| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anja Baier, Ingmar Meineckel, Steffen Gay, Thomas Pa. Apoptosis in rheumatoid arthritis. Current opinion in rheumatology. vol 15. issue 3. 2003-09-10. PMID:12707581. |
among them, downstream modulators of fas-signaling, such as sentrin-1/small ubiquitin-like modifier (sumo)-1 and fas-associated death domain-like interleukin (il)-1beta-converting enzyme-inhibitory protein (flip), as well as transcriptional regulators such as nfkappab, stat3, and p53, have been suggested to regulate apoptosis most prominently. |
2003-09-10 |
2023-08-12 |
Not clear |
| Ekaterini A Kritikou, Andrew Sharkey, Kathrine Abell, Paul J Came, Elizabeth Anderson, Richard W E Clarkson, Christine J Watso. A dual, non-redundant, role for LIF as a regulator of development and STAT3-mediated cell death in mammary gland. Development (Cambridge, England). vol 130. issue 15. 2003-09-03. PMID:12810593. |
stat3 is the key mediator of apoptosis in mammary gland. |
2003-09-03 |
2023-08-12 |
mouse |
| Ekaterini A Kritikou, Andrew Sharkey, Kathrine Abell, Paul J Came, Elizabeth Anderson, Richard W E Clarkson, Christine J Watso. A dual, non-redundant, role for LIF as a regulator of development and STAT3-mediated cell death in mammary gland. Development (Cambridge, England). vol 130. issue 15. 2003-09-03. PMID:12810593. |
similar to stat3 knockouts, lif(-/-) mammary glands exhibit delayed involution, reduced apoptosis and elevated levels of p53. |
2003-09-03 |
2023-08-12 |
mouse |
| Ekaterini A Kritikou, Andrew Sharkey, Kathrine Abell, Paul J Came, Elizabeth Anderson, Richard W E Clarkson, Christine J Watso. A dual, non-redundant, role for LIF as a regulator of development and STAT3-mediated cell death in mammary gland. Development (Cambridge, England). vol 130. issue 15. 2003-09-03. PMID:12810593. |
lif therefore signals alternately through erk1/2, then stat3, to regulate mammary growth and apoptosis. |
2003-09-03 |
2023-08-12 |
mouse |
| Gladell P Paner, Simone Silberman, Grace Hartman, Kenneth C Micetich, Gerard V Aranha, Serhan Alka. Analysis of signal transducer and activator of transcription 3 (STAT3) in gastrointestinal stromal tumors. Anticancer research. vol 23. issue 3B. 2003-08-28. PMID:12894500. |
this study demonstrates that stat3 is constitutively activated in gist and jak2 blockade leads to tumor growth inhibition and apoptosis indicating the involvement of the jak/stat signaling pathway in gist cellular survival. |
2003-08-28 |
2023-08-12 |
Not clear |
| Hongtao Liu, Yingyu Ma, Shawn M Cole, Christopher Zander, Kun-Hung Chen, Jim Karras, Richard M Pop. Serine phosphorylation of STAT3 is essential for Mcl-1 expression and macrophage survival. Blood. vol 102. issue 1. 2003-08-19. PMID:12637318. |
stat3 as, but not control, odns decreased stat3 and mcl-1 expression and resulted in macrophage apoptosis. |
2003-08-19 |
2023-08-12 |
human |
| Huang Shao, Haiyun Y Cheng, Richard G Cook, David J Tweard. Identification and characterization of signal transducer and activator of transcription 3 recruitment sites within the epidermal growth factor receptor. Cancer research. vol 63. issue 14. 2003-08-13. PMID:12873986. |
in squamous cell carcinoma of the head and neck, stat3 activation is mediated by up-regulation of the autocrine ligand-receptor pair, tumor growth factor alpha and epidermal growth factor receptor (egfr), resulting in cell growth and resistance to apoptosis. |
2003-08-13 |
2023-08-12 |
human |
| Lanxi Song, James Turkson, James G Karras, Richard Jove, Eric B Haur. Activation of Stat3 by receptor tyrosine kinases and cytokines regulates survival in human non-small cell carcinoma cells. Oncogene. vol 22. issue 27. 2003-08-01. PMID:12833138. |
treatment of a549 lung cancer cells with pd180970 or su6656, both pharmacological inhibitors of src-kinase, resulted in reduced src and stat3 activity, cell cycle arrest in g2, and reduced viability of cells accompanied by induction of apoptosis. |
2003-08-01 |
2023-08-12 |
human |
| Lanxi Song, James Turkson, James G Karras, Richard Jove, Eric B Haur. Activation of Stat3 by receptor tyrosine kinases and cytokines regulates survival in human non-small cell carcinoma cells. Oncogene. vol 22. issue 27. 2003-08-01. PMID:12833138. |
treatment of stat3-positive a549 and h358 cells with antisense stat3 oligonucleotides results in complete loss of stat3 dna-binding activity and apoptosis, while stat3-positive h1299 cells remained healthy. |
2003-08-01 |
2023-08-12 |
human |
| Lanxi Song, James Turkson, James G Karras, Richard Jove, Eric B Haur. Activation of Stat3 by receptor tyrosine kinases and cytokines regulates survival in human non-small cell carcinoma cells. Oncogene. vol 22. issue 27. 2003-08-01. PMID:12833138. |
finally, an adenoviral vector expressing a dominant-negative stat3 isoform results in loss of stat3 dna-binding activity, apoptosis, and reduced cellular viability. |
