| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Di Shao, Jessica L Fry, Jingyan Han, Xiuyun Hou, David R Pimentel, Reiko Matsui, Richard A Cohen, Markus M Bachschmi. A redox-resistant sirtuin-1 mutant protects against hepatic metabolic and oxidant stress. The Journal of biological chemistry. vol 289. issue 11. 2014-05-14. PMID:24451382. |
in a model of metabolic syndrome, sirt1 activation attenuated apoptosis of hepatocytes and improved liver function including lipid metabolism. |
2014-05-14 |
2023-08-12 |
mouse |
| Luca Vanella, Claudia Di Giacomo, Rosaria Acquaviva, Ignazio Barbagallo, Venera Cardile, Dong Hyun Kim, Nader G Abraham, Valeria Sorrent. Apoptotic markers in a prostate cancer cell line: effect of ellagic acid. Oncology reports. vol 30. issue 6. 2014-05-13. PMID:24085108. |
moreover, we demonstrated that ea induced apoptosis via downregulation of the anti-apoptotic proteins, silent information regulator 1 (sirt1), human antigen r (hur) and heme oxygenase-1 (ho-1). |
2014-05-13 |
2023-08-12 |
human |
| Jieming Ye, Zhenhua Liu, Jipeng Wei, Lingli Lu, Yanjun Huang, Lili Luo, Huifang Xi. Protective effect of SIRT1 on toxicity of microglial-derived factors induced by LPS to PC12 cells via the p53-caspase-3-dependent apoptotic pathway. Neuroscience letters. vol 553. 2014-05-08. PMID:23973301. |
pc12 cell apoptosis and sirt1 involved protection were investigated. |
2014-05-08 |
2023-08-12 |
Not clear |
| Jieming Ye, Zhenhua Liu, Jipeng Wei, Lingli Lu, Yanjun Huang, Lili Luo, Huifang Xi. Protective effect of SIRT1 on toxicity of microglial-derived factors induced by LPS to PC12 cells via the p53-caspase-3-dependent apoptotic pathway. Neuroscience letters. vol 553. 2014-05-08. PMID:23973301. |
further, we found that factors derived from activated microglia significantly decreased the level of deacetylation of p53 by reducing the expression of sirt1, an effect that increased the apoptosis of pc12 and reduced cell viability. |
2014-05-08 |
2023-08-12 |
Not clear |
| Jieming Ye, Zhenhua Liu, Jipeng Wei, Lingli Lu, Yanjun Huang, Lili Luo, Huifang Xi. Protective effect of SIRT1 on toxicity of microglial-derived factors induced by LPS to PC12 cells via the p53-caspase-3-dependent apoptotic pathway. Neuroscience letters. vol 553. 2014-05-08. PMID:23973301. |
together, these data suggests that: sirt1 inhibits lps-mediated proinflammatory cytokines release in microglia, and circumvents dopaminergic neurons injury induced by activated microglial-derived factors via p53-caspase-3-dependent mechanism of apoptosis. |
2014-05-08 |
2023-08-12 |
Not clear |
| Duarte M S Ferreira, Marta B Afonso, Pedro M Rodrigues, André L Simão, Diane M Pereira, Pedro M Borralho, Cecília M P Rodrigues, Rui E Castr. c-Jun N-terminal kinase 1/c-Jun activation of the p53/microRNA 34a/sirtuin 1 pathway contributes to apoptosis induced by deoxycholic acid in rat liver. Molecular and cellular biology. vol 34. issue 6. 2014-04-24. PMID:24421392. |
in turn, mir-34a inhibition and sirt1 overexpression significantly rescued targeting of the mir-34a pathway and apoptosis by dca. |
2014-04-24 |
2023-08-12 |
rat |
| Wen Yu, Zan Wan, Xue-Feng Qiu, Yun Chen, Yu-Tian Da. Resveratrol, an activator of SIRT1, restores erectile function in streptozotocin-induced diabetic rats. Asian journal of andrology. vol 15. issue 5. 2014-03-25. PMID:23792339. |
therefore, the ability of resveratrol to improve diabetes-induced ed is likely related to its activation of sirt1 expression, thus causing the suppression of apoptosis and resistance towards oxidative stress. |
