| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jang-Hyuk Yun, Da-Hye Lee, Han-Seok Jeong, Seung-Hoon Kim, Sang-Kyu Ye, Chung-Hyun Ch. STAT3 activation in microglia increases pericyte apoptosis in diabetic retinas through TNF-ɑ/AKT/p70S6 kinase signaling. Biochemical and biophysical research communications. vol 613. 2022-05-13. PMID:35561580. |
these results suggest that stat3 activation in microglia plays an important role in pericyte apoptosis in the diabetic retinas through increased tnf-α expression and provide stat3 activation in microglia as a potential therapeutic target for preventing pericyte loss in dr. |
2022-05-13 |
2023-08-13 |
mouse |
| Xin-Hua Guo, Yang Zheng, Jia-Hui Wang, Hong-Hong Wang, Shu-Juan Luo, Na Huang, Tie-Jian Zhao, Bo-Wen Zheng, Xin-Yun Liang, Ri-Zhou Wu, Qiu-Yi Re. [Research progress on role of traditional Chinese medicine in hepatic fibrosis based on miRNA-mediated activation of NLRP3 inflammasome]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 9. 2022-05-09. PMID:35531688. |
different mirna molecules regulated liver fibrosis by mediating nlrp3 inflammasome activation, including mirna-350-3 p(mir-350-3 p)/interleukin-6(il-6)-mediated signal transducer and activator of transcription 3(stat3)/c-myc signaling pathway, mir-148 a-induced autophagy and apoptosis of hepatic stellate cells via hedgehog signaling pathway, mir-155-mediated nlrp3 inflammasome by the negative feedback of the suppressor of cytokine signaling-1(socs-1), mir-181 a-mediated downstream nlrp3 inflammatory pathway activation through mitogen-activated protein kinase kinase(mek)/extracellular signal-regulated kinase(erk)/nuclear transcription factor κb(nf-κb) inflammatory pathway, mir-21-promoted expression of nf-κb and nlrp3 of raw264.7 cells in mice by inhibiting tumor necrosis factor-α inducible protein 3(a20), and mir-20 b-promoted expression of il-1β and il-18 by activating nlrp3 signaling pathway. |
2022-05-09 |
2023-08-13 |
mouse |
| Sukru Cekic, Huzeyfe Huriyet, Melika Hortoglu, Nurhan Kasap, Ahmet Ozen, Elif Karakoc-Aydiner, Ayse Metin, Gokhan Ocakoglu, Candan Demiroz Abakay, Sehime G Temel, Sebnem Ozemri Sag, Safa Baris, Tolga Cavas, Sara Sebnem Kili. Full Increased radiosensitivity and impaired DNA repair in patients with STAT3-LOF and ZNF341 deficiency, potentially contributing to malignant transformations. Clinical and experimental immunology. 2022-05-05. PMID:35511492. |
stat3 plays an important role in various complex and sometimes contradictory pathways such as proliferation, differentiation, migration, inflammation, and apoptosis. |
2022-05-05 |
2023-08-13 |
Not clear |
| Ting Xu, Kun Wu, Jin Shi, Lindong Ji, Xudong Song, Guoquan Tao, Shutao Zheng, Li Zhang, Baofei Jian. LINC00858 promotes colon cancer progression through activation of STAT3/5 signaling by recruiting transcription factor RAD21 to upregulate PCNP. Cell death discovery. vol 8. issue 1. 2022-04-26. PMID:35468892. |
western blot was conducted to determine rad21, pcnp, phosphorylated (p)-stat3, stat3, p-stat5 and stat5 and apoptosis related proteins. |
2022-04-26 |
2023-08-13 |
mouse |
| Victoria Abzianidze, Natalia Moiseeva, Diana Suponina, Sofya Zakharenkova, Nadezhda Rogovskaya, Lidia Laletina, Alvin A Holder, Denis Krivorotov, Alexander Bogachenkov, Alexander Garabadzhiu, Anton Ukolov, Vyacheslav Kosoruko. Natural Phaeosphaeride A Derivatives Overcome Drug Resistance of Tumor Cells and Modulate Signaling Pathways. Pharmaceuticals (Basel, Switzerland). vol 15. issue 4. 2022-04-23. PMID:35455394. |
milliplex map multi-pathway magnetic bead 9-plex was used, which allowed for the simultaneous detection of the following nine phosphorylated protein markers of the main intracellular signaling pathways: a universal transcription factor that controls the expression of immune-response genes, apoptosis and cell cycle nfκb (ps536); camp-dependent transcription factor (creb (ps133); mitogen-activated kinase p38 (pt180/py182); stress-activated protein kinase jnk (pt183/py185); ribosomal sk; transcription factors stat3 (ps727) and stat5a/b (py694/699); protein kinase b (akt) (ps473); and kinase regulated by extracellular signals erk1/2 (pt185/py187). |
2022-04-23 |
2023-08-13 |
human |