2003-08-01 |
2023-08-12 |
human |
| Virote Sriuranpong, Jong In Park, Panomwat Amornphimoltham, Vyomesh Patel, Barry D Nelkin, J Silvio Gutkin. Epidermal growth factor receptor-independent constitutive activation of STAT3 in head and neck squamous cell carcinoma is mediated by the autocrine/paracrine stimulation of the interleukin 6/gp130 cytokine system. Cancer research. vol 63. issue 11. 2003-07-31. PMID:12782602. |
treatment with a specific inhibitor of janus kinase, ag490, in hnscc cells led to a reduction of active stat3 and caused significant growth retardation and apoptosis. |
2003-07-31 |
2023-08-12 |
Not clear |
| Steve Alas, Benjamin Bonavid. Inhibition of constitutive STAT3 activity sensitizes resistant non-Hodgkin's lymphoma and multiple myeloma to chemotherapeutic drug-mediated apoptosis. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 9. issue 1. 2003-07-17. PMID:12538484. |
inhibition of constitutive stat3 activity sensitizes resistant non-hodgkin's lymphoma and multiple myeloma to chemotherapeutic drug-mediated apoptosis. |
2003-07-17 |
2023-08-12 |
Not clear |
| Chiharu Kawamura, Masahiro Kizaki, Yasuo Iked. Bone morphogenetic protein (BMP)-2 induces apoptosis in human myeloma cells. Leukemia & lymphoma. vol 43. issue 3. 2003-07-11. PMID:12002771. |
further analysis showed that bmp-2 induced down-regulation of bcl-x(l) through the inactivation of stat3, resulting in the induction of apoptosis in myeloma cells. |
2003-07-11 |
2023-08-12 |
human |
| Vladimir N Ivanov, Anindita Bhoumik, Ze'ev Rona. Death receptors and melanoma resistance to apoptosis. Oncogene. vol 22. issue 20. 2003-07-07. PMID:12789291. |
changes at genomic, transcriptional and post-translational levels of g-proteins and protein kinases (ras, b-raf) and their transcription factor effectors (c-jun, atf2, stat3 and nf-kappab) affects tnf, fas and trail receptors, which play important roles in acquiring melanoma's resistance to apoptosis. |
2003-07-07 |
2023-08-12 |
Not clear |
| Rozita Bagheri-Yarmand, Ratna K Vadlamudi, Rakesh Kuma. Activating transcription factor 4 overexpression inhibits proliferation and differentiation of mammary epithelium resulting in impaired lactation and accelerated involution. The Journal of biological chemistry. vol 278. issue 19. 2003-06-30. PMID:12611881. |
mammary glands from atf4-transgenic mice also showed significant nuclear translocation of activated stat3 and up-regulation of one of its target genes, insulin-like growth factor-binding protein-5, which is thought to facilitate apoptosis by sequestering insulin-like growth factor. |
2003-06-30 |
2023-08-12 |
mouse |
| Juan F García, Francisca I Camacho, Manuel Morente, Máximo Fraga, Carlos Montalbán, Tomás Alvaro, Carmen Bellas, Angel Castaño, Ana Díez, Teresa Flores, Carmen Martin, Miguel A Martinez, Francisco Mazorra, Javier Menárguez, Maria J Mestre, Manuela Mollejo, Ana I Sáez, Lydia Sánchez, Miguel A Piri. Hodgkin and Reed-Sternberg cells harbor alterations in the major tumor suppressor pathways and cell-cycle checkpoints: analyses using tissue microarrays. Blood. vol 101. issue 2. 2003-04-08. PMID:12393683. |
a multiparametric analysis identified proteins associated with increased growth fraction (hdm2, p53, p21, rb, cyclins a, b1, d3, and e, cdk2, cdk6, skp2, bcl-x(l), survivin, stat1, and stat3), and proteins associated with apoptosis (nf-kappab, stat1, and rb). |
2003-04-08 |
2023-08-12 |
Not clear |
| Keiko Yamauchi-Takihar. Gp130-mediated pathway and left ventricular remodeling. Journal of cardiac failure. vol 8. issue 6 Suppl. 2003-04-08. PMID:12555148. |
in this review, stat3 is highlighted as a regulator of antiogenic factors, and together with bclxl and mnsod, promotes cardiac myocyte survival by prevention of apoptosis and restoration of energy deprivation. |
2003-04-08 |
2023-08-12 |
Not clear |
| Yoshiyasu Aoki, Gerald M Feldman, Giovanna Tosat. Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma. Blood. vol 101. issue 4. 2003-03-13. PMID:12393476. |
inhibition of stat3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma. |
2003-03-13 |
2023-08-12 |
Not clear |
| Yoshiyasu Aoki, Gerald M Feldman, Giovanna Tosat. Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma. Blood. vol 101. issue 4. 2003-03-13. PMID:12393476. |
here we show that inhibition of signal transducer and activator of transcription-3 (stat3) leads to apoptosis in pel cells. |
2003-03-13 |
2023-08-12 |
Not clear |
| Yoshiyasu Aoki, Gerald M Feldman, Giovanna Tosat. Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma. Blood. vol 101. issue 4. 2003-03-13. PMID:12393476. |
although stat3 activation is known to induce expression of bcl-2 family proteins, pel cell apoptosis was independent of bcl-2, bcl-x(l), or mcl-1 protein expression. |
2003-03-13 |
2023-08-12 |
Not clear |