| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shanmiao Gou, Tao Liu, Xiangsheng Li, Jing Cui, Chidan Wan, Chunyou Wan. Pancreatic ductal cells acquire mesenchymal characteristics through cell fusion with bone marrow-derived mesenchymal stem cells and SIRT1 attenuates the apoptosis of hybrid cells. Cells, tissues, organs. vol 196. issue 2. 2013-01-17. PMID:22269821. |
pancreatic ductal cells acquire mesenchymal characteristics through cell fusion with bone marrow-derived mesenchymal stem cells and sirt1 attenuates the apoptosis of hybrid cells. |
2013-01-17 |
2023-08-12 |
mouse |
| Shanmiao Gou, Tao Liu, Xiangsheng Li, Jing Cui, Chidan Wan, Chunyou Wan. Pancreatic ductal cells acquire mesenchymal characteristics through cell fusion with bone marrow-derived mesenchymal stem cells and SIRT1 attenuates the apoptosis of hybrid cells. Cells, tissues, organs. vol 196. issue 2. 2013-01-17. PMID:22269821. |
the addition of nicotinamide (nam) inhibited the deacetylation activity of sirt1 on p53 and induced cell apoptosis in hybrid cells. |
2013-01-17 |
2023-08-12 |
mouse |
| Shanmiao Gou, Tao Liu, Xiangsheng Li, Jing Cui, Chidan Wan, Chunyou Wan. Pancreatic ductal cells acquire mesenchymal characteristics through cell fusion with bone marrow-derived mesenchymal stem cells and SIRT1 attenuates the apoptosis of hybrid cells. Cells, tissues, organs. vol 196. issue 2. 2013-01-17. PMID:22269821. |
sirt1 expression in the hybrid cells attenuated their apoptosis. |
2013-01-17 |
2023-08-12 |
mouse |
| Munehiro Kitada, Shinji Kume, Ai Takeda-Watanabe, Keizo Kanasaki, Daisuke Koy. Sirtuins and renal diseases: relationship with aging and diabetic nephropathy. Clinical science (London, England : 1979). vol 124. issue 3. 2013-01-04. PMID:23075334. |
in the kidneys, sirt1 may inhibit renal cell apoptosis, inflammation and fibrosis, and may regulate lipid metabolism, autophagy, blood pressure and sodium balance. |
2013-01-04 |
2023-08-12 |
Not clear |
| Yan Qu, Jinqian Zhang, Shuling Wu, Ben Li, Shunai Liu, Jun Chen. SIRT1 promotes proliferation and inhibits apoptosis of human malignant glioma cell lines. Neuroscience letters. vol 525. issue 2. 2012-12-10. PMID:22867969. |
sirt1 promotes proliferation and inhibits apoptosis of human malignant glioma cell lines. |
2012-12-10 |
2023-08-12 |
human |
| Guangbo Liu, Ling Su, Xuexi Hao, Ning Zhong, Diansheng Zhong, Sunil Singhal, Xiangguo Li. Salermide up-regulates death receptor 5 expression through the ATF4-ATF3-CHOP axis and leads to apoptosis in human cancer cells. Journal of cellular and molecular medicine. vol 16. issue 7. 2012-11-30. PMID:21801305. |
salermide, a reverse amide compound that inhibits sirtuin 1 (sirt1) and sirtuin 2 (sirt2), has been shown to induce apoptosis in human cancer cells. |
2012-11-30 |
2023-08-12 |
human |
| Chi-Wai Lee, Leo Lap-Yan Wong, Edith Yuk-Ting Tse, Heong-Fai Liu, Veronica Yee-Law Leong, Joyce Man-Fong Lee, D Grahame Hardie, Irene Oi-Lin Ng, Yick-Pang Chin. AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver cancer cells. Cancer research. vol 72. issue 17. 2012-11-19. PMID:22728651. |
the p53 deacetylase, sirt1, was phosphorylated and inactivated by ampk at thr344, promoting p53 acetylation and apoptosis of hcc cells. |
2012-11-19 |
2023-08-12 |
Not clear |
