| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuyang Gao, Xiaoyan Feng, Wenting Song, Hongwen Li, Cunzhen Shi, Mengyuan Jin, Zhaoming Li, Lei Zhang, Mingzhi Zhan. The Potential Efficacy and Mechanism of Bendamustine in Entra-nodal NK/T Cell Lymphoma. Hematological oncology. 2022-04-19. PMID:35439335. |
these findings demonstrate that bendamustine activates dna damage response pathway, induces the accumulation of intracellular (ros) level as well as inhibition of stat3, leading to cell apoptosis and g2/m cell cycle arrest in nktcl cells, which indicates that bendamustine dramatically suppressed nktcl both in vitro and in vivo and provides a potential therapeutic strategy in the treatment of nk/t lymphoma. |
2022-04-19 |
2023-08-13 |
mouse |
| Yingzi Liu, Xiaoyang Duan, Chunyan Zhang, Jiangwei Yuan, Junpeng Wen, Cuihong Zheng, Jian Shi, Meng Yua. KAT6B May Be Applied as a Potential Therapeutic Target for Glioma. Journal of oncology. vol 2022. 2022-04-18. PMID:35432536. |
depletion of stat3 reversed kat6b-regulated viability, apoptosis, and ferroptosis of glioma cells. |
2022-04-18 |
2023-08-13 |
Not clear |
| Jae Yoon Park, Kyung Don Yoo, Eunjin Bae, Kyu Hong Kim, Jae Wook Lee, Sung Joon Shin, Jong Soo Lee, Yon Su Kim, Seung Hee Yan. Blockade of STAT3 signaling alleviates the progression of acute kidney injury to chronic kidney disease through antiapoptosis. American journal of physiology. Renal physiology. vol 322. issue 5. 2022-04-12. PMID:35311382. |
similarly, in vitro stat3 inhibition downregulated fibrosis and apoptosis in 72-h hypoxia-induced human tubular epithelial cells and reduced pstat3α-mediated inflammation. |
2022-04-12 |
2023-08-16 |
mouse |
| Jianwei Cao, Meiling Liu, Shufang Feng, Yingying Li, Kaijun Zhen. Glaucocalyxin A alleviates lipopolysaccharide-induced inflammation and apoptosis in pulmonary microvascular endothelial cells and permeability injury by inhibiting STAT3 signaling. Experimental and therapeutic medicine. vol 23. issue 4. 2022-04-04. PMID:35369532. |
glaucocalyxin a alleviates lipopolysaccharide-induced inflammation and apoptosis in pulmonary microvascular endothelial cells and permeability injury by inhibiting stat3 signaling. |
2022-04-04 |
2023-08-13 |
Not clear |
| Sara G Manore, Daniel L Doheny, Grace L Wong, Hui-Wen L. IL-6/JAK/STAT3 Signaling in Breast Cancer Metastasis: Biology and Treatment. Frontiers in oncology. vol 12. 2022-04-04. PMID:35371975. |
constitutively active il-6/jak/stat3 signaling drives cancer cell proliferation and invasiveness while suppressing apoptosis, and stat3 enhances il-6 signaling to promote a vicious inflammatory loop. |
2022-04-04 |
2023-08-13 |
human |
| Xuejie Han, Xinying Guo, Jing Chang, Jie Zhang, Lu Chen, Hongxia Wang, Fenghe Du, Xiangjun Zeng, Caixia Gu. Integrinβ3 mediates the protective effects of soluble receptor for advanced glycation end-products during myocardial ischemia/reperfusion through AKT/STAT3 signaling pathway. Apoptosis : an international journal on programmed cell death. 2022-04-01. PMID:35359221. |
the results from cultured cardiomyocytes also proved that srage attenuated myocardial apoptosis and autophagy through interacting with integrinβ3 to activate akt and stat3 pathway during oxygen and glucose deprivation/reperfusion (ogd/r) treatment. |
2022-04-01 |
2023-08-13 |
mouse |
| Su Yao, Tairan Guo, Fen Zhang, Yu Chen, Fangping Xu, Donglan Luo, Xinlan Luo, Danyi Lin, Wendan Chen, Zhi Li, Yanhui Li. Fbw7 Inhibits the Progression of Activated B-Cell Like Diffuse Large B-Cell Lymphoma by Targeting the Positive Feedback Loop of the LDHA/lactate/miR-223 Axis. Frontiers in oncology. vol 12. 2022-04-01. PMID:35359405. |
we previously reported that fbw7 promotes apoptosis in diffuse large b-cell lymphoma (dlbcl) through fbw7-mediated ubiquitination of stat3. |
