| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Minghao Yan, Shen Gu, Chun Pan, Yabing Chen, Xiaodong Ha. MC-LR-induced interaction between M2 macrophage and biliary epithelial cell promotes biliary epithelial cell proliferation and migration through regulating STAT3. Cell biology and toxicology. vol 37. issue 6. 2021-11-18. PMID:33474710. |
in turn, the m2 macrophages could also produce amounts of il-6 and activate stat3 through jak2/stat3, mek/erk, and pi3k/akt pathways in hibecs, resulting in the promotion of cell proliferation, inhibition of apoptosis, and enhancement of migration. |
2021-11-18 |
2023-08-13 |
mouse |
| Nobuyo Kondo, Yoshiko Nagano, Atsuhiko Hasegawa, Miku Ishizawa, Kuniko Katagiri, Takeru Yoneda, Takao Masuda, Mari Kannag. Involvement of EZH2 inhibition in lenalidomide and pomalidomide-mediated growth suppression in HTLV-1-infected cells. Biochemical and biophysical research communications. vol 574. 2021-11-18. PMID:34455369. |
in three of four tested htlv-1-infected cell lines, the cells treated with lenalidomide or pomalidomide exhibited mild growth suppression without apoptosis, which was associated with decreased irf4, c-myc, and phosphorylated stat3 levels as well as enhanced socs3 expression. |
2021-11-18 |
2023-08-13 |
human |
| Loukik Arora, Chakrabhavi Dhananjaya Mohan, Min Hee Yang, Shobith Rangappa, Amudha Deivasigamani, Alan Prem Kumar, Ajaikumar B Kunnumakkara, Manoj Garg, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Tahani Awad Alahmadi, Kanchugarakoppal S Rangappa, Kam Man Hui, Gautam Sethi, Kwang Seok Ah. Tris(dibenzylideneacetone)dipalladium(0) (Tris DBA) Abrogates Tumor Progression in Hepatocellular Carcinoma and Multiple Myeloma Preclinical Models by Regulating the STAT3 Signaling Pathway. Cancers. vol 13. issue 21. 2021-11-18. PMID:34771643. |
tris dba decreased cell viability, increased apoptosis, and inhibited il-6 induced/constitutive activation of stat3, jak1, jak2, and src in hcc and mm cells. |
2021-11-18 |
2023-08-13 |
mouse |
| Liang Zhou, Xinyan Pei, Yu Zhang, Yanxia Ning, Lin Li, Xiaoyan Hu, Sri Lakshmi Chalasani, Kanika Sharma, Jewel Nkwocha, Jonathan Yu, Dipankar Bandyopadhyay, Said M Sebti, Steven Gran. Chk1 inhibition potently blocks STAT3 tyrosine705 phosphorylation, DNA binding activity, and activation of downstream targets in human multiple myeloma cells. Molecular cancer research : MCR. 2021-11-16. PMID:34782371. |
constitutively active stat3 diminished pf-mediated stat3 inactivation and down-regulate stat3-dependent proteins while significantly reducing pf-induced dna damage (rh2a.x formation) and apoptosis. |
2021-11-16 |
2023-08-13 |
human |
| Xiao-Jing Cheng, Lei Li, Ben-Qiang Xi. MiR-124 Regulates the Inflammation and Apoptosis in Myocardial Infarction Rats by Targeting STAT3. Cardiovascular toxicology. vol 21. issue 9. 2021-11-15. PMID:34037971. |
mir-124 regulates the inflammation and apoptosis in myocardial infarction rats by targeting stat3. |
2021-11-15 |
2023-08-13 |
rat |
| Xiao-Jing Cheng, Lei Li, Ben-Qiang Xi. MiR-124 Regulates the Inflammation and Apoptosis in Myocardial Infarction Rats by Targeting STAT3. Cardiovascular toxicology. vol 21. issue 9. 2021-11-15. PMID:34037971. |
silencing mir-124 could inhibit the inflammation and apoptosis of myocardial cells, thereby relieving the mi injury via upregulation of stat3. |
2021-11-15 |
2023-08-13 |
rat |
| Haiyun Huang, Yu Ren, Hongyu Liang, Xiaojia Liu, Jisangmo Nan, Hui Zhao, Xiaoling Li. Mechanism of TCONS_00147848 regulating apoptosis of nasal mucosa cells and alleviating allergic rhinitis through FOSL2-mediated JAK/STAT3 signaling pathway. Scientific reports. vol 11. issue 1. 2021-11-15. PMID:34362948. |
and in this study, we used hematoxylin-eosin (he) staining and terminal deoxynucleotidyl transferase dutp nick end labeling (tunel) to detect the histological changes of nasal mucosa and apoptosis of nasal mucosa epithelial cells in mice, cell counting kit-8 (cck-8) assay, transwell and annexin v/pi to detect proliferation, migration and apoptosis of nasal mucosa cells of mice, respectively, enzyme-linked immunosorbent assay (elisa) to detect the expression of inflammatory factors, qrt-pcr to detect tcons_00147848 expression, western blot assay to detect the expressions of fosl2, jak-2, stat3, p-stat3, bax and bcl-2, rna-binding protein immunoprecipitation (rip) assay, rna pull down assay and co-immunoprecipitation (coip) assay to identify tcons_00147848 targeting fosl2. |
