| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ralph R Alcendor, Shumin Gao, Peiyong Zhai, Daniela Zablocki, Eric Holle, Xianzhong Yu, Bin Tian, Thomas Wagner, Stephen F Vatner, Junichi Sadoshim. Sirt1 regulates aging and resistance to oxidative stress in the heart. Circulation research. vol 100. issue 10. 2007-06-07. PMID:17446436. |
in contrast, a high level (12.5-fold) of sirt1 increased apoptosis and hypertrophy and decreased cardiac function, thereby stimulating the development of cardiomyopathy. |
2007-06-07 |
2023-08-12 |
mouse |
| Ralph R Alcendor, Shumin Gao, Peiyong Zhai, Daniela Zablocki, Eric Holle, Xianzhong Yu, Bin Tian, Thomas Wagner, Stephen F Vatner, Junichi Sadoshim. Sirt1 regulates aging and resistance to oxidative stress in the heart. Circulation research. vol 100. issue 10. 2007-06-07. PMID:17446436. |
furthermore, although high levels of sirt1 increase oxidative stress, moderate expression of sirt1 induces resistance to oxidative stress and apoptosis. |
2007-06-07 |
2023-08-12 |
mouse |
| Shinji Kume, Masakazu Haneda, Keizo Kanasaki, Toshiro Sugimoto, Shin-ichi Araki, Keiji Isshiki, Motohide Isono, Takashi Uzu, Leonard Guarente, Atsunori Kashiwagi, Daisuke Koy. SIRT1 inhibits transforming growth factor beta-induced apoptosis in glomerular mesangial cells via Smad7 deacetylation. The Journal of biological chemistry. vol 282. issue 1. 2007-02-08. PMID:17098745. |
sirt1 inhibits transforming growth factor beta-induced apoptosis in glomerular mesangial cells via smad7 deacetylation. |
2007-02-08 |
2023-08-12 |
Not clear |
| Shinji Kume, Masakazu Haneda, Keizo Kanasaki, Toshiro Sugimoto, Shin-ichi Araki, Keiji Isshiki, Motohide Isono, Takashi Uzu, Leonard Guarente, Atsunori Kashiwagi, Daisuke Koy. SIRT1 inhibits transforming growth factor beta-induced apoptosis in glomerular mesangial cells via Smad7 deacetylation. The Journal of biological chemistry. vol 282. issue 1. 2007-02-08. PMID:17098745. |
sirt1, a class iii histone deacetylase, is considered a key regulator of cell survival and apoptosis through its interaction with nuclear proteins. |
2007-02-08 |
2023-08-12 |
Not clear |
| Shinji Kume, Masakazu Haneda, Keizo Kanasaki, Toshiro Sugimoto, Shin-ichi Araki, Keiji Isshiki, Motohide Isono, Takashi Uzu, Leonard Guarente, Atsunori Kashiwagi, Daisuke Koy. SIRT1 inhibits transforming growth factor beta-induced apoptosis in glomerular mesangial cells via Smad7 deacetylation. The Journal of biological chemistry. vol 282. issue 1. 2007-02-08. PMID:17098745. |
in this study, we have examined the likelihood and role of the interaction between sirt1 and smad7, which mediates transforming growth factor beta (tgfbeta)-induced apoptosis in renal glomerular mesangial cells. |
2007-02-08 |
2023-08-12 |
Not clear |
| Shinji Kume, Masakazu Haneda, Keizo Kanasaki, Toshiro Sugimoto, Shin-ichi Araki, Keiji Isshiki, Motohide Isono, Takashi Uzu, Leonard Guarente, Atsunori Kashiwagi, Daisuke Koy. SIRT1 inhibits transforming growth factor beta-induced apoptosis in glomerular mesangial cells via Smad7 deacetylation. The Journal of biological chemistry. vol 282. issue 1. 2007-02-08. PMID:17098745. |
finally, sirt1 overexpression attenuated both smad7- and tgfbeta-induced mesangial cell apoptosis, whereas sirt1 knockdown enhanced this apoptosis. |
