| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gérald J Prud'homme, Yelena Glinka, Oleksandr Udovyk, Craig Hasilo, Steven Paraskevas, Qinghua Wan. GABA protects pancreatic beta cells against apoptosis by increasing SIRT1 expression and activity. Biochemical and biophysical research communications. vol 452. issue 3. 2015-02-25. PMID:25193706. |
gaba protects pancreatic beta cells against apoptosis by increasing sirt1 expression and activity. |
2015-02-25 |
2023-08-13 |
human |
| Gérald J Prud'homme, Yelena Glinka, Oleksandr Udovyk, Craig Hasilo, Steven Paraskevas, Qinghua Wan. GABA protects pancreatic beta cells against apoptosis by increasing SIRT1 expression and activity. Biochemical and biophysical research communications. vol 452. issue 3. 2015-02-25. PMID:25193706. |
gaba increased insulin production and reduced drug-induced apoptosis, and these actions were reversed by sirt1 inhibitors. |
2015-02-25 |
2023-08-13 |
human |
| Gérald J Prud'homme, Yelena Glinka, Oleksandr Udovyk, Craig Hasilo, Steven Paraskevas, Qinghua Wan. GABA protects pancreatic beta cells against apoptosis by increasing SIRT1 expression and activity. Biochemical and biophysical research communications. vol 452. issue 3. 2015-02-25. PMID:25193706. |
it protected human islet cells against spontaneous apoptosis in culture, and this was negated by a sirt1 inhibitor. |
2015-02-25 |
2023-08-13 |
human |
| Susanne Schuster, Melanie Penke, Theresa Gorski, Stefanie Petzold-Quinque, Georg Damm, Rolf Gebhardt, Wieland Kiess, Antje Garte. Resveratrol differentially regulates NAMPT and SIRT1 in Hepatocarcinoma cells and primary human hepatocytes. PloS one. vol 9. issue 3. 2015-02-12. PMID:24603648. |
in this study, we wanted to investigate the molecular mechanisms of resveratrol-induced cell cycle arrest and apoptosis as well as the impact of resveratrol on nampt and sirt1 protein function and asked whether there are differences in hepatocarcinoma cells (hepg2, hep3b cells) and non-cancerous primary human hepatocytes. |
2015-02-12 |
2023-08-12 |
human |
| Thomas K Sin, Angus P Yu, Benjamin Y Yung, Shea Ping Yip, Lawrence W Chan, Cesar S Wong, Michael Ying, John A Rudd, Parco M Si. Modulating effect of SIRT1 activation induced by resveratrol on Foxo1-associated apoptotic signalling in senescent heart. The Journal of physiology. vol 592. issue 12. 2015-02-04. PMID:24639483. |
recent studies attempted to relate sirt1 activation by resveratrol to the regulation of apoptosis in various disease models of cardiac muscle. |
2015-02-04 |
2023-08-12 |
mouse |
| Camila Rosat Consiglio, Schauren Juliana da Silveira, Odirlei André Monticielo, Ricardo Machado Xavier, João Carlos Tavares Brenol, José Artur Bogo Chie. SIRT1 promoter polymorphisms as clinical modifiers on systemic lupus erythematosus. Molecular biology reports. vol 41. issue 7. 2015-02-02. PMID:24570024. |
silent mating type information regulator 2 homolog 1 (sirt1) is a deacetylase protein that participates in several physiological processes with importance in transcriptional silencing, apoptosis, immune system regulation and inflammation. |
2015-02-02 |
2023-08-12 |
Not clear |
| Martina Magni, Vincenzo Ruscica, Giacomo Buscemi, Ja-Eun Kim, Benjamin Tamilselvan Nachimuthu, Enrico Fontanella, Domenico Delia, Laura Zannin. Chk2 and REGγ-dependent DBC1 regulation in DNA damage induced apoptosis. Nucleic acids research. vol 42. issue 21. 2015-01-27. PMID:25361978. |
upon dna damage, dbc1 is phosphorylated by atm/atr on thr454 and this modification increases its inhibitory interaction with sirt1, leading to p53 acetylation and p53-dependent apoptosis. |
2015-01-27 |
2023-08-13 |
human |
