| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Erina Sakamoto, Fumihiko Hato, Takayuki Kato, Chikahiko Sakamoto, Mika Akahori, Masayuki Hino, Seiichi Kitagaw. Type I and type II interferons delay human neutrophil apoptosis via activation of STAT3 and up-regulation of cellular inhibitor of apoptosis 2. Journal of leukocyte biology. vol 78. issue 1. 2005-09-08. PMID:15845643. |
we have recently demonstrated that granulocyte-colony stimulating factor (g-csf) delays human neutrophil apoptosis via up-regulation of cellular inhibitor of apoptosis 2 (ciap2), which is dependent on activation of janus kinase 2 (jak2) and signal transducer and activator of transcription 3 (stat3). |
2005-09-08 |
2023-08-12 |
human |
| Shigetoshi Sano, Keith Syson Chan, Masahiro Kira, Ken Kataoka, Satoshi Takagi, Masahito Tarutani, Satoshi Itami, Kaoru Kiguchi, Masayuki Yokoi, Kaoru Sugasawa, Toshio Mori, Fumio Hanaoka, Junji Takeda, John DiGiovann. Signal transducer and activator of transcription 3 is a key regulator of keratinocyte survival and proliferation following UV irradiation. Cancer research. vol 65. issue 13. 2005-09-07. PMID:15994947. |
uvb irradiation of signal transducer and activator of transcription 3 (stat3)-deficient keratinocytes resulted in a high incidence of apoptosis compared with controls. |
2005-09-07 |
2023-08-12 |
mouse |
| Shigetoshi Sano, Keith Syson Chan, Masahiro Kira, Ken Kataoka, Satoshi Takagi, Masahito Tarutani, Satoshi Itami, Kaoru Kiguchi, Masayuki Yokoi, Kaoru Sugasawa, Toshio Mori, Fumio Hanaoka, Junji Takeda, John DiGiovann. Signal transducer and activator of transcription 3 is a key regulator of keratinocyte survival and proliferation following UV irradiation. Cancer research. vol 65. issue 13. 2005-09-07. PMID:15994947. |
conversely, forced expression of stat3 desensitized keratinocytes to uvb-induced apoptosis. |
2005-09-07 |
2023-08-12 |
mouse |
| Toru Yamashita, Kazunobu Sawamoto, Shigeaki Suzuki, Norihiro Suzuki, Kazuhide Adachi, Takeshi Kawase, Masahiko Mihara, Yoshiyuki Ohsugi, Koji Abe, Hideyuki Okan. Blockade of interleukin-6 signaling aggravates ischemic cerebral damage in mice: possible involvement of Stat3 activation in the protection of neurons. Journal of neurochemistry. vol 94. issue 2. 2005-09-07. PMID:15998296. |
these results suggest that endogenous il-6 plays a critical role in preventing damaged neurons from undergoing apoptosis in the acute phase of cerebral ischemia and that its role may be mediated by stat3 activation. |
2005-09-07 |
2023-08-12 |
mouse |
| E Puxeddu, J A Knauf, M A Sartor, N Mitsutake, E P Smith, M Medvedovic, C R Tomlinson, S Moretti, J A Fagi. RET/PTC-induced gene expression in thyroid PCCL3 cells reveals early activation of genes involved in regulation of the immune response. Endocrine-related cancer. vol 12. issue 2. 2005-08-22. PMID:15947106. |
functional clustering of genes with greater than or less than 1.75-fold expression change (86 genes) revealed ret/ptc3-induced regulation of genes with key functions in apoptosis (ripk3, tdga), cell-cell signaling (cdh6, fn1), cell cycle (il24), immune and inflammation response (cxcl10, scya2, il6, gbp2, oas1, tap1, rt1aw2, c2ta, irf1, lmp2, psme2, prkr), metabolism (aldob, ptges, nd2, gss, gstt1), signal transduction (socs3, nf1, jak2, cpg21, dusp6, socs1, stat1, stat3, cish) and transcription (nr4a1, junb, hfh1, runx1, foxe1). |
2005-08-22 |
2023-08-12 |
Not clear |
| Sangkil Nam, Ralf Buettner, James Turkson, Donghwa Kim, Jin Q Cheng, Stephan Muehlbeyer, Frankie Hippe, Sandra Vatter, Karl-Heinz Merz, Gerhard Eisenbrand, Richard Jov. Indirubin derivatives inhibit Stat3 signaling and induce apoptosis in human cancer cells. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 17. 2005-07-08. PMID:15837920. |
