| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gaopan Dong, Xiaohan Ye, Shumei Wang, Wenhua Li, Rong Cai, Lupei Du, Xiaodong Shi, Minyong L. Au-24 as a Potential Thioredoxin Reductase Inhibitor in Hepatocellular Carcinoma Cells. Pharmacological research. 2022-02-06. PMID:35124208. |
this compound can also affect the normal function of apoptosis, mapk, pi3k/akt/mtor, nf-κb, stat3 signaling pathways. |
2022-02-06 |
2023-08-13 |
Not clear |
| Jun Han, Jie Kan, Xinguo Wang, Qingling Yuan, Xiaoyan Song, Min Huang, Hao W. Polyphyllin I suppresses proliferation and promotes apoptosis of gastric cancer cell by inhibiting stat3 phosphorylation. Translational cancer research. vol 9. issue 8. 2022-02-04. PMID:35117835. |
polyphyllin i suppresses proliferation and promotes apoptosis of gastric cancer cell by inhibiting stat3 phosphorylation. |
2022-02-04 |
2023-08-13 |
Not clear |
| Yang Liu, Ying-Hua Luo, Shu-Mei Li, Gui-Nan Shen, Jia-Ru Wang, Yi Zhang, Yu-Chao Feng, Wan-Ting Xu, Yu Zhang, Tong Zhang, Hui Xue, Hong-Xing Wang, Yang Cui, Ying Wang, Cheng-Hao Ji. 2-(Naphthalene-2-thio)-5,8-dimethoxy-1,4-naphthoquinone induces apoptosis via ROS-mediated MAPK, AKT, and STAT3 signaling pathways in HepG2 human hepatocellular carcinoma cells. Drug and chemical toxicology. vol 45. issue 1. 2022-02-01. PMID:35100937. |
2-(naphthalene-2-thio)-5,8-dimethoxy-1,4-naphthoquinone induces apoptosis via ros-mediated mapk, akt, and stat3 signaling pathways in hepg2 human hepatocellular carcinoma cells. |
2022-02-01 |
2023-08-13 |
human |
| Yang Liu, Ying-Hua Luo, Shu-Mei Li, Gui-Nan Shen, Jia-Ru Wang, Yi Zhang, Yu-Chao Feng, Wan-Ting Xu, Yu Zhang, Tong Zhang, Hui Xue, Hong-Xing Wang, Yang Cui, Ying Wang, Cheng-Hao Ji. 2-(Naphthalene-2-thio)-5,8-dimethoxy-1,4-naphthoquinone induces apoptosis via ROS-mediated MAPK, AKT, and STAT3 signaling pathways in HepG2 human hepatocellular carcinoma cells. Drug and chemical toxicology. vol 45. issue 1. 2022-02-01. PMID:35100937. |
taken together, these findings suggest that ntdmnq induces apoptosis via ros-mediated mapk, akt and stat3 signaling pathways in hepg2 cells, and may be a potent anticancer agent. |
2022-02-01 |
2023-08-13 |
human |
| Anna Markowska, Joanna Stanislawiak-Rudowicz, Tomasz Kasprzak, Janina Markowska, Monika Szarszewsk. Metformin in selected malignancies in women. Ginekologia polska. 2022-01-24. PMID:35072253. |
the mechanism of the antitumor action of metformin is pleiotropic and involves several signalling pathways, including ampk/mtor (mitogen activated protein kinase/mammalian target rapamycin), stat3 (signal transducer and activator of transcription) and numerous factors: nf-kb (nuclear factor kappa), hif-1 alpha (hypoxia inducible factor 1), igf-1 (insulin-like growth factor-1), which affect cell proliferation and apoptosis. |
2022-01-24 |
2023-08-13 |
Not clear |
| Targeting STAT3 induces apoptosis and suppresses cell growth and invasion by inactivation of Slug signaling in retinoblastoma [Retraction]. International journal of clinical and experimental pathology. vol 14. issue 12. 2022-01-14. PMID:35028000. |
targeting stat3 induces apoptosis and suppresses cell growth and invasion by inactivation of slug signaling in retinoblastoma [retraction]. |
2022-01-14 |
2023-08-13 |
Not clear |
| Banumathi, Ankith Sherapura, Vikas H Malojirao, Zabiulla, B S Sharath, Prabhu Thirusangu, Riaz Mahmood, N Suchetha Kumari, Shrinath M Baliga, Shaukath Ara Khanum, B T Prabhaka. Antiproliferative pharmacophore azo-hydrazone analogue BT-1F exerts death signalling pathway targeting STAT3 in solid tumour. Pharmacological reports : PR. 2022-01-10. PMID:35001321. |