2021-11-15 |
2023-08-13 |
mouse |
| Jae-Hee Lee, Dae-Young Lee, Hyo-Jung Lee, Eunji Im, Deok-Yong Sim, Ji-Eon Park, Woon-Yi Park, Bum-Sang Shim, Sung-Hoon Ki. Inhibition of STAT3/PD-L1 and Activation of miR193a-5p Are Critically Involved in Apoptotic Effect of Compound K in Prostate Cancer Cells. Cells. vol 10. issue 8. 2021-11-15. PMID:34440920. |
taken together, these findings support evidence that ck induces apoptosis via the activation of mir193a-5p and inhibition of pd-l1 and stat3 signaling in prostate cancer cells. |
2021-11-15 |
2023-08-13 |
human |
| Rocio Flores-Fernández, Angélica Aponte-López, Mayra C Suárez-Arriaga, Patricia Gorocica-Rosete, Alberto Pizaña-Venegas, Luis Chávez-Sanchéz, Francico Blanco-Favela, Ezequiel M Fuentes-Pananá, Adriana K Chávez-Rued. Prolactin Rescues Immature B Cells from Apoptosis-Induced BCR-Aggregation through STAT3, Bcl2a1a, Bcl2l2, and Birc5 in Lupus-Prone MRL/lpr Mice. Cells. vol 10. issue 2. 2021-11-12. PMID:33557010. |
these results support a mechanism in which prolactin participates in the emergence of lupus through the rescue of self-reactive immature b cell clones from central tolerance clonal deletion through the activation of stat3 and transcriptional regulation of a complex network of genes related to apoptosis resistance. |
2021-11-12 |
2023-08-13 |
mouse |
| Kun Ma, Chuan Zhang, Wuyin L. Fascin1 mediated release of pro-inflammatory cytokines and invasion/migration in rheumatoid arthritis via the STAT3 pathway. Cell cycle (Georgetown, Tex.). vol 20. issue 21. 2021-11-12. PMID:34499588. |
we also observed a significant positive correlation between fascin1 and stat3 mrna levels in ra- flss.fascin1 silencing attenuated the expression of pro-inflammatory cytokines; reduced fls proliferation in vitro; and increased apoptosis ratio and bax, cleaved parp, and caspase-3 expression. |
2021-11-12 |
2023-08-13 |
Not clear |
| Debora Traversa, Giorgia Simonetti, Doron Tolomeo, Grazia Visci, Gemma Macchia, Martina Ghetti, Giovanni Martinelli, Lasse S Kristensen, Clelia Tiziana Storlazz. Unravelling similarities and differences in the role of circular and linear PVT1 in cancer and human disease. British journal of cancer. 2021-11-10. PMID:34754096. |
the stimulation of cell proliferation, invasion and drug resistance, cell metabolism regulation, and apoptosis inhibition is controlled through multiple targets, including myc, p21, stat3, vimentin, cadherins, the pi3k/akt, hk2, bcl2, and casp3. |
2021-11-10 |
2023-08-13 |
human |
| Bo Chen, Yingjun Yang, Jinbo Wu, Jianjiang Song, Jia L. microRNA-17-5p downregulation inhibits autophagy and myocardial remodelling after myocardial infarction by targeting STAT3. Autoimmunity. 2021-11-10. PMID:34755577. |
then, after inhibiting stat3 expression using stat3 inhibitor s31-201, the fibrosis, scarring, and cardiomyocyte apoptosis were deteriorated, along with the rise of lc3-ii/lc3-i and beclin-1 expression, the reduction of p62 expression and the reversion of mi attenuation. |
2021-11-10 |
2023-08-13 |
mouse |
| Zoleykha Asadi, Mojtaba Fathi, Elham Rismani, Zahra Bigdelou, Behrooz Johar. Application of decoy oligodeoxynucleotides strategy for inhibition of cell growth and reduction of metastatic properties in nonresistant and erlotinib-resistant SW480 cell line. Cell biology international. vol 45. issue 5. 2021-11-08. PMID:33377576. |
signal transducer and activator of transcription 3 (stat3) is a critical regulator for angiogenesis, cell cycle progression, apoptosis, and drug resistance. |
2021-11-08 |
2023-08-13 |
Not clear |
| Zoleykha Asadi, Mojtaba Fathi, Elham Rismani, Zahra Bigdelou, Behrooz Johar. Application of decoy oligodeoxynucleotides strategy for inhibition of cell growth and reduction of metastatic properties in nonresistant and erlotinib-resistant SW480 cell line. Cell biology international. vol 45. issue 5. 2021-11-08. PMID:33377576. |
