| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Liza Konnikova, Maciej Kotecki, Mathew M Kruger, Brent H Cochra. Knockdown of STAT3 expression by RNAi induces apoptosis in astrocytoma cells. BMC cancer. vol 3. 2004-06-08. PMID:13678425. |
stat3, signal transducer and activator of transcription 3, participates in several human cancers by inducing cell proliferation and inhibiting apoptosis and is frequently activated in astrocytomas. |
2004-06-08 |
2023-08-12 |
human |
| Alok C Bharti, Shishir Shishodia, James M Reuben, Donna Weber, Raymond Alexanian, Saroj Raj-Vadhan, Zeev Estrov, Moshe Talpaz, Bharat B Aggarwa. Nuclear factor-kappaB and STAT3 are constitutively active in CD138+ cells derived from multiple myeloma patients, and suppression of these transcription factors leads to apoptosis. Blood. vol 103. issue 8. 2004-05-27. PMID:15070700. |
nuclear factor-kappab and stat3 are constitutively active in cd138+ cells derived from multiple myeloma patients, and suppression of these transcription factors leads to apoptosis. |
2004-05-27 |
2023-08-12 |
Not clear |
| Alok C Bharti, Shishir Shishodia, James M Reuben, Donna Weber, Raymond Alexanian, Saroj Raj-Vadhan, Zeev Estrov, Moshe Talpaz, Bharat B Aggarwa. Nuclear factor-kappaB and STAT3 are constitutively active in CD138+ cells derived from multiple myeloma patients, and suppression of these transcription factors leads to apoptosis. Blood. vol 103. issue 8. 2004-05-27. PMID:15070700. |
because of the central role of the nuclear transcription factors nuclear factor-kappab (nf-kappab) and signal transducer and activator of transcription 3 (stat3) in chemoresistance, cell survival, and proliferation, we investigated whether mm cells derived from patients express activated nf-kappab and stat3 and if their suppression induces apoptosis. |
2004-05-27 |
2023-08-12 |
Not clear |
| Grazyna Adamus, Brad Sugden, Sharon Shiraga, Adrian M Timmers, William W Hauswirt. Anti-apoptotic effects of CNTF gene transfer on photoreceptor degeneration in experimental antibody-induced retinopathy. Journal of autoimmunity. vol 21. issue 2. 2004-05-07. PMID:12935781. |
the present study shows that an aav-mediated delivery of cntf may protect photoreceptors from antibody-induced cell death through the activation of stat3 and the suppression of caspase 3 activity, a key caspase leading to apoptosis. |
2004-05-07 |
2023-08-12 |
human |
| Xiang-Tao Ma, Shan Wang, Ying-Jiang Ye, Ru-Yu Du, Zhi-Rong Cu. [Relationship of Stat3 and its target gene products with malignancy in human colorectal carcinoma]. Ai zheng = Aizheng = Chinese journal of cancer. vol 22. issue 11. 2004-02-17. PMID:14613639. |
signal transducers and activators of transcription 3 (stat3) pathway can be activated by cytokines and growth factors, and activation of stat3 is involved in modulating cell proliferation, differentiation, and apoptosis. |
2004-02-17 |
2023-08-12 |
human |
| Biao He, Liang You, Kazutsugu Uematsu, Keling Zang, Zhidong Xu, Amie Y Lee, Joseph F Costello, Frank McCormick, David M Jablon. SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 24. 2004-02-02. PMID:14617776. |
restoration of socs-3 in lung cancer cells where socs-3 was methylation-silenced resulted in the down-regulation of active stat3, induction of apoptosis, and growth suppression. |
2004-02-02 |
2023-08-12 |
human |
