| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Patrik Oleksak, Miroslav Psotka, Marketa Vancurova, Olena Sapega, Jana Bieblova, Milan Reinis, David Rysanek, Romana Mikyskova, Katarina Chalupova, David Malinak, Jana Svobodova, Rudolf Andrys, Helena Rehulkova, Vojtech Skopek, Pham Ngoc Lam, Jiri Bartek, Zdenek Hodny, Kamil Musile. Design, synthesis, and Journal of enzyme inhibition and medicinal chemistry. vol 36. issue 1. 2021-06-24. PMID:33440995. |
the ability of selected bp-1-102 analogs to induce apoptosis and inhibition of stat3 receptor-mediated phosphorylation was confirmed. |
2021-06-24 |
2023-08-13 |
mouse |
| Xin Chou, Kunpeng Ma, Yue Shen, Zhen Min, Qing Wu, Daoyuan Su. Dual role of inositol-requiring enzyme 1α (IRE-1α) in Cd-induced apoptosis in human renal tubular epithelial cells: Endoplasmic reticulum stress and STAT3 signaling activation. Toxicology. vol 456. 2021-06-22. PMID:33813002. |
dual role of inositol-requiring enzyme 1α (ire-1α) in cd-induced apoptosis in human renal tubular epithelial cells: endoplasmic reticulum stress and stat3 signaling activation. |
2021-06-22 |
2023-08-13 |
human |
| Hong Wang, Yangchun Xu, Meishan Jin, Hongxia Li, Shanshan L. miR-383 reduces keratinocyte proliferation and induces the apoptosis in psoriasis via disruption of LCN2-dependent JAK/STAT pathway activation. International immunopharmacology. vol 96. 2021-06-22. PMID:33819732. |
notably, mir-383 overexpression or lcn2 knockdown attenuated psoriasis-like symptoms, suppressed inflammatory response, reduced the expression of jak3 and stat3, ceased keratinocyte proliferation, and promoted the apoptosis. |
2021-06-22 |
2023-08-13 |
rat |
| Yutang Wu, Zhizhao Chen, Yaoguo Wang, Fangzhan Pen. MiR-3691-5p is upregulated in docosahexaenoic acid-treated vascular endothelial cell and targets serpin family E member 1. Journal of cellular biochemistry. vol 121. issue 3. 2021-06-17. PMID:31674071. |
mir-mimics and inhibitors modulation results indicated that mir-3691-5p regulates endothelial apoptosis through activating antiapoptotic response which controlled by the stat3 signaling pathway. |
2021-06-17 |
2023-08-13 |
Not clear |
| Zhuo Chen, Shen-Jun Yuan, Ke Li, Quan Zhang, Tong-Fei Li, Hui-Chao An, Hua-Zhen Xu, Yuan Yue, Min Han, Yong-Hong Xu, Naoki Komatsu, Li Zhao, Xiao Che. Doxorubicin-polyglycerol-nanodiamond conjugates disrupt STAT3/IL-6-mediated reciprocal activation loop between glioblastoma cells and astrocytes. Journal of controlled release : official journal of the Controlled Release Society. vol 320. 2021-06-17. PMID:31987922. |
astrocyte-derived il-6 acted back on the gbc causing further activation of stat3 and leading to enhanced downstream events that promote proliferation, migration, invasion and apoptosis resistance of the gbc. |
2021-06-17 |
2023-08-13 |
Not clear |
| Xuan-Qi Zheng, Jin-Feng Huang, Jia-Liang Lin, Ya-Xin Zhu, Min-Qi Wang, Mei-Liang Guo, Xing-Jie Zan, Ai-Min W. Controlled release of baricitinib from a thermos-responsive hydrogel system inhibits inflammation by suppressing JAK2/STAT3 pathway in acute spinal cord injury. Colloids and surfaces. B, Biointerfaces. vol 199. 2021-06-17. PMID:33385822. |
baricitinib can effectively inhibit the jak2/stat3 pathway of microglia in vitro; while in vivo experiments show that bari-p hydrogel treatment can inhibit the phosphorylation of jak2, stat3 and suppress the production of inflammatory cytokines, and reduces neuronal apoptosis. |
2021-06-17 |
2023-08-13 |
rat |
| Ze-Bo Jiang, Wen-Jun Wang, Cong Xu, Ya-Jia Xie, Xuan-Run Wang, Yi-Zhong Zhang, Ju-Min Huang, Min Huang, Chun Xie, Pei Liu, Xing-Xing Fan, Yu-Po Ma, Pei-Yu Yan, Liang Liu, Xiao-Jun Yao, Qi-Biao Wu, Elaine Lai-Han Leun. Luteolin and its derivative apigenin suppress the inducible PD-L1 expression to improve anti-tumor immunity in KRAS-mutant lung cancer. Cancer letters. vol 515. 2021-06-15. PMID:34052328. |
