| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hai Bo Li, Xin Yi, Jian Mei Gao, Xi Xiang Ying, Hong Quan Guan, Jian Chun L. The mechanism of hyperoside protection of ECV-304 cells against tert-butyl hydroperoxide-induced injury. Pharmacology. vol 82. issue 2. 2008-10-23. PMID:18552516. |
the mechanism of hyperoside protecting against ecv-304 cell apoptosis by tbhp is related with resuming mitochondrial function and regulating the expression of sirt1 and bcl-2 family members. |
2008-10-23 |
2023-08-12 |
Not clear |
| Munekazu Yamakuchi, Marcella Ferlito, Charles J Lowenstei. miR-34a repression of SIRT1 regulates apoptosis. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 36. 2008-09-30. PMID:18755897. |
mir-34a repression of sirt1 regulates apoptosis. |
2008-09-30 |
2023-08-12 |
human |
| Munekazu Yamakuchi, Marcella Ferlito, Charles J Lowenstei. miR-34a repression of SIRT1 regulates apoptosis. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 36. 2008-09-30. PMID:18755897. |
mir-34 inhibition of sirt1 leads to an increase in acetylated p53 and expression of p21 and puma, transcriptional targets of p53 that regulate the cell cycle and apoptosis, respectively. |
2008-09-30 |
2023-08-12 |
human |
| Munekazu Yamakuchi, Marcella Ferlito, Charles J Lowenstei. miR-34a repression of SIRT1 regulates apoptosis. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 36. 2008-09-30. PMID:18755897. |
furthermore, mir-34 suppression of sirt1 ultimately leads to apoptosis in wt human colon cancer cells but not in human colon cancer cells lacking p53. |
2008-09-30 |
2023-08-12 |
human |
| Koichi Hasegawa, Kazuaki Yoshikaw. Necdin regulates p53 acetylation via Sirtuin1 to modulate DNA damage response in cortical neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 35. 2008-09-18. PMID:18753379. |
here we report that necdin regulates the acetylation status of p53 via sirt1 to suppress p53-dependent apoptosis in postmitotic neurons. |
2008-09-18 |
2023-08-12 |
mouse |
| Koichi Hasegawa, Kazuaki Yoshikaw. Necdin regulates p53 acetylation via Sirtuin1 to modulate DNA damage response in cortical neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 35. 2008-09-18. PMID:18753379. |
however, sirt1 knockdown increases both acetylated p53 level and apoptosis in wild-type neurons but fails to affect them in paternal ndn-deficient neurons. |
2008-09-18 |
2023-08-12 |
mouse |
| Koichi Hasegawa, Kazuaki Yoshikaw. Necdin regulates p53 acetylation via Sirtuin1 to modulate DNA damage response in cortical neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 35. 2008-09-18. PMID:18753379. |
these results suggest that necdin downregulates p53 acetylation levels by forming a stable complex with p53 and sirt1 to protect neurons from dna damage-induced apoptosis. |
2008-09-18 |
2023-08-12 |
mouse |
| Myung-Kwan Han, Eun-Kyung Song, Ying Guo, Xuan Ou, Charlie Mantel, Hal E Broxmeye. SIRT1 regulates apoptosis and Nanog expression in mouse embryonic stem cells by controlling p53 subcellular localization. Cell stem cell. vol 2. issue 3. 2008-07-01. PMID:18371449. |
sirt1 regulates apoptosis and nanog expression in mouse embryonic stem cells by controlling p53 subcellular localization. |
2008-07-01 |
2023-08-12 |
mouse |
| Myung-Kwan Han, Eun-Kyung Song, Ying Guo, Xuan Ou, Charlie Mantel, Hal E Broxmeye. SIRT1 regulates apoptosis and Nanog expression in mouse embryonic stem cells by controlling p53 subcellular localization. Cell stem cell. vol 2. issue 3. 2008-07-01. PMID:18371449. |
here we show that sirt1 blocks nuclear translocation of cytoplasmic p53 in response to endogenous reactive oxygen species (ros) and triggers mitochondrial-dependent apoptosis in mouse embryonic stem (mes) cells. |
2008-07-01 |
2023-08-12 |
mouse |
| Myung-Kwan Han, Eun-Kyung Song, Ying Guo, Xuan Ou, Charlie Mantel, Hal E Broxmeye. SIRT1 regulates apoptosis and Nanog expression in mouse embryonic stem cells by controlling p53 subcellular localization. Cell stem cell. vol 2. issue 3. 2008-07-01. PMID:18371449. |
endogenous ros triggered apoptosis of wild-type mes through mitochondrial translocation of p53 and bax but inhibited nanog expression of sirt1(-/-) mes, indicating that sirt1 makes mes cells sensitive to ros and inhibits p53-mediated suppression of nanog expression. |
2008-07-01 |
2023-08-12 |
mouse |
| Kazuhiro Hasegawa, Shu Wakino, Kyoko Yoshioka, Satoru Tatematsu, Yoshikazu Hara, Hitoshi Minakuchi, Naoki Washida, Hirobumi Tokuyama, Koichi Hayashi, Hiroshi Ito. Sirt1 protects against oxidative stress-induced renal tubular cell apoptosis by the bidirectional regulation of catalase expression. Biochemical and biophysical research communications. vol 372. issue 1. 2008-06-20. PMID:18485895. |
sirt1 protects against oxidative stress-induced renal tubular cell apoptosis by the bidirectional regulation of catalase expression. |
2008-06-20 |
2023-08-12 |
Not clear |