indirubin derivatives inhibit stat3 signaling and induce apoptosis in human cancer cells. |
2005-07-08 |
2023-08-12 |
human |
| Sangkil Nam, Ralf Buettner, James Turkson, Donghwa Kim, Jin Q Cheng, Stephan Muehlbeyer, Frankie Hippe, Sandra Vatter, Karl-Heinz Merz, Gerhard Eisenbrand, Richard Jov. Indirubin derivatives inhibit Stat3 signaling and induce apoptosis in human cancer cells. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 17. 2005-07-08. PMID:15837920. |
the antiapoptotic proteins mcl-1 and survivin, which are encoded in target genes of stat3, were down-regulated by indirubin derivatives, followed by induction of apoptosis. |
2005-07-08 |
2023-08-12 |
human |
| U Holtick, M Vockerodt, D Pinkert, N Schoof, B Stürzenhofecker, N Kussebi, K Lauber, S Wesselborg, D Löffler, F Horn, L Trümper, D Kub. STAT3 is essential for Hodgkin lymphoma cell proliferation and is a target of tyrphostin AG17 which confers sensitization for apoptosis. Leukemia. vol 19. issue 6. 2005-06-30. PMID:15912144. |
stat3 is essential for hodgkin lymphoma cell proliferation and is a target of tyrphostin ag17 which confers sensitization for apoptosis. |
2005-06-30 |
2023-08-12 |
Not clear |
| Hui Song, Renxiao Wang, Shaomeng Wang, Jiayuh Li. A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 13. 2005-06-09. PMID:15781862. |
activated stat3 may participate in oncogenesis by stimulating cell proliferation, promoting tumor angiogenesis, and resisting apoptosis. |
2005-06-09 |
2023-08-12 |
human |
| James R Matthews, Alan R Clark. p53 mediates a default programme of mammary gland involution in the absence of STAT3. Oncogene. vol 24. issue 19. 2005-05-31. PMID:15735683. |
previous studies have demonstrated a proapoptotic role for the transcription factor stat3 in involuting murine mammary epithelium, resulting in delayed involution and lower levels of apoptosis in the stat3 null gland relative to wild-type controls. |
2005-05-31 |
2023-08-12 |
Not clear |
| Jiazhi Sun, Michelle A Blaskovich, Richard Jove, Sandra K Livingston, Domenico Coppola, Saïd M Sebt. Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity. Oncogene. vol 24. issue 20. 2005-05-31. PMID:15735720. |
cuc q inhibits selectively the activation of stat3 and induces apoptosis without inhibition of jak2, src, akt, erk, or jnk activation. |
2005-05-31 |
2023-08-12 |
mouse |
| Jiazhi Sun, Michelle A Blaskovich, Richard Jove, Sandra K Livingston, Domenico Coppola, Saïd M Sebt. Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity. Oncogene. vol 24. issue 20. 2005-05-31. PMID:15735720. |
furthermore, cuc q induces apoptosis more potently in human and murine tumors that contain constitutively activated stat3 (i.e., a549, mda-mb-435, and v-src/nih 3t3) as compared to those that do not (i.e., h-ras/nih 3t3, mda-mb-453, and nih 3t3 cells). |
2005-05-31 |
2023-08-12 |
mouse |
| Jiazhi Sun, Michelle A Blaskovich, Richard Jove, Sandra K Livingston, Domenico Coppola, Saïd M Sebt. Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity. Oncogene. vol 24. issue 20. 2005-05-31. PMID:15735720. |
these studies further validate stat3 as a drug discovery target and provide evidence that pharmacological agents that can selectively reduce the p-stat3 levels in human cancer cells result in tumor apoptosis and growth inhibition. |
2005-05-31 |
2023-08-12 |
mouse |
| James Turkson, Shumin Zhang, Jay Palmer, Heidi Kay, Joseph Stanko, Linda B Mora, Said Sebti, Hua Yu, Richard Jov. Inhibition of constitutive signal transducer and activator of transcription 3 activation by novel platinum complexes with potent antitumor activity. Molecular cancer therapeutics. vol 3. issue 12. 2005-05-17. PMID:15634646. |
