| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| WenLi Mu, QingJun Zhang, XiaoQiang Tang, WenYan Fu, Wei Zheng, YunBiao Lu, HongLiang Li, YuSheng Wei, Li Li, ZhiGang She, HouZao Chen, DePei Li. Overexpression of a dominant-negative mutant of SIRT1 in mouse heart causes cardiomyocyte apoptosis and early-onset heart failure. Science China. Life sciences. vol 57. issue 9. 2015-05-15. PMID:25104317. |
furthermore, we show that cardiomyocyte apoptosis caused by suppression of sirt1 activity is, at least in part, due to increased p53 acetylation and upregulated bax expression. |
2015-05-15 |
2023-08-13 |
mouse |
| WenLi Mu, QingJun Zhang, XiaoQiang Tang, WenYan Fu, Wei Zheng, YunBiao Lu, HongLiang Li, YuSheng Wei, Li Li, ZhiGang She, HouZao Chen, DePei Li. Overexpression of a dominant-negative mutant of SIRT1 in mouse heart causes cardiomyocyte apoptosis and early-onset heart failure. Science China. Life sciences. vol 57. issue 9. 2015-05-15. PMID:25104317. |
these results indicate that dominant negative form of sirt1 (sirt1h363y) overexpression in mouse hearts causes cardiomyocyte apoptosis and early-onset heart failure, suggesting a critical role of sirt1 in preserving normal cardiac development during the early postnatal period. |
2015-05-15 |
2023-08-13 |
mouse |
| Bingqing Huang, Xixi Cheng, Dan Wang, Meiyu Peng, Zhenyi Xue, Yurong Da, Ning Zhang, Zhi Yao, Min Li, Aimin Xu, Rongxin Zhan. Adiponectin promotes pancreatic cancer progression by inhibiting apoptosis via the activation of AMPK/Sirt1/PGC-1α signaling. Oncotarget. vol 5. issue 13. 2015-05-12. PMID:25051362. |
knockdown of ampk or sirt1 can increase the apoptosis in pc cells. |
2015-05-12 |
2023-08-13 |
mouse |
| Chao-Hung Lai, Tsung-Jung Ho, Wei-Wen Kuo, Cecilia-Hsuan Day, Pei-Ying Pai, Li-Chin Chung, Po-Hsiang Liao, Feng-Huei Lin, En-Ting Wu, Chih-Yang Huan. Exercise training enhanced SIRT1 longevity signaling replaces the IGF1 survival pathway to attenuate aging-induced rat heart apoptosis. Age (Dordrecht, Netherlands). vol 36. issue 5. 2015-05-12. PMID:25148910. |
exercise training enhanced sirt1 longevity signaling replaces the igf1 survival pathway to attenuate aging-induced rat heart apoptosis. |
2015-05-12 |
2023-08-13 |
rat |
| Theresa Thor, Annette Künkele, Kristian W Pajtler, Annika K Wefers, Harald Stephan, Pieter Mestdagh, Lukas Heukamp, Wolfgang Hartmann, Jo Vandesompele, Natalie Sadowski, Lore Becker, Lillian Garrett, Sabine M Hölter, Marion Horsch, Julia Calzada-Wack, Tanja Klein-Rodewald, Ildiko Racz, Andreas Zimmer, Johannes Beckers, Frauke Neff, Thomas Klopstock, Pasqualino De Antonellis, Massimo Zollo, Wolfgang Wurst, Helmut Fuchs, Valérie Gailus-Durner, Ulrich Schüller, Martin Hrabě de Angelis, Angelika Eggert, Alexander Schramm, Johannes H Schult. MiR-34a deficiency accelerates medulloblastoma formation in vivo. International journal of cancer. vol 136. issue 10. 2015-05-12. PMID:25348795. |
re-expression of mir-34a in human medulloblastoma cells reduced cell viability and proliferation, induced apoptosis and downregulated the mir-34a target genes, mycn and sirt1. |
2015-05-12 |
2023-08-13 |
mouse |
| Carolina Martin, Luis Leyton, Yennyfer Arancibia, Alexei Cuevas, Angara Zambrano, Margarita I Concha, Carola Ott. Modulation of the AMPK/Sirt1 axis during neuronal infection by herpes simplex virus type 1. Journal of Alzheimer's disease : JAD. vol 42. issue 1. 2015-05-11. PMID:24858404. |
