| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kaberi Chatterjee, Anubroto Pal, Dibya Sundar Padhy, Rajdeep Saha, Amrita Chatterjee, Monika Bharadwaj, Biswatrish Sarkar, Papiya Mitra Mazumder, Sugato Banerje. Vitamin K2 Ameliorates Diabetes-Associated Cognitive Decline by Reducing Oxidative Stress and Neuroinflammation. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 19. issue 1. 2024-10-28. PMID:39466454. |
then different behavioural studies, including the elevated plus maze, morris water maze, passive avoidance test and novel object recognition test were performed followed by biochemical tests including ache, different oxidative stress parameters (sod, gsh, mda, catalase, sirt1, nrf2), inflammatory markers (tnfα, il1β, mcp1, nfκb), apoptosis marker (caspase 3). |
2024-10-28 |
2024-10-31 |
mouse |
| Yunguang Wang, Xinxin He, Hua Zhang, Wei H. Germacrone ameliorates acute lung injury induced by intestinal ischemia-reperfusion by regulating macrophage M1 polarization and mitochondrial defects. Acta biochimica et biophysica Sinica. 2024-10-23. PMID:39439416. |
additionally, ger (ec50: 47.16 μm) ameliorates mitochondrial dysfunction by increasing i/r-ali-induced apoptosis, increasing the expression of sirt1, and reducing the levels of hif1-α, nrf2, and ogg1 in mle-12 cells. |
2024-10-23 |
2024-10-25 |
mouse |
| Yi-Cheng Tsai, Chih-Hui Chang, Yoon Bin Chong, Chieh-Hsin Wu, Hung-Pei Tsai, Tian-Lu Cheng, Chih-Lung Li. MicroRNA-195-5p Inhibits Intracerebral Hemorrhage-Induced Inflammatory Response and Neuron Cell Apoptosis. International journal of molecular sciences. vol 25. issue 19. 2024-10-16. PMID:39408651. |
the mir-195-5p treatment significantly improved neurological function; modulated macrophage polarization by promoting anti-inflammatory marker (cd206 and arg1) production and inhibiting pro-inflammatory marker (cd68 and inos) production; enhanced akt signalling, reduced oxidative stress by increasing sirt1 and nrf2 levels, and attenuated inflammation by decreasing nf-κb activation; inhibited apoptosis via increased bcl-2 and decreased cleaved caspase-3 levels; and regulated synaptic plasticity by modulating nmdar2a, nmdar2b, bdnf, and trkb expression and erk and creb phosphorylation. |
2024-10-16 |
2024-10-18 |
rat |
| Zhang Yaoting, Li Bing, Fu Yu, Cai He, Zheng Yan. Txnip promotes autophagic apoptosis in diabetic cardiomyopathy by upregulating FoxO1 and its acetylation. Cellular signalling. 2024-10-13. PMID:39396562. |
these findings revealed that txnip mediates autophagic apoptosis in dcm by upregulating foxo1 via ros and enhancing foxo1 acetylation through the suppression of sirt1 activity. |
2024-10-13 |
2024-10-16 |
mouse |
| Jie Qiao, Chang Cheng, Gongxu Yang, Chuanqi Zhong, Jun Jin, Bin W. Jiangu Recipe Suppresses ER Stress-Induced Apoptosis and Inhibits Extracellular Matrix Degradation in Chondrocytes through Upregulating SIRT1 Expression. Current pharmaceutical biotechnology. 2024-10-08. PMID:39377404. |
jiangu recipe suppresses er stress-induced apoptosis and inhibits extracellular matrix degradation in chondrocytes through upregulating sirt1 expression. |
2024-10-08 |
2024-10-10 |
Not clear |
| Xiaolei Zhang, Shizhen Wang, Yongting Qin, Hang Gu. Downregulation of microRNA‑221‑3p promotes angiogenesis of lipoprotein(a)‑injured endothelial progenitor cells by targeting silent information regulator 1 to activate the RAF/MEK/ERK signaling pathway. Molecular medicine reports. vol 30. issue 6. 2024-10-04. PMID:39364751. |
in conclusion, mir‑221‑3p inhibitor transfection activated the raf/mek/erk signaling pathway through sirt1, promoted the proliferation, migration, adhesion and angiogenesis of epcs, and reduced apoptosis. |
2024-10-04 |
2024-10-07 |
Not clear |
| Zhongqi Wu, Tianxin Lyu, Leizhen Wu, Hui Yang, Wenqiang L. The Role of SIRT1 in Leukemia. Current treatment options in oncology. 2024-10-02. PMID:39356446. |