luteolin and apigenin significantly inhibited lung cancer cell growth, induced cell apoptosis, and down-regulated the ifn-γ-induced pd-l1 expression by suppressing the phosphorylation of stat3. |
2021-06-15 |
2023-08-13 |
mouse |
| Xin-Mei Lin, Shao-Bin Liu, Ying-Hua Luo, Wan-Ting Xu, Yu Zhang, Tong Zhang, Hui Xue, Wen-Bo Zuo, Yan-Nan Li, Bao-Xin Lu, Cheng-Hao Ji. 10-HDA Induces ROS-Mediated Apoptosis in A549 Human Lung Cancer Cells by Regulating the MAPK, STAT3, NF- BioMed research international. vol 2020. 2021-06-08. PMID:33376719. |
10-hda induces ros-mediated apoptosis in a549 human lung cancer cells by regulating the mapk, stat3, nf- 10-hydroxy-2-decenoic acid (10-hda), also known as royal jelly acid, has a variety of physiological functions, and recent studies have shown that it also has anticancer effects. |
2021-06-08 |
2023-08-13 |
human |
| Hongwei Tang, Hongbo Fang, Wenzhi Guo, Shengli Cao, Danfeng Guo, Huapeng Zhang, Jie Gao, Shuijun Zhan. Single nucleotide polymorphisms in interleukin-6 attenuates hepatocytes injury in hypoxia/re-oxygenation via STAT3 signal pathway mediated autophagy. Molecular biology reports. vol 48. issue 2. 2021-06-07. PMID:33484391. |
and the further study revealed the pre-treatment with il-6 activated the stat3 signaling pathway in the l02 cells and then caused the activation of autophagy and apoptosis inhibition. |
2021-06-07 |
2023-08-13 |
human |
| Attalla F El-Kott, Eman R ElBealy, Ali S Alshehri, Ayman E El-Kenawy, Heba S Khalifa, Amira M AlRamlaw. Salidroside induces cell apoptosis and inhibits the invasiveness of HT29 colorectal cells by regulating protein kinase R, NF-κB and STAT3. Cancer biomarkers : section A of Disease markers. vol 31. issue 1. 2021-06-07. PMID:33749640. |
salidroside induces cell apoptosis and inhibits the invasiveness of ht29 colorectal cells by regulating protein kinase r, nf-κb and stat3. |
2021-06-07 |
2023-08-13 |
Not clear |
| Zhaofeng Tan, Haibin Xue, Yuli Sun, Chuanlong Zhang, Yonglei Song, Yuanfu Q. The Role of Tumor Inflammatory Microenvironment in Lung Cancer. Frontiers in pharmacology. vol 12. 2021-06-05. PMID:34079469. |
inflammatory cells and inflammatory factors in the tumor inflammatory microenvironment promote the activation of the nf-κb and stat3 inflammatory pathways and the occurrence, development, and metastasis of lung cancer by promoting immune escape, tumor angiogenesis, epithelial-mesenchymal transition, apoptosis, and other mechanisms. |
2021-06-05 |
2023-08-13 |
Not clear |
| John D Landua, Ricardo Moraes, Ellen M Carpenter, Michael T Lewi. Hoxd10 Is Required Systemically for Secretory Activation in Lactation and Interacts Genetically with Hoxd9. Journal of mammary gland biology and neoplasia. vol 25. issue 2. 2021-06-04. PMID:32705545. |
affected regions of Δhoxd10 and Δhoxd9/d10 mutants showed reduced prolactin receptor expression, reduced signal transducer and activator transcription protein 5 (stat5) phosphorylation, reduced expression of downstream milk proteins, mislocalized glucose transporter 1 (glut1), increased stat3 expression and phosphorylation, recruitment of leukocytes, altered cell cycle status, and increased apoptosis relative to unaffected regions and wild type control glands. |
2021-06-04 |
2023-08-13 |
mouse |
| Dongfang Tang, Haoyao Jiang, Zhigang Li, Wen Gao, Yifeng Su. The mechanism of ABL1 upregulating the expression of PD-L1 and the therapeutic effect of PD-L1 and STAT3 inhibitors in lung adenocarcinoma. Neoplasma. vol 68. issue 3. 2021-06-02. PMID:33147049. |
lastly, we observed the apoptosis and expression of stat3 and pd-l1 before and after treatments in transfected and knocked down cell lines. |
