| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Taha Monadi, Zahra Mohajer, Afsaneh Soltani, Mohammad Amin Khazeei Tabari, Azadeh Manayi, Mohammad Azadbakh. The influence of apigenin on cellular responses to radiation: From protection to sensitization. BioFactors (Oxford, England). 2024-08-12. PMID:39134426. |
as a radiosensitizer, apigenin inhibits tumor growth by inducing apoptosis, suppressing vegf-c, tumor necrosis factor alpha, and stat3, reducing mmp-2/9 activity, and inhibiting cancer cell glucose uptake. |
2024-08-12 |
2024-08-16 |
Not clear |
| Lujuan Pan, Zongshuai Qin, Qinghong Zhou, Pin Zheng, Hua Li, Xihan Zhou, Yueqiu Qi. Unlocking the Therapeutic Potential: Harnessing miR-125a-5p To Enhance Autophagy and Apoptosis in Pancreatic Cancer through Targeting STAT3. Journal of Cancer. vol 15. issue 15. 2024-08-12. PMID:39132168. |
unlocking the therapeutic potential: harnessing mir-125a-5p to enhance autophagy and apoptosis in pancreatic cancer through targeting stat3. |
2024-08-12 |
2024-08-14 |
Not clear |
| Orit Uziel, Lian Lipshtein, Zinab Sarsor, Einat Beery, Shaked Bogen, Meir Lahav, Alon Regev, Vitali Kliminski, Roded Sharan, Asia Gervits, Lorenzo Federico Signorini, Shai Shimony, Pia Raanani, Uri Rozovsk. Chronic Lymphocytic Leukemia (CLL)-Derived Extracellular Vesicles Educate Endothelial Cells to Become IL-6-Producing, CLL-Supportive Cells. Biomedicines. vol 12. issue 7. 2024-07-27. PMID:39061955. |
after 15 min, stat3 became phosphorylated, and there was a 40% decrease in apoptosis rate, indicating that il-6 activated the stat3-dependent anti-apoptotic pathway. |
2024-07-27 |
2024-07-29 |
Not clear |
| Yizi Li, Manlin Tian, Jaceline Gislaine Pires Sanches, Qingqing Zhang, Li Hou, Jun Zhan. Sorcin Inhibits Mitochondrial Apoptosis by Interacting with STAT3 via NF-κB Pathway. International journal of molecular sciences. vol 25. issue 13. 2024-07-13. PMID:39000312. |
sorcin inhibits mitochondrial apoptosis by interacting with stat3 via nf-κb pathway. |
2024-07-13 |
2024-07-15 |
Not clear |
| Yizi Li, Manlin Tian, Jaceline Gislaine Pires Sanches, Qingqing Zhang, Li Hou, Jun Zhan. Sorcin Inhibits Mitochondrial Apoptosis by Interacting with STAT3 via NF-κB Pathway. International journal of molecular sciences. vol 25. issue 13. 2024-07-13. PMID:39000312. |
sri interacting with stat3 inhibits apoptosis by the nf-κb pathway and further contributes to the proliferation in hcc, which offers a novel clue and a new potential therapeutic target for hcc. |
2024-07-13 |
2024-07-15 |
Not clear |
| Misaki Kabasawa, Masateru Furuta, Yuuka Ibayashi, Kaori Kanemaru, Haruki Kohatsu, Fumiyo Kuramochi, Kenji Yamatoya, Kazuya Nakata, Yoshikazu Nakamura, Shusuke Tomoshige, Kenji Ohgane, Yuuki Furuyama, Ryoko Takasawa, Susumu Kobayashi, Fumio Sugawara, Masahiko Ikekita, Kouji Kuramoch. Plakevulin a induces apoptosis and suppresses IL-6-induced STAT3 activation in HL60 cells. Bioorganic & medicinal chemistry letters. 2024-07-12. PMID:38996938. |
plakevulin a induces apoptosis and suppresses il-6-induced stat3 activation in hl60 cells. |
2024-07-12 |
2024-07-15 |
human |
| Xianglei Fu, Yanbin Shi, Zili Gu, Hengchang Zang, Lian Li, Qingjie Wang, Yongjun Wang, Xiaogang Zhao, Hang Wu, Shengnan Qiu, Yankun Zhang, Jiamin Zhou, Xiangqin Chen, Hua Shen, Guimei Li. Immunotherapeutic hydrogel for co-delivery of STAT3 siRNA liposomes and lidocaine hydrochloride for postoperative comprehensive management of NSCLC in a single application. Asian journal of pharmaceutical sciences. vol 19. issue 3. 2024-07-06. PMID:38966285. |
once applied, msls strongly downregulated stat3 expression in the tumor microenvironment, resulting in the apoptosis of lung cancer cells and polarization of tumor-associated macrophages towards the m1-like phenotype. |
