| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jeong-Hun Lee, Kyung-Sook Chung, Hwi-Ho Lee, Dohyeong Ko, Minji Kang, Ho Yoo, JooHoon Ahn, Jae Yeol Lee, Kyung-Tae Le. Improved tumor-suppressive effect of OZ-001 combined with cisplatin mediated by mTOR/p70S6K and STAT3 inactivation in A549 human lung cancer cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 142. 2021-09-22. PMID:34329824. |
moreover, our findings showed that mechanistic target of rapamycin (mtor), ribosomal protein s6 kinase (p70s6k), and signal transducer and activator of transcription (stat3) inactivation was required for apoptosis induced by the combination of oz-001 and cisplatin in in vitro and in vivo experiments. |
2021-09-22 |
2023-08-13 |
mouse |
| Chaosheng Li, Changyan Fan, Jilai Zhao, Meiqi Di, Chenyan Sui, Likun Han, Lingling H. Panaxatriol Saponins Promote M2 Polarization of BV2 Cells to Reduce Inflammation and Apoptosis after Glucose/Oxygen Deprivation by Activating STAT3. Inflammation. vol 43. issue 6. 2021-09-21. PMID:32725513. |
panaxatriol saponins promote m2 polarization of bv2 cells to reduce inflammation and apoptosis after glucose/oxygen deprivation by activating stat3. |
2021-09-21 |
2023-08-13 |
Not clear |
| Chaosheng Li, Changyan Fan, Jilai Zhao, Meiqi Di, Chenyan Sui, Likun Han, Lingling H. Panaxatriol Saponins Promote M2 Polarization of BV2 Cells to Reduce Inflammation and Apoptosis after Glucose/Oxygen Deprivation by Activating STAT3. Inflammation. vol 43. issue 6. 2021-09-21. PMID:32725513. |
after the addition of stat3 inhibitor stattic, it was found that pts could promote m2 polarization of bv2 cells by activating the stat3 pathway, thus inhibiting cell inflammation and apoptosis. |
2021-09-21 |
2023-08-13 |
Not clear |
| Chaosheng Li, Changyan Fan, Jilai Zhao, Meiqi Di, Chenyan Sui, Likun Han, Lingling H. Panaxatriol Saponins Promote M2 Polarization of BV2 Cells to Reduce Inflammation and Apoptosis after Glucose/Oxygen Deprivation by Activating STAT3. Inflammation. vol 43. issue 6. 2021-09-21. PMID:32725513. |
pts promoted m2 polarization in microglia cells by activating the stat3 pathway, thereby reducing cell inflammation and apoptosis after glucose/oxygen deprivation. |
2021-09-21 |
2023-08-13 |
Not clear |
| Xiaokun Zhou, Liang Lv, Yuan Tan, Zhongyi Zhang, Shuyang Wei, Shaowen Xia. Tanshinone IIA sensitizes TRAIL-induced apoptosis in glioblastoma through inducing the expression of death receptors (and suppressing STAT3 activation). Brain research. vol 1766. 2021-09-21. PMID:33984327. |
tanshinone iia sensitizes trail-induced apoptosis in glioblastoma through inducing the expression of death receptors (and suppressing stat3 activation). |
2021-09-21 |
2023-08-13 |
Not clear |
| Xinran Liu, Yiping Zhang, Yijie Wang, Meiwen Yang, Fenfang Hong, Shulong Yan. Protein Phosphorylation in Cancer: Role of Nitric Oxide Signaling Pathway. Biomolecules. vol 11. issue 7. 2021-09-21. PMID:34356634. |
phosphorylation of key proteins, including p38 mapk, erk, pi3k, stat3, and p53, modified by no in various signaling pathways affects different cancer-related processes including cell apoptosis, proliferation, angiogenesis, metastasis, and several cancer therapies. |
2021-09-21 |
2023-08-13 |
Not clear |
| Yaming Xu, Shini Feng, Bing Ni. Silencing Stat3 inhibits viability and induces apoptosis in BGC-823 human gastric cancer cell line. Biotechnic & histochemistry : official publication of the Biological Stain Commission. vol 96. issue 1. 2021-09-17. PMID:32619110. |
silencing stat3 inhibits viability and induces apoptosis in bgc-823 human gastric cancer cell line. |
