via activation of mitochondrial STAT3. Acta biochimica et biophysica Sinica. vol 53. issue 4. 2021-07-16. PMID:33619515. |
interleukin 35 protects cardiomyocytes following ischemia/reperfusion-induced apoptosis via activation of mitochondrial stat3. |
2021-07-16 |
2023-08-13 |
mouse |
| Fengyun Zhou, Ting Feng, Xiangqi Lu, Huicheng Wang, Yangping Chen, Qiuxia Zhang, Xinlu Zhang, Jiancheng Xi. Interleukin 35 protects cardiomyocytes following ischemia/reperfusion-induced apoptosis via activation of mitochondrial STAT3. Acta biochimica et biophysica Sinica. vol 53. issue 4. 2021-07-16. PMID:33619515. |
meanwhile, il-35 remarkably activates mitochondrial stat3 (mitostat3) signaling, inhibits cytochrome c release, and reduces apoptosis signaling. |
2021-07-16 |
2023-08-13 |
mouse |
| Yue Zhao, Dongsheng Bai, Jiaying Du, Haochuan Ren, Zhenguo Zhang, Cheng Jiang, Na L. Induction of cell cycle arrest and apoptosis by CPUC002 through stabilization of p53 and suppression of STAT3 signaling pathway in multiple myeloma. Cell biology and toxicology. vol 37. issue 1. 2021-07-15. PMID:33126266. |
induction of cell cycle arrest and apoptosis by cpuc002 through stabilization of p53 and suppression of stat3 signaling pathway in multiple myeloma. |
2021-07-15 |
2023-08-13 |
human |
| Yue Zhao, Dongsheng Bai, Jiaying Du, Haochuan Ren, Zhenguo Zhang, Cheng Jiang, Na L. Induction of cell cycle arrest and apoptosis by CPUC002 through stabilization of p53 and suppression of STAT3 signaling pathway in multiple myeloma. Cell biology and toxicology. vol 37. issue 1. 2021-07-15. PMID:33126266. |
further studies showed that the cpuc002 also inhibited the stat3 signaling pathway, while knockdown of stat3 abolished cpuc002-induced apoptosis and cell cycle arrest. |
2021-07-15 |
2023-08-13 |
human |
| Yue Zhao, Dongsheng Bai, Jiaying Du, Haochuan Ren, Zhenguo Zhang, Cheng Jiang, Na L. Induction of cell cycle arrest and apoptosis by CPUC002 through stabilization of p53 and suppression of STAT3 signaling pathway in multiple myeloma. Cell biology and toxicology. vol 37. issue 1. 2021-07-15. PMID:33126266. |
together these findings indicate that cpuc002 induces apoptosis and g0/g1 cell cycle arrest in multiple myeloma cells by stabilizing p53 and inhibiting the stat3 signaling pathway. |
2021-07-15 |
2023-08-13 |
human |
| Shi-Zhong Cai, Qian-Wei Xiong, Li-Na Zhao, Yi-Ting Ji, Zheng-Xiang Luo, Zhou-Rui M. β-Elemene Triggers ROS-dependent Apoptosis in Glioblastoma Cells Through Suppressing STAT3 Signaling Pathway. Pathology oncology research : POR. vol 27. 2021-07-15. PMID:34257541. |
β-elemene triggers ros-dependent apoptosis in glioblastoma cells through suppressing stat3 signaling pathway. |
2021-07-15 |
2023-08-13 |
Not clear |
| Ningjuan Liang, Siwen Li, Yuehui Liang, Yu Ma, Sixuan Tang, Shuzi Ye, Fang Xia. Clusterin inhibits Cr(VI)-induced apoptosis via enhancing mitochondrial biogenesis through AKT-associated STAT3 activation in L02 hepatocytes. Ecotoxicology and environmental safety. vol 221. 2021-07-12. PMID:34175824. |
clusterin inhibits cr(vi)-induced apoptosis via enhancing mitochondrial biogenesis through akt-associated stat3 activation in l02 hepatocytes. |