2007-02-08 |
2023-08-12 |
Not clear |
| Shinji Kume, Masakazu Haneda, Keizo Kanasaki, Toshiro Sugimoto, Shin-ichi Araki, Keiji Isshiki, Motohide Isono, Takashi Uzu, Leonard Guarente, Atsunori Kashiwagi, Daisuke Koy. SIRT1 inhibits transforming growth factor beta-induced apoptosis in glomerular mesangial cells via Smad7 deacetylation. The Journal of biological chemistry. vol 282. issue 1. 2007-02-08. PMID:17098745. |
we have concluded that smad7 is a new target molecule for sirt1 and sirt1 attenuates tgfbeta-induced mesangial cell apoptosis through acceleration of smad7 degradation. |
2007-02-08 |
2023-08-12 |
Not clear |
| Jin Ming Dai, Zhi Yan Wang, Dao Chun Sun, Ru Xian Lin, Sheng Qi Wan. SIRT1 interacts with p73 and suppresses p73-dependent transcriptional activity. Journal of cellular physiology. vol 210. issue 1. 2007-02-02. PMID:16998810. |
sirt1 in human cells reduces the transcriptional activity of p73, and partly inhibits apoptosis induced by p73. |
2007-02-02 |
2023-08-12 |
human |
| Chuangui Wang, Lihong Chen, Xinghua Hou, Zhenyu Li, Neha Kabra, Yihong Ma, Shino Nemoto, Toren Finkel, Wei Gu, W Douglas Cress, Jiandong Che. Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage. Nature cell biology. vol 8. issue 9. 2006-10-18. PMID:16892051. |
this report shows that the cell-cycle and apoptosis regulator e2f1 induces sirt1 expression at the transcriptional level. |
2006-10-18 |
2023-08-12 |
Not clear |
| Shinji Kume, Masakazu Haneda, Keizo Kanasaki, Toshiro Sugimoto, Shin-ichi Araki, Motohide Isono, Keiji Isshiki, Takashi Uzu, Atsunori Kashiwagi, Daisuke Koy. Silent information regulator 2 (SIRT1) attenuates oxidative stress-induced mesangial cell apoptosis via p53 deacetylation. Free radical biology & medicine. vol 40. issue 12. 2006-08-30. PMID:16785031. |
silent information regulator 2 (sirt1) attenuates oxidative stress-induced mesangial cell apoptosis via p53 deacetylation. |
2006-08-30 |
2023-08-12 |
Not clear |
| Shinji Kume, Masakazu Haneda, Keizo Kanasaki, Toshiro Sugimoto, Shin-ichi Araki, Motohide Isono, Keiji Isshiki, Takashi Uzu, Atsunori Kashiwagi, Daisuke Koy. Silent information regulator 2 (SIRT1) attenuates oxidative stress-induced mesangial cell apoptosis via p53 deacetylation. Free radical biology & medicine. vol 40. issue 12. 2006-08-30. PMID:16785031. |
in this study, we evaluated whether mammalian silent information regulator 2 (sirt1), which has been recently identified as a cell survival factor countering various stressors, is a key regulator of oxidative stress-induced mesangial cell apoptosis. |
2006-08-30 |
2023-08-12 |
Not clear |
| Shinji Kume, Masakazu Haneda, Keizo Kanasaki, Toshiro Sugimoto, Shin-ichi Araki, Motohide Isono, Keiji Isshiki, Takashi Uzu, Atsunori Kashiwagi, Daisuke Koy. Silent information regulator 2 (SIRT1) attenuates oxidative stress-induced mesangial cell apoptosis via p53 deacetylation. Free radical biology & medicine. vol 40. issue 12. 2006-08-30. PMID:16785031. |
our results indicate that sirt1 can prevent oxidative stress-induced apoptosis through p53 deacetylation in mesangial cells. |
2006-08-30 |
2023-08-12 |
Not clear |