2014-03-25 |
2023-08-12 |
rat |
| Boris Guennewig, Martina Roos, Afzal M Dogar, Luca F R Gebert, Julian A Zagalak, Valentina Vongrad, Karin J Metzner, Jonathan Hal. Synthetic pre-microRNAs reveal dual-strand activity of miR-34a on TNF-α. RNA (New York, N.Y.). vol 20. issue 1. 2014-02-28. PMID:24249224. |
we use syn-pre-mirnas to show that mir-34a uses its 5p and 3p mirnas in two pathways: apoptosis during tgf-β signaling, where sirt1 and sp4 are suppressed by mir-34a-5p and mir-34a-3p, respectively; and the lipopolysaccharide (lps)-activation of primary human monocyte-derived macrophages, where tnf (tnfα) is suppressed by mir-34a-5p indirectly and mir-34a-3p directly. |
2014-02-28 |
2023-08-12 |
human |
| André F Nascimento, Blanche C Ip, Renata A M Luvizotto, Helmut K Seitz, Xiang-Dong Wan. Aggravation of nonalcoholic steatohepatitis by moderate alcohol consumption is associated with decreased SIRT1 activity in rats. Hepatobiliary surgery and nutrition. vol 2. issue 5. 2014-02-26. PMID:24570955. |
chronic alcohol intake decreases adiponectin and sirtuin 1 (sirt1) expressions, both of which have been implicated in various biological processes including inflammation, apoptosis and metabolism. |
2014-02-26 |
2023-08-12 |
rat |
| André F Nascimento, Blanche C Ip, Renata A M Luvizotto, Helmut K Seitz, Xiang-Dong Wan. Aggravation of nonalcoholic steatohepatitis by moderate alcohol consumption is associated with decreased SIRT1 activity in rats. Hepatobiliary surgery and nutrition. vol 2. issue 5. 2014-02-26. PMID:24570955. |
the present study indicates that suppression in sirt1 deacetylase activity contributes to alcohol-exacerbated hepatic inflammation and apoptosis in rats with pre-existing nash. |
2014-02-26 |
2023-08-12 |
rat |
| Vid Leko, Gemma J Park, Uyen Lao, Julian A Simon, Antonio Bedalo. Enterocyte-specific inactivation of SIRT1 reduces tumor load in the APC(+/min) mouse model. PloS one. vol 8. issue 6. 2014-01-30. PMID:23799088. |
additionally, tumors in sirt1-deficient mice exhibited markedly increased numbers of cells undergoing apoptosis, suggesting that sirt1 contributes to tumor growth by enabling survival of tumor cells. |
2014-01-30 |
2023-08-12 |
mouse |
| Xiaowen Feng, Nan Liang, Dexiao Zhu, Qing Gao, Lei Peng, Haiman Dong, Qingwei Yue, Haili Liu, Lihua Bao, Jing Zhang, Jing Hao, Yingmao Gao, Xuejie Yu, Jinhao Su. Resveratrol inhibits β-amyloid-induced neuronal apoptosis through regulation of SIRT1-ROCK1 signaling pathway. PloS one. vol 8. issue 3. 2014-01-07. PMID:23555824. |
our results clearly revealed that resveratrol significantly protected pc12 cells and inhibited the β-amyloid-induced cell apoptosis through the upregulation of sirt1. |
2014-01-07 |
2023-08-12 |
Not clear |
| Weirong Wang, Chunfang Yan, Jiye Zhang, Rong Lin, Qinqin Lin, Lina Yang, Feng Ren, Jianfeng Zhang, Meixi Ji, Yanxiang L. SIRT1 inhibits TNF-α-induced apoptosis of vascular adventitial fibroblasts partly through the deacetylation of FoxO1. Apoptosis : an international journal on programmed cell death. vol 18. issue 6. 2013-11-26. PMID:23479127. |
sirt1 inhibits tnf-α-induced apoptosis of vascular adventitial fibroblasts partly through the deacetylation of foxo1. |
2013-11-26 |
2023-08-12 |
Not clear |
| Weirong Wang, Chunfang Yan, Jiye Zhang, Rong Lin, Qinqin Lin, Lina Yang, Feng Ren, Jianfeng Zhang, Meixi Ji, Yanxiang L. SIRT1 inhibits TNF-α-induced apoptosis of vascular adventitial fibroblasts partly through the deacetylation of FoxO1. Apoptosis : an international journal on programmed cell death. vol 18. issue 6. 2013-11-26. PMID:23479127. |