| Mainak Majumder, Robert Steele, Asish K Ghosh, Xiao Yan Zhou, Larry Thornburg, Ranjit Ray, Nancy J Phillips, Ratna B Ra. Expression of hepatitis C virus non-structural 5A protein in the liver of transgenic mice. FEBS letters. vol 555. issue 3. 2004-01-23. PMID:14675768. |
hcv ns5a protein possesses many intriguing properties, including sequestration of p53 in the cytoplasm, downregulation of p21 protein, activation of stat3, and inhibition of tumor necrosis factor-alpha-mediated apoptosis. |
2004-01-23 |
2023-08-12 |
mouse |
| Naijie Jing, Yidong Li, Xuejun Xu, Wei Sha, Ping Li, Lili Feng, David J Tweard. Targeting Stat3 with G-quartet oligodeoxynucleotides in human cancer cells. DNA and cell biology. vol 22. issue 11. 2004-01-05. PMID:14659041. |
genetic approaches that disrupt stat3 activity result in inhibition of cancer cell growth and enhanced cell apoptosis supporting the development of novel drugs targeting stat3 for cancer therapy. |
2004-01-05 |
2023-08-12 |
human |
| Valentina Calò, Manuela Migliavacca, Viviana Bazan, Marcella Macaluso, Maria Buscemi, Nicola Gebbia, Antonio Russ. STAT proteins: from normal control of cellular events to tumorigenesis. Journal of cellular physiology. vol 197. issue 2. 2003-11-10. PMID:14502555. |
on the other hand, stat3 and 5 are considered as oncogenes, since they bring about the activation of cyclin d1, c-myc, and bcl-xl expression, and are involved in promoting cell-cycle progression, cellular transformation, and in preventing apoptosis. |
2003-11-10 |
2023-08-12 |
human |
| Michelle M Fung, Forest Rohwer, Kathleen L McGuir. IL-2 activation of a PI3K-dependent STAT3 serine phosphorylation pathway in primary human T cells. Cellular signalling. vol 15. issue 6. 2003-10-03. PMID:12681450. |
analysis of the effects of these inhibitors on cell cycle progression and apoptosis strongly suggests that pi3k-mediated events, which includes stat3 activation, are involved in il-2-mediated cell proliferation but not cell survival. |
2003-10-03 |
2023-08-12 |
human |
| Rei Shibata, Hisashi Kai, Yukihiko Seki, Seiya Kato, Yoshihiro Wada, Yasushi Hanakawa, Koji Hashimoto, Akihiko Yoshimura, Tsutomu Imaizum. Inhibition of STAT3 prevents neointima formation by inhibiting proliferation and promoting apoptosis of neointimal smooth muscle cells. Human gene therapy. vol 14. issue 7. 2003-10-02. PMID:12814098. |
inhibition of stat3 prevents neointima formation by inhibiting proliferation and promoting apoptosis of neointimal smooth muscle cells. |
2003-10-02 |
2023-08-12 |
rat |
| Anja Baier, Ingmar Meineckel, Steffen Gay, Thomas Pa. Apoptosis in rheumatoid arthritis. Current opinion in rheumatology. vol 15. issue 3. 2003-09-10. PMID:12707581. |
among them, downstream modulators of fas-signaling, such as sentrin-1/small ubiquitin-like modifier (sumo)-1 and fas-associated death domain-like interleukin (il)-1beta-converting enzyme-inhibitory protein (flip), as well as transcriptional regulators such as nfkappab, stat3, and p53, have been suggested to regulate apoptosis most prominently. |
2003-09-10 |
2023-08-12 |
Not clear |
| Ekaterini A Kritikou, Andrew Sharkey, Kathrine Abell, Paul J Came, Elizabeth Anderson, Richard W E Clarkson, Christine J Watso. A dual, non-redundant, role for LIF as a regulator of development and STAT3-mediated cell death in mammary gland. Development (Cambridge, England). vol 130. issue 15. 2003-09-03. PMID:12810593. |
stat3 is the key mediator of apoptosis in mammary gland. |
2003-09-03 |
2023-08-12 |
mouse |