in malignant cells that harbor constitutively activated stat3, cpa-1, cpa-7, and platinum (iv) tetrachloride inhibit cell growth and induce apoptosis in a manner that reflects the attenuation of persistent stat3 activity. |
2005-05-17 |
2023-08-12 |
mouse |
| Kathrine Abell, Antonio Bilancio, Richard W E Clarkson, Paul G Tiffen, Anton I Altaparmakov, Thomas G Burdon, Tomoichiro Asano, Bart Vanhaesebroeck, Christine J Watso. Stat3-induced apoptosis requires a molecular switch in PI(3)K subunit composition. Nature cell biology. vol 7. issue 4. 2005-05-16. PMID:15793565. |
in the absence of stat3 in vivo, upregulation of p55alpha and p50alpha is abrogated, levels of activated akt are sustained and apoptosis is prevented. |
2005-05-16 |
2023-08-12 |
Not clear |
| Kathrine Abell, Antonio Bilancio, Richard W E Clarkson, Paul G Tiffen, Anton I Altaparmakov, Thomas G Burdon, Tomoichiro Asano, Bart Vanhaesebroeck, Christine J Watso. Stat3-induced apoptosis requires a molecular switch in PI(3)K subunit composition. Nature cell biology. vol 7. issue 4. 2005-05-16. PMID:15793565. |
we propose a novel mechanism in which stat3 regulates apoptosis by inducing expression of distinct pi(3)k regulatory subunits to downregulate pi(3)k-akt-mediated survival signalling. |
2005-05-16 |
2023-08-12 |
Not clear |
| Beverly E Barton, Thomas F Murphy, Ping Shu, Hosea F Huang, Markus Meyenhofer, Arnold Barto. Novel single-stranded oligonucleotides that inhibit signal transducer and activator of transcription 3 induce apoptosis in vitro and in vivo in prostate cancer cell lines. Molecular cancer therapeutics. vol 3. issue 10. 2005-04-21. PMID:15486184. |
previously, we reported that antisense oligonucleotides specific for stat3 were better at inducing apoptosis than inhibitors of jak1 or jak2, the upstream activating kinases of stat3. |
2005-04-21 |
2023-08-12 |
Not clear |
| Beverly E Barton, Thomas F Murphy, Ping Shu, Hosea F Huang, Markus Meyenhofer, Arnold Barto. Novel single-stranded oligonucleotides that inhibit signal transducer and activator of transcription 3 induce apoptosis in vitro and in vivo in prostate cancer cell lines. Molecular cancer therapeutics. vol 3. issue 10. 2005-04-21. PMID:15486184. |
here, we report that novel single-stranded oligonucleotides, which putatively block stat3-dna binding, were better at inducing hormone-resistant prostate cancer apoptosis than antisense stat3 oligonucleotides. |
2005-04-21 |
2023-08-12 |
Not clear |
| Xuchen Zhang, Peiying Shan, Jawed Alam, Xin-Yuan Fu, Patty J Le. Carbon monoxide differentially modulates STAT1 and STAT3 and inhibits apoptosis via a phosphatidylinositol 3-kinase/Akt and p38 kinase-dependent STAT3 pathway during anoxia-reoxygenation injury. The Journal of biological chemistry. vol 280. issue 10. 2005-04-19. PMID:15590660. |
carbon monoxide differentially modulates stat1 and stat3 and inhibits apoptosis via a phosphatidylinositol 3-kinase/akt and p38 kinase-dependent stat3 pathway during anoxia-reoxygenation injury. |
2005-04-19 |
2023-08-12 |
Not clear |
| P Boutet, D Boulanger, L Gillet, A Vanderplasschen, R Closset, F Bureau, P Lekeu. Delayed neutrophil apoptosis in bovine subclinical mastitis. Journal of dairy science. vol 87. issue 12. 2005-04-18. PMID:15545372. |
we first addressed the hypothesis that gmcsf delays bovine neutrophil apoptosis by activation of the signal transducer and activator of transcription (stat) family members stat3 and stat5, which are critical regulators of the expression of various bcl-2 family proteins. |
2005-04-18 |
2023-08-12 |
human |