| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R S Chapman, P Lourenco, E Tonner, D Flint, S Selbert, K Takeda, S Akira, A R Clarke, C J Watso. The role of Stat3 in apoptosis and mammary gland involution. Conditional deletion of Stat3. Advances in experimental medicine and biology. vol 480. 2000-12-01. PMID:10959419. |
to clarify the role of stat3 in mammary epithelial apoptosis, we have generated a conditional knockout using the lox/cre recombination system. |
2000-12-01 |
2023-08-12 |
mouse |
| R S Chapman, P Lourenco, E Tonner, D Flint, S Selbert, K Takeda, S Akira, A R Clarke, C J Watso. The role of Stat3 in apoptosis and mammary gland involution. Conditional deletion of Stat3. Advances in experimental medicine and biology. vol 480. 2000-12-01. PMID:10959419. |
mammary glands from crosses of transgenic mice expressing cre recombinase under the control of the beta-lactoglobulin milk protein gene promoter with mice harbouring one floxed stat3 allele and one null stat3 allele, showed a decrease in epithelial apoptosis and a dramatic delay of the involution process upon forced weaning. |
2000-12-01 |
2023-08-12 |
mouse |
| C Kawamura, M Kizaki, K Yamato, H Uchida, Y Fukuchi, Y Hattori, T Koseki, T Nishihara, Y Iked. Bone morphogenetic protein-2 induces apoptosis in human myeloma cells with modulation of STAT3. Blood. vol 96. issue 6. 2000-10-04. PMID:10979940. |
bone morphogenetic protein-2 induces apoptosis in human myeloma cells with modulation of stat3. |
2000-10-04 |
2023-08-12 |
human |
| R Craig, A Larkin, A M Mingo, D J Thuerauf, C Andrews, P M McDonough, C C Glembotsk. p38 MAPK and NF-kappa B collaborate to induce interleukin-6 gene expression and release. Evidence for a cytoprotective autocrine signaling pathway in a cardiac myocyte model system. The Journal of biological chemistry. vol 275. issue 31. 2000-09-07. PMID:10781614. |
while tnf-alpha was relatively ineffective, il-6 activated myocardial cell stat3 by about 8-fold, indicating a probable role for this transcription factor in il-6-mediated protection from apoptosis. |
2000-09-07 |
2023-08-12 |
rat |
| N Kimura, R Matsuo, H Shibuya, K Nakashima, T Tag. BMP2-induced apoptosis is mediated by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6. The Journal of biological chemistry. vol 275. issue 23. 2000-07-20. PMID:10748100. |
bmp2 has no inhibitory effect on the il-6-induced tyrosine phosphorylation of stat3, and the bcl-2 gene expression which is known to be regulated by stat3, suggesting that bmp2-induced apoptosis is not attributed to alteration of the il-6-mediated bcl-2 pathway. |
2000-07-20 |
2023-08-12 |
mouse |
| J I Song, J R Grandi. STAT signaling in head and neck cancer. Oncogene. vol 19. issue 21. 2000-06-28. PMID:10851047. |
targeting stat3 leads to scchn growth inhibition, increases apoptosis and a downmodulation of bcl-xl expression in head and neck tumors. |
2000-06-28 |
2023-08-12 |
Not clear |
| S Akir. Roles of STAT3 defined by tissue-specific gene targeting. Oncogene. vol 19. issue 21. 2000-06-28. PMID:10851059. |
analyses of tissue-specific stat3-deficient mice indicate that stat3 plays a crucial role in a variety of biological functions including cell growth, suppression and induction of apoptosis, and cell motility. |
2000-06-28 |
2023-08-12 |
mouse |
| J Rubin Grandis, Q Zeng, S D Drennin. Epidermal growth factor receptor--mediated stat3 signaling blocks apoptosis in head and neck cancer. The Laryngoscope. vol 110. issue 5 Pt 1. 2000-05-18. PMID:10807365. |
epidermal growth factor receptor--mediated stat3 signaling blocks apoptosis in head and neck cancer. |
2000-05-18 |
2023-08-12 |
human |
| J R Grandis, S D Drenning, Q Zeng, S C Watkins, M F Melhem, S Endo, D E Johnson, L Huang, Y He, J D Ki. Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 8. 2000-05-17. PMID:10760290. |
constitutive activation of stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo. |
2000-05-17 |
2023-08-12 |
human |
| J R Grandis, S D Drenning, Q Zeng, S C Watkins, M F Melhem, S Endo, D E Johnson, L Huang, Y He, J D Ki. Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 8. 2000-05-17. PMID:10760290. |
in vivo liposome-mediated gene therapy with a stat3 antisense plasmid efficiently inhibited stat3 activation, increased tumor cell apoptosis, and decreased bcl-x(l) expression in a head and neck xenograft model. |
2000-05-17 |
2023-08-12 |
human |
| H Daino, I Matsumura, K Takada, J Odajima, H Tanaka, S Ueda, H Shibayama, H Ikeda, M Hibi, T Machii, T Hirano, Y Kanakur. Induction of apoptosis by extracellular ubiquitin in human hematopoietic cells: possible involvement of STAT3 degradation by proteasome pathway in interleukin 6-dependent hematopoietic cells. Blood. vol 95. issue 8. 2000-05-05. PMID:10753837. |