| Ekaterini A Kritikou, Andrew Sharkey, Kathrine Abell, Paul J Came, Elizabeth Anderson, Richard W E Clarkson, Christine J Watso. A dual, non-redundant, role for LIF as a regulator of development and STAT3-mediated cell death in mammary gland. Development (Cambridge, England). vol 130. issue 15. 2003-09-03. PMID:12810593. |
similar to stat3 knockouts, lif(-/-) mammary glands exhibit delayed involution, reduced apoptosis and elevated levels of p53. |
2003-09-03 |
2023-08-12 |
mouse |
| Ekaterini A Kritikou, Andrew Sharkey, Kathrine Abell, Paul J Came, Elizabeth Anderson, Richard W E Clarkson, Christine J Watso. A dual, non-redundant, role for LIF as a regulator of development and STAT3-mediated cell death in mammary gland. Development (Cambridge, England). vol 130. issue 15. 2003-09-03. PMID:12810593. |
lif therefore signals alternately through erk1/2, then stat3, to regulate mammary growth and apoptosis. |
2003-09-03 |
2023-08-12 |
mouse |
| Gladell P Paner, Simone Silberman, Grace Hartman, Kenneth C Micetich, Gerard V Aranha, Serhan Alka. Analysis of signal transducer and activator of transcription 3 (STAT3) in gastrointestinal stromal tumors. Anticancer research. vol 23. issue 3B. 2003-08-28. PMID:12894500. |
this study demonstrates that stat3 is constitutively activated in gist and jak2 blockade leads to tumor growth inhibition and apoptosis indicating the involvement of the jak/stat signaling pathway in gist cellular survival. |
2003-08-28 |
2023-08-12 |
Not clear |
| Hongtao Liu, Yingyu Ma, Shawn M Cole, Christopher Zander, Kun-Hung Chen, Jim Karras, Richard M Pop. Serine phosphorylation of STAT3 is essential for Mcl-1 expression and macrophage survival. Blood. vol 102. issue 1. 2003-08-19. PMID:12637318. |
stat3 as, but not control, odns decreased stat3 and mcl-1 expression and resulted in macrophage apoptosis. |
2003-08-19 |
2023-08-12 |
human |
| Huang Shao, Haiyun Y Cheng, Richard G Cook, David J Tweard. Identification and characterization of signal transducer and activator of transcription 3 recruitment sites within the epidermal growth factor receptor. Cancer research. vol 63. issue 14. 2003-08-13. PMID:12873986. |
in squamous cell carcinoma of the head and neck, stat3 activation is mediated by up-regulation of the autocrine ligand-receptor pair, tumor growth factor alpha and epidermal growth factor receptor (egfr), resulting in cell growth and resistance to apoptosis. |
2003-08-13 |
2023-08-12 |
human |
| Lanxi Song, James Turkson, James G Karras, Richard Jove, Eric B Haur. Activation of Stat3 by receptor tyrosine kinases and cytokines regulates survival in human non-small cell carcinoma cells. Oncogene. vol 22. issue 27. 2003-08-01. PMID:12833138. |
treatment of a549 lung cancer cells with pd180970 or su6656, both pharmacological inhibitors of src-kinase, resulted in reduced src and stat3 activity, cell cycle arrest in g2, and reduced viability of cells accompanied by induction of apoptosis. |
2003-08-01 |
2023-08-12 |
human |
| Lanxi Song, James Turkson, James G Karras, Richard Jove, Eric B Haur. Activation of Stat3 by receptor tyrosine kinases and cytokines regulates survival in human non-small cell carcinoma cells. Oncogene. vol 22. issue 27. 2003-08-01. PMID:12833138. |
treatment of stat3-positive a549 and h358 cells with antisense stat3 oligonucleotides results in complete loss of stat3 dna-binding activity and apoptosis, while stat3-positive h1299 cells remained healthy. |
2003-08-01 |
2023-08-12 |
human |