the over expression of stat3 in these tumours results in an evasion of apoptosis and thereby pathogenesis. |
2022-01-10 |
2023-08-13 |
Not clear |
| Juan Dong, Changquan Guo, Shuo Zhou, An Zhao, Jian Li, Yuling Mi, Caiqiao Zhan. Leukemia inhibitory factor prevents chicken follicular atresia through PI3K/AKT and Stat3 signaling pathways. Molecular and cellular endocrinology. 2022-01-06. PMID:34990741. |
further investigation revealed that lif inhibited the gc autophagic apoptosis by activating pi3k/akt and stat3 pathways, reflecting an increase of bcl-2 expression but a decrease in becn1. |
2022-01-06 |
2023-08-13 |
chicken |
| Qu Zhang, Xiao-Mei Zhou, Shao-Zhong Wei, Dian-Sheng Cui, Kang-Li Deng, Gai Liang, Yan Luo, Bo Luo, Xin-Jun Lian. STAT3 as a target for sensitizing prostate cancer cells to irradiation. Journal of radiation research. 2021-12-31. PMID:34970978. |
we demonstrated that stat3 blockade with a stat3 inhibitor or sirna increased the radiosensitivity of pca cells and that radiation together with stat3 blockade induced more apoptosis and double-strand breaks (dsbs) than radiation alone in lncap cells. |
2021-12-31 |
2023-08-13 |
human |
| Futoon Abedrabbu Al-Rawashde, Wan Rohani Wan Taib, Imilia Ismail, Muhammad Farid Johan, Abdullah Saleh Al-Wajeeh, Hamid Ali Nagi Al-Jama. Thymoquinone Induces Downregulation of BCR-ABL/JAK/STAT Pathway and Apoptosis in K562 Leukemia Cells. Asian Pacific journal of cancer prevention : APJCP. vol 22. issue 12. 2021-12-30. PMID:34967577. |
the present study aimed to evaluate the effect of tq on the expression of bcr abl, jak2, stat3, stat5a and stat5b genes and their consequences on the cell proliferation and apoptosis in k562 cml cells. |
2021-12-30 |
2023-08-13 |
Not clear |
| Po-Fu Yueh, Yuan-Hao Lee, Chun-Yu Fu, Chun-Bin Tung, Fei-Ting Hsu, Keng-Li La. Magnolol Induces the Extrinsic/Intrinsic Apoptosis Pathways and Inhibits STAT3 Signaling-Mediated Invasion of Glioblastoma Cells. Life (Basel, Switzerland). vol 11. issue 12. 2021-12-24. PMID:34947930. |
magnolol induces the extrinsic/intrinsic apoptosis pathways and inhibits stat3 signaling-mediated invasion of glioblastoma cells. |
2021-12-24 |
2023-08-13 |
Not clear |
| Yong Xia, Xing Wang, Yan Liu, Ellen Shapiro, Herbert Lepor, Moon-Shong Tang, Tung-Tien Sun, Xue-Ru W. PKM2 is essential for bladder cancer growth and maintenance. Cancer research. 2021-12-14. PMID:34903602. |
the reduction in nuclear stat3 in the absence of pkm2 also correlated with decreased autophagy and increased apoptosis. |
2021-12-14 |
2023-08-13 |
mouse |
| Zhaoyan Lin, Qingqing Li, Ying Zhao, Zixiang Lin, Nan Cheng, Di Zhang, Gang Liu, Jiahao Lin, Hong Zhang, Degui Li. Combination of Auranofin and ICG-001 Suppress the Proliferation and Metastasis of Colon Cancer. Frontiers in oncology. vol 11. 2021-12-13. PMID:34900688. |
the results showed that af and icg-001 synergistically depressed the growth and invasion of human colon cancer cells by inhibiting the phosphorylation of signal transducer and activator of transcription 3 (stat3) and its downstream mediator b-cell lymphoma-2-like 1 (bcl-xl) and inducing caspase-3-dependent apoptosis. |
2021-12-13 |
2023-08-13 |
mouse |
| Hongwu Meng, Ruowen Niu, Hongmei You, Ling Wang, Rui Feng, Cheng Huang, Jun L. Interleukin-9 attenuates inflammatory response and hepatocyte apoptosis in alcoholic liver injury. Life sciences. vol 288. 2021-12-11. PMID:34843736. |
furthermore, macrophage-derived il-9 can reduce hepatocyte apoptosis by inhibiting the activation of the stat3 pathway. |
