| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yu-Xiao Liu, Wei-Tong Su, Yu L. [Biological functions of CREB/ATF bZIP transcription factor in metabolism and cell growth]. Sheng li xue bao : [Acta physiologica Sinica]. vol 73. issue 5. 2021-10-29. PMID:34708233. |
intriguingly, crebzf also regulates cell proliferation and apoptosis via interaction with several transcription factors including stat3, p53 and hcf-1. |
2021-10-29 |
2023-08-13 |
mouse |
| Jiaqi Zhu, Peter Langer, Claas Ulrich, Jürgen Eberl. Crucial Role of Reactive Oxygen Species (ROS) for the Proapoptotic Effects of Indirubin Derivatives in Cutaneous SCC Cells. Antioxidants (Basel, Switzerland). vol 10. issue 10. 2021-10-26. PMID:34679649. |
concerning the pathways, complete activation of caspases cascades (caspases-3, -4, -6, -7, -8 and -9), loss of mitochondrial membrane potential, activation of proapoptotic pkcδ (protein kinase c delta), inhibition of stat3 (signal transducer and activator of transcription 3), downregulation of antiapoptotic xiap (x-linked inhibitor of apoptosis protein) and survivin as well as upregulation of the proapoptotic bcl-2 protein puma and the cell cycle inhibitor p21 were obtained. |
2021-10-26 |
2023-08-13 |
Not clear |
| b' N Garc\\xc3\\xada-D\\xc3\\xadaz, B Casar, R Alonso-Alonso, L Quevedo, M Rodr\\xc3\\xadguez, F Ruso-Julve, A Esteve-Codina, M Gut, A A Gru, M C Gonz\\xc3\\xa1lez-Vela, I Gut, J L Rodriguez-Peralto, I Varela, P L Ortiz-Romero, M A Piris, J P Vaqu\\xc3\\xa. PLC\\xce\\xb31/PKC\\xce\\xb8 Downstream Signaling Controls Cutaneous T-Cell Lymphoma Development And Progression. The Journal of investigative dermatology. 2021-10-23. PMID:34687742.' |
downstream of plcγ1, the pharmacological inhibition and genetic knockdown of pkcθ inhibited stat3 activation, impaired proliferation, and promoted apoptosis in ctcl cells. |
2021-10-23 |
2023-08-13 |
human |
| Kyung-Ran Park, Hyun Hee Leem, Joonyeop Lee, Il Keun Kwon, Jin Tae Hong, Hyung-Mun Yu. Anti-cancer effects of Hederoside C, a pentacyclic triterpene saponin, through the intrinsic apoptosis and STAT3 signaling pathways in osteosarcoma. American journal of cancer research. vol 11. issue 9. 2021-10-22. PMID:34659904. |
anti-cancer effects of hederoside c, a pentacyclic triterpene saponin, through the intrinsic apoptosis and stat3 signaling pathways in osteosarcoma. |
2021-10-22 |
2023-08-13 |
Not clear |
| Chuan Zhang, Kun Ma, Yanmei Yang, Fuqiang Wang, Wuyin L. Corrigendum to Glaucocalyxin A suppresses inflammatory responses and induces apoptosis in TNF-a-induced human rheumatoid arthritis via modulation of the STAT3 pathway [Chem. Biol. Interact. 2021 May 25; 341 109451]. Chemico-biological interactions. 2021-10-22. PMID:34674846. |
corrigendum to glaucocalyxin a suppresses inflammatory responses and induces apoptosis in tnf-a-induced human rheumatoid arthritis via modulation of the stat3 pathway [chem. |
2021-10-22 |
2023-08-13 |
human |
| Wei Li, Hongfei Tong, Xiaojie Huang, Wen Wang, Hao Wu, Shengzhang Li. High levels of β-catenin promote IFNγ-induced apoptosis in hepatocellular carcinoma cells. Oncology letters. vol 4. issue 5. 2021-10-21. PMID:23162658. |
the caspase inhibitor z-vad-fmk and the stat3 inhibitor blocked this ifnγ-induced apoptosis. |
2021-10-21 |
2023-08-12 |
Not clear |