taking in consideration that the stress sensors ampk and sirt1 are involved in neuronal survival and neuroprotection, we hypothesized that hsv-1 could activate the ampk/sirt1 axis as a strategy to establish latency through inhibition of apoptosis and restoration of the energy status. |
2015-05-11 |
2023-08-13 |
mouse |
| M Ming, K Soltani, C R Shea, X Li, Y Y H. Dual role of SIRT1 in UVB-induced skin tumorigenesis. Oncogene. vol 34. issue 3. 2015-04-22. PMID:24441046. |
in contrast, homozygous sirt1 deletion in mouse skin augments p53 acetylation and expression of its transcriptional target noxa, and sensitizes the epidermis to uvb-induced apoptosis in vivo, while heterozygous sirt1 deletion has no such effect. |
2015-04-22 |
2023-08-12 |
mouse |
| Ren-Tao Jiang, Chun-Suo Yao, Jin-Ye Bai, Qi Ho. [Effects of Vam3 on sodium nitroprusside-induced apoptosis and SIRT1 and p53 expression in rat articular chondrocytes]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 49. issue 5. 2015-04-22. PMID:25151729. |
[effects of vam3 on sodium nitroprusside-induced apoptosis and sirt1 and p53 expression in rat articular chondrocytes]. |
2015-04-22 |
2023-08-13 |
rat |
| Ren-Tao Jiang, Chun-Suo Yao, Jin-Ye Bai, Qi Ho. [Effects of Vam3 on sodium nitroprusside-induced apoptosis and SIRT1 and p53 expression in rat articular chondrocytes]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 49. issue 5. 2015-04-22. PMID:25151729. |
this study indicates vam3 could protect rat articular chondrocytes against snp-induced apoptosis, perhaps through the upregulation of sirt1 and deacetylation of p53. |
2015-04-22 |
2023-08-13 |
rat |
| C-Y Huang, W-W Kuo, Y-L Yeh, T-J Ho, J-Y Lin, D-Y Lin, C-H Chu, F-J Tsai, C-H Tsai, C-Y Huan. ANG II promotes IGF-IIR expression and cardiomyocyte apoptosis by inhibiting HSF1 via JNK activation and SIRT1 degradation. Cell death and differentiation. vol 21. issue 8. 2015-04-19. PMID:24786827. |
ang ii promotes igf-iir expression and cardiomyocyte apoptosis by inhibiting hsf1 via jnk activation and sirt1 degradation. |
2015-04-19 |
2023-08-13 |
Not clear |
| C-Y Huang, W-W Kuo, Y-L Yeh, T-J Ho, J-Y Lin, D-Y Lin, C-H Chu, F-J Tsai, C-H Tsai, C-Y Huan. ANG II promotes IGF-IIR expression and cardiomyocyte apoptosis by inhibiting HSF1 via JNK activation and SIRT1 degradation. Cell death and differentiation. vol 21. issue 8. 2015-04-19. PMID:24786827. |
ang ii activates jnk to degrade sirt1, resulting in hsf1 acetylation, which induces igf-iir expression and eventually results in cardiac hypertrophy and apoptosis. |
2015-04-19 |
2023-08-13 |
Not clear |
| Wootae Kim, Joo-Won Jeong, Ja-Eun Ki. CCAR2 deficiency augments genotoxic stress-induced apoptosis in the presence of melatonin in non-small cell lung cancer cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 11. 2015-04-17. PMID:25085583. |
the increase in apoptosis in ccar2-deficient cells was not dependent on sirt1. |
2015-04-17 |
2023-08-13 |
Not clear |
| Minakshi Nihal, Nihal Ahmad, Gary S Woo. SIRT1 is upregulated in cutaneous T-cell lymphoma, and its inhibition induces growth arrest and apoptosis. Cell cycle (Georgetown, Tex.). vol 13. issue 4. 2015-04-16. PMID:24343700. |
sirt1 is upregulated in cutaneous t-cell lymphoma, and its inhibition induces growth arrest and apoptosis. |