| Yongbo Zhao, Peng Luo, Qindong Guo, Sanzhong Li, Lei Zhang, Mingming Zhao, Haoxiang Xu, Yuefan Yang, Waisang Poon, Zhou Fe. Interactions between SIRT1 and MAPK/ERK regulate neuronal apoptosis induced by traumatic brain injury in vitro and in vivo. Experimental neurology. vol 237. issue 2. 2012-11-13. PMID:22828134. |
interactions between sirt1 and mapk/erk regulate neuronal apoptosis induced by traumatic brain injury in vitro and in vivo. |
2012-11-13 |
2023-08-12 |
Not clear |
| Yongbo Zhao, Peng Luo, Qindong Guo, Sanzhong Li, Lei Zhang, Mingming Zhao, Haoxiang Xu, Yuefan Yang, Waisang Poon, Zhou Fe. Interactions between SIRT1 and MAPK/ERK regulate neuronal apoptosis induced by traumatic brain injury in vitro and in vivo. Experimental neurology. vol 237. issue 2. 2012-11-13. PMID:22828134. |
inhibition of erk1/2 activation with pd98059 or u0126 (two mitogen activated protein kinase kinase inhibitors) in vitro and in vivo significantly attenuates the sirt1 and cleaved caspase-3 expression to protect neuron against tbi-induced apoptosis. |
2012-11-13 |
2023-08-12 |
Not clear |
| Yongbo Zhao, Peng Luo, Qindong Guo, Sanzhong Li, Lei Zhang, Mingming Zhao, Haoxiang Xu, Yuefan Yang, Waisang Poon, Zhou Fe. Interactions between SIRT1 and MAPK/ERK regulate neuronal apoptosis induced by traumatic brain injury in vitro and in vivo. Experimental neurology. vol 237. issue 2. 2012-11-13. PMID:22828134. |
these results reveal that sirt1 plays a neuroprotective effect against neuronal apoptosis induced by tbi. |
2012-11-13 |
2023-08-12 |
Not clear |
| Yongbo Zhao, Peng Luo, Qindong Guo, Sanzhong Li, Lei Zhang, Mingming Zhao, Haoxiang Xu, Yuefan Yang, Waisang Poon, Zhou Fe. Interactions between SIRT1 and MAPK/ERK regulate neuronal apoptosis induced by traumatic brain injury in vitro and in vivo. Experimental neurology. vol 237. issue 2. 2012-11-13. PMID:22828134. |
the interactions between sirt1 and mapk/erk pathway regulate neuronal apoptosis induced by mechanical trauma injury in vitro and in vivo. |
2012-11-13 |
2023-08-12 |
Not clear |
| Ai-jun Qiao, Jin Zhiao, Xiao-jun Liu, Di Shao, Liu-luan Zhu, An-fang Cui, Xing-xing Kong, Fu-de Fang, Yong-sheng Chan. [Research advances in Sirt1 gene]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. vol 31. issue 6. 2012-11-08. PMID:20078953. |
furthermore, sirt1 gene is an essential endogenous apoptosis inhibitor. |
2012-11-08 |
2023-08-12 |
Not clear |
| Tomohiro Kozako, Akiyoshi Aikawa, Teruhisa Shoji, Takahiro Fujimoto, Makoto Yoshimitsu, Senji Shirasawa, Hiroaki Tanaka, Shin-ichiro Honda, Hiroshi Shimeno, Naomichi Arima, Shinji Soed. High expression of the longevity gene product SIRT1 and apoptosis induction by sirtinol in adult T-cell leukemia cells. International journal of cancer. vol 131. issue 9. 2012-11-08. PMID:22322739. |
high expression of the longevity gene product sirt1 and apoptosis induction by sirtinol in adult t-cell leukemia cells. |
2012-11-08 |
2023-08-12 |
human |
| Tomohiro Kozako, Akiyoshi Aikawa, Teruhisa Shoji, Takahiro Fujimoto, Makoto Yoshimitsu, Senji Shirasawa, Hiroaki Tanaka, Shin-ichiro Honda, Hiroshi Shimeno, Naomichi Arima, Shinji Soed. High expression of the longevity gene product SIRT1 and apoptosis induction by sirtinol in adult T-cell leukemia cells. International journal of cancer. vol 131. issue 9. 2012-11-08. PMID:22322739. |
sirt1, a nicotinamide adenine dinucleotide(+)-dependent histone/protein deacetylase, plays a crucial role in various physiological processes, such as aging, metabolism, neurogenesis and apoptosis, owing to its ability to deacetylate numerous substrates, such as histone and nf-κb, which is implicated as an exacerbation factor in atl. |
