| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Undurti N Da. A defect in the activity of Delta6 and Delta5 desaturases may be a factor predisposing to the development of insulin resistance syndrome. Prostaglandins, leukotrienes, and essential fatty acids. vol 72. issue 5. 2005-09-27. PMID:15850715. |
sirt1 sequesters the proapoptotic factor bax, prevents stress-induced apoptosis of cells, and thus, prolongs survival. |
2005-09-27 |
2023-08-12 |
human |
| Gil Blander, Jerzy Olejnik, Edyta Krzymanska-Olejnik, Thomas McDonagh, Marcia Haigis, Michael B Yaffe, Leonard Guarent. SIRT1 shows no substrate specificity in vitro. The Journal of biological chemistry. vol 280. issue 11. 2005-04-25. PMID:15640142. |
the human ortholog sirt1 plays a pivotal role in the regulation of cellular differentiation, metabolism, cell cycle, and apoptosis. |
2005-04-25 |
2023-08-12 |
human |
| Maria E Giannakou, Linda Partridg. The interaction between FOXO and SIRT1: tipping the balance towards survival. Trends in cell biology. vol 14. issue 8. 2005-01-25. PMID:15308206. |
mammalian sirt1 deacetylates foxo3 and/or foxo4, thus attenuating foxo-induced apoptosis and potentiating foxo-induced cell-cycle arrest. |
2005-01-25 |
2023-08-12 |
caenorhabditis_elegans |
| Fan Yeung, Jamie E Hoberg, Catherine S Ramsey, Michael D Keller, David R Jones, Roy A Frye, Marty W May. Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. The EMBO journal. vol 23. issue 12. 2004-09-21. PMID:15152190. |
treatment of cells with resveratrol, a small-molecule agonist of sirtuin activity, potentiates chromatin-associated sirt1 protein on the ciap-2 promoter region, an effect that correlates with a loss of nf-kappab-regulated gene expression and sensitization of cells to tnfalpha-induced apoptosis. |
2004-09-21 |
2023-08-12 |
Not clear |
| Fan Yeung, Jamie E Hoberg, Catherine S Ramsey, Michael D Keller, David R Jones, Roy A Frye, Marty W May. Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. The EMBO journal. vol 23. issue 12. 2004-09-21. PMID:15152190. |
while sirt1 is capable of protecting cells from p53-induced apoptosis, our work provides evidence that sirt1 activity augments apoptosis in response to tnfalpha by the ability of the deacetylase to inhibit the transactivation potential of the rela/p65 protein. |
2004-09-21 |
2023-08-12 |
Not clear |
| Maria Carla Motta, Nullin Divecha, Madeleine Lemieux, Christopher Kamel, Delin Chen, Wei Gu, Yvette Bultsma, Michael McBurney, Leonard Guarent. Mammalian SIRT1 represses forkhead transcription factors. Cell. vol 116. issue 4. 2004-04-15. PMID:14980222. |
by restraining mammalian forkhead proteins, sirt1 also reduces forkhead-dependent apoptosis. |
2004-04-15 |
2023-08-12 |
caenorhabditis_elegans |
| Jun Sakamoto, Tetsuji Miura, Kazuaki Shimamoto, Yoshiyuki Hori. Predominant expression of Sir2alpha, an NAD-dependent histone deacetylase, in the embryonic mouse heart and brain. FEBS letters. vol 556. issue 1-3. 2004-03-08. PMID:14706864. |
the mammalian homolog sir2alpha (sirt1) has been shown to inhibit p53-dependent apoptosis, but its physiological roles are still not known. |
2004-03-08 |
2023-08-12 |
mouse |
| Hwei-Ling Cheng, Raul Mostoslavsky, Shin'ichi Saito, John P Manis, Yansong Gu, Parin Patel, Roderick Bronson, Ettore Appella, Frederick W Alt, Katrin F Chu. Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 19. 2003-10-29. PMID:12960381. |
together, our observations provide direct evidence that endogenous sirt1 protein regulates p53 acetylation and p53-dependent apoptosis, and show that the function of this enzyme is required for specific developmental processes. |
2003-10-29 |
2023-08-12 |
mouse |
| Jeffrey Smit. Human Sir2 and the 'silencing' of p53 activity. Trends in cell biology. vol 12. issue 9. 2003-02-21. PMID:12220851. |
importantly, p53 deacetylation by sirt1 also prevents cellular senescence and apoptosis induced by dna damage and stress. |
2003-02-21 |
2023-08-12 |
human |
| Kevin J Bitterman, Rozalyn M Anderson, Haim Y Cohen, Magda Latorre-Esteves, David A Sinclai. Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1. The Journal of biological chemistry. vol 277. issue 47. 2003-01-07. PMID:12297502. |
a human homologue of sir2, sirt1, regulates the activity of the p53 tumor suppressor and inhibits apoptosis. |
2003-01-07 |
2023-08-12 |
human |