2021-07-12 |
2023-08-13 |
Not clear |
| Ningjuan Liang, Siwen Li, Yuehui Liang, Yu Ma, Sixuan Tang, Shuzi Ye, Fang Xia. Clusterin inhibits Cr(VI)-induced apoptosis via enhancing mitochondrial biogenesis through AKT-associated STAT3 activation in L02 hepatocytes. Ecotoxicology and environmental safety. vol 221. 2021-07-12. PMID:34175824. |
signal transducer and activator of transcription 3 (stat3) was down-regulated in cr(vi)-induced apoptosis, and clu may regulate stat3 via protein kinase b (pkb/akt) in cr(vi)-exposed hepatocytes. |
2021-07-12 |
2023-08-13 |
Not clear |
| Ningjuan Liang, Siwen Li, Yuehui Liang, Yu Ma, Sixuan Tang, Shuzi Ye, Fang Xia. Clusterin inhibits Cr(VI)-induced apoptosis via enhancing mitochondrial biogenesis through AKT-associated STAT3 activation in L02 hepatocytes. Ecotoxicology and environmental safety. vol 221. 2021-07-12. PMID:34175824. |
we used the stat3 inhibitor c188-9 and the akt inhibitor uprosertib to eliminate the anti-apoptotic effect of clu, and found that clu inhibited cr(vi)-induced apoptosis by up-regulating akt/stat3 signal. |
2021-07-12 |
2023-08-13 |
Not clear |
| Ningjuan Liang, Siwen Li, Yuehui Liang, Yu Ma, Sixuan Tang, Shuzi Ye, Fang Xia. Clusterin inhibits Cr(VI)-induced apoptosis via enhancing mitochondrial biogenesis through AKT-associated STAT3 activation in L02 hepatocytes. Ecotoxicology and environmental safety. vol 221. 2021-07-12. PMID:34175824. |
based on the fact that both akt and stat3 are closely related to mitochondrial biogenesis and mitochondrial pathway-associated apoptosis, this study is the first time to link clu, stat3, akt and mitochondrial biogenesis function after cr(vi) exposure, to further enrich the experimental basis of cr(vi)-induced hepatotoxicity, clarify the molecular mechanism of clu helping cells to escape apoptosis, and also suggest that new ways can be sought to prevent and treat cr(vi)-induced hepatotoxicity by regulating mitochondrial biosynthesis. |
2021-07-12 |
2023-08-13 |
Not clear |
| Behrooz Johari, Mohammad Rahmati, Leila Nasehi, Yousef Mortazavi, Mohammad Hasan Faghfoori, Hamed Rezaeeja. Evaluation of STAT3 decoy oligodeoxynucleotides' synergistic effects on radiation and/or chemotherapy in metastatic breast cancer cell line. Cell biology international. vol 44. issue 12. 2021-07-09. PMID:32841450. |
synergistic effects of stat3 scr and decoy odns on cells were investigated by cell viability (mtt), cell cycle profile, apoptosis rate, migration, and invasion assays. |
2021-07-09 |
2023-08-13 |
Not clear |
| Behrooz Johari, Mohammad Rahmati, Leila Nasehi, Yousef Mortazavi, Mohammad Hasan Faghfoori, Hamed Rezaeeja. Evaluation of STAT3 decoy oligodeoxynucleotides' synergistic effects on radiation and/or chemotherapy in metastatic breast cancer cell line. Cell biology international. vol 44. issue 12. 2021-07-09. PMID:32841450. |
statistical analysis of obtained data showed that stat3 decoy odns significantly decreased the cell viability, arrested the growth at g0/g1 phase, increased apoptosis rate, and reduced migrated and invaded cells through transwell membrane, in xi, mtx, and xi/mtx exposed groups. |
2021-07-09 |
2023-08-13 |
Not clear |