| Ullas Kolthur-Seetharam, Françoise Dantzer, Michael W McBurney, Gilbert de Murcia, Paolo Sassone-Cors. Control of AIF-mediated cell death by the functional interplay of SIRT1 and PARP-1 in response to DNA damage. Cell cycle (Georgetown, Tex.). vol 5. issue 8. 2006-08-09. PMID:16628003. |
the unbalanced regulation of parp-1 in the absence of sirt1 results in aif (apoptosis inducing factor)-mediated cell death. |
2006-08-09 |
2023-08-12 |
Not clear |
| Andrew J Olaharski, Jasper Rine, Brett L Marshall, Joshua Babiarz, Luoping Zhang, Eric Verdin, Martyn T Smit. The flavoring agent dihydrocoumarin reverses epigenetic silencing and inhibits sirtuin deacetylases. PLoS genetics. vol 1. issue 6. 2006-07-31. PMID:16362078. |
thus, dhc inhibits both yeast sir2p and human sirt1 deacetylases and increases p53 acetylation and apoptosis, a phenotype associated with senescence and aging. |
2006-07-31 |
2023-08-12 |
human |
| Christopher Kamel, Meena Abrol, Karen Jardine, Xiaohong He, Michael W McBurne. SirT1 fails to affect p53-mediated biological functions. Aging cell. vol 5. issue 1. 2006-04-18. PMID:16441846. |
upon re-examination of the role of sirt1 in modulating p53 activity, we found that while sirt1 interacts with p53, the sirt1 protein had little effect on p53-dependent transcription of transfected or endogenous genes and did not affect the sensitivity of thymocytes and splenocytes to radiation-induced apoptosis. |
2006-04-18 |
2023-08-12 |
mouse |
| Jack Ford, Ming Jiang, Jo Milne. Cancer-specific functions of SIRT1 enable human epithelial cancer cell growth and survival. Cancer research. vol 65. issue 22. 2006-01-18. PMID:16288037. |
in mammalian cells, sirt1 also down-regulates stress-induced p53 and foxo pathways for apoptosis, thus favoring survival under stress. |
2006-01-18 |
2023-08-12 |
human |
| Jack Ford, Ming Jiang, Jo Milne. Cancer-specific functions of SIRT1 enable human epithelial cancer cell growth and survival. Cancer research. vol 65. issue 22. 2006-01-18. PMID:16288037. |
we also show that, in the absence of applied stress, sirt1 silencing induces growth arrest and/or apoptosis in human epithelial cancer cells. |
2006-01-18 |
2023-08-12 |
human |
| Jack Ford, Ming Jiang, Jo Milne. Cancer-specific functions of SIRT1 enable human epithelial cancer cell growth and survival. Cancer research. vol 65. issue 22. 2006-01-18. PMID:16288037. |
alternatively, sirt1 may suppress apoptosis downstream from these apoptotic factors. |
2006-01-18 |
2023-08-12 |
human |
| Wen Yong Chen, David H Wang, Raywhay Chiu Yen, Jianyuan Luo, Wei Gu, Stephen B Bayli. Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses. Cell. vol 123. issue 3. 2005-12-20. PMID:16269335. |
inactivation of hic1 results in upregulated sirt1 expression in normal or cancer cells; this deacetylates and inactivates p53, allowing cells to bypass apoptosis and survive dna damage. |
2005-12-20 |
2023-08-12 |
mouse |
| Wen Yong Chen, David H Wang, Raywhay Chiu Yen, Jianyuan Luo, Wei Gu, Stephen B Bayli. Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses. Cell. vol 123. issue 3. 2005-12-20. PMID:16269335. |
inhibition of sirt1 function in cells without hic1 abolishes the resistance to apoptosis. |
2005-12-20 |
2023-08-12 |
mouse |