induction of apoptosis by extracellular ubiquitin in human hematopoietic cells: possible involvement of stat3 degradation by proteasome pathway in interleukin 6-dependent hematopoietic cells. |
2000-05-05 |
2023-08-12 |
human |
| H Daino, I Matsumura, K Takada, J Odajima, H Tanaka, S Ueda, H Shibayama, H Ikeda, M Hibi, T Machii, T Hirano, Y Kanakur. Induction of apoptosis by extracellular ubiquitin in human hematopoietic cells: possible involvement of STAT3 degradation by proteasome pathway in interleukin 6-dependent hematopoietic cells. Blood. vol 95. issue 8. 2000-05-05. PMID:10753837. |
these results suggest that extracellular ub was incorporated into hematopoietic cells and mediated their growth suppression and apoptosis through proteasome-dependent degradation of selective cellular proteins such as stat3. |
2000-05-05 |
2023-08-12 |
human |
| M Yoshinari, M Imaizumi, A Sato, M Minegishi, K Fujii, H Suzuki, T Miura, T Funato, T Saito, S Chikaoka, T Rikiishi, M Kizaki, K Iinum. G-CSF induces apoptosis of a human acute promyelocytic leukemia cell line, UF-1: possible involvement of Stat3 activation and altered Bax expression. The Tohoku journal of experimental medicine. vol 189. issue 1. 2000-02-03. PMID:10622210. |
g-csf induces apoptosis of a human acute promyelocytic leukemia cell line, uf-1: possible involvement of stat3 activation and altered bax expression. |
2000-02-03 |
2023-08-12 |
human |
| M Yoshinari, M Imaizumi, A Sato, M Minegishi, K Fujii, H Suzuki, T Miura, T Funato, T Saito, S Chikaoka, T Rikiishi, M Kizaki, K Iinum. G-CSF induces apoptosis of a human acute promyelocytic leukemia cell line, UF-1: possible involvement of Stat3 activation and altered Bax expression. The Tohoku journal of experimental medicine. vol 189. issue 1. 2000-02-03. PMID:10622210. |
these findings suggest that uf-1 may be a valuable tool in investigating the aberrant regulation of apoptosis, especially the stat3 involvement in the mechanism of apoptosis induction. |
2000-02-03 |
2023-08-12 |
human |
| R S Chapman, P C Lourenco, E Tonner, D J Flint, S Selbert, K Takeda, S Akira, A R Clarke, C J Watso. Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3. Genes & development. vol 13. issue 19. 1999-11-18. PMID:10521404. |
suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of stat3. |
1999-11-18 |
2023-08-12 |
mouse |
| R S Chapman, P C Lourenco, E Tonner, D J Flint, S Selbert, K Takeda, S Akira, A R Clarke, C J Watso. Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3. Genes & development. vol 13. issue 19. 1999-11-18. PMID:10521404. |
to address the function of this signaling molecule in mammary epithelial apoptosis, we have generated a conditional knockout of stat3 using the cre-lox recombination system. |
1999-11-18 |
2023-08-12 |
mouse |
| R S Chapman, P C Lourenco, E Tonner, D J Flint, S Selbert, K Takeda, S Akira, A R Clarke, C J Watso. Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3. Genes & development. vol 13. issue 19. 1999-11-18. PMID:10521404. |
following weaning, a decrease in apoptosis and a dramatic delay of involution occurred in stat3 null mammary tissue. |
1999-11-18 |
2023-08-12 |
mouse |
| W S Dalton, R Jov. Drug resistance in multiple myeloma: approaches to circumvention. Seminars in oncology. vol 26. issue 5 Suppl 13. 1999-10-22. PMID:10528891. |
in vitro blocking of an interleukin-6-dependent pathway with either a jak inhibitor (tyrphostin, ag490) or stat3 dominant negative (stat3-dn) reduced expression of bcl-xl (an antiapoptosis protein), increased spontaneous apoptosis, and enhanced sensitivity to fas-mediated apoptosis. |
1999-10-22 |
2023-08-12 |
Not clear |
| J B Demoulin, E Van Roost, M Stevens, B Groner, J C Renaul. Distinct roles for STAT1, STAT3, and STAT5 in differentiation gene induction and apoptosis inhibition by interleukin-9. The Journal of biological chemistry. vol 274. issue 36. 1999-10-07. PMID:10464327. |
distinct roles for stat1, stat3, and stat5 in differentiation gene induction and apoptosis inhibition by interleukin-9. |
1999-10-07 |
2023-08-12 |
Not clear |
| J B Demoulin, E Van Roost, M Stevens, B Groner, J C Renaul. Distinct roles for STAT1, STAT3, and STAT5 in differentiation gene induction and apoptosis inhibition by interleukin-9. The Journal of biological chemistry. vol 274. issue 36. 1999-10-07. PMID:10464327. |
both mutant receptors were able to prevent apoptosis, but only the mutant that activated stat1 and stat3 was able to support induction of granzyme a and l-selectin. |
1999-10-07 |
2023-08-12 |
Not clear |