2021-09-17 |
2023-08-13 |
human |
| Yaming Xu, Shini Feng, Bing Ni. Silencing Stat3 inhibits viability and induces apoptosis in BGC-823 human gastric cancer cell line. Biotechnic & histochemistry : official publication of the Biological Stain Commission. vol 96. issue 1. 2021-09-17. PMID:32619110. |
we investigated the effects of silencing stat3 and stat5b on the viability and apoptosis of the human gastric cancer cell line, bgc-823. |
2021-09-17 |
2023-08-13 |
human |
| Yaming Xu, Shini Feng, Bing Ni. Silencing Stat3 inhibits viability and induces apoptosis in BGC-823 human gastric cancer cell line. Biotechnic & histochemistry : official publication of the Biological Stain Commission. vol 96. issue 1. 2021-09-17. PMID:32619110. |
silencing of stat3 caused significantly decreased viability and increased apoptosis, as well as attenuated b-cell lymphoma-2 (bcl-2) expression in bgc-823 cells. |
2021-09-17 |
2023-08-13 |
human |
| Yaming Xu, Shini Feng, Bing Ni. Silencing Stat3 inhibits viability and induces apoptosis in BGC-823 human gastric cancer cell line. Biotechnic & histochemistry : official publication of the Biological Stain Commission. vol 96. issue 1. 2021-09-17. PMID:32619110. |
stat3, but not stat5b, plays an important role in the viability and apoptosis of human gastric cancer cell line, bgc-823, which suggests that stat3 is a potential target for gastric cancer therapy. |
2021-09-17 |
2023-08-13 |
human |
| Mi-So Jeong, Kang-Wook Lee, Yu-Jeong Choi, Yun-Gyeong Kim, Hyun-Ha Hwang, Seo-Yeon Lee, Se-Eun Jung, Sun-Ah Park, Jin-Hee Lee, Yong-Joon Joo, Sung-Gook Cho, Seong-Gyu K. Synergistic Antitumor Activity of SH003 and Docetaxel via EGFR Signaling Inhibition in Non-Small Cell Lung Cancer. International journal of molecular sciences. vol 22. issue 16. 2021-09-16. PMID:34445110. |
moreover, sh003 and dtx induced the apoptosis of h460 cells via the suppression of the egfr and signal transducer and activator of transcription 3 (stat3) signaling pathways. |
2021-09-16 |
2023-08-13 |
human |
| Zuohua Xie, Bing Lin, Xinju Jia, Ting Su, Ying Wei, Jiping Tang, Chengzhi Yang, Chuanbao Cui, Jinxiang Li. Enhanced IL-10 inhibits proliferation and promotes apoptosis of HUVECs through STAT3 signaling pathway in sepsis. Histology and histopathology. 2021-09-16. PMID:34528700. |
enhanced il-10 inhibits proliferation and promotes apoptosis of huvecs through stat3 signaling pathway in sepsis. |
2021-09-16 |
2023-08-13 |
Not clear |
| Leandro M Colli, Lea Jessop, Timothy A Myers, Sabrina Y Camp, Mitchell J Machiela, Jiyeon Choi, Renato Cunha, Olusegun Onabajo, Grace C Mills, Virginia Schmid, Seth A Brodie, Olivier Delattre, David R Mole, Mark P Purdue, Kai Yu, Kevin M Brown, Stephen J Chanoc. Altered regulation of DPF3, a member of the SWI/SNF complexes, underlies the 14q24 renal cancer susceptibility locus. American journal of human genetics. vol 108. issue 9. 2021-09-15. PMID:34390653. |
our results indicate that germline variation in dpf3, a component of the baf complex, part of the swi/snf complexes, can lead to reduced apoptosis and activation of the stat3 pathway, both critical in rcc carcinogenesis. |
2021-09-15 |
2023-08-13 |
Not clear |
| Jungjoong Hwang, Insuk Song, Kwangho Lee, Hyoung Rae Kim, Eun-Hye Hong, Jung Soon Hwang, Sung-Hoon Ahn, Jongkook Le. KRCA-0008 suppresses ALK-positive anaplastic large-cell lymphoma growth. Investigational new drugs. vol 38. issue 5. 2021-09-14. PMID:31956933. |
additionally, it induced g0/g1 cell cycle arrest and apoptosis by blocking downstream signals including stat3, akt, and erk1/2. |
2021-09-14 |
2023-08-13 |
mouse |
