| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jie Zeng, Wei-Wei Gao, Hao Yang, Ya-Nang Wang, Yang Mei, Ting-Ting Liu, Min Wang, Li Tang, Dong-Chuan Ma, Wei L. Sodium tanshinone IIA sulfonate suppresses microglia polarization and neuroinflammation possibly via regulating miR-125b-5p/STAT3 axis to ameliorate neuropathic pain. European journal of pharmacology. 2024-03-29. PMID:38552937. |
sts pretreatment inhibited lps-stimulated pro-inflammatory cytokine secretion, reduced stat3 pathway related-proteins and apoptosis, increased mir-125b-5p and proopiomelanocortin expression, and enhanced microglia transformation from m1 to m2 phenotype in bv-2 cells. |
2024-03-29 |
2024-04-01 |
rat |
| Xiaofan Gu, Shanshan Lu, Meng Fan, Shuang Xu, Guangyu Lin, Yun Zhao, Weili Zhao, Xuan Liu, Xiaochun Dong, Xiongwen Zhan. Compound Z526 alleviates chemotherapy-induced cachectic muscle loss by ameliorating oxidative stress-driven protein metabolic imbalance and apoptosis. European journal of pharmacology. 2024-03-29. PMID:38552940. |
the pharmacological effects of z526 were based on its potency in reducing oxidative stress in cachectic myocytes and muscle tissues, which inhibited the activation of nf-κb and stat3 to decrease atrogin-1-mediated protein degradation, activated the akt/mtor signaling pathway to promote protein synthesis, regulated bcl-2/bax ratio to reduce caspase-3-triggered apoptosis. |
2024-03-29 |
2024-04-01 |
mouse |
| Anqi Fan, Mengxiang Gao, Xuhuan Tang, Mengya Jiao, Chenchen Wang, Yingying Wei, Quan Gong, Jixin Zhon. HMGB1/RAGE axis in tumor development: unraveling its significance. Frontiers in oncology. vol 14. 2024-03-26. PMID:38529373. |
this axis is instrumental in tumor progression, promoting tumor cell proliferation, autophagy, metastasis, and angiogenesis while inhibiting apoptosis, through pivotal signaling pathways, including mapk, nf-κb, pi3k/akt, erk, and stat3. |
2024-03-26 |
2024-03-28 |
Not clear |
| Jiang Cao, Xiao Yu, Jingcheng Liu, Jiaju Fu, Binyu Wang, Chaoqin Wu, Sheng Zhang, Hongtao Chen, Zi Wang, Yinyang Xu, Tao Sui, Jie Chang, Xiaojian Ca. Ruxolitinib improves the inflammatory microenvironment, restores glutamate homeostasis, and promotes functional recovery after spinal cord injury. Neural regeneration research. vol 19. issue 11. 2024-03-25. PMID:38526286. |
additionally, in glutamate-induced excitotoxicity astrocytes, ruxolitinib restored eaat2 expression and increased glutamate uptake by inhibiting the activation of stat3, thereby reducing glutamate-induced neurotoxicity, calcium influx, oxidative stress, and cell apoptosis, and increasing the complexity of dendritic branching. |
2024-03-25 |
2024-03-27 |
mouse |
| Zhipan Liang, Qiuyun Chen, Liuying Pan, Xiaowei She, Tengfei Che. Mebendazole induces apoptosis and inhibits migration via the reactive oxygen species-mediated STAT3 signaling downregulation in non-small cell lung cancer. Journal of thoracic disease. vol 16. issue 2. 2024-03-20. PMID:38505087. |
mebendazole induces apoptosis and inhibits migration via the reactive oxygen species-mediated stat3 signaling downregulation in non-small cell lung cancer. |
2024-03-20 |
2024-03-23 |
Not clear |
| Saleh A Almatroodi, Ahmad Almatroudi, Hajed Obaid A Alharbi, Amjad Ali Khan, Arshad Husain Rahman. Effects and Mechanisms of Luteolin, a Plant-Based Flavonoid, in the Prevention of Cancers via Modulation of Inflammation and Cell Signaling Molecules. Molecules (Basel, Switzerland). vol 29. issue 5. 2024-03-13. PMID:38474604. |
the studies have confirmed that luteolin can inhibit cancer-cell survival and proliferation, angiogenesis, invasion, metastasis, mtor/pi3k/akt, stat3, wnt/β-catenin, and cell-cycle arrest, and induce apoptosis. |