2024-07-06 |
2024-07-08 |
mouse |
| Huize Zhang, Yong Li, Yi Li. An updated review of the pharmacological effects and potential mechanisms of hederagenin and its derivatives. Frontiers in pharmacology. vol 15. 2024-07-04. PMID:38962311. |
previous studies have confirmed that hg and its derivatives combat cancer by exerting cytotoxicity, inhibiting proliferation, inducing apoptosis, modulating autophagy, and reversing chemotherapy resistance in cancer cells, and the action targets involved mainly include stat3, aurora b, kif7, pi3k/akt, nf-κb, nrf2/are, drp1, and p-gp. |
2024-07-04 |
2024-07-10 |
Not clear |
| Manoj Kumar Baniya, Eun-Hee Kim, Kyung-Soo Chu. Terfenadine, a histamine H1 receptor antagonist, induces apoptosis by suppressing STAT3 signaling in human colorectal cancer HCT116 cells. Frontiers in pharmacology. vol 15. 2024-06-28. PMID:38939837. |
terfenadine, a histamine h1 receptor antagonist, induces apoptosis by suppressing stat3 signaling in human colorectal cancer hct116 cells. |
2024-06-28 |
2024-06-30 |
human |
| Jianyu Lv, Yuchen Fu, Yu Ga, Chao Han, Yimeng Fan, Yuanyuan Wei, Sijia Hao, Zhihui Ha. Lianweng Granules Alleviate Intestinal Barrier Damage via the IL-6/STAT3/PI3K/AKT Signaling Pathway with Dampness-Heat Syndrome Diarrhea. Antioxidants (Basel, Switzerland). vol 13. issue 6. 2024-06-27. PMID:38929100. |
lwg targeted stat3 to inhibit inflammation, oxidative stress, and apoptosis in the colon, thereby restoring the intestinal barrier function to some extent and exerting a therapeutic effect on dhsd. |
2024-06-27 |
2024-06-29 |
mouse |
| Chuqing Li, Xia Liu, Jiali Li, Jia Lai, Jingyao Su, Bing Zhu, Buyun Gao, Yinghua Li, Mingqi Zha. Selenomethionine Inhibited HADV-Induced Apoptosis Mediated by ROS through the JAK-STAT3 Signaling Pathway. Nutrients. vol 16. issue 12. 2024-06-27. PMID:38931321. |
conclusions: selenomethionine improved the regulation of ros-mediated apoptosis by modulating the expression of jak1/2, stat3, and bcl-xl, which led to the inhibition of apoptosis. |
2024-06-27 |
2024-06-29 |
human |
| Xijun Guo, Leping He, Weifeng Xu, Wanrong Wang, Xiaoli Feng, Yuanfeng Fu, Xiaofan Zhang, Ren-Bo Ding, Xingzhu Qi, Jiaolin Bao, Sulan Lu. αO-Conotoxin GeXIVA[1,2] Suppresses In Vivo Tumor Growth of Triple-Negative Breast Cancer by Inhibiting AKT-mTOR, STAT3 and NF-κB Signaling Mediated Proliferation and Inducing Apoptosis. Marine drugs. vol 22. issue 6. 2024-06-26. PMID:38921563. |
αo-conotoxin gexiva[1,2] suppresses in vivo tumor growth of triple-negative breast cancer by inhibiting akt-mtor, stat3 and nf-κb signaling mediated proliferation and inducing apoptosis. |
2024-06-26 |
2024-06-29 |
Not clear |
| Toshimichi Onuma, Meshach Asare-Werehene, Yuko Fujita, Yoshio Yoshida, Benjamin K Tsan. Plasma Gelsolin Inhibits Natural Killer Cell Function and Confers Chemoresistance in Epithelial Ovarian Cancer. Cells. vol 13. issue 11. 2024-06-19. PMID:38891037. |
the immunoregulatory effects of pgsn on nk cells were assessed using apoptosis assay, cytokine secretion, immune checkpoint-receptor expression, and phosphorylation of stat3. |
2024-06-19 |
2024-06-21 |
Not clear |
| Shuwen Kuang, Jiajun Zhang, Ning Huang, Jing Zhang, Bo Chen, Liming Wang, Mei Li. The cumulative antitumor effects of regorafenib and radiotherapy in hepatocellular carcinoma. Molecular carcinogenesis. 2024-06-05. PMID:38837427. |
