| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Masumeh Sanaei, Fraidoon Kavoosi, Mohammad Pourahmad. Effect of Decitabine (5-aza-2'-deoxycytidine, 5-aza-CdR) in Comparison with Vorinostat (Suberoylanilide Hydroxamic Acid, SAHA) on DNMT1, DNMT3a and DNMT3b, HDAC 1-3, SOCS 1, SOCS 3, JAK2, and STAT3 Gene Expression in Hepatocellular Carcinoma HLE and LCL-PI 11 Cell Lines. Asian Pacific journal of cancer prevention : APJCP. vol 22. issue 7. 2021-11-27. PMID:34319031. |
the current study aimed to investigate the effect of decitabine (5-aza-2'-deoxycytidine, 5-aza-cdr) in comparison to vorinostat (suberoylanilide hydroxamic acid, saha) on dnmt1, dnmt3a and dnmt3b, hdac 1-3, socs 1, socs 3, jak2, and stat3 gene expression, cell growth inhibition, and apoptosis induction of hcc hle and lcl-pi 11 cell lines. |
2021-11-27 |
2023-08-13 |
Not clear |
| Lian Zeng, Aohan Li, Zhen Zhang, Fuyu Zhang, Huaxian Chen, Ying Wang, Xudong Ding, Huiyu Lu. Ropivacaine Induces Cell Cycle Arrest in the G0/G1 Phase and Apoptosis of PC12 Cells via Inhibiting Mitochondrial STAT3 Translocation. Inflammation. vol 44. issue 6. 2021-11-26. PMID:34417665. |
ropivacaine induces cell cycle arrest in the g0/g1 phase and apoptosis of pc12 cells via inhibiting mitochondrial stat3 translocation. |
2021-11-26 |
2023-08-13 |
Not clear |
| Lian Zeng, Aohan Li, Zhen Zhang, Fuyu Zhang, Huaxian Chen, Ying Wang, Xudong Ding, Huiyu Lu. Ropivacaine Induces Cell Cycle Arrest in the G0/G1 Phase and Apoptosis of PC12 Cells via Inhibiting Mitochondrial STAT3 Translocation. Inflammation. vol 44. issue 6. 2021-11-26. PMID:34417665. |
our previous study revealed that apoptosis was an important mechanism of ropivacaine-induced neurotoxicity; this study is to illustrate the relationship between stat3 with ropivacaine-induced apoptosis. |
2021-11-26 |
2023-08-13 |
Not clear |
| Lian Zeng, Aohan Li, Zhen Zhang, Fuyu Zhang, Huaxian Chen, Ying Wang, Xudong Ding, Huiyu Lu. Ropivacaine Induces Cell Cycle Arrest in the G0/G1 Phase and Apoptosis of PC12 Cells via Inhibiting Mitochondrial STAT3 Translocation. Inflammation. vol 44. issue 6. 2021-11-26. PMID:34417665. |
in addition, the activator and inhibitor of mitostat3 translocation were used to demonstrate it was involved in ropivacaine-induced apoptosis; the results showed that enhancing the mitochondrial stat3 translocation could prevent ropivacaine-induced apoptosis. |
2021-11-26 |
2023-08-13 |
Not clear |
| Lian Zeng, Aohan Li, Zhen Zhang, Fuyu Zhang, Huaxian Chen, Ying Wang, Xudong Ding, Huiyu Lu. Ropivacaine Induces Cell Cycle Arrest in the G0/G1 Phase and Apoptosis of PC12 Cells via Inhibiting Mitochondrial STAT3 Translocation. Inflammation. vol 44. issue 6. 2021-11-26. PMID:34417665. |
we demonstrated that ropivacaine induced apoptosis by inhibiting the phosphorylation of stat3 at ser727 and the mitochondrial stat3 translocation. |
2021-11-26 |
2023-08-13 |
Not clear |
| Xin Liu, Lijuan Bian, Xiaoqin Duan, Xinming Zhuang, Yujie Sui, Longfei Yan. Alantolactone: A sesquiterpene lactone with diverse pharmacological effects. Chemical biology & drug design. vol 98. issue 6. 2021-11-25. PMID:34624172. |
the antitumor effects of ala have been demonstrated in vitro and in vivo via inducing intrinsic apoptosis, oxidative stress, er stress, cell cycle arrest and inhibiting autophagy and stat3 phosphorylation, which are also involved in its combination or synergy with other antitumor drugs. |
2021-11-25 |
2023-08-13 |
Not clear |
| Haosu Huang, Meng Wang, Zimeng Guo, Di Wu, Hanyue Wang, Yan Jia, Honghui Liu, Junjie Ding, Jie Pen. Rutaecarpine alleviates acute pancreatitis in mice and AR42J cells by suppressing the MAPK and NF-κB signaling pathways via calcitonin gene-related peptide. Phytotherapy research : PTR. vol 35. issue 11. 2021-11-25. PMID:34661951. |
cell-based studies revealed that rut significantly improved cell viability while suppressing the apoptosis of ar42j cells with cerulein-induced ap, downregulating il-6 and tnf-α, stimulating il-10 release, and inhibiting mapk, nf-κb, and stat3 signaling activation, all in a cgrp-dependent manner. |
2021-11-25 |