2012-11-08 |
2023-08-12 |
human |
| Tomohiro Kozako, Akiyoshi Aikawa, Teruhisa Shoji, Takahiro Fujimoto, Makoto Yoshimitsu, Senji Shirasawa, Hiroaki Tanaka, Shin-ichiro Honda, Hiroshi Shimeno, Naomichi Arima, Shinji Soed. High expression of the longevity gene product SIRT1 and apoptosis induction by sirtinol in adult T-cell leukemia cells. International journal of cancer. vol 131. issue 9. 2012-11-08. PMID:22322739. |
sirtinol, a sirt1 inhibitor, induced significant growth inhibition or apoptosis in cells from atl patients and leukemic cell lines, especially htlv-1-related cell lines. |
2012-11-08 |
2023-08-12 |
human |
| Tomohiro Kozako, Akiyoshi Aikawa, Teruhisa Shoji, Takahiro Fujimoto, Makoto Yoshimitsu, Senji Shirasawa, Hiroaki Tanaka, Shin-ichiro Honda, Hiroshi Shimeno, Naomichi Arima, Shinji Soed. High expression of the longevity gene product SIRT1 and apoptosis induction by sirtinol in adult T-cell leukemia cells. International journal of cancer. vol 131. issue 9. 2012-11-08. PMID:22322739. |
sirtinol-induced apoptosis was mediated by activation of the caspase family and degradation of sirt1 in the nucleus. |
2012-11-08 |
2023-08-12 |
human |
| Tomohiro Kozako, Akiyoshi Aikawa, Teruhisa Shoji, Takahiro Fujimoto, Makoto Yoshimitsu, Senji Shirasawa, Hiroaki Tanaka, Shin-ichiro Honda, Hiroshi Shimeno, Naomichi Arima, Shinji Soed. High expression of the longevity gene product SIRT1 and apoptosis induction by sirtinol in adult T-cell leukemia cells. International journal of cancer. vol 131. issue 9. 2012-11-08. PMID:22322739. |
furthermore, sirt1 knockdown by sirt1-specific small interfering rna caused apoptosis via activation of caspase-3 and parp in mt-2 cells, htlv-1-related cell line. |
2012-11-08 |
2023-08-12 |
human |
| Si-Hyong Jang, Kyeung-Whan Min, Seung Sam Paik, Ki-Seok Jan. Loss of SIRT1 histone deacetylase expression associates with tumour progression in colorectal adenocarcinoma. Journal of clinical pathology. vol 65. issue 8. 2012-10-10. PMID:22554968. |
the class iii histone deacetylase sirt1 is a nicotinamide adenine dinucleotide (nad(+))-dependent deacetylase, and has been reported to serve diverse roles in various biological processes, such as caloric restriction, apoptosis, neuronal protection, cell growth, differentiation and tumourigenesis. |
2012-10-10 |
2023-08-12 |
Not clear |
| Hsieh-Cheng Chen, Yung-Ming Jeng, Ray-Hwang Yuan, Hey-Chi Hsu, Yu-Ling Che. SIRT1 promotes tumorigenesis and resistance to chemotherapy in hepatocellular carcinoma and its expression predicts poor prognosis. Annals of surgical oncology. vol 19. issue 6. 2012-10-09. PMID:22146883. |
sirt1 is a nad+-dependent deacetylase that plays crucial roles in many biological processes, including stress response, apoptosis, cellular metabolism, adaptation to calorie restriction, aging, and tumorigenesis. |
2012-10-09 |
2023-08-12 |
Not clear |
| Vincenzo Carafa, Angela Nebbioso, Lucia Altucc. Sirtuins and disease: the road ahead. Frontiers in pharmacology. vol 3. 2012-10-02. PMID:22319497. |
sirt1 may play a critical role in tumor initiation and progression as well as drug resistance by blocking senescence and apoptosis, and by promoting cell growth and angiogenesis. |
2012-10-02 |
2023-08-12 |
human |