in this study, we explored whether regorafenib and rt exert a synergetic effect on the treatment of hcc. the antitumor effect and mechanisms of the combination of regorafenib and rt were verified in a xenograft mouse model in vivo and in hcc cells in vitro. the combination treatment significantly inhibited cell proliferation and promoted apoptosis both in vitro and in vivo. pdgfrl, a potential target of regorafenib, was increased after cumulative treatment in hcc cells, and pdgfrl suppressed hcc cell proliferation and promoted apoptosis by inhibiting stat3 pathway activation. |
2024-06-05 |
2024-06-08 |
mouse |
| Na-Na Yin, Xin Chen, Ying-Yin Sun, Lei Yang, Ya-Fei Zhang, Xue-Ni Niu, Heng Song, Cheng Huang, Jun L. PSTPIP2 protects against alcoholic liver injury and invokes STAT3-mediated suppression of apoptosis. Biochemical pharmacology. 2024-06-02. PMID:38824967. |
in conclusion, our findings provide compelling evidence that pstpip2 has a regulatory role in hepatocyte apoptosis via the stat3 pathway in ali, suggesting pstpip2 as a promising therapeutic target for ali. |
2024-06-02 |
2024-06-05 |
mouse |
| Kun Zhao, Qi Zhao, Xinzhi Dai, Xue Wen, Xing Luo, Yi Duan, Zhihui Yang, Qiong Da. Alantolactone enhances the sensitivity of melanoma to MAPK pathway inhibitors by targeting inhibition of STAT3 activation and down-regulating stem cell markers. Cancer cell international. vol 24. issue 1. 2024-06-01. PMID:38822350. |
our results confirmed that alantolactone suppressed cell proliferation and promoted apoptosis by inhibiting stat3 feedback activation induced by mapki and downregulating the expression of downstream oct4 and sox2. |
2024-06-01 |
2024-06-02 |
Not clear |
| Kirti S Prabhu, Serah Jessy, Shilpa Kuttikrishnan, Farina Mujeeb, Zahwa Mariyam, Ummu Habeeba, Nuha Ahmad, Ajaz A Bhat, Shahab Uddi. Anticancer Potential and Molecular Targets of Pristimerin in Human Malignancies. Pharmaceuticals (Basel, Switzerland). vol 17. issue 5. 2024-05-25. PMID:38794148. |
ps modulates several key cellular processes, including apoptosis, autophagy, cell migration and invasion, angiogenesis, and resistance to chemotherapy, targeting crucial signaling pathways such as those involving nf-κb, p53, and stat3, among others. |
2024-05-25 |
2024-05-27 |
human |
| Tingting Xua. Tripartite Motif-containing Protein 11 Silencing Inhibits Proliferation and Glycolysis and Promotes Apoptosis of Esophageal Squamous Cell Carcinoma Cells by Inactivating Signal Transduction and Activation of Transcription Factor 3/c-Myc Signaling. Journal of physiological investigation. vol 67. issue 1. 2024-05-23. PMID:38780271. |
of note, the stat3 activator partially reversed the effects of trim11 depletion on the proliferation, apoptosis, and glycolysis in escc cells. |
2024-05-23 |
2024-05-27 |
human |
| Zhen Tian, Haoran Gao, Wenjun Xia, Zhaohui Lo. S1PR3 suppresses the inflammatory response and extracellular matrix degradation in human nucleus pulposus cells. Experimental and therapeutic medicine. vol 27. issue 6. 2024-05-18. PMID:38756905. |
in conclusion, stat3 overexpression suppressed viability injury, the inflammatory response and the level of apoptosis and alleviated ecm protein deposition in hnpcs through the tlr2/stat3 and tlr2/mapk pathways, which may offer a promising candidate for the amelioration of intervertebral disc degeneration. |
2024-05-18 |
2024-05-27 |
human |
| Young Yun Jung, Ninh The Son, Chakrabhavi Dhananjaya Mohan, Jairo Kenupp Bastos, Nguyen Dinh Luyen, Le Mai Huong, Kwang Seok Ah. Kaempferide triggers apoptosis and paraptosis in pancreatic tumor cells by modulating the ROS production, SHP-1 expression, and the STAT3 pathway. IUBMB life. 2024-05-06. PMID:38708996. |
kaempferide triggers apoptosis and paraptosis in pancreatic tumor cells by modulating the ros production, shp-1 expression, and the stat3 pathway. |
2024-05-06 |
2024-05-08 |
Not clear |