2023-08-13 |
mouse |
| Xu Chen, Yan Li, Haiqian Dai, Hao Zhang, Danyang Wan, Xinli Zhou, Chenghao Situ, Hui Zh. Cyclin-dependent kinase 7 is essential for spermatogenesis by regulating retinoic acid signaling pathways and the STAT3 molecular pathway. IUBMB life. vol 73. issue 12. 2021-11-24. PMID:34717033. |
we demonstrated that cdk7 affects germ cell apoptosis and sperm motility by activating stat3 and that stat3 further regulates cortactin expression to influence the nuclear elongation, chromatin condensation, and acrosome formation of sperm. |
2021-11-24 |
2023-08-13 |
mouse |
| Hyun-Ju Kim, Young-Jin Kim, Wansu Par. Berberine modulates hyper-inflammation in mouse macrophages stimulated with polyinosinic-polycytidylic acid via calcium-CHOP/STAT pathway. Scientific reports. vol 11. issue 1. 2021-11-19. PMID:34050236. |
levels of nitric oxide (no), prostaglandin e2 (pge2), first apoptosis signal receptor (fas; cd95), cytokines, intracellular calcium, phosphorylated i-kappa-b-alpha (ikb-α), phosphorylated p38 mitogen-activated protein kinase (mapk), phosphorylated erk1/2, phosphorylated signal transducer and activated transcription 3 (stat3), and mrna expression of inflammatory genes in poly i:c-induced raw 264.7 mouse macrophages were evaluated. |
2021-11-19 |
2023-08-13 |
mouse |
| Minghao Yan, Shen Gu, Chun Pan, Yabing Chen, Xiaodong Ha. MC-LR-induced interaction between M2 macrophage and biliary epithelial cell promotes biliary epithelial cell proliferation and migration through regulating STAT3. Cell biology and toxicology. vol 37. issue 6. 2021-11-18. PMID:33474710. |
in turn, the m2 macrophages could also produce amounts of il-6 and activate stat3 through jak2/stat3, mek/erk, and pi3k/akt pathways in hibecs, resulting in the promotion of cell proliferation, inhibition of apoptosis, and enhancement of migration. |
2021-11-18 |
2023-08-13 |
mouse |
| Nobuyo Kondo, Yoshiko Nagano, Atsuhiko Hasegawa, Miku Ishizawa, Kuniko Katagiri, Takeru Yoneda, Takao Masuda, Mari Kannag. Involvement of EZH2 inhibition in lenalidomide and pomalidomide-mediated growth suppression in HTLV-1-infected cells. Biochemical and biophysical research communications. vol 574. 2021-11-18. PMID:34455369. |
in three of four tested htlv-1-infected cell lines, the cells treated with lenalidomide or pomalidomide exhibited mild growth suppression without apoptosis, which was associated with decreased irf4, c-myc, and phosphorylated stat3 levels as well as enhanced socs3 expression. |
2021-11-18 |
2023-08-13 |
human |
| Loukik Arora, Chakrabhavi Dhananjaya Mohan, Min Hee Yang, Shobith Rangappa, Amudha Deivasigamani, Alan Prem Kumar, Ajaikumar B Kunnumakkara, Manoj Garg, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Tahani Awad Alahmadi, Kanchugarakoppal S Rangappa, Kam Man Hui, Gautam Sethi, Kwang Seok Ah. Tris(dibenzylideneacetone)dipalladium(0) (Tris DBA) Abrogates Tumor Progression in Hepatocellular Carcinoma and Multiple Myeloma Preclinical Models by Regulating the STAT3 Signaling Pathway. Cancers. vol 13. issue 21. 2021-11-18. PMID:34771643. |
tris dba decreased cell viability, increased apoptosis, and inhibited il-6 induced/constitutive activation of stat3, jak1, jak2, and src in hcc and mm cells. |
2021-11-18 |
2023-08-13 |
mouse |
| Liang Zhou, Xinyan Pei, Yu Zhang, Yanxia Ning, Lin Li, Xiaoyan Hu, Sri Lakshmi Chalasani, Kanika Sharma, Jewel Nkwocha, Jonathan Yu, Dipankar Bandyopadhyay, Said M Sebti, Steven Gran. Chk1 inhibition potently blocks STAT3 tyrosine705 phosphorylation, DNA binding activity, and activation of downstream targets in human multiple myeloma cells. Molecular cancer research : MCR. 2021-11-16. PMID:34782371. |
constitutively active stat3 diminished pf-mediated stat3 inactivation and down-regulate stat3-dependent proteins while significantly reducing pf-induced dna damage (rh2a.x formation) and apoptosis. |
2021-11-16 |
2023-08-13 |
human |
| Xiao-Jing Cheng, Lei Li, Ben-Qiang Xi. MiR-124 Regulates the Inflammation and Apoptosis in Myocardial Infarction Rats by Targeting STAT3. Cardiovascular toxicology. vol 21. issue 9. 2021-11-15. PMID:34037971. |