sirtuin 1 (sirt1), a nad(+)-dependent class iii histone deacetylase, participates in regulating cellular apoptosis, senescence and metabolism by deacetylating histones and multiple transcription factors. |
2013-11-26 |
2023-08-12 |
Not clear |
| Weirong Wang, Chunfang Yan, Jiye Zhang, Rong Lin, Qinqin Lin, Lina Yang, Feng Ren, Jianfeng Zhang, Meixi Ji, Yanxiang L. SIRT1 inhibits TNF-α-induced apoptosis of vascular adventitial fibroblasts partly through the deacetylation of FoxO1. Apoptosis : an international journal on programmed cell death. vol 18. issue 6. 2013-11-26. PMID:23479127. |
in this study, we aimed to determine the effect of sirt1 on the apoptosis of vascular adventitial fibroblasts (vafs) and related signaling pathways. |
2013-11-26 |
2023-08-12 |
Not clear |
| Weirong Wang, Chunfang Yan, Jiye Zhang, Rong Lin, Qinqin Lin, Lina Yang, Feng Ren, Jianfeng Zhang, Meixi Ji, Yanxiang L. SIRT1 inhibits TNF-α-induced apoptosis of vascular adventitial fibroblasts partly through the deacetylation of FoxO1. Apoptosis : an international journal on programmed cell death. vol 18. issue 6. 2013-11-26. PMID:23479127. |
activation of sirt1 by resveratrol (rsv) or overexpression of sirt1 attenuated tnf-α-induced vaf apoptosis by decreasing the percentage of apoptotic cells and cleaved caspase-3 protein expression and increasing the bcl-2/bax ratio. |
2013-11-26 |
2023-08-12 |
Not clear |
| Weirong Wang, Chunfang Yan, Jiye Zhang, Rong Lin, Qinqin Lin, Lina Yang, Feng Ren, Jianfeng Zhang, Meixi Ji, Yanxiang L. SIRT1 inhibits TNF-α-induced apoptosis of vascular adventitial fibroblasts partly through the deacetylation of FoxO1. Apoptosis : an international journal on programmed cell death. vol 18. issue 6. 2013-11-26. PMID:23479127. |
in contrast, inhibition of sirt1 by sirtinol/nicotinamide or knockdown of sirt1 enhanced apoptosis of vafs. |
2013-11-26 |
2023-08-12 |
Not clear |
| Weirong Wang, Chunfang Yan, Jiye Zhang, Rong Lin, Qinqin Lin, Lina Yang, Feng Ren, Jianfeng Zhang, Meixi Ji, Yanxiang L. SIRT1 inhibits TNF-α-induced apoptosis of vascular adventitial fibroblasts partly through the deacetylation of FoxO1. Apoptosis : an international journal on programmed cell death. vol 18. issue 6. 2013-11-26. PMID:23479127. |
taken together, these findings indicate that sirt1 inhibits the apoptosis of vafs, whereas foxo1 promotes vaf apoptosis. |
2013-11-26 |
2023-08-12 |
Not clear |
| Weirong Wang, Chunfang Yan, Jiye Zhang, Rong Lin, Qinqin Lin, Lina Yang, Feng Ren, Jianfeng Zhang, Meixi Ji, Yanxiang L. SIRT1 inhibits TNF-α-induced apoptosis of vascular adventitial fibroblasts partly through the deacetylation of FoxO1. Apoptosis : an international journal on programmed cell death. vol 18. issue 6. 2013-11-26. PMID:23479127. |
furthermore, the inhibitory effect of sirt1 on vaf apoptosis is partly mediated by the deacetylation of foxo1. |
2013-11-26 |
2023-08-12 |
Not clear |
| Wei Zheng, Yun-Biao Lu, Shu-Ting Liang, Qing-Jun Zhang, Jing Xu, Zhi-Gang She, Zhu-Qin Zhang, Rui-Feng Yang, Bei-Bei Mao, Zhen Xu, Li Li, De-Long Hao, Jie Lu, Yu-Sheng Wei, Hou-Zao Chen, De-Pei Li. SIRT1 mediates the protective function of Nkx2.5 during stress in cardiomyocytes. Basic research in cardiology. vol 108. issue 4. 2013-11-19. PMID:23744058. |
sirt1, a member of the sirtuin family of proteins, was found to be a direct transcriptional target of nkx2.5 and was required for the nkx2.5-mediated protection of cardiomyocytes from doxorubicin (dox)-induced apoptosis. |
2013-11-19 |
2023-08-12 |
mouse |