| Tian-Xiao Wang, Zhong-Qing Zhang, Yue Cong, Xiao-Yan Shi, Ying-Hua Liu, Fang-Li Zha. Prosapogenin A induces apoptosis in human cancer cells Oncology letters. vol 6. issue 5. 2021-10-21. PMID:24179517. |
prosapogenin a induces apoptosis in human cancer cells signal transducer and activator of transcription 3 (stat3) is considered to be an oncogene. |
2021-10-21 |
2023-08-12 |
human |
| Tian-Xiao Wang, Zhong-Qing Zhang, Yue Cong, Xiao-Yan Shi, Ying-Hua Liu, Fang-Li Zha. Prosapogenin A induces apoptosis in human cancer cells Oncology letters. vol 6. issue 5. 2021-10-21. PMID:24179517. |
blocking stat3 signaling may induce growth arrest and apoptosis in different types of tumors. |
2021-10-21 |
2023-08-12 |
human |
| Ling Liu, Feng Ding, Jiwei Chen, Boyong Wang, Zhisu Li. hSulf-1 inhibits cell proliferation and migration and promotes apoptosis by suppressing stat3 signaling in hepatocellular carcinoma. Oncology letters. vol 7. issue 4. 2021-10-21. PMID:24944651. |
hsulf-1 inhibits cell proliferation and migration and promotes apoptosis by suppressing stat3 signaling in hepatocellular carcinoma. |
2021-10-21 |
2023-08-13 |
human |
| Ling Liu, Feng Ding, Jiwei Chen, Boyong Wang, Zhisu Li. hSulf-1 inhibits cell proliferation and migration and promotes apoptosis by suppressing stat3 signaling in hepatocellular carcinoma. Oncology letters. vol 7. issue 4. 2021-10-21. PMID:24944651. |
however, hsulf-1 has not been previously shown to mediate the signal transducer and activator of transcription 3 (stat3) signaling pathway, which is known to regulate cell proliferation, motility and apoptosis. |
2021-10-21 |
2023-08-13 |
human |
| Viktoria von Manstein, Chul Min Yang, Diane Richter, Natalia Delis, Vida Vafaizadeh, Bernd Grone. Resistance of Cancer Cells to Targeted Therapies Through the Activation of Compensating Signaling Loops. Current signal transduction therapy. vol 8. issue 3. 2021-10-21. PMID:25045345. |
the treatment of hnscc with a specific inhibitor of c-src, initially resulted in reduced stat3 and stat5 activation and subsequently an arrest of cell proliferation and increased apoptosis. |
2021-10-21 |
2023-08-13 |
Not clear |
| Jianyong Chen, Longchuan Bai, Denzil Bernard, Zaneta Nikolovska-Coleska, Cindy Gomez, Jian Zhang, Han Yi, Shaomeng Wan. Structure-Based Design of Conformationally Constrained, Cell-Permeable STAT3 Inhibitors. ACS medicinal chemistry letters. vol 1. issue 2. 2021-10-20. PMID:20596242. |
compound 11 (cj-1383) binds to stat3 with a k(i) value of 0.95 µm, dose-dependently inhibits cellular stat3 signaling and cancer cell growth, and induces apoptosis in the mda-mb-468 cancer cell line with constitutively activated stat3. |
2021-10-20 |
2023-08-12 |
Not clear |
| Yang Du, Chuize Kon. STAT3 regulates miR93-mediated apoptosis through inhibiting DAPK1 in renal cell carcinoma. Cancer gene therapy. vol 28. issue 5. 2021-10-18. PMID:33230258. |
stat3 regulates mir93-mediated apoptosis through inhibiting dapk1 in renal cell carcinoma. |
2021-10-18 |
2023-08-13 |
Not clear |
| Xiufeng Wang, Zhijun Liu, Fang Wan. MicroRNA-93 Blocks Signal Transducers and Activator of Transcription 3 to Reduce Neuronal Damage in Parkinson's Disease. Neurochemical research. vol 46. issue 7. 2021-10-18. PMID:33900518. |
furthermore, both mir-93 overexpression and stat3 knockdown reduced lps-induced bv2 cell apoptosis, whereas stat3 overexpression eliminated the inhibitory effect of mir-93 on lps-induced bv2 cell apoptosis. |