2015-04-16 |
2023-08-12 |
Not clear |
| Minakshi Nihal, Nihal Ahmad, Gary S Woo. SIRT1 is upregulated in cutaneous T-cell lymphoma, and its inhibition induces growth arrest and apoptosis. Cell cycle (Georgetown, Tex.). vol 13. issue 4. 2015-04-16. PMID:24343700. |
sirt1 knockdown resulted in reduced cellular metabolism and proliferation, increased apoptosis, and parp cleavage products. |
2015-04-16 |
2023-08-12 |
Not clear |
| Minakshi Nihal, Nihal Ahmad, Gary S Woo. SIRT1 is upregulated in cutaneous T-cell lymphoma, and its inhibition induces growth arrest and apoptosis. Cell cycle (Georgetown, Tex.). vol 13. issue 4. 2015-04-16. PMID:24343700. |
tenovin-1, which reversibly inhibits class iii hdacs (sirt1 and sirt2), reduced sirt enzymatic activity and sirt1 expression and led to increased apoptosis. |
2015-04-16 |
2023-08-12 |
Not clear |
| Yao Fong, Yin-Chieh Lin, Chang-Yi Wu, Hui-Min David Wang, Li-Li Lin, Han Lin Chou, Yen-Ni Teng, Shyng-Shiou Yuan, Chien-Chih Chi. The antiproliferative and apoptotic effects of sirtinol, a sirtuin inhibitor on human lung cancer cells by modulating Akt/β-catenin-Foxo3a axis. TheScientificWorldJournal. vol 2014. 2015-04-10. PMID:25184156. |
sirtinol, a specific inhibitor of sirt1, has been shown to induce apoptosis of cancer cells by elevating endogenous level of reactive oxygen species. |
2015-04-10 |
2023-08-13 |
human |
| Yao Fong, Yin-Chieh Lin, Chang-Yi Wu, Hui-Min David Wang, Li-Li Lin, Han Lin Chou, Yen-Ni Teng, Shyng-Shiou Yuan, Chien-Chih Chi. The antiproliferative and apoptotic effects of sirtinol, a sirtuin inhibitor on human lung cancer cells by modulating Akt/β-catenin-Foxo3a axis. TheScientificWorldJournal. vol 2014. 2015-04-10. PMID:25184156. |
overall, this study demonstrates that sirtinol attenuates the proliferation and induces apoptosis of nsclc cells, indicating the potential treatment against nsclc cells by inhibiting sirt1 in future applications. |
2015-04-10 |
2023-08-13 |
human |
| Kenneth Maies. SIRT1 and stem cells: In the forefront with cardiovascular disease, neurodegeneration and cancer. World journal of stem cells. vol 7. issue 2. 2015-03-27. PMID:25815111. |
ultimately, the ability of sirt1 to control the programmed cell death pathways of apoptosis and autophagy can determine not only cardiac, vascular, and neuronal stem cell development and longevity, but also the onset of tumorigenesis and the resistance against chemotherapy. |
2015-03-27 |
2023-08-13 |
Not clear |
| Jingjie Yi, Xiangyang Huang, Yuxia Yang, Wei-Guo Zhu, Wei Gu, Jianyuan Lu. Regulation of histone acetyltransferase TIP60 function by histone deacetylase 3. The Journal of biological chemistry. vol 289. issue 49. 2015-03-03. PMID:25301942. |
the deacetylation of tip60 by both sirt1 and hdac3 reduces apoptosis induced by dna damage. |
2015-03-03 |
2023-08-13 |
Not clear |
| Weirong Wang, Jianfeng Zhang, Yanxiang Li, Xiaofeng Yang, Yanhao He, Tingting Li, Feng Ren, Jiye Zhang, Rong Li. Divalproex sodium enhances the anti-leukemic effects of imatinib in chronic myeloid leukemia cells partly through SIRT1. Cancer letters. vol 356. issue 2 Pt B. 2015-03-03. PMID:25449787. |
furthermore, knockdown of sirt1 promoted apoptosis of k562-g cells treated with im and dvpx. |
2015-03-03 |
2023-08-13 |
Not clear |