| Rishabh Khera, Sidharth Mehan, Sumit Kumar, Pranshul Sethi, Sonalika Bhalla, Aradhana Prajapat. Role of JAK-STAT and PPAR-Gamma Signalling Modulators in the Prevention of Autism and Neurological Dysfunctions. Molecular neurobiology. 2022-04-19. PMID:35437700. |
jak activation phosphorylates stat3 in astrocytes and microglia, and this phosphorylation has been linked to mitochondrial damage, apoptosis, neuroinflammation, reactive astrogliosis, and genetic mutations. |
2022-04-19 |
2023-08-13 |
Not clear |
| Wei-Ting Chang, Jhih-Yuan Shih, Yu-Wen Lin, Zhih-Cherng Chen, Wei-Chih Kan, Tsung-Hsien Lin, Chon-Seng Hon. Dapagliflozin protects against doxorubicin-induced cardiotoxicity by restoring STAT3. Archives of toxicology. 2022-04-19. PMID:35438302. |
using stat3 sirna, we further examined the effects of stat3 effect on dapa-associated protection against dox-induced apoptosis. |
2022-04-19 |
2023-08-13 |
rat |
| Wei-Ting Chang, Jhih-Yuan Shih, Yu-Wen Lin, Zhih-Cherng Chen, Wei-Chih Kan, Tsung-Hsien Lin, Chon-Seng Hon. Dapagliflozin protects against doxorubicin-induced cardiotoxicity by restoring STAT3. Archives of toxicology. 2022-04-19. PMID:35438302. |
conversely, knocking down stat3 in cardiomyocytes reversed the dapa-related protective effects on dox-induced cell apoptosis and ros. |
2022-04-19 |
2023-08-13 |
rat |
| Yuyang Gao, Xiaoyan Feng, Wenting Song, Hongwen Li, Cunzhen Shi, Mengyuan Jin, Zhaoming Li, Lei Zhang, Mingzhi Zhan. The Potential Efficacy and Mechanism of Bendamustine in Entra-nodal NK/T Cell Lymphoma. Hematological oncology. 2022-04-19. PMID:35439335. |
bendamustine also inhibited phosphorylation of transcriptional factor stat3, contributing to cell apoptosis and proliferation inhibition. |
2022-04-19 |
2023-08-13 |
mouse |
| Yuyang Gao, Xiaoyan Feng, Wenting Song, Hongwen Li, Cunzhen Shi, Mengyuan Jin, Zhaoming Li, Lei Zhang, Mingzhi Zhan. The Potential Efficacy and Mechanism of Bendamustine in Entra-nodal NK/T Cell Lymphoma. Hematological oncology. 2022-04-19. PMID:35439335. |
these findings demonstrate that bendamustine activates dna damage response pathway, induces the accumulation of intracellular (ros) level as well as inhibition of stat3, leading to cell apoptosis and g2/m cell cycle arrest in nktcl cells, which indicates that bendamustine dramatically suppressed nktcl both in vitro and in vivo and provides a potential therapeutic strategy in the treatment of nk/t lymphoma. |
2022-04-19 |
2023-08-13 |
mouse |
| Yingzi Liu, Xiaoyang Duan, Chunyan Zhang, Jiangwei Yuan, Junpeng Wen, Cuihong Zheng, Jian Shi, Meng Yua. KAT6B May Be Applied as a Potential Therapeutic Target for Glioma. Journal of oncology. vol 2022. 2022-04-18. PMID:35432536. |
depletion of stat3 reversed kat6b-regulated viability, apoptosis, and ferroptosis of glioma cells. |
2022-04-18 |
2023-08-13 |
Not clear |
| Jae Yoon Park, Kyung Don Yoo, Eunjin Bae, Kyu Hong Kim, Jae Wook Lee, Sung Joon Shin, Jong Soo Lee, Yon Su Kim, Seung Hee Yan. Blockade of STAT3 signaling alleviates the progression of acute kidney injury to chronic kidney disease through antiapoptosis. American journal of physiology. Renal physiology. vol 322. issue 5. 2022-04-12. PMID:35311382. |
similarly, in vitro stat3 inhibition downregulated fibrosis and apoptosis in 72-h hypoxia-induced human tubular epithelial cells and reduced pstat3α-mediated inflammation. |
2022-04-12 |
2023-08-16 |
mouse |
| Jianwei Cao, Meiling Liu, Shufang Feng, Yingying Li, Kaijun Zhen. Glaucocalyxin A alleviates lipopolysaccharide-induced inflammation and apoptosis in pulmonary microvascular endothelial cells and permeability injury by inhibiting STAT3 signaling. Experimental and therapeutic medicine. vol 23. issue 4. 2022-04-04. PMID:35369532. |
glaucocalyxin a alleviates lipopolysaccharide-induced inflammation and apoptosis in pulmonary microvascular endothelial cells and permeability injury by inhibiting stat3 signaling. |
2022-04-04 |
2023-08-13 |
Not clear |
| Sara G Manore, Daniel L Doheny, Grace L Wong, Hui-Wen L. IL-6/JAK/STAT3 Signaling in Breast Cancer Metastasis: Biology and Treatment. Frontiers in oncology. vol 12. 2022-04-04. PMID:35371975. |