| Mo-Li Wu, Hong Li, Li-Jun Yu, Xiao-Yan Chen, Qing-You Kong, Xue Song, Xiao-Hong Shu, Jia Li. Short-term resveratrol exposure causes in vitro and in vivo growth inhibition and apoptosis of bladder cancer cells. PloS one. vol 9. issue 2. 2015-01-22. PMID:24587049. |
the results revealed that 2 h 150 µm or 200 µm resveratrol treatment leaded to remarkable s phase arrest and apoptosis at 72 h time-point, accompanied with attenuated phosphorylation, nuclear translocation and transcription of stat3, down-regulation of stat3 downstream genes (survivin, cyclind1, c-myc and vegf) and nuclear translocations of sirt1 and p53. |
2015-01-22 |
2023-08-12 |
mouse |
| Srividhya Iyer, Li Han, Shoshana M Bartell, Ha-Neui Kim, Igor Gubrij, Rafael de Cabo, Charles A O'Brien, Stavros C Manolagas, Maria Almeid. Sirtuin1 (Sirt1) promotes cortical bone formation by preventing β-catenin sequestration by FoxO transcription factors in osteoblast progenitors. The Journal of biological chemistry. vol 289. issue 35. 2015-01-22. PMID:25002589. |
in line with this, osteoprogenitor cell cultures from the sirt1(Δosx1) mice exhibited lower alkaline phosphatase activity and mineralization, as well as decreased proliferation and increased apoptosis. |
2015-01-22 |
2023-08-13 |
mouse |
| Jianguo Li, Li Feng, Yonghua Xing, Yan Wang, Liqing Du, Chang Xu, Jia Cao, Qin Wang, Saijun Fan, Qiang Liu, Feiyue Fa. Radioprotective and antioxidant effect of resveratrol in hippocampus by activating Sirt1. International journal of molecular sciences. vol 15. issue 4. 2015-01-19. PMID:24722566. |
our results demonstrate that resveratrol inhibits apoptosis induced by radiation via the activation of sirt1. |
2015-01-19 |
2023-08-13 |
Not clear |
| Giulia Antoniali, Lisa Lirussi, Chiara D'Ambrosio, Fabrizio Dal Piaz, Carlo Vascotto, Elena Casarano, Daniela Marasco, Andrea Scaloni, Federico Fogolari, Gianluca Tel. SIRT1 gene expression upon genotoxic damage is regulated by APE1 through nCaRE-promoter elements. Molecular biology of the cell. vol 25. issue 4. 2015-01-13. PMID:24356447. |
we focused on sirtuin-1 (sirt1) deacetylase due to its involvement in cell stress, including senescence, apoptosis, and tumorigenesis, and its role in the deacetylation of ape1 after genotoxic stress. |
2015-01-13 |
2023-08-12 |
human |
| Yingmei Zhang, Shou-Ling Mi, Nan Hu, Thomas A Doser, Aijun Sun, Junbo Ge, Jun Re. Mitochondrial aldehyde dehydrogenase 2 accentuates aging-induced cardiac remodeling and contractile dysfunction: role of AMPK, Sirt1, and mitochondrial function. Free radical biology & medicine. vol 71. 2015-01-06. PMID:24675227. |
cardiac histology, mitochondrial integrity, o2(-) generation, apoptosis, and signaling cascades, including ampk activation and sirt1 level were evaluated. |
2015-01-06 |
2023-08-12 |
mouse |
| Eirini Pantazi, Mohamed Amine Zaouali, Mohamed Bejaoui, Anna Serafin, Emma Folch-Puy, Valerie Petegnief, Nuria De Vera, Hassen Ben Abdennebi, Antoni Rimola, Joan Roselló-Catafa. Silent information regulator 1 protects the liver against ischemia-reperfusion injury: implications in steatotic liver ischemic preconditioning. Transplant international : official journal of the European Society for Organ Transplantation. vol 27. issue 5. 2015-01-02. PMID:24472096. |
sirt1 protein levels and activity, as well as other parameters involved in pc protective mechanisms (adenosine monophosphate protein kinase, enos, hsp70, map kinases, apoptosis), were also measured. |
2015-01-02 |
2023-08-12 |
rat |
| Gang Du, Yunlin Song, Tao Zhang, Long Ma, Ning Bian, Xiaoming Chen, Jianyi Feng, Qing Chang, Zicheng L. Simvastatin attenuates TNF‑α‑induced apoptosis in endothelial progenitor cells via the upregulation of SIRT1. International journal of molecular medicine. vol 34. issue 1. 2014-12-30. PMID:24718722. |