2021-10-18 |
2023-08-13 |
mouse |
| Li Pan, Ruijie Zhang, Ling Ma, Christopher R Pierson, Jonathan L Finlay, Chenglong Li, Jiayuh Li. STAT3 inhibitor in combination with irradiation significantly inhibits cell viability, cell migration, invasion and tumorsphere growth of human medulloblastoma cells. Cancer biology & therapy. vol 22. issue 7-9. 2021-10-15. PMID:34254873. |
combining either stat3 inhibitor with irradiation reduces the expression of stat3 downstream targets, cyclin d1 and survivin, and induces apoptosis in medulloblastoma cells. |
2021-10-15 |
2023-08-13 |
human |
| Binglin Zeng, Yu Cheng, Kailu Zheng, Shuoxiao Liu, Longying Shen, Jinping Hu, Yan Li, Xiandao Pa. Design, synthesis and in vivo anticancer activity of novel parthenolide and micheliolide derivatives as NF-κB and STAT3 inhibitors. Bioorganic chemistry. vol 111. 2021-10-14. PMID:34004586. |
anticancer mechanism studies revealed that 9-oxomicheliolide exhibited inhibition effect against nf-κb and stat3 signaling pathways, as well as induction effects of cell apoptosis. |
2021-10-14 |
2023-08-13 |
mouse |
| Xiang Chen, Li Pan, Jia Wei, Ruijie Zhang, Xiaozhi Yang, Jinhua Song, Ren-Yuan Bai, Shengling Fu, Christopher R Pierson, Jonathan L Finlay, Chenglong Li, Jiayuh Li. LLL12B, a small molecule STAT3 inhibitor, induces growth arrest, apoptosis, and enhances cisplatin-mediated cytotoxicity in medulloblastoma cells. Scientific reports. vol 11. issue 1. 2021-10-13. PMID:33753770. |
lll12b, a small molecule stat3 inhibitor, induces growth arrest, apoptosis, and enhances cisplatin-mediated cytotoxicity in medulloblastoma cells. |
2021-10-13 |
2023-08-13 |
human |
| Jonggul Lee, Donggu Lee, Yangjin Ki. Mathematical model of STAT signalling pathways in cancer development and optimal control approaches. Royal Society open science. vol 8. issue 9. 2021-10-12. PMID:34631119. |
in this study, we investigate how an intracellular signalling network (stat1, stat3, bcl-2 and bax) regulates important cellular states, either anti-apoptosis or apoptosis of cancer cells. |
2021-10-12 |
2023-08-13 |
Not clear |
| Saeko Ando, Katsumi Fukamachi, Eri Yoshimoto, Harutoshi Matsumoto, Munekazu Iinuma, Masumi Suzu. Palmitoyl piperidinopiperidine, a novel derivative of 10‑hydroxy‑2‑decenoic acid, as a potent and selective anticancer agent against human colon carcinoma cell lines. International journal of oncology. vol 58. issue 2. 2021-10-11. PMID:33491745. |
as regards the possible molecular mechanisms, it is suggested that the inhibition of stat3 by ppi may affect the function of molecules that are related to apoptosis, angiogenesis and cell cycle progression, eventually contributing to the ppi‑induced growth inhibitory effects. |
2021-10-11 |
2023-08-13 |
human |
| Zijia Qin, Hang Tong, Tinghao Li, Honghao Cao, Junlong Zhu, Siwen Yin, Weiyang H. SPHK1 contributes to cisplatin resistance in bladder cancer cells via the NONO/STAT3 axis. International journal of molecular medicine. vol 48. issue 5. 2021-10-08. PMID:34549307. |
a potential mechanism underlying sphk1‑induced cisplatin resistance and apoptosis inhibition may be activation of stat3 via binding non‑pou domain containing octamer binding. |
2021-10-08 |
2023-08-13 |
Not clear |