2022-04-01 |
2023-08-13 |
Not clear |
| V S Nikiforov, E A Blinova, A I Kotikova, A V Akleye. Transcriptional activity of repair, apoptosis and cell cycle genes (TP53, MDM2, ATM, BAX, BCL-2, CDKN1A, OGG1, XPC, PADI4, MAPK8, NF-KB1, STAT3, GATA3) in chronically exposed persons with different intensity of apoptosis of peripheral blood lymphocytes. Vavilovskii zhurnal genetiki i selektsii. vol 26. issue 1. 2022-03-28. PMID:35342850. |
transcriptional activity of repair, apoptosis and cell cycle genes (tp53, mdm2, atm, bax, bcl-2, cdkn1a, ogg1, xpc, padi4, mapk8, nf-kb1, stat3, gata3) in chronically exposed persons with different intensity of apoptosis of peripheral blood lymphocytes. |
2022-03-28 |
2023-08-13 |
Not clear |
| V S Nikiforov, E A Blinova, A I Kotikova, A V Akleye. Transcriptional activity of repair, apoptosis and cell cycle genes (TP53, MDM2, ATM, BAX, BCL-2, CDKN1A, OGG1, XPC, PADI4, MAPK8, NF-KB1, STAT3, GATA3) in chronically exposed persons with different intensity of apoptosis of peripheral blood lymphocytes. Vavilovskii zhurnal genetiki i selektsii. vol 26. issue 1. 2022-03-28. PMID:35342850. |
transcriptional activity of genes involved in maintaining genetic homeostasis (genes for repair, cell cycle and apoptosis: tp53, mdm2, atm, bax, bcl-2, cdkn1a, ogg1, xpc, padi4, mapk8, nf-kb1, stat3, gata3) was studied in chronically exposed persons with an increased intensity of early and late stages of apoptosis and necrosis of peripheral blood lymphocytes. |
2022-03-28 |
2023-08-13 |
Not clear |
| Xue Zhen Wang, Lei Xia, Xiao Yu Zhang, Qian Chen, Xiao Li, Yue Mou, Tong Wang, Ya Nan Zhan. The multifaceted mechanisms of Paeoniflorin in the treatment of tumors: State-of-the-Art. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 149. 2022-03-12. PMID:35279012. |
it can induce cell apoptosis, inhibit proliferation, invasion and metastasis via different molecular mechanisms, which are mainly involved in nuclear transcription factor kappα (nf-κb), b-cell lymphoma-2(bcl-2) family, microrna, neural precursor cell expressed developmentally down-regulated protein 4(nedd4) signaling pathway, transcription activating factor (stat3), p21, p53/14-3-3 signaling pathway, transforming growth factor-β1(tgf-β1)/smads signaling pathway, mitogen-activated protein kinase (mapk) signaling pathway and notch-1. |
2022-03-12 |
2023-08-13 |
Not clear |
| Yinan Wang, Chuanhe Yang, Michelle M Sims, Joshua R Sacher, Mithun Raje, Hemantkumar Deokar, Peibin Yue, James Turkson, John K Buolamwini, Lawrence M Pfeffe. SS-4 is a highly selective small molecule inhibitor of STAT3 tyrosine phosphorylation that potently inhibits GBM tumorigenesis in vitro and in vivo. Cancer letters. 2022-03-04. PMID:35245627. |
ss-4 strongly and selectively inhibited stat3 tyrosine (y)-705 phosphorylation in mt330 and ln229 gbm cells and inhibited their proliferation and induced apoptosis with an ic |
2022-03-04 |
2023-08-13 |
Not clear |
| Naohiro Yanagimura, Shinji Takeuchi, Koji Fukuda, Sachiko Arai, Azusa Tanimoto, Akihiro Nishiyama, Naohisa Ogo, Hiroyuki Takahashi, Akira Asai, Satoshi Watanabe, Toshiaki Kikuchi, Seiji Yan. STAT3 inhibition suppresses adaptive survival of ALK-rearranged lung cancer cells through transcriptional modulation of apoptosis. NPJ precision oncology. vol 6. issue 1. 2022-03-01. PMID:35228642. |
stat3 inhibition suppresses adaptive survival of alk-rearranged lung cancer cells through transcriptional modulation of apoptosis. |
2022-03-01 |
2023-08-13 |
Not clear |
| Naohiro Yanagimura, Shinji Takeuchi, Koji Fukuda, Sachiko Arai, Azusa Tanimoto, Akihiro Nishiyama, Naohisa Ogo, Hiroyuki Takahashi, Akira Asai, Satoshi Watanabe, Toshiaki Kikuchi, Seiji Yan. STAT3 inhibition suppresses adaptive survival of ALK-rearranged lung cancer cells through transcriptional modulation of apoptosis. NPJ precision oncology. vol 6. issue 1. 2022-03-01. PMID:35228642. |