2024-03-13 |
2024-03-15 |
Not clear |
| Min-Yung Kuo, Wen-Chyi Dai, Jie-Li Chang, Jo-Shu Chang, Tse-Min Lee, Chia-Che Chan. Fucoxanthin induces human melanoma cytotoxicity by thwarting the JAK2/STAT3/BCL-xL signaling axis. Environmental toxicology. 2024-03-06. PMID:38444163. |
notably, ectopic expression of stat3-c, a dominant-active stat3 mutant, abolished fucoxanthin-elicited melanoma cell apoptosis and clonogenicity inhibition, supporting the pivotal role of stat3 blockage in fucoxanthin's melanoma cytotoxicity. |
2024-03-06 |
2024-03-08 |
human |
| Ying Fu, Yu Xiang, Jie Zha, Guochun Chen, Zheng Don. Enhanced STAT3/PIK3R1/mTOR Signaling Triggers Tubular Cell Inflammation and Apoptosis in Septic-Induced Acute Kidney Injury: Implications for Therapeutic Intervention. Clinical science (London, England : 1979). 2024-02-27. PMID:38411015. |
in these models, renal inflammation and tubular cell apoptosis were accompanied by the aberrant activation of the mechanistic target of rapamycin (mtor) and the signal transducer and activator of transcription 3 (stat3) signaling pathways. |
2024-02-27 |
2024-03-02 |
mouse |
| Ying Fu, Yu Xiang, Jie Zha, Guochun Chen, Zheng Don. Enhanced STAT3/PIK3R1/mTOR Signaling Triggers Tubular Cell Inflammation and Apoptosis in Septic-Induced Acute Kidney Injury: Implications for Therapeutic Intervention. Clinical science (London, England : 1979). 2024-02-27. PMID:38411015. |
pharmacological inhibition of either mtor or stat3 significantly improved renal function and reduced apoptosis and inflammation. |
2024-02-27 |
2024-03-02 |
mouse |
| Fan Cao, Mengru Li, Weijie Wang, Yi Yi, Ying Chen, Hongrui Li. A coumarin-furoxan hybrid as novel nitric oxide donor induced cell apoptosis and ferroptosis in NSCLC by promoting S-nitrosylation of STAT3 and negative regulation of JAK2-STAT3 pathway. Biochemical pharmacology. 2024-02-22. PMID:38387529. |
a coumarin-furoxan hybrid as novel nitric oxide donor induced cell apoptosis and ferroptosis in nsclc by promoting s-nitrosylation of stat3 and negative regulation of jak2-stat3 pathway. |
2024-02-22 |
2024-02-25 |
Not clear |
| Fan Cao, Mengru Li, Weijie Wang, Yi Yi, Ying Chen, Hongrui Li. A coumarin-furoxan hybrid as novel nitric oxide donor induced cell apoptosis and ferroptosis in NSCLC by promoting S-nitrosylation of STAT3 and negative regulation of JAK2-STAT3 pathway. Biochemical pharmacology. 2024-02-22. PMID:38387529. |
moreover, compound 9 inhibits jak2/stat3 protein phosphorylation and induces s-nitrosylation modification of stat3, ultimately resulting in endogenous apoptosis in nsclc. |
2024-02-22 |
2024-02-25 |
Not clear |
| Yiquan Wu, Victoria Wang, Robert Yarchoa. Pacritinib inhibits proliferation of primary effusion lymphoma cells and production of viral interleukin-6 induced cytokines. Scientific reports. vol 14. issue 1. 2024-02-20. PMID:38374336. |
pacritinib induced apoptosis in pel cells and inhibited stat3 and nf-κb activity as evidenced by reduced amount of phosphorylated moieties. |
2024-02-20 |
2024-02-22 |
human |
| Q Ye, L Ren, Z M Jiang, X Y Li, G Y Wei, Y F Ren, L H Re. Cryptanshinone extract of Salvia miltiorrhiza stimulates pediatric acute myeloid leukemia stem cell apoptosis and the anti-inflammatory mechanism via accelerating microRNA-211-5p to supress Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway activation. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 74. issue 6. 2024-02-13. PMID:38345448. |