recent studies have shown that silent information regulator 1 (sirt1) is involved in the proliferation, apoptosis, metabolism, and senescence of leukemia cells. |
2024-10-02 |
2024-10-04 |
Not clear |
| Samyah T Alanazi, Samir A Salama, Musaad M Althobaiti, Rana A Alotaibi, Ammar A AlAbdullatif, Arafa Musa, Gamaleldin I Haris. Alleviation of Copper-Induced Hepatotoxicity by Bergenin: Diminution of Oxidative Stress, Inflammation, and Apoptosis via Targeting SIRT1/FOXO3a/NF-κB Axes and p38 MAPK Signaling. Biological trace element research. 2024-09-30. PMID:39347884. |
collectively, these findings highlight the alleviating activity of bergenin against the copper-induced hepatotoxicity via controlling oxidative stress, inflammation, and apoptosis potentially through upregulation of sirt1, activation of foxo3a along with suppression of nf-κb and p38 mapk signaling. |
2024-09-30 |
2024-10-02 |
rat |
| Xiaoli Yang, Lixin Han, Di Zhang, Cuixiang Xu, Zhankui Jin, Yongmin Xion. Downregulated Expression and Hypermethylation of SIRT1 in Patients with Kashin-Beck Disease-Mediated Chondrocyte Apoptosis May Potentially Be Ameliorated by Selenium Supplement. Biological trace element research. 2024-09-23. PMID:39312125. |
downregulated expression and hypermethylation of sirt1 in patients with kashin-beck disease-mediated chondrocyte apoptosis may potentially be ameliorated by selenium supplement. |
2024-09-23 |
2024-09-26 |
Not clear |
| Xiaoli Yang, Lixin Han, Di Zhang, Cuixiang Xu, Zhankui Jin, Yongmin Xion. Downregulated Expression and Hypermethylation of SIRT1 in Patients with Kashin-Beck Disease-Mediated Chondrocyte Apoptosis May Potentially Be Ameliorated by Selenium Supplement. Biological trace element research. 2024-09-23. PMID:39312125. |
this study aims to elucidate the role of silent information regulator 2 homologue 1 (sirt1) in cartilage damage in kashin-beck disease (kbd) by exploring the correlation between sirt1 and kbd and the potential effect of sirt1 expression and methylation on chondrocyte apoptosis. |
2024-09-23 |
2024-09-26 |
Not clear |
| Xiaoli Yang, Lixin Han, Di Zhang, Cuixiang Xu, Zhankui Jin, Yongmin Xion. Downregulated Expression and Hypermethylation of SIRT1 in Patients with Kashin-Beck Disease-Mediated Chondrocyte Apoptosis May Potentially Be Ameliorated by Selenium Supplement. Biological trace element research. 2024-09-23. PMID:39312125. |
furthermore, apoptosis rates, dnmt1 mrna level, and sirt1 methylation level were increased in chondrocytes treated with se deficiency and t-2 toxin, but sirt1 mrna level was downregulated, whereas the opposite trend was observed in chondrocytes treated with se supplement. |
2024-09-23 |
2024-09-26 |
Not clear |
| Xiaoli Yang, Lixin Han, Di Zhang, Cuixiang Xu, Zhankui Jin, Yongmin Xion. Downregulated Expression and Hypermethylation of SIRT1 in Patients with Kashin-Beck Disease-Mediated Chondrocyte Apoptosis May Potentially Be Ameliorated by Selenium Supplement. Biological trace element research. 2024-09-23. PMID:39312125. |
low sirt1 expression and cpg hypermethylation in kbd patients are associated with increased disease risk, which mediated chondrocyte apoptosis can be ameliorated by se supplement. |
2024-09-23 |
2024-09-26 |
Not clear |
| Zhihang Zhang, Yalan Luo, Xijing Zhuang, Haifeng Gao, Qi Yang, Hailong Che. Emodin alleviates lung injury via the miR-217-5p/Sirt1 axis in rats with severe acute pancreatitis. Journal of pharmacological sciences. vol 156. issue 3. 2024-09-23. PMID:39313277. |
in conclusion, mir-217-5p inhibition exerts protective effects on sap-ali in vitro and in vivo by repressing apoptosis, inflammation, and oxidative stress through sirt1 activation. |
2024-09-23 |
2024-09-26 |
rat |