| Kazuhiro Hasegawa, Shu Wakino, Kyoko Yoshioka, Satoru Tatematsu, Yoshikazu Hara, Hitoshi Minakuchi, Naoki Washida, Hirobumi Tokuyama, Koichi Hayashi, Hiroshi Ito. Sirt1 protects against oxidative stress-induced renal tubular cell apoptosis by the bidirectional regulation of catalase expression. Biochemical and biophysical research communications. vol 372. issue 1. 2008-06-20. PMID:18485895. |
nad(+)-dependent protein deacetylase sirt1 regulates cellular apoptosis. |
2008-06-20 |
2023-08-12 |
Not clear |
| Kazuhiro Hasegawa, Shu Wakino, Kyoko Yoshioka, Satoru Tatematsu, Yoshikazu Hara, Hitoshi Minakuchi, Naoki Washida, Hirobumi Tokuyama, Koichi Hayashi, Hiroshi Ito. Sirt1 protects against oxidative stress-induced renal tubular cell apoptosis by the bidirectional regulation of catalase expression. Biochemical and biophysical research communications. vol 372. issue 1. 2008-06-20. PMID:18485895. |
we examined the role of sirt1 in renal tubular cell apoptosis by using hk-2 cells, proximal tubular cell lines with or without reactive oxygen species (ros), h(2)o(2). |
2008-06-20 |
2023-08-12 |
Not clear |
| Kazuhiro Hasegawa, Shu Wakino, Kyoko Yoshioka, Satoru Tatematsu, Yoshikazu Hara, Hitoshi Minakuchi, Naoki Washida, Hirobumi Tokuyama, Koichi Hayashi, Hiroshi Ito. Sirt1 protects against oxidative stress-induced renal tubular cell apoptosis by the bidirectional regulation of catalase expression. Biochemical and biophysical research communications. vol 372. issue 1. 2008-06-20. PMID:18485895. |
without any ros, sirt1 inhibitors enhanced apoptosis and the expression of ros scavenger, catalase, and sirt1 overexpression downregulated catalase. |
2008-06-20 |
2023-08-12 |
Not clear |
| Kazuhiro Hasegawa, Shu Wakino, Kyoko Yoshioka, Satoru Tatematsu, Yoshikazu Hara, Hitoshi Minakuchi, Naoki Washida, Hirobumi Tokuyama, Koichi Hayashi, Hiroshi Ito. Sirt1 protects against oxidative stress-induced renal tubular cell apoptosis by the bidirectional regulation of catalase expression. Biochemical and biophysical research communications. vol 372. issue 1. 2008-06-20. PMID:18485895. |
when apoptosis was induced with h(2)o(2), sirt1 was upregulated with the concomitant increase in catalase expression. |
2008-06-20 |
2023-08-12 |
Not clear |
| Kazuhiro Hasegawa, Shu Wakino, Kyoko Yoshioka, Satoru Tatematsu, Yoshikazu Hara, Hitoshi Minakuchi, Naoki Washida, Hirobumi Tokuyama, Koichi Hayashi, Hiroshi Ito. Sirt1 protects against oxidative stress-induced renal tubular cell apoptosis by the bidirectional regulation of catalase expression. Biochemical and biophysical research communications. vol 372. issue 1. 2008-06-20. PMID:18485895. |
sirt1 overexpression rescued h(2)o(2)-induced apoptosis through the upregulation of catalase. |
2008-06-20 |
2023-08-12 |
Not clear |
| Kazuhiro Hasegawa, Shu Wakino, Kyoko Yoshioka, Satoru Tatematsu, Yoshikazu Hara, Hitoshi Minakuchi, Naoki Washida, Hirobumi Tokuyama, Koichi Hayashi, Hiroshi Ito. Sirt1 protects against oxidative stress-induced renal tubular cell apoptosis by the bidirectional regulation of catalase expression. Biochemical and biophysical research communications. vol 372. issue 1. 2008-06-20. PMID:18485895. |
in contrast, excess ros upregulates sirt1, which activates foxo3a and catalase leading to rescuing apoptosis. |
2008-06-20 |
2023-08-12 |
Not clear |
| Kazuhiro Hasegawa, Shu Wakino, Kyoko Yoshioka, Satoru Tatematsu, Yoshikazu Hara, Hitoshi Minakuchi, Naoki Washida, Hirobumi Tokuyama, Koichi Hayashi, Hiroshi Ito. Sirt1 protects against oxidative stress-induced renal tubular cell apoptosis by the bidirectional regulation of catalase expression. Biochemical and biophysical research communications. vol 372. issue 1. 2008-06-20. PMID:18485895. |
thus, sirt1 constitutes a determinant of renal tubular cell apoptosis by regulating cellular ros levels. |
2008-06-20 |
2023-08-12 |
Not clear |
| Yuning Sun, Daochun Sun, Fang Li, Linlin Tian, Chunrong Li, Lu Li, Ruxian Lin, Shengqi Wan. Downregulation of Sirt1 by antisense oligonucleotides induces apoptosis and enhances radiation sensitization in A549 lung cancer cells. Lung cancer (Amsterdam, Netherlands). vol 58. issue 1. 2008-04-11. PMID:17624472. |
downregulation of sirt1 by antisense oligonucleotides induces apoptosis and enhances radiation sensitization in a549 lung cancer cells. |
2008-04-11 |
2023-08-12 |
human |
| Yuning Sun, Daochun Sun, Fang Li, Linlin Tian, Chunrong Li, Lu Li, Ruxian Lin, Shengqi Wan. Downregulation of Sirt1 by antisense oligonucleotides induces apoptosis and enhances radiation sensitization in A549 lung cancer cells. Lung cancer (Amsterdam, Netherlands). vol 58. issue 1. 2008-04-11. PMID:17624472. |
the purpose of this study was to determine whether inhibition of sirt1 by using antisense oligonucleotides (asodn) induces apoptosis and enhances radiation sensitization in a549 lung cancer cells. |
2008-04-11 |
2023-08-12 |
human |