this study was designed to explore cryptanshinone (cpt) extract of salvia miltiorrhiza stimulating pediatric acute myeloid leukemia (aml) stem cell (lsc) apoptosis and anti-inflammatory mechanism via accelerating microrna (mir)-211-5p to restrain janus kinase 2 (jak2)/signal transducer and activator of transcription 3 (stat3) pathway activation. |
2024-02-13 |
2024-02-15 |
human |
| Ruyue Yang, Wenhui Yue, Dong Hu, Guidan Wang, Longfei Mao, Jiahe Huang, Huili Wang, Gaofeng Lian. Synthesis of compounds based on the active domain of cabotegravir and their application in inhibiting tumor cells activity. ChemistryOpen. 2024-02-05. PMID:38315083. |
we further demonstrated these derivatives induce cell apoptosis in kyse30 cells by inhibiting the expression of stat3 protein and smad2/3 protein. |
2024-02-05 |
2024-02-09 |
Not clear |
| Chun Yu Zhang, Cheng-Huei Hung, Yi-Ling Hsiao, Tung-Miao Chang, Yu-Chieh Su, Li-Chiu Wang, Shih-Min Wang, Shun-Hua Che. Miltefosine reduces coxsackievirus B3 lethality of mice with enhanced STAT3 activation. Antiviral research. 2024-02-03. PMID:38309307. |
parasite and cancer studies showed that the cellular protein kinase b (akt) decreases interferon (ifn), apoptosis, and interleukin (il)-6-induced stat3 responses, which suppress cvb3 replication. |
2024-02-03 |
2024-02-06 |
mouse |
| Chun Yu Zhang, Cheng-Huei Hung, Yi-Ling Hsiao, Tung-Miao Chang, Yu-Chieh Su, Li-Chiu Wang, Shih-Min Wang, Shun-Hua Che. Miltefosine reduces coxsackievirus B3 lethality of mice with enhanced STAT3 activation. Antiviral research. 2024-02-03. PMID:38309307. |
mouse studies demonstrated that miltefosine pretreatment reduced cvb3 lethality of mice with decreased virus loads, organ damage, and apoptosis, but enhanced stat3 activation. |
2024-02-03 |
2024-02-06 |
mouse |
| Sowmiya Arun, Praveen Kumar Patel, Kaviarasan Lakhmanan, Rajangopal Kalirajan, Gowramma Byra. Targeting STAT3 Enzyme for Cancer Treatment. Mini reviews in medicinal chemistry. 2024-02-01. PMID:38299278. |
tumor cells undergo apoptosis when stat3 activation is suppressed. |
2024-02-01 |
2024-02-03 |
human |
| JongYeob Choi, MinWha Jo, EunYoung Lee, Sung Eun Kim, Dong-Yun Lee, DooSeok Cho. Dienogest attenuates STAT3 activation in ovarian endometriotic cysts. European journal of obstetrics, gynecology, and reproductive biology. vol 294. 2024-02-01. PMID:38301500. |
recent studies have suggested that endometriosis could be the result of excessive activation of signal transducer and activator of transcription 3 (stat3), which is associated with the regulation of essential cellular mechanisms such as proliferation, invasion, and apoptosis. |
2024-02-01 |
2024-02-04 |
Not clear |
| Nian Jiang, Sanhua Li, Lingjie Meng, Yao Zhang, Changyan Yu, Yi Xiao, Yun Li. Gamabufotalin inhibits colitis-associated colorectal cancer by suppressing transcription factor STAT3. European journal of pharmacology. 2024-02-01. PMID:38301817. |
furthermore, gam induced apoptosis to inhibit the viability of hct-116 and ht-29 cell lines in dose-dependent manner by suppressing the transcription factor stat3. |
2024-02-01 |
2024-02-04 |
mouse |
| JiaHao Lu, XiuYang Yan, WuJi Lai, Li-He Jiang, Li-Qun Shen, Ai-Qun Wu, Chengguang Zha. Design, synthesis, and biological evaluation of naphthoylamide derivatives as inhibitors of STAT3 phosphorylation. Archiv der Pharmazie. 2024-01-31. PMID:38294206. |
the results showed that 3d and 4d have exceptional inhibitory ability against three different colorectal cancer (crc) cell lines, and can induce apoptosis of crc cells by inhibiting stat3 phosphorylation, while having no killing effect on normal human cells. |
2024-01-31 |
2024-02-02 |
mouse |