a considerable decrease in proliferation of colon cancer cells was observed with blockade of stat3 signaling due to cell cycle arrest and induced apoptosis via downregulation of cyclin d1 and bcl-xl, respectively. |
2021-11-08 |
2023-08-13 |
Not clear |
| Shujun Yang, Yaodong Song, Qiaofang Wang, Yanna Liu, Zhongwei Wu, Xiaojia Duan, Yan Zhang, Xiuqian Bi, Yuanzhang Geng, Sanyang Chen, Changju Zh. Daphnetin ameliorates acute lung injury in mice with severe acute pancreatitis by inhibiting the JAK2-STAT3 pathway. Scientific reports. vol 11. issue 1. 2021-11-03. PMID:34075160. |
immunostaining of inflammatory and apoptotic cells was used to demonstrate lung tissue inflammation and apoptosis; elisa analysis of serum and tissue cytokine levels; and western blotting and immunohistochemical staining for the activated janus kinase 2 (jak2)-signal transducer and activator of transcription protein 3 (stat3) signalling pathway in lung tissues. |
2021-11-03 |
2023-08-13 |
mouse |
| Kauê R Martins, Cristina S Haas, Monique T Rovani, Fabiana Moreira, André L F Goetten, Juliana G Ferst, Valério M Portela, Raj Duggavathi, Vilceu Bordignon, Paulo B D Gonçalves, Bernardo G Gasperin, Thomaz Luci. Regulation and function of leptin during ovarian follicular development in cows. Animal reproduction science. vol 227. 2021-11-01. PMID:33667875. |
supplementation of in vitro culture medium with different leptin concentations did not affect (p > 0.05) the relative abundance of hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 (hsd3b1), cytochrome p450 family 11 subfamily a member 1 (cyp11a1), signal transducer and activator of transcription 3 (stat3) and x-linked inhibitor of apoptosis protein (xiap) mrna transcripts in granulosa cells. |
2021-11-01 |
2023-08-13 |
cattle |
| Chengliang Yuan, Guoping Chen, Chengbao Jing, Mengxue Liu, Bo Liang, Guojin Gong, Mei Y. Eriocitrin, a dietary flavonoid suppressed cell proliferation, induced apoptosis through modulation of JAK2/STAT3 and JNK/p38 MAPKs signaling pathway in MCF-7 cells. Journal of biochemical and molecular toxicology. 2021-11-01. PMID:34724282. |
oxidative stress causes abnormal stimulation of signal transducer and activator of transcription 3 (stat3) and c-jun nh2-terminal kinase (jnk), p38 mitogen-activated protein kinases (mapks) signaling has been strongly connected with the ruling of cell survival and apoptosis of cancer cells. |
2021-11-01 |
2023-08-13 |
Not clear |
| Chengliang Yuan, Guoping Chen, Chengbao Jing, Mengxue Liu, Bo Liang, Guojin Gong, Mei Y. Eriocitrin, a dietary flavonoid suppressed cell proliferation, induced apoptosis through modulation of JAK2/STAT3 and JNK/p38 MAPKs signaling pathway in MCF-7 cells. Journal of biochemical and molecular toxicology. 2021-11-01. PMID:34724282. |
eriocitrin induced apoptosis via suppression of stat3 signaling regulated proteins, activating proapoptotic factors bax, caspase 7, 8, 9 and suppressing bcl-2, bcl-x expression in mcf-7 cells. |
2021-11-01 |
2023-08-13 |
Not clear |
| Yingying Chen, Fujue Wang, Pengqiang Wu, Shuaige Gong, Jie Gao, Huan Tao, Qianqing Shen, Shuoting Wang, Zhencang Zhou, Yongqian Ji. Artesunate induces apoptosis, autophagy and ferroptosis in diffuse large B cell lymphoma cells by impairing STAT3 signaling. Cellular signalling. vol 88. 2021-10-29. PMID:34628002. |
artesunate induces apoptosis, autophagy and ferroptosis in diffuse large b cell lymphoma cells by impairing stat3 signaling. |
2021-10-29 |
2023-08-13 |
Not clear |
| Yingying Chen, Fujue Wang, Pengqiang Wu, Shuaige Gong, Jie Gao, Huan Tao, Qianqing Shen, Shuoting Wang, Zhencang Zhou, Yongqian Ji. Artesunate induces apoptosis, autophagy and ferroptosis in diffuse large B cell lymphoma cells by impairing STAT3 signaling. Cellular signalling. vol 88. 2021-10-29. PMID:34628002. |
in conclusion, the findings of the current study suggested that art may induce apoptosis and cell cycle arrest to inhibit cell proliferation, and regulate autophagy and ferroptosis via impairing the stat3 signaling pathway in dlbcl cells. |
2021-10-29 |
2023-08-13 |
Not clear |