mir-124 regulates the inflammation and apoptosis in myocardial infarction rats by targeting stat3. |
2021-11-15 |
2023-08-13 |
rat |
| Xiao-Jing Cheng, Lei Li, Ben-Qiang Xi. MiR-124 Regulates the Inflammation and Apoptosis in Myocardial Infarction Rats by Targeting STAT3. Cardiovascular toxicology. vol 21. issue 9. 2021-11-15. PMID:34037971. |
silencing mir-124 could inhibit the inflammation and apoptosis of myocardial cells, thereby relieving the mi injury via upregulation of stat3. |
2021-11-15 |
2023-08-13 |
rat |
| Haiyun Huang, Yu Ren, Hongyu Liang, Xiaojia Liu, Jisangmo Nan, Hui Zhao, Xiaoling Li. Mechanism of TCONS_00147848 regulating apoptosis of nasal mucosa cells and alleviating allergic rhinitis through FOSL2-mediated JAK/STAT3 signaling pathway. Scientific reports. vol 11. issue 1. 2021-11-15. PMID:34362948. |
and in this study, we used hematoxylin-eosin (he) staining and terminal deoxynucleotidyl transferase dutp nick end labeling (tunel) to detect the histological changes of nasal mucosa and apoptosis of nasal mucosa epithelial cells in mice, cell counting kit-8 (cck-8) assay, transwell and annexin v/pi to detect proliferation, migration and apoptosis of nasal mucosa cells of mice, respectively, enzyme-linked immunosorbent assay (elisa) to detect the expression of inflammatory factors, qrt-pcr to detect tcons_00147848 expression, western blot assay to detect the expressions of fosl2, jak-2, stat3, p-stat3, bax and bcl-2, rna-binding protein immunoprecipitation (rip) assay, rna pull down assay and co-immunoprecipitation (coip) assay to identify tcons_00147848 targeting fosl2. |
2021-11-15 |
2023-08-13 |
mouse |
| Jae-Hee Lee, Dae-Young Lee, Hyo-Jung Lee, Eunji Im, Deok-Yong Sim, Ji-Eon Park, Woon-Yi Park, Bum-Sang Shim, Sung-Hoon Ki. Inhibition of STAT3/PD-L1 and Activation of miR193a-5p Are Critically Involved in Apoptotic Effect of Compound K in Prostate Cancer Cells. Cells. vol 10. issue 8. 2021-11-15. PMID:34440920. |
taken together, these findings support evidence that ck induces apoptosis via the activation of mir193a-5p and inhibition of pd-l1 and stat3 signaling in prostate cancer cells. |
2021-11-15 |
2023-08-13 |
human |
| Rocio Flores-Fernández, Angélica Aponte-López, Mayra C Suárez-Arriaga, Patricia Gorocica-Rosete, Alberto Pizaña-Venegas, Luis Chávez-Sanchéz, Francico Blanco-Favela, Ezequiel M Fuentes-Pananá, Adriana K Chávez-Rued. Prolactin Rescues Immature B Cells from Apoptosis-Induced BCR-Aggregation through STAT3, Bcl2a1a, Bcl2l2, and Birc5 in Lupus-Prone MRL/lpr Mice. Cells. vol 10. issue 2. 2021-11-12. PMID:33557010. |
these results support a mechanism in which prolactin participates in the emergence of lupus through the rescue of self-reactive immature b cell clones from central tolerance clonal deletion through the activation of stat3 and transcriptional regulation of a complex network of genes related to apoptosis resistance. |
2021-11-12 |
2023-08-13 |
mouse |
| Kun Ma, Chuan Zhang, Wuyin L. Fascin1 mediated release of pro-inflammatory cytokines and invasion/migration in rheumatoid arthritis via the STAT3 pathway. Cell cycle (Georgetown, Tex.). vol 20. issue 21. 2021-11-12. PMID:34499588. |
we also observed a significant positive correlation between fascin1 and stat3 mrna levels in ra- flss.fascin1 silencing attenuated the expression of pro-inflammatory cytokines; reduced fls proliferation in vitro; and increased apoptosis ratio and bax, cleaved parp, and caspase-3 expression. |
2021-11-12 |
2023-08-13 |
Not clear |
| Debora Traversa, Giorgia Simonetti, Doron Tolomeo, Grazia Visci, Gemma Macchia, Martina Ghetti, Giovanni Martinelli, Lasse S Kristensen, Clelia Tiziana Storlazz. Unravelling similarities and differences in the role of circular and linear PVT1 in cancer and human disease. British journal of cancer. 2021-11-10. PMID:34754096. |
the stimulation of cell proliferation, invasion and drug resistance, cell metabolism regulation, and apoptosis inhibition is controlled through multiple targets, including myc, p21, stat3, vimentin, cadherins, the pi3k/akt, hk2, bcl2, and casp3. |
2021-11-10 |
2023-08-13 |
human |