constitutively active il-6/jak/stat3 signaling drives cancer cell proliferation and invasiveness while suppressing apoptosis, and stat3 enhances il-6 signaling to promote a vicious inflammatory loop. |
2022-04-04 |
2023-08-13 |
human |
| Xuejie Han, Xinying Guo, Jing Chang, Jie Zhang, Lu Chen, Hongxia Wang, Fenghe Du, Xiangjun Zeng, Caixia Gu. Integrinβ3 mediates the protective effects of soluble receptor for advanced glycation end-products during myocardial ischemia/reperfusion through AKT/STAT3 signaling pathway. Apoptosis : an international journal on programmed cell death. 2022-04-01. PMID:35359221. |
the results from cultured cardiomyocytes also proved that srage attenuated myocardial apoptosis and autophagy through interacting with integrinβ3 to activate akt and stat3 pathway during oxygen and glucose deprivation/reperfusion (ogd/r) treatment. |
2022-04-01 |
2023-08-13 |
mouse |
| Su Yao, Tairan Guo, Fen Zhang, Yu Chen, Fangping Xu, Donglan Luo, Xinlan Luo, Danyi Lin, Wendan Chen, Zhi Li, Yanhui Li. Fbw7 Inhibits the Progression of Activated B-Cell Like Diffuse Large B-Cell Lymphoma by Targeting the Positive Feedback Loop of the LDHA/lactate/miR-223 Axis. Frontiers in oncology. vol 12. 2022-04-01. PMID:35359405. |
we previously reported that fbw7 promotes apoptosis in diffuse large b-cell lymphoma (dlbcl) through fbw7-mediated ubiquitination of stat3. |
2022-04-01 |
2023-08-13 |
Not clear |
| V S Nikiforov, E A Blinova, A I Kotikova, A V Akleye. Transcriptional activity of repair, apoptosis and cell cycle genes (TP53, MDM2, ATM, BAX, BCL-2, CDKN1A, OGG1, XPC, PADI4, MAPK8, NF-KB1, STAT3, GATA3) in chronically exposed persons with different intensity of apoptosis of peripheral blood lymphocytes. Vavilovskii zhurnal genetiki i selektsii. vol 26. issue 1. 2022-03-28. PMID:35342850. |
transcriptional activity of repair, apoptosis and cell cycle genes (tp53, mdm2, atm, bax, bcl-2, cdkn1a, ogg1, xpc, padi4, mapk8, nf-kb1, stat3, gata3) in chronically exposed persons with different intensity of apoptosis of peripheral blood lymphocytes. |
2022-03-28 |
2023-08-13 |
Not clear |
| V S Nikiforov, E A Blinova, A I Kotikova, A V Akleye. Transcriptional activity of repair, apoptosis and cell cycle genes (TP53, MDM2, ATM, BAX, BCL-2, CDKN1A, OGG1, XPC, PADI4, MAPK8, NF-KB1, STAT3, GATA3) in chronically exposed persons with different intensity of apoptosis of peripheral blood lymphocytes. Vavilovskii zhurnal genetiki i selektsii. vol 26. issue 1. 2022-03-28. PMID:35342850. |
transcriptional activity of genes involved in maintaining genetic homeostasis (genes for repair, cell cycle and apoptosis: tp53, mdm2, atm, bax, bcl-2, cdkn1a, ogg1, xpc, padi4, mapk8, nf-kb1, stat3, gata3) was studied in chronically exposed persons with an increased intensity of early and late stages of apoptosis and necrosis of peripheral blood lymphocytes. |
2022-03-28 |
2023-08-13 |
Not clear |
| Xue Zhen Wang, Lei Xia, Xiao Yu Zhang, Qian Chen, Xiao Li, Yue Mou, Tong Wang, Ya Nan Zhan. The multifaceted mechanisms of Paeoniflorin in the treatment of tumors: State-of-the-Art. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 149. 2022-03-12. PMID:35279012. |
it can induce cell apoptosis, inhibit proliferation, invasion and metastasis via different molecular mechanisms, which are mainly involved in nuclear transcription factor kappα (nf-κb), b-cell lymphoma-2(bcl-2) family, microrna, neural precursor cell expressed developmentally down-regulated protein 4(nedd4) signaling pathway, transcription activating factor (stat3), p21, p53/14-3-3 signaling pathway, transforming growth factor-β1(tgf-β1)/smads signaling pathway, mitogen-activated protein kinase (mapk) signaling pathway and notch-1. |
2022-03-12 |
2023-08-13 |
Not clear |
| Yinan Wang, Chuanhe Yang, Michelle M Sims, Joshua R Sacher, Mithun Raje, Hemantkumar Deokar, Peibin Yue, James Turkson, John K Buolamwini, Lawrence M Pfeffe. SS-4 is a highly selective small molecule inhibitor of STAT3 tyrosine phosphorylation that potently inhibits GBM tumorigenesis in vitro and in vivo. Cancer letters. 2022-03-04. PMID:35245627. |
ss-4 strongly and selectively inhibited stat3 tyrosine (y)-705 phosphorylation in mt330 and ln229 gbm cells and inhibited their proliferation and induced apoptosis with an ic |
2022-03-04 |
2023-08-13 |
Not clear |