| Papitcha Jongwachirachai, Waralee Ruankham, Setthawut Apiraksattayakul, Saruta Intharakham, Veda Prachayasittikul, Wilasinee Suwanjang, Virapong Prachayasittikul, Supaluk Prachayasittikul, Kamonrat Phopi. Neuroprotective Properties of Coriander-Derived Compounds on Neuronal Cell Damage under Oxidative Stress-Induced SH-SY5Y Neuroblastoma and in Silico ADMET Analysis. Neurochemical research. 2024-09-19. PMID:39298035. |
the results showed that linalool, linalyl acetate, and geranyl acetate elicited their neuroprotection against oxidative stress via protecting cell death, reducing ros production, preventing cell apoptosis, and modulating sirt1 longevity. |
2024-09-19 |
2024-09-22 |
Not clear |
| Xiang Qin, Xi Chen, Fan Wang, Fangfang Zhong, Yan Zeng, Wenjun Li. Huaier inhibits autophagy and promotes apoptosis in T-cell acute lymphoblastic leukemia by down-regulating SIRT1. Heliyon. vol 10. issue 17. 2024-09-17. PMID:39286166. |
huaier inhibits autophagy and promotes apoptosis in t-cell acute lymphoblastic leukemia by down-regulating sirt1. |
2024-09-17 |
2024-09-19 |
Not clear |
| Suleiman Ibrahim Shelash Mohammad, Asokan Vasudevan, Felix Oghenemaro Enwa, Jaya Bansal, Mamata Chahar, Mamdouh Eldesoqui, Muhammad Ikram Ullah, Zhanna R Gardanova, Hanen Mahmod Hulail, Ahmed Hussein Zwame. The Sirt1/Nrf2 pathway is a key factor for drug therapy in chemotherapy-induced cardiotoxicity: a Mini-Review. Medical oncology (Northwood, London, England). vol 41. issue 10. 2024-09-11. PMID:39259412. |
reports suggest that the sirtuin-1 (sirt1)/nuclear factor e2-associated factor 2 (nrf2) signaling pathway has been considered an alternative path for counteracting cardiotoxicity by suppressing oxidative stress, inflammation, and apoptosis. |
2024-09-11 |
2024-09-13 |
Not clear |
| Mengru Ma, Lian Yi, Yifei Pei, Qimin Zhang, Chao Tong, Manyu Zhao, Yuanhong Chen, Jinghan Zhu, Wanguang Zhang, Fan Yao, Pengyuan Yang, Peijing Zhan. USP26 as a hepatitis B virus-induced deubiquitinase primes hepatocellular carcinogenesis by epigenetic remodeling. Nature communications. vol 15. issue 1. 2024-09-09. PMID:39251623. |
hbx consequently promotes the association of usp26 with sirt1 to synergistically stabilize sirt1 by deubiquitination, which promotes cell proliferation and impedes cell apoptosis to accelerate hcc tumorigenesis. |
2024-09-09 |
2024-09-13 |
human |
| Yaping Zhao, Li Wang, Yu Huang, Paul C Evans, Peter J Little, Xiaoyu Tian, Jianping Weng, Suowen X. Anthocyanins in Vascular Health and Disease: Mechanisms of Action and Therapeutic Potential. Journal of cardiovascular pharmacology. vol 84. issue 3. 2024-09-06. PMID:39240726. |
at the cellular and molecular level, anthocyanins and their metabolites could protect endothelial cells from senescence, apoptosis, and inflammation by activating the phosphoinositide 3-kinase/protein kinase b/endothelial nitric oxide synthases, silent information regulator 1 (sirt1), or nuclear factor erythroid2-related factor 2 pathways and inhibiting the nuclear factor kappa b, bax, or p38 mitogen-activated protein kinase pathways. |
2024-09-06 |
2024-09-09 |
Not clear |
| Jiawei Chen, Kebin Chen, Shuai Zhang, Xiaopeng Huan. SIRT1 silencing ameliorates malignancy of non-small cell lung cancer via activating FOXO1. Scientific reports. vol 14. issue 1. 2024-08-29. PMID:39198693. |
the depletion of sirt1 retarded the capabilities of proliferation, migration and invasion, while enhancing apoptosis in nsclc cells. |
2024-08-29 |
2024-09-01 |
human |
| Swapnil Tripathi, Dharati Parmar, Samir Raval, Rajeev Mishra, Gyanendra Sing. Attenuation of chromium (VI) and arsenic (III)-induced oxidative stress and hepatic apoptosis by phloretin, biochanin-A, and coenzyme Q10 via activation of SIRT1/Nrf2/HO-1/NQO1 signaling. Journal of biochemical and molecular toxicology. vol 38. issue 9. 2024-08-23. PMID:39177155. |
importantly, the treatment with nutraceuticals not only restored the antioxidant activity but also favorably altered the expressions of sirt1, nrf2, ho-1, and nqo1 signaling and apoptosis markers. |
2024-08-23 |
2024-08-25 |
mouse |