stat3 inhibition effectively suppressed the adaptive survival of alk-rearranged lung cancer cells by enhancing alk inhibition-induced apoptosis. |
2022-03-01 |
2023-08-13 |
Not clear |
| Jixiu Wang, Qianhui Sun, Guowen Wang, Huanling Wang, Hong Li. The effects of blunt snout bream (Megalobrama amblycephala) IL-6 trans-signaling on immunity and iron metabolism via JAK/STAT3 pathway. Developmental and comparative immunology. 2022-02-26. PMID:35217123. |
the enrichment analysis of go and kegg showed that mail-6 trans-signaling is mainly involved in stress and inflammation response, and the activation of stat3 is mainly related to cell proliferation, apoptosis and immune regulation. |
2022-02-26 |
2023-08-13 |
Not clear |
| Wenbo Shao, Cunxin Zhang, Kang Li, Ziang Lu, Zihao Zhao, Kai Gao, Chaoliang L. Wogonin inhibits inflammation and apoptosis through STAT3 signal pathway to promote the recovery of spinal cord injury. Brain research. 2022-02-24. PMID:35202619. |
wogonin inhibits inflammation and apoptosis through stat3 signal pathway to promote the recovery of spinal cord injury. |
2022-02-24 |
2023-08-13 |
rat |
| Wenbo Shao, Cunxin Zhang, Kang Li, Ziang Lu, Zihao Zhao, Kai Gao, Chaoliang L. Wogonin inhibits inflammation and apoptosis through STAT3 signal pathway to promote the recovery of spinal cord injury. Brain research. 2022-02-24. PMID:35202619. |
western blot, tunel staining, and immunofluorescence were used to detect changes in the neuronal inflammation, apoptosis, and stat3 signal pathway. |
2022-02-24 |
2023-08-13 |
rat |
| Wenbo Shao, Cunxin Zhang, Kang Li, Ziang Lu, Zihao Zhao, Kai Gao, Chaoliang L. Wogonin inhibits inflammation and apoptosis through STAT3 signal pathway to promote the recovery of spinal cord injury. Brain research. 2022-02-24. PMID:35202619. |
experimental results in vivo and in vitro showed that wogonin could promote the recovery of motor function, improve the histopathological morphology, inhibit the activation of the stat3 signal pathway, and reduce the neuronal inflammation and apoptosis in the rats with sci. |
2022-02-24 |
2023-08-13 |
rat |
| Wenbo Shao, Cunxin Zhang, Kang Li, Ziang Lu, Zihao Zhao, Kai Gao, Chaoliang L. Wogonin inhibits inflammation and apoptosis through STAT3 signal pathway to promote the recovery of spinal cord injury. Brain research. 2022-02-24. PMID:35202619. |
therefore, wogonin could inhibit inflammation and apoptosis by inhibiting the stat3 signal pathway and promote the functional recovery of rats with sci. |
2022-02-24 |
2023-08-13 |
rat |
| Tao Zhao, Nan Hu, Xiaojuan Yu, Tao S. Case Report: Endocapillary Glomerulopathy Associated With Large Granular T Lymphocyte Leukemia. Frontiers in immunology. vol 12. 2022-02-11. PMID:35145513. |
the clonal proliferation of t cells, which is related to stat3 gene mutation and abnormal fas-mediated apoptosis pathway after cell activation, plays a major role in disease progression. |
2022-02-11 |
2023-08-13 |
Not clear |
| You-Shan Tsai, Yen-Po Chen, Shih-Wei Lin, Yen-Lien Chen, Chin-Chu Chen, Guan-Jhong Huan. Lactobacillus rhamnosus GKLC1 ameliorates cisplatin-induced chronic nephrotoxicity by inhibiting cell inflammation and apoptosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 147. 2022-02-08. PMID:35131657. |
an llc-pk1 kidney cell assay revealed that l. rhamnosus gklc1 suppressed the nephrotoxicity of cisplatin by reducing the inflammation via the mapks/nf-ĸb/cox-2 pathway, inhibiting apoptosis via the p53/bax/caspase-3 pathway, and ameliorating fibrosis via the stat3 pathway. |
2022-02-08 |
2023-08-13 |
mouse |