2021-06-02 |
2023-08-13 |
Not clear |
| Dongfang Tang, Haoyao Jiang, Zhigang Li, Wen Gao, Yifeng Su. The mechanism of ABL1 upregulating the expression of PD-L1 and the therapeutic effect of PD-L1 and STAT3 inhibitors in lung adenocarcinoma. Neoplasma. vol 68. issue 3. 2021-06-02. PMID:33147049. |
furthermore, the stat3 inhibitor might induce more apoptosis than the pd-l1 inhibitor in both h1975 and pc-9 cell lines (both p<0.01) the stat3 inhibitor combined with pd-l1 inhibitor had a synergistic effect on the pc-9 cell line, and the antagonistic effect was observed on the h1975 cell line. |
2021-06-02 |
2023-08-13 |
Not clear |
| Heriberto Torres-Moreno, Maria C Marcotullio, Carlos Velazquez, Víctor M Arenas-Luna, Salomón Hernández-Gutiérrez, Ramón E Robles-Zeped. Cucurbitacin IIb from Ibervillea sonorae Induces Apoptosis and Cell Cycle Arrest via STAT3 Inhibition. Anti-cancer agents in medicinal chemistry. vol 20. issue 10. 2021-05-28. PMID:32294048. |
cucurbitacin iib from ibervillea sonorae induces apoptosis and cell cycle arrest via stat3 inhibition. |
2021-05-28 |
2023-08-13 |
Not clear |
| Shiwen Xu, Chunyan Yu, Xiaoxia Ma, Yan Li, Yangyang Shen, Yan Chen, Suhui Huang, Tongshuo Zhang, Weimin Deng, Yue Wan. IL-6 promotes nuclear translocation of HIF-1α to aggravate chemoresistance of ovarian cancer cells. European journal of pharmacology. vol 894. 2021-05-28. PMID:33345849. |
proliferation assay and apoptosis assay were applied and proved that il-6 enhances the chemoresistance of ovca cells against cisplatin through the upregulation of hif-1α via the stat3 signaling in vitro. |
2021-05-28 |
2023-08-13 |
Not clear |
| Il Je Cho, Jae Kwang Kim, Eun Ok Kim, Sang Mi Park, Sang Chan Kim, Sung Hwan Ki, Sae Kwang K. Hemistepsin a Induces Apoptosis of Hepatocellular Carcinoma Cells by Downregulating STAT3. International journal of molecular sciences. vol 22. issue 9. 2021-05-28. PMID:33947048. |
hemistepsin a induces apoptosis of hepatocellular carcinoma cells by downregulating stat3. |
2021-05-28 |
2023-08-13 |
Not clear |
| Jisheng Wang, Binghao Bao, Junlong Feng, Qi Zhao, Hengheng Dai, Fanchao Meng, Sheng Deng, Bin Wang, Haisong L. Effects of Diabetes Mellitus on Sperm Quality in the Db/Db Mouse Model and the Role of the FoxO1 Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 27. 2021-05-24. PMID:33589581. |
conclusions this study demonstrated that dm inhibited the expression of pi3k, akt, and stat3 proteins and mrnas in the foxo1 pathway and promoted the expression of foxo1, fasl, and il-6 proteins and mrnas, leading to abnormal apoptosis of testicular tissue cells and functional damage, and eventually spermatogenic dysfunction. |
2021-05-24 |
2023-08-13 |
mouse |
| Yifeng Ni, Hao Zhang, Jing Zhang, Zhi Li, Zubing L. Inhibition of JAK2 by AG490 promotes TNF-α-induced apoptosis by inhibiting autophagy in MC3T3-E1 cells. Die Pharmazie. vol 75. issue 6. 2021-05-20. PMID:32539921. |
this study demonstrated for the first time that jak2 inhibition by ag490 may play a crucial role in tnf-α-induced apoptosis by inhibiting autophagy and inhibiting the stat3, akt, and erk signaling pathways. |
2021-05-20 |
2023-08-13 |
Not clear |
| Xiaobo Zhang, Ying Zhu, Ying Zhou, Bingru Fe. Interleukin 37 (IL-37) Reduces High Glucose-Induced Inflammation, Oxidative Stress, and Apoptosis of Podocytes by Inhibiting the STAT3-Cyclophilin A (CypA) Signaling Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-05-20. PMID:32931486. |
overexpression of stat3 and cypa inhibited the effects of il-37 on the alleviation of inflammation and oxidative stress and on the reduction of apoptosis of high glucose-treated podocytes. |
2021-05-20 |
2023-08-13 |
Not clear |