| Wenfeng Lin, Jingkai Sun, Takuya Sadahira, Naijin Xu, Koichiro Wada, Chunxiao Liu, Motoo Araki, Abai Xu, Masami Watanabe, Yasutomo Nasu, Peng Huan. Discovery and Validation of Nitroxoline as a Novel STAT3 Inhibitor in Drug-resistant Urothelial Bladder Cancer. International journal of biological sciences. vol 17. issue 12. 2021-09-10. PMID:34421363. |
these results suggested that ntx-induced p-gp reversal, g0/g1 arrest, and apoptosis in drug-resistant ubc were mediated by inhibition of stat3 signaling. |
2021-09-10 |
2023-08-13 |
mouse |
| Wenfeng Lin, Jingkai Sun, Takuya Sadahira, Naijin Xu, Koichiro Wada, Chunxiao Liu, Motoo Araki, Abai Xu, Masami Watanabe, Yasutomo Nasu, Peng Huan. Discovery and Validation of Nitroxoline as a Novel STAT3 Inhibitor in Drug-resistant Urothelial Bladder Cancer. International journal of biological sciences. vol 17. issue 12. 2021-09-10. PMID:34421363. |
our findings repurpose ntx as a novel stat3 inhibitor to induce p-gp reversal, g0/g1 arrest, and apoptosis in drug-resistant ubc. |
2021-09-10 |
2023-08-13 |
mouse |
| Jingjie Sun, Yuping Du, Xinxin Zhang, Zhuoya Wang, Yuxi Lin, Qiaoling Song, Xiao Wang, Jihui Guo, Shanshan Li, Jing Nan, Jinbo Yan. Discovery and evaluation of Atopaxar hydrobromide, a novel JAK1 and JAK2 inhibitor, selectively induces apoptosis of cancer cells with constitutively activated STAT3. Investigational new drugs. vol 38. issue 4. 2021-09-09. PMID:31612426. |
discovery and evaluation of atopaxar hydrobromide, a novel jak1 and jak2 inhibitor, selectively induces apoptosis of cancer cells with constitutively activated stat3. |
2021-09-09 |
2023-08-13 |
Not clear |
| Sayeh Mottaghi, Hassan Abbaszade. The anticarcinogenic and anticancer effects of the dietary flavonoid, morin: Current status, challenges, and future perspectives. Phytotherapy research : PTR. 2021-09-09. PMID:34498311. |
a variety of molecular targets and signaling pathways such as apoptosis, cell cycle, reactive oxygen species (ros), matrix metalloproteinases (mmps), epithelial-mesenchymal transition (emt), and micrornas (mirnas) as well as signal transducer and activator of transcription 3 (stat3), nf-κb, phosphatidylinositol 3-kinase (pi3k)/akt, mitogen-activated protein kinase (mapk), and hippo pathways have been found to be involved in the anticancer effects of morin. |
2021-09-09 |
2023-08-13 |
Not clear |
| Wu Liu, Eskandar Qaed, Han Guo Zhu, Ma Xiao Dong, ZeYao Tan. Non-energy mechanism of phosphocreatine on the protection of cell survival. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 141. 2021-09-08. PMID:34174505. |
interestingly, pcr results in delaying the time to enter pathological metabolism through the delayed activation of ampk pathway, which is different from previous studies, now we propose the hypothesis that the "mirna-jak2/stat3 -cypd pathway" may take part in protecting cells from apoptosis, pcr may be further be involved in the dynamic relationship between cypd and stat3. |
2021-09-08 |
2023-08-13 |
Not clear |
| Ting Zhang, Liang He, Zhihong Wang, Wenwu Dong, Wei Sun, Yuan Qin, Ping Zhang, Hao Zhan. Calcitriol enhances Doxorubicin-induced apoptosis in papillary thyroid carcinoma cells via regulating VDR/PTPN2/p-STAT3 pathway. Journal of cellular and molecular medicine. vol 24. issue 10. 2021-09-07. PMID:32285621. |
calcitriol treatment up-regulated vdr and protein tyrosine phosphatase n 2 (ptpn2) expression, down-regulated signal transducers and activators of transcription (stat3) phosphorylation and thereby facilitating chemotherapy drug doxorubicin-induced apoptosis in ptc cell lines. |
2021-09-07 |
2023-08-13 |
Not clear |