2021-12-11 |
2023-08-13 |
mouse |
| Zunwei Liu, Bo Wang, Qihang Gu. MiR-26b-5p-modified hUB-MSCs derived exosomes attenuate early brain injury during subarachnoid hemorrhage via MAT2A-mediated the p38 MAPK/STAT3 signaling pathway. Brain research bulletin. vol 175. 2021-12-10. PMID:34284075. |
oxyhb treated pc cells incubated with exosomes were transfected with mir-26b-5p inhibitor alone or together with si-mat2a, respectively, and it was observed that exosomes decreased the phosphorylation levels of p38 mapk and stat3 proteins, inhibited cell apoptosis and inflammatory mediator expression, and mir-26b-5p inhibitor abrogated the effects of exosomes, while transfection of si-mat2a reversed the effects of mir-26b-5p inhibitor. |
2021-12-10 |
2023-08-13 |
human |
| Yiwen Huang, Yuanyuan Wang, Xiaobin Liu, Yingjun Ouyan. Silencing lncRNA HOTAIR improves the recovery of neurological function in ischemic stroke via the miR-148a-3p/KLF6 axis. Brain research bulletin. vol 176. 2021-12-10. PMID:34391823. |
to summarize, this study demonstrated that lncrna hotair absorbed mir-148a-3p and up-regulated klf6 expression through cerna mechanism, and inhibited stat3 pathway, promoted apoptosis and inflammation, and aggravated neurological injury post-is. |
2021-12-10 |
2023-08-13 |
Not clear |
| Shenglin Wang, Yunqing Wang, Zhen Huang, Hongxiang Wei, Xinwen Wang, Rongkai Shen, Wenbin Lan, Guangxian Zhong, Jianhua Li. Stattic sensitizes osteosarcoma cells to epidermal growth factor receptor inhibitors via blocking the interleukin 6-induced STAT3 pathway. Acta biochimica et biophysica Sinica. vol 53. issue 12. 2021-12-10. PMID:34693451. |
combined treatment with gefitinib and stattic, an inhibitor for stat3 phosphorylation, engenders more evident inhibitory effects on cell proliferation, migration, and invasion and promotive effects on cell apoptosis and g1 phase arrest in os, compared with the single exposure to gefitinib or stattic. |
2021-12-10 |
2023-08-13 |
Not clear |
| Chunliu Mi, Xiangxiang Cao, Kai Ma, Mian Wei, Wenjing Xu, Yan Lin, Jihong Zhang, Tian-Yun Wan. Digitoxin promotes apoptosis and inhibits proliferation and migration by reducing HIF-1α and STAT3 in KRAS mutant human colon cancer cells. Chemico-biological interactions. vol 351. 2021-12-10. PMID:34717917. |
digitoxin promotes apoptosis and inhibits proliferation and migration by reducing hif-1α and stat3 in kras mutant human colon cancer cells. |
2021-12-10 |
2023-08-13 |
mouse |
| Chunliu Mi, Xiangxiang Cao, Kai Ma, Mian Wei, Wenjing Xu, Yan Lin, Jihong Zhang, Tian-Yun Wan. Digitoxin promotes apoptosis and inhibits proliferation and migration by reducing HIF-1α and STAT3 in KRAS mutant human colon cancer cells. Chemico-biological interactions. vol 351. 2021-12-10. PMID:34717917. |
moreover, digitoxin promoted apoptosis and inhibited proliferation and migration, which was potentially mediated by suppression of hif-1α and stat3. |
2021-12-10 |
2023-08-13 |
mouse |
| Wei Han, Desong Kong, Qin Lu, Wei Zhang, Zhimin Fa. Aloperine inhibits colorectal cancer cell proliferation and metastasis progress via regulating miR-296-5p/STAT3 axis. Tissue & cell. vol 74. 2021-12-09. PMID:34883316. |
up-regulation of mir-296-5p and alo treatment both suppressed stat3 expression, inhibited crc cell proliferation, migration, invasion as well as the expressions of bcl-2 and n-cadherin, but promoted apoptosis and expressions of bax and e-cadherin, which were all reversed by overexpressed stat3. |
2021-12-09 |
2023-08-13 |
Not clear |