simvastatin attenuates tnf‑α‑induced apoptosis in endothelial progenitor cells via the upregulation of sirt1. |
2014-12-30 |
2023-08-13 |
Not clear |
| Gang Du, Yunlin Song, Tao Zhang, Long Ma, Ning Bian, Xiaoming Chen, Jianyi Feng, Qing Chang, Zicheng L. Simvastatin attenuates TNF‑α‑induced apoptosis in endothelial progenitor cells via the upregulation of SIRT1. International journal of molecular medicine. vol 34. issue 1. 2014-12-30. PMID:24718722. |
additionally, a member of the sirtuin family, silent information regulator type-1 (sirt1), promotes cell survival by repressing p53- and non-p53-dependent apoptosis in response to dna damage and oxidative stress. |
2014-12-30 |
2023-08-13 |
Not clear |
| Gang Du, Yunlin Song, Tao Zhang, Long Ma, Ning Bian, Xiaoming Chen, Jianyi Feng, Qing Chang, Zicheng L. Simvastatin attenuates TNF‑α‑induced apoptosis in endothelial progenitor cells via the upregulation of SIRT1. International journal of molecular medicine. vol 34. issue 1. 2014-12-30. PMID:24718722. |
in conclusion, findings of this study showed that simvastatin is crucial in counteracting the tnf-α-induced apoptosis of epcs and that this protection may involve the actions of sirt1. |
2014-12-30 |
2023-08-13 |
Not clear |
| Xiao-Ming Zhou, Xin Zhang, Xiang-Sheng Zhang, Zong Zhuang, Wei Li, Qing Sun, Tao Li, Chun-Xi Wang, Lin Zhu, Ji-Xin Shi, Meng-Liang Zho. SIRT1 inhibition by sirtinol aggravates brain edema after experimental subarachnoid hemorrhage. Journal of neuroscience research. vol 92. issue 6. 2014-11-25. PMID:24482345. |
sirtinol treatment significantly lowered sirt1 expression, accompanied by deteriorated neurologic function, bbb disruption, brain edema, increased endothelial cell apoptosis, and increased mmp-9 gelatinase activity compared with the rats treated with vehicle only. |
2014-11-25 |
2023-08-12 |
rat |
| Ling Liu, Ping Wang, Xinwei Liu, Dongwei He, Canxin Liang, Ying Y. Exogenous NAD(+) supplementation protects H9c2 cardiac myoblasts against hypoxia/reoxygenation injury via Sirt1-p53 pathway. Fundamental & clinical pharmacology. vol 28. issue 2. 2014-10-27. PMID:23384296. |
nad(+) replenishment restored sirt1 activity, reduced the acetylation level of p53 (lys373 & 382), and attenuated cell apoptosis in hr-stressed h9c2 cells, whereas inhibition of sirt1 activity alleviated the effects of nad(+) replenishment. |
2014-10-27 |
2023-08-12 |
Not clear |
| Ling Liu, Ping Wang, Xinwei Liu, Dongwei He, Canxin Liang, Ying Y. Exogenous NAD(+) supplementation protects H9c2 cardiac myoblasts against hypoxia/reoxygenation injury via Sirt1-p53 pathway. Fundamental & clinical pharmacology. vol 28. issue 2. 2014-10-27. PMID:23384296. |
these results indicated that exogenous nad(+) supplementation attenuated hr-induced cell apoptosis, which was at least partly mediated by restoring sirt1 activity and subsequently inhibiting p53 activity via deacetylating p53 at lysine 373 and 382. |
2014-10-27 |
2023-08-12 |
Not clear |
| Chutima Kaewpiboon, Ratakorn Srisuttee, Waraporn Malilas, Jeong Moon, Sirichat Kaowinn, Il-Rae Cho, Randal N Johnston, Wanchai Assavalapsakul, Young-Hwa Chun. Extract of Bryophyllum laetivirens reverses etoposide resistance in human lung A549 cancer cells by downregulation of NF-κB. Oncology reports. vol 31. issue 1. 2014-09-05. PMID:24220725. |
during a search for anticancer drug candidates from medicinal plant sources, we found that an extract fraction (f14) of bryophyllum laetivirens leaves downregulated expression of nf-κb and sirt1, sensitizing the levels of a549rt-eto cells to apoptosis through downregulation of p-glycoprotein (p-gp), which is encoded by the mdr1 gene. |
2014-09-05 |
2023-08-12 |
human |